Click here to switch to the map view.

The map label for this gene is degP [H]

Identifier: 225852876

GI number: 225852876

Start: 1368551

End: 1370125

Strand: Reverse

Name: degP [H]

Synonym: BMEA_A1441

Alternate gene names: 225852876

Gene position: 1370125-1368551 (Counterclockwise)

Preceding gene: 225852877

Following gene: 225852875

Centisome position: 64.46

GC content: 58.6

Gene sequence:

>1575_bases
ATGGCAATTGCACCAAAGGCGGGTTTTGCTCGCACCCTTTTCGCAACCGTTGCACTGGGGGCGATGAGTGTCGCGGGCAC
TGTGTCGATGGGAACGCCGCCCGCGCTGGCTGCGCAAGGTCCCGCTTCGGTGGCCGATCTTGCCGAAGGGCTTCTGGATG
CAGTCGTGAATATCTCCACATCGCAGACCGTGAAGGACGATGGCGAGGGGGACGGCCCGGTGCCGATGCCGCAGGTGCCG
GAAGGTTCGCCCTTCCAGGAATTCTTCAAAGACTTCTTCAATGACAAGGATGGCGCGCAGGGCGATGATTCACGCAAGGT
GCAGTCGCTGGGTTCGGGTTTCATCATCGATGCCGAAAAGGGTTACATCGTCACCAACAATCACGTCATCGCCGATGCCG
ACGAGATTGAGGTGAATTTCAACGATGGTTCCAAGCTCAAGGCGGAGCTCGTTGGCAAGGATACGAAGACCGATCTTGCG
ATCCTGAAAGTCGACCCTTCCAAGCATAAGCTCAAGGCGGTGCATTTCGGCAATTCGGAAAAGGCGCGCATTGGCGATTG
GGTTCTGGCGATCGGCAATCCGTTCGGCCTTGGCGGTACTGTCACGGCAGGCATCATTTCAGCACGCAAGCGCGATATCA
ATTCCGGCCCCTATGACGATTTCATTCAGACGGATGCCGCGATCAATCGCGGCAATTCCGGCGGGCCGCTGTTTGATATG
GACGGCAAGGTGATCGGCATCAATACGGCGATCATTTCGCCTTCTGGCGGGTCGATCGGCATTGGTTTTGCTATTCCGGC
GGAAATGGCCGCCGGTGTCATCGATCAGTTGAAGGAATTTGGCGAAGTGCGCCGCGGCTGGCTTGGCGTCCGTCTTCAGC
CGATGACGGAAGACATTGCCCAGAGCCTCGGGCTGAAAGAGACCAAGGGCGCGCTGATTGCCGGTCTCATCGAAAATTCC
GGTGTCGATAACAAGGCGATAGAGGCGGGCGATGTGGTGATCCGCTTTGACGGCAAACCGGTGGATACGGCGCGCGATCT
TCCGCGCCTCGTGGCGGAAAGCCCGGTTGGCAAGGAAGTGGAAATCGTCGTTATCCGTCAGGGCGCGGAAAAGACCCTGA
AGGTCAAGCTTGGCTGTCTGGTCGAGGACGACAAGAGCACGGAGCCGGCGGTTGAAGATCAGGTGCCCGCGCCGGATGAC
GGCGAACAGCCGGGAGCCCGGCAGGAGACGCCGGACAAGTCGGACAAGCCGAAGAAGGAACACAAGAGCGATGCTGCTCC
AAGCGTTCTCGGCATGAAGCTCAGCAAGCTCGATGATGATATTCGCGGCGAGTTTGGCATTGCCGAAGATGTGGAGGGCG
TTGCCATCCTCTATGTTGCACCGGGGACGGCTGCCGGCGAAAAGCGCATCGAAACGGGCGATGTCATTGTCGATATCGGT
CAGGTGACGGTGAAGACGCCGGAAGATGTGAAAAAGCGTATCGATGCACTGCGCCGCGAGGGGCGCAAGAATGCGCTTTT
GATGCTGGCTTCGCGTTCCGGGGAGTTGCGTTTCGTGACGATCCGTATCGACTGA

Upstream 100 bases:

>100_bases
CAAAACAAATGGTTAGAGCGGTTCCAGCGATTCTGTTAGAACGAGGGCCGCGCTAAACTTGGACAACGACCGCAAGCAGA
CAGGAACGGAGCAGAGCTTC

Downstream 100 bases:

>100_bases
TTGTTTTTGGATGGATGAAGGACGGCGCCGAACGGAAACCTGCGGTGCCGTTTTGTTTCATGGTTTGAATCGCTTGGCGG
CAAGTGCGCAGAAAGTGATT

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MAIAPKAGFARTLFATVALGAMSVAGTVSMGTPPALAAQGPASVADLAEGLLDAVVNISTSQTVKDDGEGDGPVPMPQVP
EGSPFQEFFKDFFNDKDGAQGDDSRKVQSLGSGFIIDAEKGYIVTNNHVIADADEIEVNFNDGSKLKAELVGKDTKTDLA
ILKVDPSKHKLKAVHFGNSEKARIGDWVLAIGNPFGLGGTVTAGIISARKRDINSGPYDDFIQTDAAINRGNSGGPLFDM
DGKVIGINTAIISPSGGSIGIGFAIPAEMAAGVIDQLKEFGEVRRGWLGVRLQPMTEDIAQSLGLKETKGALIAGLIENS
GVDNKAIEAGDVVIRFDGKPVDTARDLPRLVAESPVGKEVEIVVIRQGAEKTLKVKLGCLVEDDKSTEPAVEDQVPAPDD
GEQPGARQETPDKSDKPKKEHKSDAAPSVLGMKLSKLDDDIRGEFGIAEDVEGVAILYVAPGTAAGEKRIETGDVIVDIG
QVTVKTPEDVKKRIDALRREGRKNALLMLASRSGELRFVTIRID

Sequences:

>Translated_524_residues
MAIAPKAGFARTLFATVALGAMSVAGTVSMGTPPALAAQGPASVADLAEGLLDAVVNISTSQTVKDDGEGDGPVPMPQVP
EGSPFQEFFKDFFNDKDGAQGDDSRKVQSLGSGFIIDAEKGYIVTNNHVIADADEIEVNFNDGSKLKAELVGKDTKTDLA
ILKVDPSKHKLKAVHFGNSEKARIGDWVLAIGNPFGLGGTVTAGIISARKRDINSGPYDDFIQTDAAINRGNSGGPLFDM
DGKVIGINTAIISPSGGSIGIGFAIPAEMAAGVIDQLKEFGEVRRGWLGVRLQPMTEDIAQSLGLKETKGALIAGLIENS
GVDNKAIEAGDVVIRFDGKPVDTARDLPRLVAESPVGKEVEIVVIRQGAEKTLKVKLGCLVEDDKSTEPAVEDQVPAPDD
GEQPGARQETPDKSDKPKKEHKSDAAPSVLGMKLSKLDDDIRGEFGIAEDVEGVAILYVAPGTAAGEKRIETGDVIVDIG
QVTVKTPEDVKKRIDALRREGRKNALLMLASRSGELRFVTIRID
>Mature_523_residues
AIAPKAGFARTLFATVALGAMSVAGTVSMGTPPALAAQGPASVADLAEGLLDAVVNISTSQTVKDDGEGDGPVPMPQVPE
GSPFQEFFKDFFNDKDGAQGDDSRKVQSLGSGFIIDAEKGYIVTNNHVIADADEIEVNFNDGSKLKAELVGKDTKTDLAI
LKVDPSKHKLKAVHFGNSEKARIGDWVLAIGNPFGLGGTVTAGIISARKRDINSGPYDDFIQTDAAINRGNSGGPLFDMD
GKVIGINTAIISPSGGSIGIGFAIPAEMAAGVIDQLKEFGEVRRGWLGVRLQPMTEDIAQSLGLKETKGALIAGLIENSG
VDNKAIEAGDVVIRFDGKPVDTARDLPRLVAESPVGKEVEIVVIRQGAEKTLKVKLGCLVEDDKSTEPAVEDQVPAPDDG
EQPGARQETPDKSDKPKKEHKSDAAPSVLGMKLSKLDDDIRGEFGIAEDVEGVAILYVAPGTAAGEKRIETGDVIVDIGQ
VTVKTPEDVKKRIDALRREGRKNALLMLASRSGELRFVTIRID

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=272, Percent_Identity=34.5588235294118, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4506141, Length=279, Percent_Identity=34.4086021505376, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI24308541, Length=252, Percent_Identity=32.9365079365079, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI7019477, Length=291, Percent_Identity=35.0515463917526, Blast_Score=119, Evalue=5e-27,
Organism=Escherichia coli, GI1786356, Length=482, Percent_Identity=34.2323651452282, Blast_Score=265, Evalue=6e-72,
Organism=Escherichia coli, GI1789629, Length=366, Percent_Identity=39.8907103825137, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI1789630, Length=291, Percent_Identity=38.4879725085911, Blast_Score=177, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6324206, Length=295, Percent_Identity=26.4406779661017, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24646839, Length=286, Percent_Identity=31.8181818181818, Blast_Score=132, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 55237; Mature: 55106

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIAPKAGFARTLFATVALGAMSVAGTVSMGTPPALAAQGPASVADLAEGLLDAVVNIST
CCCCCCCCHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
SQTVKDDGEGDGPVPMPQVPEGSPFQEFFKDFFNDKDGAQGDDSRKVQSLGSGFIIDAEK
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCCCEEEECCC
GYIVTNNHVIADADEIEVNFNDGSKLKAELVGKDTKTDLAILKVDPSKHKLKAVHFGNSE
CEEEECCEEEECCCEEEEEECCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEEEECCCC
KARIGDWVLAIGNPFGLGGTVTAGIISARKRDINSGPYDDFIQTDAAINRGNSGGPLFDM
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHCCHHHCCCCCCCCEEEC
DGKVIGINTAIISPSGGSIGIGFAIPAEMAAGVIDQLKEFGEVRRGWLGVRLQPMTEDIA
CCEEEEEEEEEECCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCEECEEEECHHHHHH
QSLGLKETKGALIAGLIENSGVDNKAIEAGDVVIRFDGKPVDTARDLPRLVAESPVGKEV
HHCCCCCCCCCEEEEEHHCCCCCCCCEECCCEEEEECCCCCCHHHHHHHHHHCCCCCCCE
EIVVIRQGAEKTLKVKLGCLVEDDKSTEPAVEDQVPAPDDGEQPGARQETPDKSDKPKKE
EEEEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
HKSDAAPSVLGMKLSKLDDDIRGEFGIAEDVEGVAILYVAPGTAAGEKRIETGDVIVDIG
HCCCCCCHHHHHHHHHCCHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEC
QVTVKTPEDVKKRIDALRREGRKNALLMLASRSGELRFVTIRID
CEEECCHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEEC
>Mature Secondary Structure 
AIAPKAGFARTLFATVALGAMSVAGTVSMGTPPALAAQGPASVADLAEGLLDAVVNIST
CCCCCCCHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
SQTVKDDGEGDGPVPMPQVPEGSPFQEFFKDFFNDKDGAQGDDSRKVQSLGSGFIIDAEK
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCCCEEEECCC
GYIVTNNHVIADADEIEVNFNDGSKLKAELVGKDTKTDLAILKVDPSKHKLKAVHFGNSE
CEEEECCEEEECCCEEEEEECCCCEEEEEECCCCCCCCEEEEEECCCCCEEEEEEECCCC
KARIGDWVLAIGNPFGLGGTVTAGIISARKRDINSGPYDDFIQTDAAINRGNSGGPLFDM
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHCCHHHCCCCCCCCEEEC
DGKVIGINTAIISPSGGSIGIGFAIPAEMAAGVIDQLKEFGEVRRGWLGVRLQPMTEDIA
CCEEEEEEEEEECCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHCEECEEEECHHHHHH
QSLGLKETKGALIAGLIENSGVDNKAIEAGDVVIRFDGKPVDTARDLPRLVAESPVGKEV
HHCCCCCCCCCEEEEEHHCCCCCCCCEECCCEEEEECCCCCCHHHHHHHHHHCCCCCCCE
EIVVIRQGAEKTLKVKLGCLVEDDKSTEPAVEDQVPAPDDGEQPGARQETPDKSDKPKKE
EEEEEECCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHH
HKSDAAPSVLGMKLSKLDDDIRGEFGIAEDVEGVAILYVAPGTAAGEKRIETGDVIVDIG
HCCCCCCHHHHHHHHHCCHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEEC
QVTVKTPEDVKKRIDALRREGRKNALLMLASRSGELRFVTIRID
CEEECCHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550509; 11481430 [H]