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The map label for this gene is proP [H]

Identifier: 225853138

GI number: 225853138

Start: 1641670

End: 1643022

Strand: Direct

Name: proP [H]

Synonym: BMEA_A1734

Alternate gene names: 225853138

Gene position: 1641670-1643022 (Clockwise)

Preceding gene: 225853137

Following gene: 225853156

Centisome position: 77.23

GC content: 59.94

Gene sequence:

>1353_bases
ATGGCATCGACGAACCTCCACACAGGCAACAGTCCCCGTCCGCTTAACCGGCAGGATTTCCGCACGCTCGGCCTTTCGGC
TCTTGGCGGTGCGCTGGAGTTTTACGATTTCATCATCTTCGTGTTCTTTGCGAGTGTCATCGGGCACCTTTTCTTTCCGC
CCGATATGCCGGACTGGCTGGTGCTGATCCAGACGTTCGGCATTTTTGCGGCGGGTTATCTGGTGCGTCCGGTGGGCGGC
ATCGTGCTGGCGCATTTCGGCGACAAGTTCGGGCGCAAGCGCGTCTTCGCCTTTTCGGTCTTCCTGATGTCGATCTCGAC
GCTGGCCATGGCGGCGCTGCCGACCTATGCGACGCTCGGCGTGGGTGCACCGATCCTGCTGATTGTCTTCCGCATGTTGC
AGGGGGCAGCCATTGGCGGCGAAGTACCGGGCGCATGGACCTTCGTGGCCGAACATGTTCCGGCCAACCGCGTCGGCATG
GCCTGCGGTTTCCTGTGCTCCGGCCTGACGCTCGGCATCATGATCGGCTCGCTGATTGCGACTGCCATCAACTGGATTTT
CACGCCCGAAGAACTGTCCGCCTATGCTTGGCGCATTCCCTTCTTCATCGGCGGCATATTCGGCCTGCTTGCGGTTTATC
TGCGCCGCTGGCTGGCGGAAACGCCAATCTTCACCGAGATGAAGAACAGCCGCCTGCTGAAAGACAAGCTGCCGCTTGGT
ACAGTCCTTCGCAACCATATGCATGGCGTTGTCATTTCGGTGCTGCTCACCTGGATTCTATCGGCCGGTATCGTTGTCAC
CACGCTGATGACGGCGACCTTCTTGCAAAAACTCTACGGATACACGCCGTTGCAATCGCTGGCCGCGACAAGTTTCGGCA
CATTGTTCCTGATGTTCGGCACGGTGAGCGCGGGTGCCATCGTGGACCGCATCGGCAGTGGCCGCTTCTTTGCCGTTGCC
GGCATTTTCTTCGGCGTCGCGACCTTCGTGTTCTACACCTATGCGGCGGTTTCGCTGCCGGTCCTGTTTGCGCTTTATGC
GGTGATGGGGCTTTCGGTCGGCATGGTGGGTGCTGCGCCTTATGTGATGGTGCGCGCCTTCCCGGCGCCGGTCCGCTTTT
CGGGCCTGTCGTTTTCCTACAATGTTTCCTATGCGGTTTTTGGCGGCTTGACGCCGGTGATCGTCACTTCGCTTCTGGCG
GTCAACCCGATGGCACATGCGTGGTATCTGGTGTTCATCGCCGTTCTGACCTGCGGCCTCGGTCTTTACCTGATGGCCCG
CAGCGATCAGGTCGAAGGCGAGATCGGCCTGACCAAGCTTTCGACCAGCGACGCCGTTCCGCAGGTACAGTGA

Upstream 100 bases:

>100_bases
TCGTGACGCATTAACTTATGGTTTGGCGTCACGACAACCTGCAACGCGGCCCTGCAATGAGGGCAGCATATCAGCGACCC
AATCAGAAGAGAGCGAATCG

Downstream 100 bases:

>100_bases
TAGGAAGGGCCGCGTGACGCGGCCTCAGATTGATGAAAAACCCCTCGATTTTTGGCAGCAGCCTGAGGCCGCATGAAGCG
GCCTTTTTATTTGTTCTGCC

Product: hypothetical protein

Products: betaine [Cytoplasm]; Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MASTNLHTGNSPRPLNRQDFRTLGLSALGGALEFYDFIIFVFFASVIGHLFFPPDMPDWLVLIQTFGIFAAGYLVRPVGG
IVLAHFGDKFGRKRVFAFSVFLMSISTLAMAALPTYATLGVGAPILLIVFRMLQGAAIGGEVPGAWTFVAEHVPANRVGM
ACGFLCSGLTLGIMIGSLIATAINWIFTPEELSAYAWRIPFFIGGIFGLLAVYLRRWLAETPIFTEMKNSRLLKDKLPLG
TVLRNHMHGVVISVLLTWILSAGIVVTTLMTATFLQKLYGYTPLQSLAATSFGTLFLMFGTVSAGAIVDRIGSGRFFAVA
GIFFGVATFVFYTYAAVSLPVLFALYAVMGLSVGMVGAAPYVMVRAFPAPVRFSGLSFSYNVSYAVFGGLTPVIVTSLLA
VNPMAHAWYLVFIAVLTCGLGLYLMARSDQVEGEIGLTKLSTSDAVPQVQ

Sequences:

>Translated_450_residues
MASTNLHTGNSPRPLNRQDFRTLGLSALGGALEFYDFIIFVFFASVIGHLFFPPDMPDWLVLIQTFGIFAAGYLVRPVGG
IVLAHFGDKFGRKRVFAFSVFLMSISTLAMAALPTYATLGVGAPILLIVFRMLQGAAIGGEVPGAWTFVAEHVPANRVGM
ACGFLCSGLTLGIMIGSLIATAINWIFTPEELSAYAWRIPFFIGGIFGLLAVYLRRWLAETPIFTEMKNSRLLKDKLPLG
TVLRNHMHGVVISVLLTWILSAGIVVTTLMTATFLQKLYGYTPLQSLAATSFGTLFLMFGTVSAGAIVDRIGSGRFFAVA
GIFFGVATFVFYTYAAVSLPVLFALYAVMGLSVGMVGAAPYVMVRAFPAPVRFSGLSFSYNVSYAVFGGLTPVIVTSLLA
VNPMAHAWYLVFIAVLTCGLGLYLMARSDQVEGEIGLTKLSTSDAVPQVQ
>Mature_449_residues
ASTNLHTGNSPRPLNRQDFRTLGLSALGGALEFYDFIIFVFFASVIGHLFFPPDMPDWLVLIQTFGIFAAGYLVRPVGGI
VLAHFGDKFGRKRVFAFSVFLMSISTLAMAALPTYATLGVGAPILLIVFRMLQGAAIGGEVPGAWTFVAEHVPANRVGMA
CGFLCSGLTLGIMIGSLIATAINWIFTPEELSAYAWRIPFFIGGIFGLLAVYLRRWLAETPIFTEMKNSRLLKDKLPLGT
VLRNHMHGVVISVLLTWILSAGIVVTTLMTATFLQKLYGYTPLQSLAATSFGTLFLMFGTVSAGAIVDRIGSGRFFAVAG
IFFGVATFVFYTYAAVSLPVLFALYAVMGLSVGMVGAAPYVMVRAFPAPVRFSGLSFSYNVSYAVFGGLTPVIVTSLLAV
NPMAHAWYLVFIAVLTCGLGLYLMARSDQVEGEIGLTKLSTSDAVPQVQ

Specific function: May be a proton symporter invoved in the uptake of osmolytes such as proline and glycine betaine [H]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790550, Length=411, Percent_Identity=28.9537712895377, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1788292, Length=433, Percent_Identity=27.4826789838337, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1789941, Length=415, Percent_Identity=31.0843373493976, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1788942, Length=419, Percent_Identity=29.5942720763723, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI87082404, Length=390, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082231, Length=226, Percent_Identity=27.4336283185841, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48445; Mature: 48314

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASTNLHTGNSPRPLNRQDFRTLGLSALGGALEFYDFIIFVFFASVIGHLFFPPDMPDWL
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
VLIQTFGIFAAGYLVRPVGGIVLAHFGDKFGRKRVFAFSVFLMSISTLAMAALPTYATLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGAPILLIVFRMLQGAAIGGEVPGAWTFVAEHVPANRVGMACGFLCSGLTLGIMIGSLIA
CCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TAINWIFTPEELSAYAWRIPFFIGGIFGLLAVYLRRWLAETPIFTEMKNSRLLKDKLPLG
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHCCCHH
TVLRNHMHGVVISVLLTWILSAGIVVTTLMTATFLQKLYGYTPLQSLAATSFGTLFLMFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
TVSAGAIVDRIGSGRFFAVAGIFFGVATFVFYTYAAVSLPVLFALYAVMGLSVGMVGAAP
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
YVMVRAFPAPVRFSGLSFSYNVSYAVFGGLTPVIVTSLLAVNPMAHAWYLVFIAVLTCGL
HHHHEECCCCEEECCCEEEEECCHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHCH
GLYLMARSDQVEGEIGLTKLSTSDAVPQVQ
HHEEEECCCCCCCCCCEEEECCCCCCCCCC
>Mature Secondary Structure 
ASTNLHTGNSPRPLNRQDFRTLGLSALGGALEFYDFIIFVFFASVIGHLFFPPDMPDWL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH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HHEEEECCCCCCCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: betaine [Periplasm]; Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + betaine [Periplasm] = Proton [Cytoplasm] + betaine [Cytoplasm] Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA