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The map label for this gene is bhbA [H]

Identifier: 225852686

GI number: 225852686

Start: 1184656

End: 1186794

Strand: Direct

Name: bhbA [H]

Synonym: BMEA_A1234

Alternate gene names: 225852686

Gene position: 1184656-1186794 (Clockwise)

Preceding gene: 225852685

Following gene: 225852693

Centisome position: 55.73

GC content: 58.95

Gene sequence:

>2139_bases
ATGACGAAGAAAACCCGCGCTGATTGGGAAACGTTGGCTGAAAAAGAACTGAAGCGGCCTGCCGACAGCCTCGTCTGGCA
CACACCGGAAGGCATCGACGTCAAGCCGCTTTATACGCAAGACGATCTGGAAGGTATCGGCCATCTGGGTACCCTGCCCG
GCTTTGAGCCGTTCCTGCGCGGGCCGCGCGCAACCATGTATGCGGGCCGTCCATGGACGATCCGGCAATATGCGGGCTTC
TCCACTGCGGAGGAATCAAACGCCTTTTATCGCAAGGCGCTTGCCGCCGGTCAGCAGGGCGTATCGGTTGCCTTCGACCT
AGCCACCCACCGCGGCTATGACAGCGATCACCCGCGCGTGGAAGGCGATGTCGGCAAGGCCGGCGTGGCGATCGACTCCG
TCGAGGACATGAAAATCCTTTTCGATGGCATTCCGCTGGAAAAGATTTCCGTTTCCATGACCATGAACGGTGCGGTTATC
CCGATCCTTGCCAATTTCATCGTCGCTGGCGAAGAACAGGGCGTGCCCCGCGCACAGCTTTCCGGCACCATTCAGAACGA
CATTCTCAAGGAGTTCATGGTCCGCAACACCTATATCTATCCGCCGGAACCCTCCATGCGGATCATTGCGGACATCATCG
CCTATACGGCGCAGGAAATGCCGAAGTTCAACTCCATTTCCATCTCCGGCTATCATATGCAGGAGGCTGGCGCGACACTG
GTGCAGGAGCTGGCCTTCACACTGGCCGACGGGCGCGAATATGTGCGTGCGGCGCTCAAGAAGGGCCTCAATGTCGATGA
TTTTGCAGGCCGGCTGTCGTTCTTCTTCGCCATCGGCATGAATTTCTTCATGGAAATTGCCAAGTTGCGCGCTGCGCGCC
TGCTCTGGTCACGCATCATGAAGGAATTTGATCCGAAGAAGCCGGGCTCGCTGATGCTGCGCACCCACTGCCAGACCTCC
GGCGTTTCCCTGCAGGAACAGGATCCTTATAACAATATCGTCCGCACAGCCTTCGAGGCCATGTCGGCGGCACTTGGCGG
CACGCAATCACTTCACACCAACTCTTTCGACGAAGCCATTGCCCTGCCTACGGAATTTTCCGCACGCATCGCCCGCAACA
CGCAGCTCATCCTGCAAAACGAAACCGGCGTGACCAAGGTGGTCGATCCGCTGGCAGGCTCCTATTACATCGAAAGCCTC
ACCAACGAACTGGCCGAAAAGGCATGGGCGCTGATCGAGGAAGTCGAGACGCTCGGCGGCATGACCAAGGCTGTCGAAAG
CGGCTTGCCCAAACGCTTGATCGAAGAAGCCGCCACCAGGCGACAGGCGGCCGTTGACAAGGGTGAGGAAGTTATCGTCG
GCGTCAACAAGTTCCGGCTGGAACAGGAAGACGAAATCGATATTCTCGAAATCGACAATTCGGCTGTCCGCCAATCGCAG
ATTGCGCGCCTCAACCGCATCAAGGAAATGCGCAACAAGCAAAAGGTCGAAGCCGCCCTTGCCGAACTGGAAAAGGTCGC
CCGCAGCGGCGAAGGCAACCTTCTGGCCGCAGCGGTAGAAGCCTCGCGCGCACGCGCCACGGTGGGTGAAATTTCCGACG
CCATGCGCCGCGCCTTCGGCGATCATGCCGCCGTTCCAAAGGTCGTGAAGAAAGTTTACGGCACAGCCTATAAGGACGAG
CCGGAATACCAGACCCTTGTTGATCGCCTCGGAGAATTTGCGAAACAGGCTGGCGAGAAGCCGCGCGTCATGGTCGCGAA
ACTCGGTCAGGACGGGCATGATCGCGGCGCGAAGATCATCGCCTCAGCCTTTGGCGACATCGGCTTTGAAGTGCTGGCGG
GGCCATTGTTCCAGACGCCCGACGAAGCCGCCGATATGGCCATCAAGGCCAAGGTGCATGTGCTGGGCGTGTCGTCGCTT
GCTGCCGGCCACAAGACGCTCCTGCCCCAGCTTGTGGAAACGCTGCGCAAAAAGGGTGCGGAAAACATTATCGTGGTCTG
CGGCGGCGTCGTGCCGCGTCAGGATTATCAGTACCTGTTCGATCATGGCGTGGCAGCCGTTTTCGGCCCCGGCACGAATG
TGCTGGACTGCGCACGCGCCGTGCTGGACCTGATGGAAGGCAAACTCAGAAACCTGTAA

