Click here to switch to the map view.

The map label for this gene is 225853238

Identifier: 225853238

GI number: 225853238

Start: 1740267

End: 1741268

Strand: Reverse

Name: 225853238

Synonym: BMEA_A1842

Alternate gene names: NA

Gene position: 1741268-1740267 (Counterclockwise)

Preceding gene: 225853241

Following gene: 225853237

Centisome position: 81.92

GC content: 58.98

Gene sequence:

>1002_bases
ATGGCAAGACATTCCTTCTTCTGCGTCGATGGGCATACATGCGGCAACCCTGTGCGGCTGGTGGCTGGCGGCGGGCCGAA
CCTCAATGGATCGACCATGATGGAAAAGTGCGCGCATTTCCTGGCGGAATATGACTGGATCCGCACCGGCCTCATGTTCG
AGCCGCGCGGCCACGACATGATGTCCGGTTCCATTCTCTATCCGCCGACAAGGCCGGATTGCGACGTGGCGGTGCTGTTC
ATCGAAACCTCGGGCTGCCTGCCGATGTGCGGCCATGGCACCATCGGCACGGTGACGATGGCAATCGAGCAGGGACTGGT
GACGCCCAAGACGCCGGGCAAGCTCAATCTCGACACGCCCGCCGGCCTGGTGGCGATCGAATATGAGCAGGACGGTCAGT
ATGTGGAGCGTGTGCGCCTCACCAATGTCCCAGCTTTCCTTTATGCCGAAGGCCTGGAGGTCGAATGCCCCGATCTTGGC
CCGATCAAGGTCGATGTTGCTTATGGTGGTAATTTCTACGCCATTGTCGAACCGCAGGAAAACTACACGGATATGGACGA
TTACTCCGCGCTTCAGCTTATTGCCTGGAGCCCGGTCCTGCGCCAGCGGCTGAATGAAAAATACAAGTTCCAGCACCCGG
AACTGCCTGATATCAACCGTCTCAGCCATATTCTCTGGACCGGAAAGCCGAAGCACCCGCAAGCCCATGCGCGCAATGCC
GTGTTTTATGGCGACAAGGCTATCGACCGTTCGCCCTGCGGCACCGGCACCTCGGTGCGCATGGCCCAGCTTGCCGCCAA
GGGCAAGCTGAAACCGGGCGATGAATTTATTCATGAATCGATCATCGGCTCGCTATTCCATGGTCGTGTGGAGCGCGCCG
CCGAGGTTGCCGGGCGCCCCGCAATTGTGCCTTCCATTGCAGGCTGGGCGCGGATGACGGGCTATAATACGATTTTTATC
GACGATCGCGATCCGTTTGCTCATGGGTTCAGCGTGGCATAA

Upstream 100 bases:

>100_bases
CGGCGGCGACGGCGCGGCTTATCCGCGACCTCATCACGGGTAGCGAACCTGCAATCGATATCGAACCTTTCAAGCCTCAA
CGTTTTCGGAACTGACCATA

Downstream 100 bases:

>100_bases
AGTGGGTATAACAGGCGAAATTATTTCCACCTTCCCATTTATTTGCCTTTTCGTGTGTGGGAAAAATATGGAATAACGTA
GGCCGGGTAGGAGAAAAAGA

Product: hydroxyproline-2-epimerase

Products: NA

Alternate protein names: Hydroxyproline-2-epimerase; HyPRE [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MARHSFFCVDGHTCGNPVRLVAGGGPNLNGSTMMEKCAHFLAEYDWIRTGLMFEPRGHDMMSGSILYPPTRPDCDVAVLF
IETSGCLPMCGHGTIGTVTMAIEQGLVTPKTPGKLNLDTPAGLVAIEYEQDGQYVERVRLTNVPAFLYAEGLEVECPDLG
PIKVDVAYGGNFYAIVEPQENYTDMDDYSALQLIAWSPVLRQRLNEKYKFQHPELPDINRLSHILWTGKPKHPQAHARNA
VFYGDKAIDRSPCGTGTSVRMAQLAAKGKLKPGDEFIHESIIGSLFHGRVERAAEVAGRPAIVPSIAGWARMTGYNTIFI
DDRDPFAHGFSVA

Sequences:

