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The map label for this gene is aceA [H]

Identifier: 225853085

GI number: 225853085

Start: 1582114

End: 1583403

Strand: Direct

Name: aceA [H]

Synonym: BMEA_A1667

Alternate gene names: 225853085

Gene position: 1582114-1583403 (Clockwise)

Preceding gene: 225853080

Following gene: 225853086

Centisome position: 74.43

GC content: 60.47

Gene sequence:

>1290_bases
ATGACAGATTTTTACAGCCTCATCCCTTCGGCACCCAAGGGCCGCTTCGACGGCATTGAACGTGCGCATACGGCCGAAGA
CGTGAAAAGGCTGCGCGGTTCGGTGGAGATAAAGTATTCGCTGGCCGAAATGGGTGCAAACCGCCTCTGGAAGCTGATCC
ACGAGGAAGATTTCGTCAATGCGCTGGGCGCGCTTTCCGGCAACCAGGCCATGCAGATGGTTCGCGCCGGGTTGAAGGCG
ATCTACCTTTCCGGCTGGCAGGTTGCAGCAGACGCCAACACGGCATCAGCCATGTATCCCGACCAGTCGCTCTATCCGGC
CAATGCCGGGCCAGAGCTTGCAAAGCGCATCAACCGCACGCTGCAACGCGCCGACCAGATCGAAACCGCCGAAGGCAAGG
GGCTTTCGGTTGACACATGGTTCGCGCCCATCGTGGCGGATGCCGAGGCAGGCTTTGGCGACCCGCTGGATGCCTTCGAG
ATCATGAAAGCCTATATCGAGGCCGGTGCTGCGGGCGTTCACTTTGAAGACCAGCTTGCTTCGGAAAAGAAGTGCGGCCA
TCTGGGCGGCAAGGTTCTGATCCCGACCGCAGCGCACATCCGCAACCTCAACGCGGCACGCCTTGCAGCCGACGTCATGG
GCACGCCGACCCTCATCGTGGCGCGCACGGATGCGGAAGCAGCCAAGCTTCTGACGTCGGATATCGACGAGCGCGACCAG
CCTTTCGTCGATTACGAAGCAGGCCGCACGGCGGAAGGCTTCTATCAGGTGAAGAATGGCATCGAGCCATGCATCGCCCG
TGCGATTGCCTATGCGCCTTATTGCGATCTGATCTGGATGGAAACGTCCAAGCCTGATCTCGCACAGGCCCGTCGCTTCG
CGGAAGCCGTGCACAAGGCGCATCCGGGCAAGCTGCTCGCCTATAACTGCTCGCCGTCGTTCAACTGGAAAAAGAACCTC
GACGACGCGACGATTGCCAAGTTCCAGCGCGAGCTGGGCGCGATGGGCTACAAGTTCCAGTTCATCACGCTGGCTGGCTT
CCACCAGCTCAACTACGGCATGTTCGAGCTGGCACGCGGCTACAAGGATCGTCAGATGGCGGCTTATTCCGAGCTGCAAC
AGGCGGAATTTGCAGCCGAAGCCGATGGCTACACGGCAACCAAGCACCAGCGCGAAGTCGGCACCGGCTATTTCGATGCC
GTGTCGCTCGCAATCACCGGCGGCCAGTCTTCGACCACCGCCATGAAGGAATCGACCGAAACCGCACAGTTCAAGCCGGC
TGCCGAGTAG

Upstream 100 bases:

>100_bases
TTTCTGGCGCATCGGCCCGGGCGATTGTAAATCTGGTCACAGAAAGAGCGCCCATTGAGCGACCTTCAAAAACCGGATAT
CACCACGAGGAGACACCGAA

Downstream 100 bases:

>100_bases
CAGCCGGGACCACCGAACCAGGAGGACCAGTACCATGAATTCGCCAGCACGCGTCAAGGAAAGAGCAGAAGAACAATCCT
CGAGCATGAACACGGATCAG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTDFYSLIPSAPKGRFDGIERAHTAEDVKRLRGSVEIKYSLAEMGANRLWKLIHEEDFVNALGALSGNQAMQMVRAGLKA
IYLSGWQVAADANTASAMYPDQSLYPANAGPELAKRINRTLQRADQIETAEGKGLSVDTWFAPIVADAEAGFGDPLDAFE
IMKAYIEAGAAGVHFEDQLASEKKCGHLGGKVLIPTAAHIRNLNAARLAADVMGTPTLIVARTDAEAAKLLTSDIDERDQ
PFVDYEAGRTAEGFYQVKNGIEPCIARAIAYAPYCDLIWMETSKPDLAQARRFAEAVHKAHPGKLLAYNCSPSFNWKKNL
DDATIAKFQRELGAMGYKFQFITLAGFHQLNYGMFELARGYKDRQMAAYSELQQAEFAAEADGYTATKHQREVGTGYFDA
VSLAITGGQSSTTAMKESTETAQFKPAAE

Sequences:

>Translated_429_residues
MTDFYSLIPSAPKGRFDGIERAHTAEDVKRLRGSVEIKYSLAEMGANRLWKLIHEEDFVNALGALSGNQAMQMVRAGLKA
IYLSGWQVAADANTASAMYPDQSLYPANAGPELAKRINRTLQRADQIETAEGKGLSVDTWFAPIVADAEAGFGDPLDAFE
IMKAYIEAGAAGVHFEDQLASEKKCGHLGGKVLIPTAAHIRNLNAARLAADVMGTPTLIVARTDAEAAKLLTSDIDERDQ
PFVDYEAGRTAEGFYQVKNGIEPCIARAIAYAPYCDLIWMETSKPDLAQARRFAEAVHKAHPGKLLAYNCSPSFNWKKNL
DDATIAKFQRELGAMGYKFQFITLAGFHQLNYGMFELARGYKDRQMAAYSELQQAEFAAEADGYTATKHQREVGTGYFDA
VSLAITGGQSSTTAMKESTETAQFKPAAE
>Mature_428_residues
TDFYSLIPSAPKGRFDGIERAHTAEDVKRLRGSVEIKYSLAEMGANRLWKLIHEEDFVNALGALSGNQAMQMVRAGLKAI
YLSGWQVAADANTASAMYPDQSLYPANAGPELAKRINRTLQRADQIETAEGKGLSVDTWFAPIVADAEAGFGDPLDAFEI
MKAYIEAGAAGVHFEDQLASEKKCGHLGGKVLIPTAAHIRNLNAARLAADVMGTPTLIVARTDAEAAKLLTSDIDERDQP
FVDYEAGRTAEGFYQVKNGIEPCIARAIAYAPYCDLIWMETSKPDLAQARRFAEAVHKAHPGKLLAYNCSPSFNWKKNLD
DATIAKFQRELGAMGYKFQFITLAGFHQLNYGMFELARGYKDRQMAAYSELQQAEFAAEADGYTATKHQREVGTGYFDAV
SLAITGGQSSTTAMKESTETAQFKPAAE

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=419, Percent_Identity=61.3365155131265, Blast_Score=514, Evalue=1e-147,
Organism=Caenorhabditis elegans, GI17561814, Length=429, Percent_Identity=70.8624708624709, Blast_Score=637, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71982926, Length=429, Percent_Identity=70.8624708624709, Blast_Score=637, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6325263, Length=240, Percent_Identity=37.0833333333333, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6320908, Length=261, Percent_Identity=36.0153256704981, Blast_Score=151, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 46854; Mature: 46723

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFYSLIPSAPKGRFDGIERAHTAEDVKRLRGSVEIKYSLAEMGANRLWKLIHEEDFVN
CCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEHHHHCHHHHHHHHHHHHHHH
ALGALSGNQAMQMVRAGLKAIYLSGWQVAADANTASAMYPDQSLYPANAGPELAKRINRT
HHHHCCCHHHHHHHHHHHHHEEECCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
LQRADQIETAEGKGLSVDTWFAPIVADAEAGFGDPLDAFEIMKAYIEAGAAGVHFEDQLA
HHHHHHHCCCCCCCCEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHH
SEKKCGHLGGKVLIPTAAHIRNLNAARLAADVMGTPTLIVARTDAEAAKLLTSDIDERDQ
HHHHHHHCCCEEEECCHHHHHCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCC
PFVDYEAGRTAEGFYQVKNGIEPCIARAIAYAPYCDLIWMETSKPDLAQARRFAEAVHKA
CCEECCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHC
HPGKLLAYNCSPSFNWKKNLDDATIAKFQRELGAMGYKFQFITLAGFHQLNYGMFELARG
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEECHHHHCCHHHHHHCC
YKDRQMAAYSELQQAEFAAEADGYTATKHQREVGTGYFDAVSLAITGGQSSTTAMKESTE
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHEEEEEEECCCCCHHHHHHCCC
TAQFKPAAE
CCCCCCCCC
>Mature Secondary Structure 
TDFYSLIPSAPKGRFDGIERAHTAEDVKRLRGSVEIKYSLAEMGANRLWKLIHEEDFVN
CCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEHHHHCHHHHHHHHHHHHHHH
ALGALSGNQAMQMVRAGLKAIYLSGWQVAADANTASAMYPDQSLYPANAGPELAKRINRT
HHHHCCCHHHHHHHHHHHHHEEECCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
LQRADQIETAEGKGLSVDTWFAPIVADAEAGFGDPLDAFEIMKAYIEAGAAGVHFEDQLA
HHHHHHHCCCCCCCCEEHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHH
SEKKCGHLGGKVLIPTAAHIRNLNAARLAADVMGTPTLIVARTDAEAAKLLTSDIDERDQ
HHHHHHHCCCEEEECCHHHHHCCCHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCCCC
PFVDYEAGRTAEGFYQVKNGIEPCIARAIAYAPYCDLIWMETSKPDLAQARRFAEAVHKA
CCEECCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHC
HPGKLLAYNCSPSFNWKKNLDDATIAKFQRELGAMGYKFQFITLAGFHQLNYGMFELARG
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEECHHHHCCHHHHHHCC
YKDRQMAAYSELQQAEFAAEADGYTATKHQREVGTGYFDAVSLAITGGQSSTTAMKESTE
CCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCHHHEEEEEEECCCCCHHHHHHCCC
TAQFKPAAE
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]