Upstream 100 bases:

>100_bases
CAGCTTGGCCGTTGATGAGCTGATAATGGAATTTGAGTAACCCCGAATGCGGTGCCTTGCACCGGATCAGGGTGCGAGTT
TATGGGATGGAGATGAGCCA

Downstream 100 bases:

>100_bases
TTTCGTTCCATATCATAGGGATAAAACGAAAACAGGAATCATTTTCTCAAGATGAAAGGCCGAGGCAACCGCCTCGGCCT
TTTTGTCAGGGAAACTCTCA

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 712; Mature: 711

Protein sequence:

>712_residues
MTKKTRADWETLAEKELKRPADSLVWHTPEGIDVKPLYTQDDLEGIGHLGTLPGFEPFLRGPRATMYAGRPWTIRQYAGF
STAEESNAFYRKALAAGQQGVSVAFDLATHRGYDSDHPRVEGDVGKAGVAIDSVEDMKILFDGIPLEKISVSMTMNGAVI
PILANFIVAGEEQGVPRAQLSGTIQNDILKEFMVRNTYIYPPEPSMRIIADIIAYTAQEMPKFNSISISGYHMQEAGATL
VQELAFTLADGREYVRAALKKGLNVDDFAGRLSFFFAIGMNFFMEIAKLRAARLLWSRIMKEFDPKKPGSLMLRTHCQTS
GVSLQEQDPYNNIVRTAFEAMSAALGGTQSLHTNSFDEAIALPTEFSARIARNTQLILQNETGVTKVVDPLAGSYYIESL
TNELAEKAWALIEEVETLGGMTKAVESGLPKRLIEEAATRRQAAVDKGEEVIVGVNKFRLEQEDEIDILEIDNSAVRQSQ
IARLNRIKEMRNKQKVEAALAELEKVARSGEGNLLAAAVEASRARATVGEISDAMRRAFGDHAAVPKVVKKVYGTAYKDE
PEYQTLVDRLGEFAKQAGEKPRVMVAKLGQDGHDRGAKIIASAFGDIGFEVLAGPLFQTPDEAADMAIKAKVHVLGVSSL
AAGHKTLLPQLVETLRKKGAENIIVVCGGVVPRQDYQYLFDHGVAAVFGPGTNVLDCARAVLDLMEGKLRNL

Sequences:

