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The map label for this gene is cobA [H]

Identifier: 225852788

GI number: 225852788

Start: 1277980

End: 1278858

Strand: Reverse

Name: cobA [H]

Synonym: BMEA_A1344

Alternate gene names: 225852788

Gene position: 1278858-1277980 (Counterclockwise)

Preceding gene: 225852791

Following gene: 225852787

Centisome position: 60.16

GC content: 61.89

Gene sequence:

>879_bases
ATGAGCAAAGCTGACGAAGCGGCTGCCTGTGTGATCGCGAAAAGCAAAGTGGCTTTGCCCGTGATGGAGCCCGGCCATGT
CTGGCTTGTCGGGGCCGGTCCGGGCGATCCCGGTCTTTTGACCCTCCATGCGGTGAACGCTTTGCAACAGGCGGATGTGA
TCGTCTATGACGCGCTGGTCGATGATTCCTGTCTTTCGCTGAAGAATGCTACCGCCACGTTGGAATATGCCGGCAAGCGC
GGCGGCAAACCATCGCCCAGGCAACGCGACATCTCGCTGCGGCTGGTGGAGCTTGCACGGCAAGGCAAGAAGGTGCTGCG
GCTCAAGGGTGGCGATCCTTTCGTGTTCGGGCGCGGGGCGGAAGAGGCGCTCACGCTTGTTGAGTATCATGTTCCGTTTC
GCATCGTGCCGGGGGTCACAGCCGGGGTTGGCGGGCTTGCCTATGCGGGAATTGCCGCCACGCATCGCGATATCAATCAG
GCGGTAACGTTTCTGACCGGGCATGACGCAACCGGCGCCATGCCCGATGGCGTCGATTGGGCGGGTATTGCCCGATCGTC
GCCGGTCATCGTCATGTATATGGCGATGAAACATATCGGCCTCATAGCCGGGCGGCTGATCGAGGCTGGACGTTCGCCAG
ATGAGCCGGTGGCCTTCGTCTGCAATGCCAGCCTGCCGGACCAGACCGTGCTTGAAACAACGTTGGGCCGGGCTGCAATC
GAGGTGGAAGCAGCCGGGCTGCAACCGCCAGCCATTGTGGTTGTGGGTGAGGTGGTGCGCTTGCGTGCCGGGCTGGACTG
GATCGGCGCAATGGCGGGAAAAAGCCTTGTCAGCGATCCGCTGGGCAAGAGAACGCAACAGGGAGTGCAGAGCGCATGA

Upstream 100 bases:

>100_bases
TTTCAGGGTTTTTATTTGCGGGGGTAGTTTCGTCGTTCATGGACGACTTATAATGTATCTGATAGCTGTGCGGCTAGTAA
ATTGAACGTGGTTGTAGAGT

Downstream 100 bases:

>100_bases
AGGGATTCATGATTGCCGCACCGGCCTCCGGGTCGGGCAAGACGACCGTGACCTTGGGTTTGTTGCGCGCCCTGAAACGC
AGGGGCGAGGTGCTTGCGCC

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MSKADEAAACVIAKSKVALPVMEPGHVWLVGAGPGDPGLLTLHAVNALQQADVIVYDALVDDSCLSLKNATATLEYAGKR
GGKPSPRQRDISLRLVELARQGKKVLRLKGGDPFVFGRGAEEALTLVEYHVPFRIVPGVTAGVGGLAYAGIAATHRDINQ
AVTFLTGHDATGAMPDGVDWAGIARSSPVIVMYMAMKHIGLIAGRLIEAGRSPDEPVAFVCNASLPDQTVLETTLGRAAI
EVEAAGLQPPAIVVVGEVVRLRAGLDWIGAMAGKSLVSDPLGKRTQQGVQSA

Sequences:

>Translated_292_residues
MSKADEAAACVIAKSKVALPVMEPGHVWLVGAGPGDPGLLTLHAVNALQQADVIVYDALVDDSCLSLKNATATLEYAGKR
GGKPSPRQRDISLRLVELARQGKKVLRLKGGDPFVFGRGAEEALTLVEYHVPFRIVPGVTAGVGGLAYAGIAATHRDINQ
AVTFLTGHDATGAMPDGVDWAGIARSSPVIVMYMAMKHIGLIAGRLIEAGRSPDEPVAFVCNASLPDQTVLETTLGRAAI
EVEAAGLQPPAIVVVGEVVRLRAGLDWIGAMAGKSLVSDPLGKRTQQGVQSA
>Mature_291_residues
SKADEAAACVIAKSKVALPVMEPGHVWLVGAGPGDPGLLTLHAVNALQQADVIVYDALVDDSCLSLKNATATLEYAGKRG
GKPSPRQRDISLRLVELARQGKKVLRLKGGDPFVFGRGAEEALTLVEYHVPFRIVPGVTAGVGGLAYAGIAATHRDINQA
VTFLTGHDATGAMPDGVDWAGIARSSPVIVMYMAMKHIGLIAGRLIEAGRSPDEPVAFVCNASLPDQTVLETTLGRAAIE
VEAAGLQPPAIVVVGEVVRLRAGLDWIGAMAGKSLVSDPLGKRTQQGVQSA

Specific function: Catalyzes the methylation of both C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=268, Percent_Identity=41.4179104477612, Blast_Score=199, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6322922, Length=256, Percent_Identity=32.8125, Blast_Score=119, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 30407; Mature: 30275

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKADEAAACVIAKSKVALPVMEPGHVWLVGAGPGDPGLLTLHAVNALQQADVIVYDALV
CCCCCCCEEEEEECCCEEEEEECCCCEEEEECCCCCCCEEEEHHHHHHHHCCEEEEEEHH
DDSCLSLKNATATLEYAGKRGGKPSPRQRDISLRLVELARQGKKVLRLKGGDPFVFGRGA
CCHHHHHCCCEEEEEEHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCEEECCCH
EEALTLVEYHVPFRIVPGVTAGVGGLAYAGIAATHRDINQAVTFLTGHDATGAMPDGVDW
HHHHEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCC
AGIARSSPVIVMYMAMKHIGLIAGRLIEAGRSPDEPVAFVCNASLPDQTVLETTLGRAAI
CCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHCCEEE
EVEAAGLQPPAIVVVGEVVRLRAGLDWIGAMAGKSLVSDPLGKRTQQGVQSA
EEEECCCCCCEEEEHHHHHHHHHCHHHHHHHHCHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure 
SKADEAAACVIAKSKVALPVMEPGHVWLVGAGPGDPGLLTLHAVNALQQADVIVYDALV
CCCCCCEEEEEECCCEEEEEECCCCEEEEECCCCCCCEEEEHHHHHHHHCCEEEEEEHH
DDSCLSLKNATATLEYAGKRGGKPSPRQRDISLRLVELARQGKKVLRLKGGDPFVFGRGA
CCHHHHHCCCEEEEEEHHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCEEECCCH
EEALTLVEYHVPFRIVPGVTAGVGGLAYAGIAATHRDINQAVTFLTGHDATGAMPDGVDW
HHHHEEEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCC
AGIARSSPVIVMYMAMKHIGLIAGRLIEAGRSPDEPVAFVCNASLPDQTVLETTLGRAAI
CCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHCCEEE
EVEAAGLQPPAIVVVGEVVRLRAGLDWIGAMAGKSLVSDPLGKRTQQGVQSA
EEEECCCCCCEEEEHHHHHHHHHCHHHHHHHHCHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211520; 2546914 [H]