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The map label for this gene is lysN [H]

Identifier: 225852861

GI number: 225852861

Start: 1354025

End: 1355257

Strand: Reverse

Name: lysN [H]

Synonym: BMEA_A1425

Alternate gene names: 225852861

Gene position: 1355257-1354025 (Counterclockwise)

Preceding gene: 225852862

Following gene: 225852859

Centisome position: 63.76

GC content: 57.34

Gene sequence:

>1233_bases
GTGTTGGACTGGGAAAATGTATTTGCAACGCGCTCGAAACGTATGCGCGCATCGGAAATCCGTGAACTGTTGAAGCTTCT
GGAACGGCCAGATATCATTTCCTTCGCAGGCGGCATTCCTGATCCCGCTCTTTTCCCGCATGATGAATTCCAGGCAGCCT
ACAAGGATATTTTGGGTGGCCCGGAAGCCAATGCTGCGCTGCAATATTCCATTTCGGAAGGCTACAAGCCGCTGCGCACA
TGGCTGGTTGGCGAACTCGCCAAGATCGGCATTCCCTGCACCGAAGATAATGTGTTCATCACGTCTGGCTCGCAGCAGGC
GCTCGATTATCTGGGCAAGCTGTTTCTGTCGCCGGGCGATACTGCGCTCGTAACTGCGCCGACATATCTTGGCGCGCTGC
AAGCCTTCAACGCCTATGAACCGAACTATGACACGCTGGCGCTTAAGGGCAATCGCACGCCGCAATCCTATGCGCAGACT
GCGCAGAAGGCTGGCGGACAGGTCAAGTTCGCTTATCTTTCGGCTGATTTCAGCAATCCGACTGGCGAGACGGTCGATCG
TGCGGGTCGCGAAAAGCTGCTGGCACATGCCGACGAACTGGATATCCCAGTGATCGAAGATGCCGCCTATCAGTATCTTC
GCTATAATGGCGATGCGATCCCGCCGATCCTGGCGCTCGACATTGCCCGCAATGGCGGCGATATCGAGAAGACCCGCACC
ATCTATTGCGGCTCGTTCTCCAAGACGCTGGCACCGGGCTTGCGCGTCGGCTATGTGGTTGCCTCCAAGACCGTCATCCG
CAAGCTCGTCCTGATGAAGCAGGCGGCGGACCTTCATTCTTCCACCATCAACCAGATTGCGATCCAGCACGTTGCGGTGC
ATGGCTTCGATGCACAGGTGGCAAAGCTGCACGGCGTTTACAAACATCGCCGTGACAGGATGCTGGAGGCTCTGGCGAAA
TATATGCCGGAAGGCGTTCACTGGACAAAGCCGGAAGGCGGGATGTTCGTCTGGGTCACACTGCCGGAAGGCATGGACGG
CGCTTCGCTGCTGGCCGCTTCCATCGACAGTGAAAAGGTGGCATTCGTTCCGGGCAAGGCGTTCTTTGCCGACGGAACCG
GTGCGAATACGCTGCGCCTTAGCTATTCCTGCGCCAATGACGAGATGATCGATGAAGGCATCAAGCGGCTTGGCCGCCTG
ATCCGCGCGCATACGAAATCCGCTGCGGCGTAA

Upstream 100 bases:

>100_bases
AATTGCGCTAAACCACCATCGTCAATAGCTGGGTTTGAGGAGACTTCGCTATTACAAGTTCCGCTGCAAGAGGCGGATAG
TCTAATTGAGGAGACTTCCC

Downstream 100 bases:

>100_bases
GATTTTGTATCAAAGGTAAAAAAAACCGGGCCTTGCGCCCGGTTTTTTATTGGAATGGAGAATTGCAGCTTTGCCGTGGT
CCGGCGAAGGGCTGGTAAGT

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MLDWENVFATRSKRMRASEIRELLKLLERPDIISFAGGIPDPALFPHDEFQAAYKDILGGPEANAALQYSISEGYKPLRT
WLVGELAKIGIPCTEDNVFITSGSQQALDYLGKLFLSPGDTALVTAPTYLGALQAFNAYEPNYDTLALKGNRTPQSYAQT
AQKAGGQVKFAYLSADFSNPTGETVDRAGREKLLAHADELDIPVIEDAAYQYLRYNGDAIPPILALDIARNGGDIEKTRT
IYCGSFSKTLAPGLRVGYVVASKTVIRKLVLMKQAADLHSSTINQIAIQHVAVHGFDAQVAKLHGVYKHRRDRMLEALAK
YMPEGVHWTKPEGGMFVWVTLPEGMDGASLLAASIDSEKVAFVPGKAFFADGTGANTLRLSYSCANDEMIDEGIKRLGRL
IRAHTKSAAA

Sequences:

>Translated_410_residues
MLDWENVFATRSKRMRASEIRELLKLLERPDIISFAGGIPDPALFPHDEFQAAYKDILGGPEANAALQYSISEGYKPLRT
WLVGELAKIGIPCTEDNVFITSGSQQALDYLGKLFLSPGDTALVTAPTYLGALQAFNAYEPNYDTLALKGNRTPQSYAQT
AQKAGGQVKFAYLSADFSNPTGETVDRAGREKLLAHADELDIPVIEDAAYQYLRYNGDAIPPILALDIARNGGDIEKTRT
IYCGSFSKTLAPGLRVGYVVASKTVIRKLVLMKQAADLHSSTINQIAIQHVAVHGFDAQVAKLHGVYKHRRDRMLEALAK
YMPEGVHWTKPEGGMFVWVTLPEGMDGASLLAASIDSEKVAFVPGKAFFADGTGANTLRLSYSCANDEMIDEGIKRLGRL
IRAHTKSAAA
>Mature_410_residues
MLDWENVFATRSKRMRASEIRELLKLLERPDIISFAGGIPDPALFPHDEFQAAYKDILGGPEANAALQYSISEGYKPLRT
WLVGELAKIGIPCTEDNVFITSGSQQALDYLGKLFLSPGDTALVTAPTYLGALQAFNAYEPNYDTLALKGNRTPQSYAQT
AQKAGGQVKFAYLSADFSNPTGETVDRAGREKLLAHADELDIPVIEDAAYQYLRYNGDAIPPILALDIARNGGDIEKTRT
IYCGSFSKTLAPGLRVGYVVASKTVIRKLVLMKQAADLHSSTINQIAIQHVAVHGFDAQVAKLHGVYKHRRDRMLEALAK
YMPEGVHWTKPEGGMFVWVTLPEGMDGASLLAASIDSEKVAFVPGKAFFADGTGANTLRLSYSCANDEMIDEGIKRLGRL
IRAHTKSAAA

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=419, Percent_Identity=30.5489260143198, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI33469970, Length=419, Percent_Identity=30.5489260143198, Blast_Score=177, Evalue=2e-44,
Organism=Escherichia coli, GI1787710, Length=384, Percent_Identity=27.0833333333333, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI1790797, Length=338, Percent_Identity=25.4437869822485, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI48994949, Length=408, Percent_Identity=26.4705882352941, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1788722, Length=383, Percent_Identity=27.4151436031332, Blast_Score=83, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321000, Length=275, Percent_Identity=29.4545454545455, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21356535, Length=418, Percent_Identity=23.2057416267943, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 44715; Mature: 44715

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDWENVFATRSKRMRASEIRELLKLLERPDIISFAGGIPDPALFPHDEFQAAYKDILGG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCC
PEANAALQYSISEGYKPLRTWLVGELAKIGIPCTEDNVFITSGSQQALDYLGKLFLSPGD
CCCCCEEEEEHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCC
TALVTAPTYLGALQAFNAYEPNYDTLALKGNRTPQSYAQTAQKAGGQVKFAYLSADFSNP
CEEEECHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEEEEECCCCC
TGETVDRAGREKLLAHADELDIPVIEDAAYQYLRYNGDAIPPILALDIARNGGDIEKTRT
CCHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCEE
IYCGSFSKTLAPGLRVGYVVASKTVIRKLVLMKQAADLHSSTINQIAIQHVAVHGFDAQV
EEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHH
AKLHGVYKHRRDRMLEALAKYMPEGVHWTKPEGGMFVWVTLPEGMDGASLLAASIDSEKV
HHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEECCCCCCCHHHHHCCCCCCEE
AFVPGKAFFADGTGANTLRLSYSCANDEMIDEGIKRLGRLIRAHTKSAAA
EEECCCEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDWENVFATRSKRMRASEIRELLKLLERPDIISFAGGIPDPALFPHDEFQAAYKDILGG
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHCC
PEANAALQYSISEGYKPLRTWLVGELAKIGIPCTEDNVFITSGSQQALDYLGKLFLSPGD
CCCCCEEEEEHHHCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCC
TALVTAPTYLGALQAFNAYEPNYDTLALKGNRTPQSYAQTAQKAGGQVKFAYLSADFSNP
CEEEECHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEEEEECCCCC
TGETVDRAGREKLLAHADELDIPVIEDAAYQYLRYNGDAIPPILALDIARNGGDIEKTRT
CCHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCEE
IYCGSFSKTLAPGLRVGYVVASKTVIRKLVLMKQAADLHSSTINQIAIQHVAVHGFDAQV
EEECCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHH
AKLHGVYKHRRDRMLEALAKYMPEGVHWTKPEGGMFVWVTLPEGMDGASLLAASIDSEKV
HHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEECCCCCCCHHHHHCCCCCCEE
AFVPGKAFFADGTGANTLRLSYSCANDEMIDEGIKRLGRLIRAHTKSAAA
EEECCCEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA