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The map label for this gene is folP [H]

Identifier: 225852533

GI number: 225852533

Start: 1014505

End: 1015344

Strand: Direct

Name: folP [H]

Synonym: BMEA_A1070

Alternate gene names: 225852533

Gene position: 1014505-1015344 (Clockwise)

Preceding gene: 225852531

Following gene: 225852534

Centisome position: 47.73

GC content: 58.1

Gene sequence:

>840_bases
ATGACCAAAGAATGGCAGCTTGCCCATGAACGCAGCCTCCATCTCGGAAAAACCGCCATCATTATGGGAGTACTGAACGT
TACGCCGGATTCTTTCTCGGATGGCGGGCGTTATAACGATCTTGATCGTGCCATCGCCGCTGCCGAAACGATGCTGGAGG
AAGGCGCGACCATTGTGGACGTTGGGGGCGAATCGACGCGACCGGGCGCTACTGCTGTGGATGCGCAGACAGAAGCCAGC
CGTGTGGTTCCGGTAATCCGGGAACTGGTGAGGCGCTTCGATTGTATCATTTCCGTGGACACTTATCGTGCTTCTACCGC
GCGGCTTGCGGTGGAGGCCGGCGCGCATATCGTCAATGATGTCTGGGGGCTTCAGCGCGAACCGGAAATTGCCCAGCTTG
CCAGAGAAACGGGGGCAGGGCTTGTCATCATGCATACGAGCCGCGACCGCCTCACGAATCCCGACGTGATCGAAGATCAG
TTTATGTTCCTGAACAGGTCGCTGAAAATTGCCGGGGATGCAGGCATCGAGCCATCGCGCATCGTGCTTGATCCGGGTTT
CGGCTTCGGCAAGGAGCGGGATGAAGACATTGCGTTGATGGCGCGTATGTCTGAATTGCAGGCCTTCGGACTCCCCCTGC
TGGTCGGTACATCGCGCAAGCGGTTCGTTGGCGCAATGACGGGGCAGGCCGATCCGCGGAACCGCGATATCGGCACAGCG
GCTACTTCCGTGGCCCTTCGCCTGGCGGGAGCCGACATCTTCCGTGTTCACAATGTCGCTTTTAACAGAGATGCACTTGC
AGTTGCGGATGCTATCCTGCAAAGCAACGTCAGGATCTAA

Upstream 100 bases:

>100_bases
CACGCAAAGGTCAAGAGAACTATAACGCCACTCATGAAATGAACGCTATGCGAAATGGTTGCGCCTTTTCGCATAGCGAG
ACGACAGGAATATCGCCGTT

Downstream 100 bases:

>100_bases
CAATAGGAAGTGAAGCCCGTGTACACGATCCGCATCATGAACTGTGCCTTTTTTGCGCATCACGGTGTCTTCGATGAAGA
ACACAAGCTCGGACAACGAT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MTKEWQLAHERSLHLGKTAIIMGVLNVTPDSFSDGGRYNDLDRAIAAAETMLEEGATIVDVGGESTRPGATAVDAQTEAS
RVVPVIRELVRRFDCIISVDTYRASTARLAVEAGAHIVNDVWGLQREPEIAQLARETGAGLVIMHTSRDRLTNPDVIEDQ
FMFLNRSLKIAGDAGIEPSRIVLDPGFGFGKERDEDIALMARMSELQAFGLPLLVGTSRKRFVGAMTGQADPRNRDIGTA
ATSVALRLAGADIFRVHNVAFNRDALAVADAILQSNVRI

Sequences:

>Translated_279_residues
MTKEWQLAHERSLHLGKTAIIMGVLNVTPDSFSDGGRYNDLDRAIAAAETMLEEGATIVDVGGESTRPGATAVDAQTEAS
RVVPVIRELVRRFDCIISVDTYRASTARLAVEAGAHIVNDVWGLQREPEIAQLARETGAGLVIMHTSRDRLTNPDVIEDQ
FMFLNRSLKIAGDAGIEPSRIVLDPGFGFGKERDEDIALMARMSELQAFGLPLLVGTSRKRFVGAMTGQADPRNRDIGTA
ATSVALRLAGADIFRVHNVAFNRDALAVADAILQSNVRI
>Mature_278_residues
TKEWQLAHERSLHLGKTAIIMGVLNVTPDSFSDGGRYNDLDRAIAAAETMLEEGATIVDVGGESTRPGATAVDAQTEASR
VVPVIRELVRRFDCIISVDTYRASTARLAVEAGAHIVNDVWGLQREPEIAQLARETGAGLVIMHTSRDRLTNPDVIEDQF
MFLNRSLKIAGDAGIEPSRIVLDPGFGFGKERDEDIALMARMSELQAFGLPLLVGTSRKRFVGAMTGQADPRNRDIGTAA
TSVALRLAGADIFRVHNVAFNRDALAVADAILQSNVRI

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=262, Percent_Identity=43.1297709923664, Blast_Score=202, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6324073, Length=319, Percent_Identity=27.2727272727273, Blast_Score=123, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30222; Mature: 30091

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKEWQLAHERSLHLGKTAIIMGVLNVTPDSFSDGGRYNDLDRAIAAAETMLEEGATIVD
CCCCCCCHHHHCCCCCCCEEEEEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEE
VGGESTRPGATAVDAQTEASRVVPVIRELVRRFDCIISVDTYRASTARLAVEAGAHIVND
ECCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHCHHHHHH
VWGLQREPEIAQLARETGAGLVIMHTSRDRLTNPDVIEDQFMFLNRSLKIAGDAGIEPSR
HHCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCE
IVLDPGFGFGKERDEDIALMARMSELQAFGLPLLVGTSRKRFVGAMTGQADPRNRDIGTA
EEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCHHEEEECCCCCCCCCCCCHHH
ATSVALRLAGADIFRVHNVAFNRDALAVADAILQSNVRI
HHHHHHHHCCCCEEEEEHHHCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TKEWQLAHERSLHLGKTAIIMGVLNVTPDSFSDGGRYNDLDRAIAAAETMLEEGATIVD
CCCCCCHHHHCCCCCCCEEEEEEHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEE
VGGESTRPGATAVDAQTEASRVVPVIRELVRRFDCIISVDTYRASTARLAVEAGAHIVND
ECCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHCHHHHHH
VWGLQREPEIAQLARETGAGLVIMHTSRDRLTNPDVIEDQFMFLNRSLKIAGDAGIEPSR
HHCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCE
IVLDPGFGFGKERDEDIALMARMSELQAFGLPLLVGTSRKRFVGAMTGQADPRNRDIGTA
EEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCHHEEEECCCCCCCCCCCCHHH
ATSVALRLAGADIFRVHNVAFNRDALAVADAILQSNVRI
HHHHHHHHCCCCEEEEEHHHCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2123867; 7584024; 9384377 [H]