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The map label for this gene is thiE [H]

Identifier: 225853163

GI number: 225853163

Start: 1669168

End: 1669833

Strand: Direct

Name: thiE [H]

Synonym: BMEA_A1760

Alternate gene names: 225853163

Gene position: 1669168-1669833 (Clockwise)

Preceding gene: 225853156

Following gene: 225853164

Centisome position: 78.52

GC content: 61.71

Gene sequence:

>666_bases
ATGAACACGCGCGCTCCCCAGACTGAACCCGAACGCTGCCGCATCGTGCTGGTCGCGCCGCCGATTGCCGATGGCGCAGC
ACTTGCAAAGCTCCTGACCGCCGCTCTTTCCGGCGGCGATGTGGCAAGTGTCATCCTCGACACGGGCGACCTTGATGAAG
CGACTTTTCAGGCCGTGGCCGAAAAGACGGTTCCCGTCATTCAGGAAAAGGGCGTTGCCGCCCTCATTCTCAACGACACG
CGCATTGCAGGCCGCGTCGGGGCAGATGGCATCCATATCGAGGGCAAGCCTGCCGATCTGGCGGAAGCCATTGAAAAACA
CGCACCGAAAATGATCGTCGGCACCGGCAACCTGCGCGACCGTCACGGCGCGATCGAGGTAGGCGAATTGCAGCCGGACT
ATCTCTTCTTCGGCAAGATCGGCGCGGACAACAAGCCGGATGCCCATCCGCGCAACCTTTCCCTTGCTGGATGGTGGGCG
GAAATGGTGGAGATTCCCTGCATCGCCCAGGCCGGAAGCGCGCTTGAAAGCATCGTGCGCGCTGCCGAAACCGGCGCGGA
TTTCGTGGCGCTCGGGCGTGCGGTTTTCGATGCGCAAGACCCGGCAGAGGCCGTTGCGCAAGCCAACCGGCTTCTTGATG
AAAAAGCACCCCGTTTTGAAAACTGA

Upstream 100 bases:

>100_bases
AATGCCAATGCCTCGCCCGCAGGCCCCAAAAGGGCTGTTCAACACGGCGCACTTACTTTATGCCCGAATTCGATCATTTT
TTTCTCGTTAGGCTTGGCCC

Downstream 100 bases:

>100_bases
TTGTTGCGACATTTCCTCCAGGTCTTGTGGATGCCCATGAAGCGCAAATTTCTTCTCGCTGCCGTTTTGACATTTGCCAT
GCCTGCCCTGCCCGCTCTGG

Product: thiamine-phosphate pyrophosphorylase

Products: NA

Alternate protein names: TMP pyrophosphorylase; TMP-PPase; Thiamine-phosphate synthase [H]

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MNTRAPQTEPERCRIVLVAPPIADGAALAKLLTAALSGGDVASVILDTGDLDEATFQAVAEKTVPVIQEKGVAALILNDT
RIAGRVGADGIHIEGKPADLAEAIEKHAPKMIVGTGNLRDRHGAIEVGELQPDYLFFGKIGADNKPDAHPRNLSLAGWWA
EMVEIPCIAQAGSALESIVRAAETGADFVALGRAVFDAQDPAEAVAQANRLLDEKAPRFEN

Sequences:

>Translated_221_residues
MNTRAPQTEPERCRIVLVAPPIADGAALAKLLTAALSGGDVASVILDTGDLDEATFQAVAEKTVPVIQEKGVAALILNDT
RIAGRVGADGIHIEGKPADLAEAIEKHAPKMIVGTGNLRDRHGAIEVGELQPDYLFFGKIGADNKPDAHPRNLSLAGWWA
EMVEIPCIAQAGSALESIVRAAETGADFVALGRAVFDAQDPAEAVAQANRLLDEKAPRFEN
>Mature_221_residues
MNTRAPQTEPERCRIVLVAPPIADGAALAKLLTAALSGGDVASVILDTGDLDEATFQAVAEKTVPVIQEKGVAALILNDT
RIAGRVGADGIHIEGKPADLAEAIEKHAPKMIVGTGNLRDRHGAIEVGELQPDYLFFGKIGADNKPDAHPRNLSLAGWWA
EMVEIPCIAQAGSALESIVRAAETGADFVALGRAVFDAQDPAEAVAQANRLLDEKAPRFEN

Specific function: Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) [H]

COG id: COG0352

COG function: function code H; Thiamine monophosphate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TMP-PPase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR022998
- InterPro:   IPR003733 [H]

Pfam domain/function: PF02581 TMP-TENI [H]

EC number: =2.5.1.3 [H]

Molecular weight: Translated: 23243; Mature: 23243

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTRAPQTEPERCRIVLVAPPIADGAALAKLLTAALSGGDVASVILDTGDLDEATFQAVA
CCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHH
EKTVPVIQEKGVAALILNDTRIAGRVGADGIHIEGKPADLAEAIEKHAPKMIVGTGNLRD
HHHHHHHHCCCEEEEEEECCEEECCCCCCCEEECCCCHHHHHHHHHHCCEEEEECCCCCC
RHGAIEVGELQPDYLFFGKIGADNKPDAHPRNLSLAGWWAEMVEIPCIAQAGSALESIVR
CCCCEEECCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
AAETGADFVALGRAVFDAQDPAEAVAQANRLLDEKAPRFEN
HHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNTRAPQTEPERCRIVLVAPPIADGAALAKLLTAALSGGDVASVILDTGDLDEATFQAVA
CCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHH
EKTVPVIQEKGVAALILNDTRIAGRVGADGIHIEGKPADLAEAIEKHAPKMIVGTGNLRD
HHHHHHHHCCCEEEEEEECCEEECCCCCCCEEECCCCHHHHHHHHHHCCEEEEECCCCCC
RHGAIEVGELQPDYLFFGKIGADNKPDAHPRNLSLAGWWAEMVEIPCIAQAGSALESIVR
CCCCEEECCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
AAETGADFVALGRAVFDAQDPAEAVAQANRLLDEKAPRFEN
HHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA