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The map label for this gene is folE

Identifier: 225852576

GI number: 225852576

Start: 1064360

End: 1065001

Strand: Direct

Name: folE

Synonym: BMEA_A1116

Alternate gene names: 225852576

Gene position: 1064360-1065001 (Clockwise)

Preceding gene: 225852572

Following gene: 225852577

Centisome position: 50.07

GC content: 57.01

Gene sequence:

>642_bases
ATGGACGCTCGCATCCTCCAAGATAACGACGACACCAGCCTGCCTGTCAATCAGGCATCCGTAACCAGAATACACAAAAA
GCCAGGCAAGGCCGAAGCGGAAGCTGCCGTTCGCACCCTGCTTTTGTGGGCCGGCGAAGACCCCGATCGTGAAGGCTTGC
TGGAAACGCCCAAGCGCGTCGCAAAAGCCTATCAGGAACTTTTCGGCGGCTATTCGGAAAGCCCGGAAGAGGTTCTTGGA
ACCACTTTCGAGGAAGTCGCAGGTTACGACGATATGGTTCTGGTGAAGGATATTTCCTTCTTCTCCCATTGCGAACACCA
CATGGTGCCGATCATCGGCAAGGCGCACGTCGCCTATCTGCCGGAAGGCCGTGTCGTCGGCCTGTCGAAGATTGCGCGTG
TCGTCGATATTTTTGCCCGCCGCCTGCAAACGCAGGAAAGCATCACAGCGCAGATTGCCGACAGCATCCAGCGCATTTTG
AAGCCACGCGGCGTCGCCGTCATGATCGAGGCGGAACATATGTGCATGGCCATGCGCAGCATCCGCAAGCAGGGTTCCAG
CACGATCACCACCACCTTTACCGGCGATTTCAAGGAAAAGGCGGACCAGCAGGTTCGCTTCATGACCCTGATCCGCACTT
GA

Upstream 100 bases:

>100_bases
TTGCTGCTGCCGGATCAATACATCGCCCGCTCGTAAAGCGCATCGTTGTATTGTCCGTTTAACTCGTTTCCTCCTTGAAG
GAAACTACTGGAGAATACTG

Downstream 100 bases:

>100_bases
ACACAGCATTCAGGCATAGACGATGAGCATTTTTCCTGCCCAGCCTTCCGACAAGAAGGCCGTTGAAGAAGGCGCGGCAT
TCATGCCGCGCTTTGATGCA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MDARILQDNDDTSLPVNQASVTRIHKKPGKAEAEAAVRTLLLWAGEDPDREGLLETPKRVAKAYQELFGGYSESPEEVLG
TTFEEVAGYDDMVLVKDISFFSHCEHHMVPIIGKAHVAYLPEGRVVGLSKIARVVDIFARRLQTQESITAQIADSIQRIL
KPRGVAVMIEAEHMCMAMRSIRKQGSSTITTTFTGDFKEKADQQVRFMTLIRT

Sequences:

>Translated_213_residues
MDARILQDNDDTSLPVNQASVTRIHKKPGKAEAEAAVRTLLLWAGEDPDREGLLETPKRVAKAYQELFGGYSESPEEVLG
TTFEEVAGYDDMVLVKDISFFSHCEHHMVPIIGKAHVAYLPEGRVVGLSKIARVVDIFARRLQTQESITAQIADSIQRIL
KPRGVAVMIEAEHMCMAMRSIRKQGSSTITTTFTGDFKEKADQQVRFMTLIRT
>Mature_213_residues
MDARILQDNDDTSLPVNQASVTRIHKKPGKAEAEAAVRTLLLWAGEDPDREGLLETPKRVAKAYQELFGGYSESPEEVLG
TTFEEVAGYDDMVLVKDISFFSHCEHHMVPIIGKAHVAYLPEGRVVGLSKIARVVDIFARRLQTQESITAQIADSIQRIL
KPRGVAVMIEAEHMCMAMRSIRKQGSSTITTTFTGDFKEKADQQVRFMTLIRT

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family

Homologues:

Organism=Homo sapiens, GI66932968, Length=180, Percent_Identity=50, Blast_Score=185, Evalue=2e-47,
Organism=Homo sapiens, GI4503949, Length=180, Percent_Identity=50, Blast_Score=185, Evalue=2e-47,
Organism=Homo sapiens, GI66932970, Length=138, Percent_Identity=51.4492753623188, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI66932972, Length=138, Percent_Identity=51.4492753623188, Blast_Score=142, Evalue=2e-34,
Organism=Escherichia coli, GI1788476, Length=165, Percent_Identity=44.2424242424242, Blast_Score=122, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17560486, Length=178, Percent_Identity=46.0674157303371, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6321706, Length=179, Percent_Identity=47.4860335195531, Blast_Score=174, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24656782, Length=194, Percent_Identity=45.360824742268, Blast_Score=167, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24656796, Length=194, Percent_Identity=45.360824742268, Blast_Score=167, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24656791, Length=194, Percent_Identity=45.360824742268, Blast_Score=167, Evalue=4e-42,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): GCH1_BRUA1 (B2S5T0)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001935001.1
- ProteinModelPortal:   B2S5T0
- SMR:   B2S5T0
- GeneID:   6328566
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I10180
- HOGENOM:   HBG370191
- OMA:   ARFMSMI
- ProtClustDB:   PRK09347
- GO:   GO:0005737
- HAMAP:   MF_00223
- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234
- TIGRFAMs:   TIGR00063

Pfam domain/function: PF01227 GTP_cyclohydroI

EC number: =3.5.4.16

Molecular weight: Translated: 23777; Mature: 23777

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDARILQDNDDTSLPVNQASVTRIHKKPGKAEAEAAVRTLLLWAGEDPDREGLLETPKRV
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHCCHHHH
AKAYQELFGGYSESPEEVLGTTFEEVAGYDDMVLVKDISFFSHCEHHMVPIIGKAHVAYL
HHHHHHHHCCCCCCHHHHHCCCHHHHCCCCCEEHHHHHHHHHHHHHCCCCEECCCEEEEC
PEGRVVGLSKIARVVDIFARRLQTQESITAQIADSIQRILKPRGVAVMIEAEHMCMAMRS
CCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHH
IRKQGSSTITTTFTGDFKEKADQQVRFMTLIRT
HHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDARILQDNDDTSLPVNQASVTRIHKKPGKAEAEAAVRTLLLWAGEDPDREGLLETPKRV
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCHHCCHHHH
AKAYQELFGGYSESPEEVLGTTFEEVAGYDDMVLVKDISFFSHCEHHMVPIIGKAHVAYL
HHHHHHHHCCCCCCHHHHHCCCHHHHCCCCCEEHHHHHHHHHHHHHCCCCEECCCEEEEC
PEGRVVGLSKIARVVDIFARRLQTQESITAQIADSIQRILKPRGVAVMIEAEHMCMAMRS
CCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHH
IRKQGSSTITTTFTGDFKEKADQQVRFMTLIRT
HHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA