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The map label for this gene is cpxA [H]

Identifier: 225852999

GI number: 225852999

Start: 1493595

End: 1494938

Strand: Direct

Name: cpxA [H]

Synonym: BMEA_A1574

Alternate gene names: 225852999

Gene position: 1493595-1494938 (Clockwise)

Preceding gene: 225852998

Following gene: 225853000

Centisome position: 70.26

GC content: 59.52

Gene sequence:

>1344_bases
ATGAGATCGCCCTTCAGAAGATTCTCCCGTTGGTTGACGCGCATCATGCCCAAGGGGCTTTATGCGCGCTCGCTCATCAT
CATTATCGCGCCCATGGTGCTGCTCCAGTCGGTCATTGCCTATGTGTTCATGGAGCGCCACTGGCAGATGGTGACGGAAC
GCCTTTCGACGGCAGTGGTTCGCGATATCGCAGCAATCATCGATCTTCTTGAAACCTATCCGCAGGAGCCGGGTTACGAC
AATCTGATCCGCATCGCGCAGCAGCGGCTGGCGTTGAACATTTCCATCCTGCCCCCCGATCCACTGCCGCCGCCGGGGCC
GAAACCCTTCTTCGCCATTCTCGACTATTTCCTGAGCGAAGAGATCACCCGGCAGATCAACCGCCCTTTCTGGATCGATA
CTGTGGGTGATTCCGATCTGATCGAAATCCGCATCAAGCTTGAAGACAAGGTATTGCGCGTTTTTGCCCGGCGCAGCCAG
GCCTATGCGTCCAATACCGGCATCTTCCTCACATGGATGGTGGGCACGGCGCTGGTTCTGCTTATCATTGCCATCGCCTT
CCTGCGCAACCAGATCAAGCCTATCCAGCAATTGGCGCAGGCCGCCGAAAGCTTCGGCAAGGGGCGGCCCATGCCGGAAG
GTTTTCACCCGCGCGGGGCGGAGGAAGTGCGCCGCGCTGGCCTCGCCTTTATCCAGATGCGCTCGCGTATCGAACGCCAG
ATCGAGCAGCGCACCGCCATGCTTTCCGGTGTCAGCCACGACCTGCGTACCATTCTCACCCGCTTCAAGCTGCAACTGGC
CCTCGCCGGCCATTCCATCGATACCGAGCCGCTCAATCAGGATATTGCCGACATGCAGACCATGCTGGAGGGGTATCTGG
CCTTTGCGCGCGGTGAGGGAGCAGAAGAAACCGCGACTTTCGACGTCACCCGGCTTTGCGAAAAACTGGAAAGCGAAGCG
CGCCTGCGCGAGCGCGGTTTCAAGTACACGATAGAGGGCGACCGCGAAATCAACGTGCGCCCGAACGCCTTCTCACGACT
TGTCAGCAATCTGGTTTCAAACGCCTTCCGTCACGCGCAGAATGTCGAGCTTTCGATTTCGCATGTGGACGGCTGGCTTA
AAGTCATCGTGGACGATGATGGACCGGGCATGCCCGAAAATCGCAGGGAGGACGTCTTCAAGCCTTTCGTGCGGCTTGAT
GAGGCACGAACGCAGGATTCAGGCGGCACCGGCGGGCTTGGCCTTGCGATTGCCCGCGACATCGCACGCAGCCATGGCGG
CGACATTGCGCTGGAGGATTCGCCGCTCGGCGGCCTGCGCGCCACCATTCATATTCCGGCTTGA

Upstream 100 bases:

>100_bases
TTTTTCAAAACGCAGGGCGACGTGTACAAAAGGTACAACCGCAATGTGGTTCATGGAAAGCACAACCGTGCGGTCTCAGG
CGTAGGGACGTTTTAACACG

Downstream 100 bases:

>100_bases
GACATGTCTTCCGAAAGCGGCAAACGGTTGCAGACACGCCGGGAAAACAGACAGCGAACAGAACCCTATGTATCAACCCT
TTGGAAACATTATTTTTCCG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MRSPFRRFSRWLTRIMPKGLYARSLIIIIAPMVLLQSVIAYVFMERHWQMVTERLSTAVVRDIAAIIDLLETYPQEPGYD
NLIRIAQQRLALNISILPPDPLPPPGPKPFFAILDYFLSEEITRQINRPFWIDTVGDSDLIEIRIKLEDKVLRVFARRSQ
AYASNTGIFLTWMVGTALVLLIIAIAFLRNQIKPIQQLAQAAESFGKGRPMPEGFHPRGAEEVRRAGLAFIQMRSRIERQ
IEQRTAMLSGVSHDLRTILTRFKLQLALAGHSIDTEPLNQDIADMQTMLEGYLAFARGEGAEETATFDVTRLCEKLESEA
RLRERGFKYTIEGDREINVRPNAFSRLVSNLVSNAFRHAQNVELSISHVDGWLKVIVDDDGPGMPENRREDVFKPFVRLD
EARTQDSGGTGGLGLAIARDIARSHGGDIALEDSPLGGLRATIHIPA

Sequences:

>Translated_447_residues
MRSPFRRFSRWLTRIMPKGLYARSLIIIIAPMVLLQSVIAYVFMERHWQMVTERLSTAVVRDIAAIIDLLETYPQEPGYD
NLIRIAQQRLALNISILPPDPLPPPGPKPFFAILDYFLSEEITRQINRPFWIDTVGDSDLIEIRIKLEDKVLRVFARRSQ
AYASNTGIFLTWMVGTALVLLIIAIAFLRNQIKPIQQLAQAAESFGKGRPMPEGFHPRGAEEVRRAGLAFIQMRSRIERQ
IEQRTAMLSGVSHDLRTILTRFKLQLALAGHSIDTEPLNQDIADMQTMLEGYLAFARGEGAEETATFDVTRLCEKLESEA
RLRERGFKYTIEGDREINVRPNAFSRLVSNLVSNAFRHAQNVELSISHVDGWLKVIVDDDGPGMPENRREDVFKPFVRLD
EARTQDSGGTGGLGLAIARDIARSHGGDIALEDSPLGGLRATIHIPA
>Mature_447_residues
MRSPFRRFSRWLTRIMPKGLYARSLIIIIAPMVLLQSVIAYVFMERHWQMVTERLSTAVVRDIAAIIDLLETYPQEPGYD
NLIRIAQQRLALNISILPPDPLPPPGPKPFFAILDYFLSEEITRQINRPFWIDTVGDSDLIEIRIKLEDKVLRVFARRSQ
AYASNTGIFLTWMVGTALVLLIIAIAFLRNQIKPIQQLAQAAESFGKGRPMPEGFHPRGAEEVRRAGLAFIQMRSRIERQ
IEQRTAMLSGVSHDLRTILTRFKLQLALAGHSIDTEPLNQDIADMQTMLEGYLAFARGEGAEETATFDVTRLCEKLESEA
RLRERGFKYTIEGDREINVRPNAFSRLVSNLVSNAFRHAQNVELSISHVDGWLKVIVDDDGPGMPENRREDVFKPFVRLD
EARTQDSGGTGGLGLAIARDIARSHGGDIALEDSPLGGLRATIHIPA

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=34.8148148148148, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1789808, Length=294, Percent_Identity=34.6938775510204, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1787894, Length=291, Percent_Identity=29.553264604811, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788393, Length=287, Percent_Identity=24.7386759581882, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1786912, Length=246, Percent_Identity=30.4878048780488, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1790551, Length=288, Percent_Identity=26.3888888888889, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786783, Length=298, Percent_Identity=23.489932885906, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787374, Length=223, Percent_Identity=29.1479820627803, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87082128, Length=288, Percent_Identity=23.9583333333333, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788713, Length=117, Percent_Identity=30.7692307692308, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=26.3392857142857, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50391; Mature: 50391

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSPFRRFSRWLTRIMPKGLYARSLIIIIAPMVLLQSVIAYVFMERHWQMVTERLSTAVV
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDIAAIIDLLETYPQEPGYDNLIRIAQQRLALNISILPPDPLPPPGPKPFFAILDYFLSE
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHH
EITRQINRPFWIDTVGDSDLIEIRIKLEDKVLRVFARRSQAYASNTGIFLTWMVGTALVL
HHHHHCCCCEEEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
LIIAIAFLRNQIKPIQQLAQAAESFGKGRPMPEGFHPRGAEEVRRAGLAFIQMRSRIERQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
IEQRTAMLSGVSHDLRTILTRFKLQLALAGHSIDTEPLNQDIADMQTMLEGYLAFARGEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
AEETATFDVTRLCEKLESEARLRERGFKYTIEGDREINVRPNAFSRLVSNLVSNAFRHAQ
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHC
NVELSISHVDGWLKVIVDDDGPGMPENRREDVFKPFVRLDEARTQDSGGTGGLGLAIARD
CCEEEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
IARSHGGDIALEDSPLGGLRATIHIPA
HHHHCCCCEEECCCCCCCCEEEEEECC
>Mature Secondary Structure
MRSPFRRFSRWLTRIMPKGLYARSLIIIIAPMVLLQSVIAYVFMERHWQMVTERLSTAVV
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDIAAIIDLLETYPQEPGYDNLIRIAQQRLALNISILPPDPLPPPGPKPFFAILDYFLSE
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHH
EITRQINRPFWIDTVGDSDLIEIRIKLEDKVLRVFARRSQAYASNTGIFLTWMVGTALVL
HHHHHCCCCEEEEECCCCCEEEEEEEHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHH
LIIAIAFLRNQIKPIQQLAQAAESFGKGRPMPEGFHPRGAEEVRRAGLAFIQMRSRIERQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
IEQRTAMLSGVSHDLRTILTRFKLQLALAGHSIDTEPLNQDIADMQTMLEGYLAFARGEG
HHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
AEETATFDVTRLCEKLESEARLRERGFKYTIEGDREINVRPNAFSRLVSNLVSNAFRHAQ
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHC
NVELSISHVDGWLKVIVDDDGPGMPENRREDVFKPFVRLDEARTQDSGGTGGLGLAIARD
CCEEEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
IARSHGGDIALEDSPLGGLRATIHIPA
HHHHCCCCEEECCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]