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The map label for this gene is choW [H]

Identifier: 225853055

GI number: 225853055

Start: 1548483

End: 1549319

Strand: Direct

Name: choW [H]

Synonym: BMEA_A1633

Alternate gene names: 225853055

Gene position: 1548483-1549319 (Clockwise)

Preceding gene: 225853054

Following gene: 225853056

Centisome position: 72.85

GC content: 56.63

Gene sequence:

>837_bases
TTGAACTGGCTGACGGATTACAAGATACCTGTCGGGCCAACCGCCAAATCGGTGGTGGACTGGCTGACGACCCATCTGGG
ACTTTTCTTCGACACTCTGGCCGCAGTCATGCAGAGCTTGATTGACGGTTTGCTGTATCTCCTGGAACTCCCTCACCCCC
TCCTTCTGATCGCCATCTTTGCAATCATTGCATGGCTCATTCAGCGTCGTATCTCGGTCGTTCTGCTCACCATTCTGGGT
TTCCTTTTCATCATCAACCAGGGCTATTGGGAACCCACCCTGAAAACACTCACCCTCGTTCTGTCATCATGTTTTGTCTG
CATGGTGATCGGCGTACCACTTGGAATCGCCGCAGCCCATCGCCCGGCCCTTTACGCCGCGATGCGCCCTGTGCTCGACC
TGATGCAAACGCTGCCGACTTTCGTGTATCTGATCCCGGCGATTGTTTTCTTTGGTATCGGCATGGTGCCGGGTCTTCTC
GCCACCGTCATCTTCGTGATCCCTGCTCCTATCCGCCTGACCCAGCTCAGCATTTCCTCAACACCCGCCTCGCTCATCGA
AGCCGGCGAAGCTTTCGGCGCGTCACGCTCGCAGCTTCTCTGGAAGGTTGAACTGCCCTACGCGATGCCGCAAATTCTGG
CCGGCCTCACCCAGACGATCATGCTGTCGCTTTCGATGGTGGTCATTGCAGCCCTTGTCGGTGCCGATGGCCTCGGCGTG
CCTGTGGTTCGCGGCCTTAACTCCGTCAATATTTCGCTGGGTTTTGAAGCAGGTTTCATCATCGTCGTGGTCGCCATCGT
GCTCGACCGTATCTTCCGCGCCGGACGTGAGAAATAG

Upstream 100 bases:

>100_bases
CTCGGCCTCTGATCCTGAATATCAACAGGGTCGCGGGCAAACCGCGGCCTTAAAATTATGCCCCCCTCCCACAAGAGGCA
CGCAGCAGGAGACTTGATCG

Downstream 100 bases:

>100_bases
CATGATCCCGAAAAGCAGAAACCGGTTTTCCGACACGATCATGCCCAGACGAAGAGACCTGGCGACATGTTTTGATTAAA
TCATTGGACAGGCTCTATCC

Product: choline ABC transporter permease

Products: ADP; phosphate; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MNWLTDYKIPVGPTAKSVVDWLTTHLGLFFDTLAAVMQSLIDGLLYLLELPHPLLLIAIFAIIAWLIQRRISVVLLTILG
FLFIINQGYWEPTLKTLTLVLSSCFVCMVIGVPLGIAAAHRPALYAAMRPVLDLMQTLPTFVYLIPAIVFFGIGMVPGLL
ATVIFVIPAPIRLTQLSISSTPASLIEAGEAFGASRSQLLWKVELPYAMPQILAGLTQTIMLSLSMVVIAALVGADGLGV
PVVRGLNSVNISLGFEAGFIIVVVAIVLDRIFRAGREK

Sequences:

>Translated_278_residues
MNWLTDYKIPVGPTAKSVVDWLTTHLGLFFDTLAAVMQSLIDGLLYLLELPHPLLLIAIFAIIAWLIQRRISVVLLTILG
FLFIINQGYWEPTLKTLTLVLSSCFVCMVIGVPLGIAAAHRPALYAAMRPVLDLMQTLPTFVYLIPAIVFFGIGMVPGLL
ATVIFVIPAPIRLTQLSISSTPASLIEAGEAFGASRSQLLWKVELPYAMPQILAGLTQTIMLSLSMVVIAALVGADGLGV
PVVRGLNSVNISLGFEAGFIIVVVAIVLDRIFRAGREK
>Mature_278_residues
MNWLTDYKIPVGPTAKSVVDWLTTHLGLFFDTLAAVMQSLIDGLLYLLELPHPLLLIAIFAIIAWLIQRRISVVLLTILG
FLFIINQGYWEPTLKTLTLVLSSCFVCMVIGVPLGIAAAHRPALYAAMRPVLDLMQTLPTFVYLIPAIVFFGIGMVPGLL
ATVIFVIPAPIRLTQLSISSTPASLIEAGEAFGASRSQLLWKVELPYAMPQILAGLTQTIMLSLSMVVIAALVGADGLGV
PVVRGLNSVNISLGFEAGFIIVVVAIVLDRIFRAGREK

Specific function: Involved in a multicomponent binding-protein-dependent transport system for glycine betaine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4176

COG function: function code E; ABC-type proline/glycine betaine transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789033, Length=272, Percent_Identity=43.75, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1788449, Length=175, Percent_Identity=31.4285714285714, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1786564, Length=167, Percent_Identity=33.5329341317365, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788451, Length=194, Percent_Identity=31.4432989690722, Blast_Score=79, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 30079; Mature: 30079

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWLTDYKIPVGPTAKSVVDWLTTHLGLFFDTLAAVMQSLIDGLLYLLELPHPLLLIAIF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AIIAWLIQRRISVVLLTILGFLFIINQGYWEPTLKTLTLVLSSCFVCMVIGVPLGIAAAH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPALYAAMRPVLDLMQTLPTFVYLIPAIVFFGIGMVPGLLATVIFVIPAPIRLTQLSISS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCC
TPASLIEAGEAFGASRSQLLWKVELPYAMPQILAGLTQTIMLSLSMVVIAALVGADGLGV
CHHHHHHHHHHHCCCHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
PVVRGLNSVNISLGFEAGFIIVVVAIVLDRIFRAGREK
HHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNWLTDYKIPVGPTAKSVVDWLTTHLGLFFDTLAAVMQSLIDGLLYLLELPHPLLLIAIF
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AIIAWLIQRRISVVLLTILGFLFIINQGYWEPTLKTLTLVLSSCFVCMVIGVPLGIAAAH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RPALYAAMRPVLDLMQTLPTFVYLIPAIVFFGIGMVPGLLATVIFVIPAPIRLTQLSISS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCC
TPASLIEAGEAFGASRSQLLWKVELPYAMPQILAGLTQTIMLSLSMVVIAALVGADGLGV
CHHHHHHHHHHHCCCHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
PVVRGLNSVNISLGFEAGFIIVVVAIVLDRIFRAGREK
HHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-proline [Periplasm]; H2O [C]

Specific reaction: ATP + L-proline [Periplasm] + H2O = ADP + phosphate + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7622480; 8969502; 9384377 [H]