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The map label for this gene is acsA [H]

Identifier: 225853255

GI number: 225853255

Start: 1758725

End: 1760680

Strand: Direct

Name: acsA [H]

Synonym: BMEA_A1861

Alternate gene names: 225853255

Gene position: 1758725-1760680 (Clockwise)

Preceding gene: 225853252

Following gene: 225853257

Centisome position: 82.74

GC content: 59.2

Gene sequence:

>1956_bases
ATGTCGGAAAAGCTTTACCCCGTGCTGCCGGAGGCAAAGAAAAACACGCTCATCGACAACGAGACTTATCTCGAATGGTA
TGAGGAGAGCGTGAGCGACCCGGATGGCTTCTGGGCCAAGCACGGCCGGCGTATCGACTGGTTCAAGCCTTTCACCAAGG
TCAAGAACACCGATTTCAACGGCGATGTAACGATCAAGTGGTATGAGGATGGCGTCACCAACGTCTCATATAATTGCATC
GACCGCCATCTGAAGAGCCGCGGCGACAAGGTCGCCATCATCTGGGAAGGCGACAACCCCTATATCGACAAGAAGATCAC
CTATCGCGAGCTTTACGAGAATGTCTGCCGCATGGCGAATGTGCTCAAGAAGCATGGGGTGAAGAAGGGCGACCGCGTCA
CGATCTATCTGCCGATGATCCCGGAAGCCGCCTATGCCATGCTCGCCTGCGCGCGCATCGGCGCCGTGCATTCGGTCGTC
TTTGCCGGTTTCTCGCCGGAGGCGCTCGCTGGCCGCATCGTTGACTGCGAATCCACTTTCGTCATCACCGCCGATGAAGG
TGTGCGCGGCGGCAAGCCTGTTGCGCTGAAGGAAAACACCGATACCGCCATCGACATCGCCGCCAAGCAATATGTGATGG
TCAACAAGGTGCTGGTCGTGCGCCGCACCGGCGGCAAGGTAAGCTGGGGCCGCGGCCGCGATCTGTGGTACCATCAGGAA
GTCGCAAGCGTCGAACCGCATTGCGAACCGGAACCGATGAATGCGGAAGACCCGCTTTTCATTCTCTACACATCCGGTTC
CACCGGCAAGCCGAAGGGTGTGCTGCATACCACCGGCGGCTACCTCGTCTATGCCTCGATGACGCATCAATATGTCTTCG
ATTACCATGATGGCGAGATCTACTGGTGCACGGCGGATGTGGGTTGGGTAACGGGCCACTCCTATATCGTCTACGGACCG
CTGGCCAATGGCGCGACAACGCTGATGTTTGAAGGCGTGCCCAACTTCCCCGATCAGGGCCGTTTCTGGGAAGTCGTCGA
CAAGCACCATGTCAATATCTTCTACACCGCGCCAACCGCGCTGCGCGCGCTTATGGGCGCGGGCGATGAATTCGTAACCC
GCTCATCGCGTTCGACGCTGCGCCTGCTGGGCTCGGTCGGCGAGCCGATCAATCCAGAGGCCTGGGAGTGGTATTACAAT
GTCGTGGGCGACCAGAAATGCCCCATCGTCGATACCTGGTGGCAGACGGAAAATGGCGGCATCCTCATCACCCCACTTCC
CGGCGCGACCGATTTGAAACCCGGTTCGGCAACACGCCCGTTCTTCGGCGTCAAGCCGGTGCTGGTGGACAATGAAGGCA
ATGTGCAGGAGTGCGTAGCCGACGGCAACCTGTGCATCTCCGACTCCTGGCCGGGCCAGATGCGCACCGTCTATGGCGAC
CACAAGCGTTTCATCGAAACCTACTTCTCCACCTATAAGGGGATGTATTTTTCGGGCGATGGCTGCCGCCGCGACGAGGA
CGGCTATTACTGGATCACCGGCCGCGTCGATGACGTGCTGAATATTTCCGGCCATCGCCTCGGCACGGCGGAAATCGAAT
CGGCACTTGTCTCGCATCACTCGGTTTCGGAAGCCGCCGTGGTCGGCTATCCGCACCCGATCAAGGGACAGGGCATCTAT
TGCTATGTCACGCTGATGACCGGCGCAGACGCGCAGGACCCGGACGAGTTGCGCAAGGAACTGGTCCAGCATGTGCGCAA
GGAAATCGGCCCCATCGCCACACCGGACAAGATCCAGTTTGCGCCCGGACTGCCGAAAACCCGTTCCGGCAAGATCATGC
GCCGCATCCTGCGCAAGATCGCCGAAGACGAGTTCGGCGCATTGGGCGACACCTCAACGCTCGCCGATCGGGGCGTGGTG
GACGACCTGATCGAAAATCGCCAGAACAAGAAATGA

