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The map label for this gene is lrp [H]

Identifier: 225853048

GI number: 225853048

Start: 1542429

End: 1542890

Strand: Direct

Name: lrp [H]

Synonym: BMEA_A1626

Alternate gene names: 225853048

Gene position: 1542429-1542890 (Clockwise)

Preceding gene: 225853046

Following gene: 225853049

Centisome position: 72.56

GC content: 54.98

Gene sequence:

>462_bases
ATGAAAAATCTCGATGCGATGGACAGAAGTATTCTGCGCGCGCTTCAGGAAAATGGACGCCTGACCAATACCGAACTTGC
CGATCGCATAAATCTTTCGCAGACGGCCACCGCCGAACGCGTCAAACGCCTGACGCGCGAAGGCTATATTCTGGGCTATT
CCGCGCGGCTTTCGCCCAAAAGGCTCGACCGCGCCATGCTGGTATTCATTGAAATCAAGCTTGACCGCACGACGTCGGAA
GTCTTTGAAACCTTTTCCACATTCACCCGCAGCAACCCGGACATTCTGGAATGCCACATGGTCGCAGGCGGCTTTGATTA
TCTGGTCAAGGCACGCGTATCGGACATGGACCACTACCGCCGGTTCCTTTCCGAAGCCCTGCTTTCGCTGCCGGGCGTAC
GCGAATCCCACACTTATGCGGTGATGGAAGAAGTGAAGGAAACGGCTGACATCGCCGTTTGA

Upstream 100 bases:

>100_bases
TCTTGCGTCGGAAACGGATTTCGGATTCATTTCCGGTGCAACTCATCTACAAATTAAGAAGAGAGCCGTTGCCCACAAAC
GGCCAACCGGGGACAGTTTG

Downstream 100 bases:

>100_bases
AATAGCCGGCACAAAAGCTATCGGGTAATAAACGCAAGCCTTGCCTGCCATTGGGATTGCTGTCAGCGGCATGACAGCAA
CCGGCAAGCTGGCGCTCTTT

Product: leucine-responsive regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MKNLDAMDRSILRALQENGRLTNTELADRINLSQTATAERVKRLTREGYILGYSARLSPKRLDRAMLVFIEIKLDRTTSE
VFETFSTFTRSNPDILECHMVAGGFDYLVKARVSDMDHYRRFLSEALLSLPGVRESHTYAVMEEVKETADIAV

Sequences:

>Translated_153_residues
MKNLDAMDRSILRALQENGRLTNTELADRINLSQTATAERVKRLTREGYILGYSARLSPKRLDRAMLVFIEIKLDRTTSE
VFETFSTFTRSNPDILECHMVAGGFDYLVKARVSDMDHYRRFLSEALLSLPGVRESHTYAVMEEVKETADIAV
>Mature_153_residues
MKNLDAMDRSILRALQENGRLTNTELADRINLSQTATAERVKRLTREGYILGYSARLSPKRLDRAMLVFIEIKLDRTTSE
VFETFSTFTRSNPDILECHMVAGGFDYLVKARVSDMDHYRRFLSEALLSLPGVRESHTYAVMEEVKETADIAV

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=152, Percent_Identity=51.3157894736842, Blast_Score=168, Evalue=2e-43,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=32, Blast_Score=95, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17492; Mature: 17492

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLDAMDRSILRALQENGRLTNTELADRINLSQTATAERVKRLTREGYILGYSARLSPK
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCEEEEEECCCCHH
RLDRAMLVFIEIKLDRTTSEVFETFSTFTRSNPDILECHMVAGGFDYLVKARVSDMDHYR
HHHHEEEEEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEEHHCCHHHHHHHHHHHHHHHH
RFLSEALLSLPGVRESHTYAVMEEVKETADIAV
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKNLDAMDRSILRALQENGRLTNTELADRINLSQTATAERVKRLTREGYILGYSARLSPK
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCEEEEEECCCCHH
RLDRAMLVFIEIKLDRTTSEVFETFSTFTRSNPDILECHMVAGGFDYLVKARVSDMDHYR
HHHHEEEEEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEEHHCCHHHHHHHHHHHHHHHH
RFLSEALLSLPGVRESHTYAVMEEVKETADIAV
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]