>Translated_712_residues
MTKKTRADWETLAEKELKRPADSLVWHTPEGIDVKPLYTQDDLEGIGHLGTLPGFEPFLRGPRATMYAGRPWTIRQYAGF
STAEESNAFYRKALAAGQQGVSVAFDLATHRGYDSDHPRVEGDVGKAGVAIDSVEDMKILFDGIPLEKISVSMTMNGAVI
PILANFIVAGEEQGVPRAQLSGTIQNDILKEFMVRNTYIYPPEPSMRIIADIIAYTAQEMPKFNSISISGYHMQEAGATL
VQELAFTLADGREYVRAALKKGLNVDDFAGRLSFFFAIGMNFFMEIAKLRAARLLWSRIMKEFDPKKPGSLMLRTHCQTS
GVSLQEQDPYNNIVRTAFEAMSAALGGTQSLHTNSFDEAIALPTEFSARIARNTQLILQNETGVTKVVDPLAGSYYIESL
TNELAEKAWALIEEVETLGGMTKAVESGLPKRLIEEAATRRQAAVDKGEEVIVGVNKFRLEQEDEIDILEIDNSAVRQSQ
IARLNRIKEMRNKQKVEAALAELEKVARSGEGNLLAAAVEASRARATVGEISDAMRRAFGDHAAVPKVVKKVYGTAYKDE
PEYQTLVDRLGEFAKQAGEKPRVMVAKLGQDGHDRGAKIIASAFGDIGFEVLAGPLFQTPDEAADMAIKAKVHVLGVSSL
AAGHKTLLPQLVETLRKKGAENIIVVCGGVVPRQDYQYLFDHGVAAVFGPGTNVLDCARAVLDLMEGKLRNL
>Mature_711_residues
TKKTRADWETLAEKELKRPADSLVWHTPEGIDVKPLYTQDDLEGIGHLGTLPGFEPFLRGPRATMYAGRPWTIRQYAGFS
TAEESNAFYRKALAAGQQGVSVAFDLATHRGYDSDHPRVEGDVGKAGVAIDSVEDMKILFDGIPLEKISVSMTMNGAVIP
ILANFIVAGEEQGVPRAQLSGTIQNDILKEFMVRNTYIYPPEPSMRIIADIIAYTAQEMPKFNSISISGYHMQEAGATLV
QELAFTLADGREYVRAALKKGLNVDDFAGRLSFFFAIGMNFFMEIAKLRAARLLWSRIMKEFDPKKPGSLMLRTHCQTSG
VSLQEQDPYNNIVRTAFEAMSAALGGTQSLHTNSFDEAIALPTEFSARIARNTQLILQNETGVTKVVDPLAGSYYIESLT
NELAEKAWALIEEVETLGGMTKAVESGLPKRLIEEAATRRQAAVDKGEEVIVGVNKFRLEQEDEIDILEIDNSAVRQSQI
ARLNRIKEMRNKQKVEAALAELEKVARSGEGNLLAAAVEASRARATVGEISDAMRRAFGDHAAVPKVVKKVYGTAYKDEP
EYQTLVDRLGEFAKQAGEKPRVMVAKLGQDGHDRGAKIIASAFGDIGFEVLAGPLFQTPDEAADMAIKAKVHVLGVSSLA
AGHKTLLPQLVETLRKKGAENIIVVCGGVVPRQDYQYLFDHGVAAVFGPGTNVLDCARAVLDLMEGKLRNL

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=704, Percent_Identity=62.6420454545455, Blast_Score=925, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=706, Percent_Identity=62.4645892351275, Blast_Score=895, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=704, Percent_Identity=62.2159090909091, Blast_Score=909, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 77950; Mature: 77819

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKTRADWETLAEKELKRPADSLVWHTPEGIDVKPLYTQDDLEGIGHLGTLPGFEPFLR
CCCCCCCHHHHHHHHHHHCCHHHCEEECCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHC
GPRATMYAGRPWTIRQYAGFSTAEESNAFYRKALAAGQQGVSVAFDLATHRGYDSDHPRV
CCCCEEECCCCEEEHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCCC
EGDVGKAGVAIDSVEDMKILFDGIPLEKISVSMTMNGAVIPILANFIVAGEEQGVPRAQL
CCCCCCCCEEECCHHHHHHHHCCCCHHHEEEEEEECCCHHHHHHHHHHCCCCCCCCHHHH
SGTIQNDILKEFMVRNTYIYPPEPSMRIIADIIAYTAQEMPKFNSISISGYHMQEAGATL
CCHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHH
VQELAFTLADGREYVRAALKKGLNVDDFAGRLSFFFAIGMNFFMEIAKLRAARLLWSRIM
HHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEFDPKKPGSLMLRTHCQTSGVSLQEQDPYNNIVRTAFEAMSAALGGTQSLHTNSFDEAI
HHCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
ALPTEFSARIARNTQLILQNETGVTKVVDPLAGSYYIESLTNELAEKAWALIEEVETLGG
CCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTKAVESGLPKRLIEEAATRRQAAVDKGEEVIVGVNKFRLEQEDEIDILEIDNSAVRQSQ
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCCCCEEECCCHHHHHHH
IARLNRIKEMRNKQKVEAALAELEKVARSGEGNLLAAAVEASRARATVGEISDAMRRAFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHC
DHAAVPKVVKKVYGTAYKDEPEYQTLVDRLGEFAKQAGEKPRVMVAKLGQDGHDRGAKII
CCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHH
ASAFGDIGFEVLAGPLFQTPDEAADMAIKAKVHVLGVSSLAAGHKTLLPQLVETLRKKGA
HHHHHHHHHHHHHCCCCCCCCHHHHHEEEEEEEEEEHHHHHCCHHHHHHHHHHHHHHCCC
ENIIVVCGGVVPRQDYQYLFDHGVAAVFGPGTNVLDCARAVLDLMEGKLRNL
CEEEEEECCCCCCHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKKTRADWETLAEKELKRPADSLVWHTPEGIDVKPLYTQDDLEGIGHLGTLPGFEPFLR
CCCCCCHHHHHHHHHHHCCHHHCEEECCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHC
GPRATMYAGRPWTIRQYAGFSTAEESNAFYRKALAAGQQGVSVAFDLATHRGYDSDHPRV
CCCCEEECCCCEEEHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHCCCCCCCCCC
EGDVGKAGVAIDSVEDMKILFDGIPLEKISVSMTMNGAVIPILANFIVAGEEQGVPRAQL
CCCCCCCCEEECCHHHHHHHHCCCCHHHEEEEEEECCCHHHHHHHHHHCCCCCCCCHHHH
SGTIQNDILKEFMVRNTYIYPPEPSMRIIADIIAYTAQEMPKFNSISISGYHMQEAGATL
CCHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHH
VQELAFTLADGREYVRAALKKGLNVDDFAGRLSFFFAIGMNFFMEIAKLRAARLLWSRIM
HHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEFDPKKPGSLMLRTHCQTSGVSLQEQDPYNNIVRTAFEAMSAALGGTQSLHTNSFDEAI
HHCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
ALPTEFSARIARNTQLILQNETGVTKVVDPLAGSYYIESLTNELAEKAWALIEEVETLGG
CCCCHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTKAVESGLPKRLIEEAATRRQAAVDKGEEVIVGVNKFRLEQEDEIDILEIDNSAVRQSQ
HHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCCCCCEEECCCHHHHHHH
IARLNRIKEMRNKQKVEAALAELEKVARSGEGNLLAAAVEASRARATVGEISDAMRRAFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHC
DHAAVPKVVKKVYGTAYKDEPEYQTLVDRLGEFAKQAGEKPRVMVAKLGQDGHDRGAKII
CCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHH
ASAFGDIGFEVLAGPLFQTPDEAADMAIKAKVHVLGVSSLAAGHKTLLPQLVETLRKKGA
HHHHHHHHHHHHHCCCCCCCCHHHHHEEEEEEEEEEHHHHHCCHHHHHHHHHHHHHHCCC
ENIIVVCGGVVPRQDYQYLFDHGVAAVFGPGTNVLDCARAVLDLMEGKLRNL
CEEEEEECCCCCCHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]