>Translated_333_residues
MARHSFFCVDGHTCGNPVRLVAGGGPNLNGSTMMEKCAHFLAEYDWIRTGLMFEPRGHDMMSGSILYPPTRPDCDVAVLF
IETSGCLPMCGHGTIGTVTMAIEQGLVTPKTPGKLNLDTPAGLVAIEYEQDGQYVERVRLTNVPAFLYAEGLEVECPDLG
PIKVDVAYGGNFYAIVEPQENYTDMDDYSALQLIAWSPVLRQRLNEKYKFQHPELPDINRLSHILWTGKPKHPQAHARNA
VFYGDKAIDRSPCGTGTSVRMAQLAAKGKLKPGDEFIHESIIGSLFHGRVERAAEVAGRPAIVPSIAGWARMTGYNTIFI
DDRDPFAHGFSVA
>Mature_332_residues
ARHSFFCVDGHTCGNPVRLVAGGGPNLNGSTMMEKCAHFLAEYDWIRTGLMFEPRGHDMMSGSILYPPTRPDCDVAVLFI
ETSGCLPMCGHGTIGTVTMAIEQGLVTPKTPGKLNLDTPAGLVAIEYEQDGQYVERVRLTNVPAFLYAEGLEVECPDLGP
IKVDVAYGGNFYAIVEPQENYTDMDDYSALQLIAWSPVLRQRLNEKYKFQHPELPDINRLSHILWTGKPKHPQAHARNAV
FYGDKAIDRSPCGTGTSVRMAQLAAKGKLKPGDEFIHESIIGSLFHGRVERAAEVAGRPAIVPSIAGWARMTGYNTIFID
DRDPFAHGFSVA

Specific function: Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4- hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell

COG id: COG3938

COG function: function code E; Proline racemase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the proline racemase family. 4- hydroxyproline epimerase subfamily [H]

Homologues:

Organism=Homo sapiens, GI21389361, Length=330, Percent_Identity=34.5454545454545, Blast_Score=188, Evalue=6e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008794 [H]

Pfam domain/function: PF05544 Pro_racemase [H]

EC number: =5.1.1.8 [H]

Molecular weight: Translated: 36567; Mature: 36436

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARHSFFCVDGHTCGNPVRLVAGGGPNLNGSTMMEKCAHFLAEYDWIRTGLMFEPRGHDM
CCCCEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCCCCC
MSGSILYPPTRPDCDVAVLFIETSGCLPMCGHGTIGTVTMAIEQGLVTPKTPGKLNLDTP
CCCCEECCCCCCCCCEEEEEEECCCCCEECCCCCHHEEEEEHHCCCCCCCCCCEEECCCC
AGLVAIEYEQDGQYVERVRLTNVPAFLYAEGLEVECPDLGPIKVDVAYGGNFYAIVEPQE
CCEEEEEECCCCCEEHHHHHCCCCCEEEECCCEEECCCCCCEEEEEEECCCEEEEECCCC
NYTDMDDYSALQLIAWSPVLRQRLNEKYKFQHPELPDINRLSHILWTGKPKHPQAHARNA
CCCCCCCCCCEEEEECCHHHHHHCCHHHCCCCCCCCCHHHHHHHEECCCCCCCHHHHCCE
VFYGDKAIDRSPCGTGTSVRMAQLAAKGKLKPGDEFIHESIIGSLFHGRVERAAEVAGRP
EEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
AIVPSIAGWARMTGYNTIFIDDRDPFAHGFSVA
CCCCCCCCHHHHCCCEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
ARHSFFCVDGHTCGNPVRLVAGGGPNLNGSTMMEKCAHFLAEYDWIRTGLMFEPRGHDM
CCCEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCEECCCCCCC
MSGSILYPPTRPDCDVAVLFIETSGCLPMCGHGTIGTVTMAIEQGLVTPKTPGKLNLDTP
CCCCEECCCCCCCCCEEEEEEECCCCCEECCCCCHHEEEEEHHCCCCCCCCCCEEECCCC
AGLVAIEYEQDGQYVERVRLTNVPAFLYAEGLEVECPDLGPIKVDVAYGGNFYAIVEPQE
CCEEEEEECCCCCEEHHHHHCCCCCEEEECCCEEECCCCCCEEEEEEECCCEEEEECCCC
NYTDMDDYSALQLIAWSPVLRQRLNEKYKFQHPELPDINRLSHILWTGKPKHPQAHARNA
CCCCCCCCCCEEEEECCHHHHHHCCHHHCCCCCCCCCHHHHHHHEECCCCCCCHHHHCCE
VFYGDKAIDRSPCGTGTSVRMAQLAAKGKLKPGDEFIHESIIGSLFHGRVERAAEVAGRP
EEECCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
AIVPSIAGWARMTGYNTIFIDDRDPFAHGFSVA
CCCCCCCCHHHHCCCEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA