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The map label for this gene is emrA [H]

Identifier: 225852563

GI number: 225852563

Start: 1049290

End: 1050390

Strand: Reverse

Name: emrA [H]

Synonym: BMEA_A1101

Alternate gene names: 225852563

Gene position: 1050390-1049290 (Counterclockwise)

Preceding gene: 225852565

Following gene: 225852562

Centisome position: 49.41

GC content: 57.67

Gene sequence:

>1101_bases
GTGGCCGAAACCAATACCTCGCCTTCTCCCGCTCAAGACCAGTCTCCCAAACATCCAATGCTACGTCGGATTCTGCTTAT
CGTAGGGCCGGTCGTCGCGATTGCCATCGGCCTGTGGATCTATTTCAGTGGAGGGCAATATGTGAGCGAGGATGATTCCT
ATGTCGGCGCGGCGGCAGTGGCCATAACACCGCAGGTTTCCGGTCAGGTTATACGTGTCGCCGTTGGCCCGAACCAGCCC
GTCAAGGAAGGCGATCTTCTGTTTGAAATAGACCCACAGCCGTTCCAGATCGAACTTGACCAGGCAAAGGCCAATCTGGC
GCAAGCGAGCGAAAAACTCGCAGGGCTTGTCCTCACCTACAAGCAACAATTGGCAAGTGTGGCTCAGGCAAAGGACGATG
TCACCTTCGCACAGGAGCAATTCAACCGTGTTTCGGCACTGGTTCACGACAAGTTTGAGGCGCGCGCGCAATTCGATCAG
GCTGAGCGGGCCTTGCAGGTGGCCAAGCAGGAGCAAAATGCCGCCGCGTCGGCAGCCGCCGCAACACTGGCACAGCTTGG
CGGCACACTCGATAAACCGTTACAACAACATGCATCCTATCTGGCGGCCAAAGCCGAAGTGGAGCTTGCCGAACGCAATG
TCAGGCTAACCCGCGTGCTCGCCCCATTCGCCGGAACAGTGACGCAAGTGGAAAACATCCAGCCGGGAAGTTTTCTTGCC
GTAGGCGATCCGGCTTTCACCCTGATCGGCGCCGATGCCTGGGTAAACAGCAATATCAAGGAAACGGACCTGACCCATAT
CAAGGTTGGCGATCCTGCCACGGTCGTGCTCGATTCCTATCTGGACCAGCCCCTGCAAGGCGAGGTGCAGAGCATAACGC
CCGCAAGCGGTTCTGTTTTTGCCCTGCTGCCCGCCCAGAATGCCGCCGGCAACTGGGTCAAGGTGGTGCAGCGCATGCCG
GTGCGGATCAAGATTACAAAACCCCATCCTGACGTGGTGATGCGTGATGGCGGCAGCGCAACCGTTACCATCAATACAGG
CTATCATCGCACATTTGCTACCTTGTGGCGCGATCTGACCGGCATGGTGGGGATCGACTGA

Upstream 100 bases:

>100_bases
TCCCGCCGGGCAAACGGAACCGCCAAATGAAATTGTGGTTCATGCCGAGATTGTACATCGGCGACCAAAGATTTTTCGAT
GCACTGCCCCGGAGGATACT

Downstream 100 bases:

>100_bases
TGGCCGAGGCAACGGCAATTGCAGCAAGCGGGTCGAAGCGCCTTGCCGTCACCATCTGCGTGATGATGGCGACGCTGATG
CAGGCGCTGGATTCCACCAT

Product: secretion protein HlyD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MAETNTSPSPAQDQSPKHPMLRRILLIVGPVVAIAIGLWIYFSGGQYVSEDDSYVGAAAVAITPQVSGQVIRVAVGPNQP
VKEGDLLFEIDPQPFQIELDQAKANLAQASEKLAGLVLTYKQQLASVAQAKDDVTFAQEQFNRVSALVHDKFEARAQFDQ
AERALQVAKQEQNAAASAAAATLAQLGGTLDKPLQQHASYLAAKAEVELAERNVRLTRVLAPFAGTVTQVENIQPGSFLA
VGDPAFTLIGADAWVNSNIKETDLTHIKVGDPATVVLDSYLDQPLQGEVQSITPASGSVFALLPAQNAAGNWVKVVQRMP
VRIKITKPHPDVVMRDGGSATVTINTGYHRTFATLWRDLTGMVGID

Sequences:

>Translated_366_residues
MAETNTSPSPAQDQSPKHPMLRRILLIVGPVVAIAIGLWIYFSGGQYVSEDDSYVGAAAVAITPQVSGQVIRVAVGPNQP
VKEGDLLFEIDPQPFQIELDQAKANLAQASEKLAGLVLTYKQQLASVAQAKDDVTFAQEQFNRVSALVHDKFEARAQFDQ
AERALQVAKQEQNAAASAAAATLAQLGGTLDKPLQQHASYLAAKAEVELAERNVRLTRVLAPFAGTVTQVENIQPGSFLA
VGDPAFTLIGADAWVNSNIKETDLTHIKVGDPATVVLDSYLDQPLQGEVQSITPASGSVFALLPAQNAAGNWVKVVQRMP
VRIKITKPHPDVVMRDGGSATVTINTGYHRTFATLWRDLTGMVGID
>Mature_365_residues
AETNTSPSPAQDQSPKHPMLRRILLIVGPVVAIAIGLWIYFSGGQYVSEDDSYVGAAAVAITPQVSGQVIRVAVGPNQPV
KEGDLLFEIDPQPFQIELDQAKANLAQASEKLAGLVLTYKQQLASVAQAKDDVTFAQEQFNRVSALVHDKFEARAQFDQA
ERALQVAKQEQNAAASAAAATLAQLGGTLDKPLQQHASYLAAKAEVELAERNVRLTRVLAPFAGTVTQVENIQPGSFLAV
GDPAFTLIGADAWVNSNIKETDLTHIKVGDPATVVLDSYLDQPLQGEVQSITPASGSVFALLPAQNAAGNWVKVVQRMPV
RIKITKPHPDVVMRDGGSATVTINTGYHRTFATLWRDLTGMVGID

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=350, Percent_Identity=32.5714285714286, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1790519, Length=312, Percent_Identity=33.6538461538462, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI1788711, Length=343, Percent_Identity=31.7784256559767, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI87081951, Length=324, Percent_Identity=29.9382716049383, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1790012, Length=247, Percent_Identity=28.7449392712551, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1790024, Length=246, Percent_Identity=28.8617886178862, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1787013, Length=250, Percent_Identity=26.8, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39194; Mature: 39063

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAETNTSPSPAQDQSPKHPMLRRILLIVGPVVAIAIGLWIYFSGGQYVSEDDSYVGAAAV
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCEECCCCCCCEEEEE
AITPQVSGQVIRVAVGPNQPVKEGDLLFEIDPQPFQIELDQAKANLAQASEKLAGLVLTY
EECCCCCCEEEEEEECCCCCCCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
KQQLASVAQAKDDVTFAQEQFNRVSALVHDKFEARAQFDQAERALQVAKQEQNAAASAAA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATLAQLGGTLDKPLQQHASYLAAKAEVELAERNVRLTRVLAPFAGTVTQVENIQPGSFLA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHCCHHHHCCCCCCCEEE
VGDPAFTLIGADAWVNSNIKETDLTHIKVGDPATVVLDSYLDQPLQGEVQSITPASGSVF
ECCCEEEEEECHHHHCCCCCCCCCCEEECCCCHHHHHHHHHCCCCCCCHHCCCCCCCCEE
ALLPAQNAAGNWVKVVQRMPVRIKITKPHPDVVMRDGGSATVTINTGYHRTFATLWRDLT
EEEECCCCCCHHHHHHHHCCEEEEEECCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHH
GMVGID
CCCCCC
>Mature Secondary Structure 
AETNTSPSPAQDQSPKHPMLRRILLIVGPVVAIAIGLWIYFSGGQYVSEDDSYVGAAAV
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCEECCCCCCCEEEEE
AITPQVSGQVIRVAVGPNQPVKEGDLLFEIDPQPFQIELDQAKANLAQASEKLAGLVLTY
EECCCCCCEEEEEEECCCCCCCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
KQQLASVAQAKDDVTFAQEQFNRVSALVHDKFEARAQFDQAERALQVAKQEQNAAASAAA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATLAQLGGTLDKPLQQHASYLAAKAEVELAERNVRLTRVLAPFAGTVTQVENIQPGSFLA
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHCCHHHHCCCCCCCEEE
VGDPAFTLIGADAWVNSNIKETDLTHIKVGDPATVVLDSYLDQPLQGEVQSITPASGSVF
ECCCEEEEEECHHHHCCCCCCCCCCEEECCCCHHHHHHHHHCCCCCCCHHCCCCCCCCEE
ALLPAQNAAGNWVKVVQRMPVRIKITKPHPDVVMRDGGSATVTINTGYHRTFATLWRDLT
EEEECCCCCCHHHHHHHHCCEEEEEECCCCCEEEECCCCEEEEEECCCHHHHHHHHHHHH
GMVGID
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]