Upstream 100 bases:

>100_bases
GGCCGCTTCATCCGGCTGGAGGAAGCCGGGCAATTTGTTTTGGGTGCATTATGCAATGCCGGATGGTTCTATTTGGCTGC
AAATGCTGAAGGAGGAAATC

Downstream 100 bases:

>100_bases
CAACAGAAAGGCCGGGAGACTTCCCGGCCTTTCTGCTTTGAAAATACCCACCCTCATCATCCTGAGCCCGCCCTCCTCGT
CCTTCGACACGGTGCTGCGC

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 651; Mature: 650

Protein sequence:

>651_residues
MSEKLYPVLPEAKKNTLIDNETYLEWYEESVSDPDGFWAKHGRRIDWFKPFTKVKNTDFNGDVTIKWYEDGVTNVSYNCI
DRHLKSRGDKVAIIWEGDNPYIDKKITYRELYENVCRMANVLKKHGVKKGDRVTIYLPMIPEAAYAMLACARIGAVHSVV
FAGFSPEALAGRIVDCESTFVITADEGVRGGKPVALKENTDTAIDIAAKQYVMVNKVLVVRRTGGKVSWGRGRDLWYHQE
VASVEPHCEPEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYASMTHQYVFDYHDGEIYWCTADVGWVTGHSYIVYGP
LANGATTLMFEGVPNFPDQGRFWEVVDKHHVNIFYTAPTALRALMGAGDEFVTRSSRSTLRLLGSVGEPINPEAWEWYYN
VVGDQKCPIVDTWWQTENGGILITPLPGATDLKPGSATRPFFGVKPVLVDNEGNVQECVADGNLCISDSWPGQMRTVYGD
HKRFIETYFSTYKGMYFSGDGCRRDEDGYYWITGRVDDVLNISGHRLGTAEIESALVSHHSVSEAAVVGYPHPIKGQGIY
CYVTLMTGADAQDPDELRKELVQHVRKEIGPIATPDKIQFAPGLPKTRSGKIMRRILRKIAEDEFGALGDTSTLADRGVV
DDLIENRQNKK

Sequences:

>Translated_651_residues
MSEKLYPVLPEAKKNTLIDNETYLEWYEESVSDPDGFWAKHGRRIDWFKPFTKVKNTDFNGDVTIKWYEDGVTNVSYNCI
DRHLKSRGDKVAIIWEGDNPYIDKKITYRELYENVCRMANVLKKHGVKKGDRVTIYLPMIPEAAYAMLACARIGAVHSVV
FAGFSPEALAGRIVDCESTFVITADEGVRGGKPVALKENTDTAIDIAAKQYVMVNKVLVVRRTGGKVSWGRGRDLWYHQE
VASVEPHCEPEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYASMTHQYVFDYHDGEIYWCTADVGWVTGHSYIVYGP
LANGATTLMFEGVPNFPDQGRFWEVVDKHHVNIFYTAPTALRALMGAGDEFVTRSSRSTLRLLGSVGEPINPEAWEWYYN
VVGDQKCPIVDTWWQTENGGILITPLPGATDLKPGSATRPFFGVKPVLVDNEGNVQECVADGNLCISDSWPGQMRTVYGD
HKRFIETYFSTYKGMYFSGDGCRRDEDGYYWITGRVDDVLNISGHRLGTAEIESALVSHHSVSEAAVVGYPHPIKGQGIY
CYVTLMTGADAQDPDELRKELVQHVRKEIGPIATPDKIQFAPGLPKTRSGKIMRRILRKIAEDEFGALGDTSTLADRGVV
DDLIENRQNKK
>Mature_650_residues
SEKLYPVLPEAKKNTLIDNETYLEWYEESVSDPDGFWAKHGRRIDWFKPFTKVKNTDFNGDVTIKWYEDGVTNVSYNCID
RHLKSRGDKVAIIWEGDNPYIDKKITYRELYENVCRMANVLKKHGVKKGDRVTIYLPMIPEAAYAMLACARIGAVHSVVF
AGFSPEALAGRIVDCESTFVITADEGVRGGKPVALKENTDTAIDIAAKQYVMVNKVLVVRRTGGKVSWGRGRDLWYHQEV
ASVEPHCEPEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYASMTHQYVFDYHDGEIYWCTADVGWVTGHSYIVYGPL
ANGATTLMFEGVPNFPDQGRFWEVVDKHHVNIFYTAPTALRALMGAGDEFVTRSSRSTLRLLGSVGEPINPEAWEWYYNV
VGDQKCPIVDTWWQTENGGILITPLPGATDLKPGSATRPFFGVKPVLVDNEGNVQECVADGNLCISDSWPGQMRTVYGDH
KRFIETYFSTYKGMYFSGDGCRRDEDGYYWITGRVDDVLNISGHRLGTAEIESALVSHHSVSEAAVVGYPHPIKGQGIYC
YVTLMTGADAQDPDELRKELVQHVRKEIGPIATPDKIQFAPGLPKTRSGKIMRRILRKIAEDEFGALGDTSTLADRGVVD
DLIENRQNKK

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=667, Percent_Identity=52.9235382308846, Blast_Score=713, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=680, Percent_Identity=51.9117647058824, Blast_Score=709, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=634, Percent_Identity=51.5772870662461, Blast_Score=662, Evalue=0.0,
Organism=Homo sapiens, GI13375727, Length=634, Percent_Identity=37.2239747634069, Blast_Score=415, Evalue=1e-116,
Organism=Homo sapiens, GI38505220, Length=520, Percent_Identity=31.1538461538462, Blast_Score=207, Evalue=3e-53,
Organism=Homo sapiens, GI42544132, Length=517, Percent_Identity=30.174081237911, Blast_Score=205, Evalue=1e-52,
Organism=Homo sapiens, GI122937307, Length=569, Percent_Identity=27.4165202108963, Blast_Score=187, Evalue=3e-47,
Organism=Homo sapiens, GI115511026, Length=543, Percent_Identity=27.9926335174954, Blast_Score=186, Evalue=8e-47,
Organism=Homo sapiens, GI58082049, Length=513, Percent_Identity=28.0701754385965, Blast_Score=178, Evalue=2e-44,
Organism=Homo sapiens, GI31982927, Length=675, Percent_Identity=24.5925925925926, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI157311624, Length=513, Percent_Identity=27.2904483430799, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI157311622, Length=513, Percent_Identity=27.2904483430799, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI195947378, Length=483, Percent_Identity=24.8447204968944, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI187761345, Length=388, Percent_Identity=27.0618556701031, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI187761343, Length=388, Percent_Identity=27.0618556701031, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI42544134, Length=335, Percent_Identity=25.9701492537313, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI156151445, Length=560, Percent_Identity=22.3214285714286, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1790505, Length=633, Percent_Identity=65.8767772511848, Blast_Score=877, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=635, Percent_Identity=37.1653543307087, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1788107, Length=540, Percent_Identity=23.3333333333333, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI145693145, Length=127, Percent_Identity=33.8582677165354, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71982997, Length=645, Percent_Identity=50.6976744186047, Blast_Score=635, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71983001, Length=645, Percent_Identity=50.6976744186047, Blast_Score=635, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17569507, Length=618, Percent_Identity=22.4919093851133, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17558820, Length=553, Percent_Identity=23.6889692585895, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17538037, Length=575, Percent_Identity=22.6086956521739, Blast_Score=88, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323182, Length=656, Percent_Identity=48.780487804878, Blast_Score=627, Evalue=1e-180,
Organism=Saccharomyces cerevisiae, GI6319264, Length=664, Percent_Identity=46.2349397590361, Blast_Score=580, Evalue=1e-166,
Organism=Saccharomyces cerevisiae, GI6319699, Length=370, Percent_Identity=23.7837837837838, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24667955, Length=664, Percent_Identity=53.3132530120482, Blast_Score=710, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=564, Percent_Identity=57.2695035460993, Blast_Score=653, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=522, Percent_Identity=57.088122605364, Blast_Score=604, Evalue=1e-173,
Organism=Drosophila melanogaster, GI21355225, Length=622, Percent_Identity=36.0128617363344, Blast_Score=371, Evalue=1e-102,
Organism=Drosophila melanogaster, GI18859661, Length=552, Percent_Identity=24.0942028985507, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21355181, Length=583, Percent_Identity=22.8130360205832, Blast_Score=92, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72837; Mature: 72706

