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The map label for this gene is hemF [H]

Identifier: 225853029

GI number: 225853029

Start: 1519690

End: 1520601

Strand: Direct

Name: hemF [H]

Synonym: BMEA_A1605

Alternate gene names: 225853029

Gene position: 1519690-1520601 (Clockwise)

Preceding gene: 225853027

Following gene: 225853034

Centisome position: 71.49

GC content: 57.79

Gene sequence:

>912_bases
ATGAAACGCGAAGACATCCCTGCGATCATCCCGGCCGATATCGAAGAAAAGAAAAAGGCGGCGCAAAGCTGGTTCGAGGA
GTTGCGCGACCGCATCTGCGCAAGTTACGAGCAACTGGAAGACGAATTGCAGGGCCCGCTTTCGGATCGTGAACCGGGCC
GTTTCGTACGCACGCCCTGGCAGAAGGATGACGGCAATGGCGGCGGTGTGATGTCGATCATGCATGGCCGCGTCTTTGAA
AAAGTGGGGGTTCACGTTTCGACTGTCCATGGCGAGTTCTCACCGGAATTCCGCAAGCAGATTCCCGGAGCCGAGGAGGA
CCCGCGCTATTGGGCAAGCGGCATTTCGCTCATCGCCCATCCGCAAAATCCCAACGTGCCAGCCGTTCATATGAACACAC
GCATGATCGTGACTACCCGCCAGTGGTTCGCGGGCGGGGCGGACCTGACGCCCGTTCTCGACCGCCGCCGCACACAGGAA
GACCCCGATACGCTCGCCTTTCACAAAGCGTTCCGCTTCATTTGCGAAAAGCACAAGGATATCGTCGATTATCAACGCCT
CAAGGAGTGGTGCGACGAATATTTCTTCCTGCCGCACCGCGACGAACCGCGCGGTATTGGCGGCATTTTCTATGACTGGC
TGCATTCACCGGAAGAAAAAGGCGGATGGGATAGCGACTTCGCCTTTACGCGCGATGTCGGGCGCGGCTTCTCCGTGGTT
TATCCGCATCTGGTGCGCCAGAACTTCAACAAGGACTGGACCGAAGCCGACCGTGACGAACAGCTCATCCGCCGTGGCCG
TTATGTCGAATTCAACCTGCTTTATGATCGCGGCACAATCTTCGGCCTCAAGACCGGCGGGAATATGAATGCCATCCTGT
CTTCCATGCCGCCCGTGGTGAAATGGCCCTGA

Upstream 100 bases:

>100_bases
TCAACAGCCCAGGCTGGACGATAGTAGCTCAATCCATTTCCCCTTGACTGCGCGATCCTGTCAGCCTTGTCGGGCAGGCT
TCGCCGGAAGGAAAAGCACA

Downstream 100 bases:

>100_bases
TGAAGCGGAAAGGGCCGGTTTCCCGGCCCTTTTTCATGCATCGAATGCCGCATGATAGGCAACATCGCCTTGCGGCATAT
CCGGACCGAAGGCCAGACAC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MKREDIPAIIPADIEEKKKAAQSWFEELRDRICASYEQLEDELQGPLSDREPGRFVRTPWQKDDGNGGGVMSIMHGRVFE
KVGVHVSTVHGEFSPEFRKQIPGAEEDPRYWASGISLIAHPQNPNVPAVHMNTRMIVTTRQWFAGGADLTPVLDRRRTQE
DPDTLAFHKAFRFICEKHKDIVDYQRLKEWCDEYFFLPHRDEPRGIGGIFYDWLHSPEEKGGWDSDFAFTRDVGRGFSVV
YPHLVRQNFNKDWTEADRDEQLIRRGRYVEFNLLYDRGTIFGLKTGGNMNAILSSMPPVVKWP

Sequences:

>Translated_303_residues
MKREDIPAIIPADIEEKKKAAQSWFEELRDRICASYEQLEDELQGPLSDREPGRFVRTPWQKDDGNGGGVMSIMHGRVFE
KVGVHVSTVHGEFSPEFRKQIPGAEEDPRYWASGISLIAHPQNPNVPAVHMNTRMIVTTRQWFAGGADLTPVLDRRRTQE
DPDTLAFHKAFRFICEKHKDIVDYQRLKEWCDEYFFLPHRDEPRGIGGIFYDWLHSPEEKGGWDSDFAFTRDVGRGFSVV
YPHLVRQNFNKDWTEADRDEQLIRRGRYVEFNLLYDRGTIFGLKTGGNMNAILSSMPPVVKWP
>Mature_303_residues
MKREDIPAIIPADIEEKKKAAQSWFEELRDRICASYEQLEDELQGPLSDREPGRFVRTPWQKDDGNGGGVMSIMHGRVFE
KVGVHVSTVHGEFSPEFRKQIPGAEEDPRYWASGISLIAHPQNPNVPAVHMNTRMIVTTRQWFAGGADLTPVLDRRRTQE
DPDTLAFHKAFRFICEKHKDIVDYQRLKEWCDEYFFLPHRDEPRGIGGIFYDWLHSPEEKGGWDSDFAFTRDVGRGFSVV
YPHLVRQNFNKDWTEADRDEQLIRRGRYVEFNLLYDRGTIFGLKTGGNMNAILSSMPPVVKWP

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=257, Percent_Identity=39.6887159533074, Blast_Score=176, Evalue=2e-44,
Organism=Escherichia coli, GI1788777, Length=275, Percent_Identity=41.0909090909091, Blast_Score=202, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6320249, Length=302, Percent_Identity=36.0927152317881, Blast_Score=167, Evalue=2e-42,
Organism=Drosophila melanogaster, GI17864388, Length=304, Percent_Identity=36.5131578947368, Blast_Score=184, Evalue=6e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 35111; Mature: 35111

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKREDIPAIIPADIEEKKKAAQSWFEELRDRICASYEQLEDELQGPLSDREPGRFVRTPW
CCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCC
QKDDGNGGGVMSIMHGRVFEKVGVHVSTVHGEFSPEFRKQIPGAEEDPRYWASGISLIAH
CCCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCHHHHHHCCCCCCCCHHHHCCCEEEEC
PQNPNVPAVHMNTRMIVTTRQWFAGGADLTPVLDRRRTQEDPDTLAFHKAFRFICEKHKD
CCCCCCCEEEECCEEEEEEHHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
IVDYQRLKEWCDEYFFLPHRDEPRGIGGIFYDWLHSPEEKGGWDSDFAFTRDVGRGFSVV
HHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHCCCHHHH
YPHLVRQNFNKDWTEADRDEQLIRRGRYVEFNLLYDRGTIFGLKTGGNMNAILSSMPPVV
HHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEEEECCEEEEEECCCCHHHHHHCCCCCC
KWP
CCC
>Mature Secondary Structure
MKREDIPAIIPADIEEKKKAAQSWFEELRDRICASYEQLEDELQGPLSDREPGRFVRTPW
CCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCC
QKDDGNGGGVMSIMHGRVFEKVGVHVSTVHGEFSPEFRKQIPGAEEDPRYWASGISLIAH
CCCCCCCCCCHHHHHHHHHHHHCCEEEEECCCCCHHHHHHCCCCCCCCHHHHCCCEEEEC
PQNPNVPAVHMNTRMIVTTRQWFAGGADLTPVLDRRRTQEDPDTLAFHKAFRFICEKHKD
CCCCCCCEEEECCEEEEEEHHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
IVDYQRLKEWCDEYFFLPHRDEPRGIGGIFYDWLHSPEEKGGWDSDFAFTRDVGRGFSVV
HHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHCCCHHHH
YPHLVRQNFNKDWTEADRDEQLIRRGRYVEFNLLYDRGTIFGLKTGGNMNAILSSMPPVV
HHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEEEEEECCEEEEEECCCCHHHHHHCCCCCC
KWP
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA