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The map label for this gene is cobM [H]

Identifier: 225852791

GI number: 225852791

Start: 1280750

End: 1281508

Strand: Reverse

Name: cobM [H]

Synonym: BMEA_A1347

Alternate gene names: 225852791

Gene position: 1281508-1280750 (Counterclockwise)

Preceding gene: 225852792

Following gene: 225852788

Centisome position: 60.29

GC content: 58.63

Gene sequence:

>759_bases
GTGACTGTTCATTTCATTGGCGCCGGTCCGGGCGCAGCCGATCTTATCACGGTGCGGGGTTTGCGGCTGATCGAAAACTG
CCCTGTCTGCATCTATGCGGGCTCGCTTGTGCCGAAGGAGGTTGTTGCCGGGGCGCCGAAGAATGCGCGTCTGATCGACA
GTTCTTCGCTGACGCTCGATGAGATTATTGCCGAAATGGAAGTGGCACATGCCCAGGGTCTCGACGTTGCGCGGGTGCAT
TCTGGCGACTCGTCGATTTATGGCGCGATGGCAGAACAGATGCGCCGGCTGGATGCGCTTGGTATTGCCTATGACGTGAC
GCCGGGTGTGCCTGCCTTTGCGGCGGCGGCTGCCGCGATGAAGCAGGAACTGACTATTCCGGAACTCAACCAGACCATTA
TCCTCACGCGCACGTCCATGAAATCATCGGCCATGCCGGAAGGCGAGGATCTTGCAGCGCTTGGCAAATCCGGTGCGACG
CTGGTGATTCATCTTTCCATTCGCAATCTGGCAAAAATCGAAAGCGACCTGACACCCCTTTACGGTGCTGACTGCCCGGT
GGTGGTCGCTTACCGGGTCGGCTGGCCGGACGAGCAGATTTTGCGCGGAACGCTTTGCGACATTGCCGGGAAAATTGAAG
CGTCCGGCCTCAGGCGCACGGCGATGATCTTTGTCGGGCGTGGGCTCGATCCCAAAAACTTTCGCGATTCGGCCCTCTAT
CATGAAGCGCATAGCCACGCGGCGCGCTCAAAAGTTTAA

Upstream 100 bases:

>100_bases
CCACCGCCGCCCTGGCGATGGTTCCAACGTTTCCGTTATAATCGGAACCGCTCTATCAAGGCGGGGTCTGTCAGCATCCG
CGCTTCAGGAAGGGAAAATC

Downstream 100 bases:

>100_bases
AACAGAGCGGGCAAAGGCGATGGCTTGTGGCACTGTCGCAACCACGGTTTTCGCCGCAACCGGCGGGCGGGCGATCATCA
TCACCGGCAGGGCCAGATCG

Product: precorrin-4 C11-methyltransferase

Products: NA

Alternate protein names: Precorrin-3 methylase [H]

Number of amino acids: Translated: 252; Mature: 251

Protein sequence:

>252_residues
MTVHFIGAGPGAADLITVRGLRLIENCPVCIYAGSLVPKEVVAGAPKNARLIDSSSLTLDEIIAEMEVAHAQGLDVARVH
SGDSSIYGAMAEQMRRLDALGIAYDVTPGVPAFAAAAAAMKQELTIPELNQTIILTRTSMKSSAMPEGEDLAALGKSGAT
LVIHLSIRNLAKIESDLTPLYGADCPVVVAYRVGWPDEQILRGTLCDIAGKIEASGLRRTAMIFVGRGLDPKNFRDSALY
HEAHSHAARSKV

Sequences:

>Translated_252_residues
MTVHFIGAGPGAADLITVRGLRLIENCPVCIYAGSLVPKEVVAGAPKNARLIDSSSLTLDEIIAEMEVAHAQGLDVARVH
SGDSSIYGAMAEQMRRLDALGIAYDVTPGVPAFAAAAAAMKQELTIPELNQTIILTRTSMKSSAMPEGEDLAALGKSGAT
LVIHLSIRNLAKIESDLTPLYGADCPVVVAYRVGWPDEQILRGTLCDIAGKIEASGLRRTAMIFVGRGLDPKNFRDSALY
HEAHSHAARSKV
>Mature_251_residues
TVHFIGAGPGAADLITVRGLRLIENCPVCIYAGSLVPKEVVAGAPKNARLIDSSSLTLDEIIAEMEVAHAQGLDVARVHS
GDSSIYGAMAEQMRRLDALGIAYDVTPGVPAFAAAAAAMKQELTIPELNQTIILTRTSMKSSAMPEGEDLAALGKSGATL
VIHLSIRNLAKIESDLTPLYGADCPVVVAYRVGWPDEQILRGTLCDIAGKIEASGLRRTAMIFVGRGLDPKNFRDSALYH
EAHSHAARSKV

Specific function: Catalyzes the methylation of C-11 in precorrin-4 to form precorrin-5 [H]

COG id: COG2875

COG function: function code H; Precorrin-4 methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=250, Percent_Identity=25.2, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006362
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.133 [H]

Molecular weight: Translated: 26700; Mature: 26569

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVHFIGAGPGAADLITVRGLRLIENCPVCIYAGSLVPKEVVAGAPKNARLIDSSSLTLD
CEEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCCCCEEECCCCCCHH
EIIAEMEVAHAQGLDVARVHSGDSSIYGAMAEQMRRLDALGIAYDVTPGVPAFAAAAAAM
HHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHH
KQELTIPELNQTIILTRTSMKSSAMPEGEDLAALGKSGATLVIHLSIRNLAKIESDLTPL
HHCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHCCCCCEEEEEEEHHHHHHHHHCCCCC
YGADCPVVVAYRVGWPDEQILRGTLCDIAGKIEASGLRRTAMIFVGRGLDPKNFRDSALY
CCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCHHHHH
HEAHSHAARSKV
HHHHHHHHHCCC
>Mature Secondary Structure 
TVHFIGAGPGAADLITVRGLRLIENCPVCIYAGSLVPKEVVAGAPKNARLIDSSSLTLD
EEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCCCCEEECCCCCCHH
EIIAEMEVAHAQGLDVARVHSGDSSIYGAMAEQMRRLDALGIAYDVTPGVPAFAAAAAAM
HHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHH
KQELTIPELNQTIILTRTSMKSSAMPEGEDLAALGKSGATLVIHLSIRNLAKIESDLTPL
HHCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHHCCCCCEEEEEEEHHHHHHHHHCCCCC
YGADCPVVVAYRVGWPDEQILRGTLCDIAGKIEASGLRRTAMIFVGRGLDPKNFRDSALY
CCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCHHHHH
HEAHSHAARSKV
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211521; 8226690 [H]