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKLYPVLPEAKKNTLIDNETYLEWYEESVSDPDGFWAKHGRRIDWFKPFTKVKNTDFN
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHCCCCCCHHCCHHHHCCCCCC
GDVTIKWYEDGVTNVSYNCIDRHLKSRGDKVAIIWEGDNPYIDKKITYRELYENVCRMAN
CCEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCEECCCCCHHHHHHHHHHHHH
VLKKHGVKKGDRVTIYLPMIPEAAYAMLACARIGAVHSVVFAGFSPEALAGRIVDCESTF
HHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCEEEECCCEE
VITADEGVRGGKPVALKENTDTAIDIAAKQYVMVNKVLVVRRTGGKVSWGRGRDLWYHQE
EEECCCCCCCCCCEEEECCCCCEEEHHHHHEEEEEEEEEEEECCCEEECCCCCCCEEEHH
VASVEPHCEPEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYASMTHQYVFDYHDGEI
HHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEEECEEEEEEEECCEE
YWCTADVGWVTGHSYIVYGPLANGATTLMFEGVPNFPDQGRFWEVVDKHHVNIFYTAPTA
EEEECCCCEEECCCEEEEECCCCCEEEEEECCCCCCCCCCCCEEEECCCEEEEEEECHHH
LRALMGAGDEFVTRSSRSTLRLLGSVGEPINPEAWEWYYNVVGDQKCPIVDTWWQTENGG
HHHHHCCCHHHHHCCCHHHHHHHHHCCCCCCCCHHHHEEEECCCCCCCEEEEEEEECCCC
ILITPLPGATDLKPGSATRPFFGVKPVLVDNEGNVQECVADGNLCISDSWPGQMRTVYGD
EEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHCCCCEEEECCCCCCEEEEHHH
HKRFIETYFSTYKGMYFSGDGCRRDEDGYYWITGRVDDVLNISGHRLGTAEIESALVSHH
HHHHHHHHHHHHCCEEECCCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHC
SVSEAAVVGYPHPIKGQGIYCYVTLMTGADAQDPDELRKELVQHVRKEIGPIATPDKIQF
CCCCEEEECCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEE
APGLPKTRSGKIMRRILRKIAEDEFGALGDTSTLADRGVVDDLIENRQNKK
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHCCCCC
>Mature Secondary Structure 
SEKLYPVLPEAKKNTLIDNETYLEWYEESVSDPDGFWAKHGRRIDWFKPFTKVKNTDFN
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHCCCCCCHHCCHHHHCCCCCC
GDVTIKWYEDGVTNVSYNCIDRHLKSRGDKVAIIWEGDNPYIDKKITYRELYENVCRMAN
CCEEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCEECCCCCHHHHHHHHHHHHH
VLKKHGVKKGDRVTIYLPMIPEAAYAMLACARIGAVHSVVFAGFSPEALAGRIVDCESTF
HHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCEEEECCCEE
VITADEGVRGGKPVALKENTDTAIDIAAKQYVMVNKVLVVRRTGGKVSWGRGRDLWYHQE
EEECCCCCCCCCCEEEECCCCCEEEHHHHHEEEEEEEEEEEECCCEEECCCCCCCEEEHH
VASVEPHCEPEPMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYASMTHQYVFDYHDGEI
HHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEECCCEEEEEEECEEEEEEEECCEE
YWCTADVGWVTGHSYIVYGPLANGATTLMFEGVPNFPDQGRFWEVVDKHHVNIFYTAPTA
EEEECCCCEEECCCEEEEECCCCCEEEEEECCCCCCCCCCCCEEEECCCEEEEEEECHHH
LRALMGAGDEFVTRSSRSTLRLLGSVGEPINPEAWEWYYNVVGDQKCPIVDTWWQTENGG
HHHHHCCCHHHHHCCCHHHHHHHHHCCCCCCCCHHHHEEEECCCCCCCEEEEEEEECCCC
ILITPLPGATDLKPGSATRPFFGVKPVLVDNEGNVQECVADGNLCISDSWPGQMRTVYGD
EEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHCCCCEEEECCCCCCEEEEHHH
HKRFIETYFSTYKGMYFSGDGCRRDEDGYYWITGRVDDVLNISGHRLGTAEIESALVSHH
HHHHHHHHHHHHCCEEECCCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHC
SVSEAAVVGYPHPIKGQGIYCYVTLMTGADAQDPDELRKELVQHVRKEIGPIATPDKIQF
CCCCEEEECCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEE
APGLPKTRSGKIMRRILRKIAEDEFGALGDTSTLADRGVVDDLIENRQNKK
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA