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The map label for this gene is rpiA

Identifier: 225852515

GI number: 225852515

Start: 990971

End: 991669

Strand: Direct

Name: rpiA

Synonym: BMEA_A1051

Alternate gene names: 225852515

Gene position: 990971-991669 (Clockwise)

Preceding gene: 225852514

Following gene: 225852516

Centisome position: 46.62

GC content: 57.22

Gene sequence:

>699_bases
ATGGATGAAGCACGCAAGCTCAAGATTGCGGCGGCAGCCGAAGCGCTGACTTATGTAAAAGACGGAATGCGGTTGGGCAT
CGGCACCGGCTCGACGGCGGAAGAATTTGTGCGTCTGCTGGCTGAAAAGGTGAAGGGTGGCTTTCGCGTCATTGGTGTTC
CGACTTCGGAGCGCACAGCAAAACTGTGTGAGGAACTGGGCGTTGCGCTCACCACACTCGAAGAAACGCCGCATCTGGAC
CTGACAATTGACGGTGCGGATGAAGTTGACGGCGAACTCAGCCTTATCAAAGGCGGAGGCGGCGCGCTGCTTCGCGAGAA
GATTGTTGCTGCGGCTTCCGATTCCATGATCGTGATTGCCGACCAGTCTAAAGTTGTGGAAACGCTGGGGCGTTTTCCCC
TGCCGATTGAAGTCAACCGCTTCGGCCTTGGCGCGACAATCCGGGCGATTGAGGCGGCGGCTGTAAAGTGTGGTCTTGCA
GGGCCGCTGAACCTGCGGTTAAAAGACGGTTCACCTTTCCTCACCGACGGTGGGCACTACATCGTGGATGCATCTTTTGG
CCGCATTCCCGATCCAAAGACATTATCTGACGCTCTCTTCGCCATACCGGGCGTAGTCGAGCATGGACTTTTCATCGAAC
TGGCGCGTGCGGCGATTATCGCCGGCACCGACGGTATCCGCACCATGAACCGGTCTTGA

Upstream 100 bases:

>100_bases
CGAGTTAGGGCGTTTCCAACGATTGTGATAAAATAGGAACCGCTCTGGAGGCGAAGAAGCAGGATTGAGAATCCGCGGGG
GAAGAAACGGGAATTCTGGA

Downstream 100 bases:

>100_bases
ACTGATTGAACGGAGTAATGACCTTATGATCCCGGCAACTGGCTTTCGCCGTCTGATTGCACCGTTTTCCGCGCTCGTCC
TGATGGCGGGTGTGCATTCG

Product: ribose-5-phosphate isomerase A

Products: NA

Alternate protein names: Phosphoriboisomerase A; PRI

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MDEARKLKIAAAAEALTYVKDGMRLGIGTGSTAEEFVRLLAEKVKGGFRVIGVPTSERTAKLCEELGVALTTLEETPHLD
LTIDGADEVDGELSLIKGGGGALLREKIVAAASDSMIVIADQSKVVETLGRFPLPIEVNRFGLGATIRAIEAAAVKCGLA
GPLNLRLKDGSPFLTDGGHYIVDASFGRIPDPKTLSDALFAIPGVVEHGLFIELARAAIIAGTDGIRTMNRS

Sequences:

>Translated_232_residues
MDEARKLKIAAAAEALTYVKDGMRLGIGTGSTAEEFVRLLAEKVKGGFRVIGVPTSERTAKLCEELGVALTTLEETPHLD
LTIDGADEVDGELSLIKGGGGALLREKIVAAASDSMIVIADQSKVVETLGRFPLPIEVNRFGLGATIRAIEAAAVKCGLA
GPLNLRLKDGSPFLTDGGHYIVDASFGRIPDPKTLSDALFAIPGVVEHGLFIELARAAIIAGTDGIRTMNRS
>Mature_232_residues
MDEARKLKIAAAAEALTYVKDGMRLGIGTGSTAEEFVRLLAEKVKGGFRVIGVPTSERTAKLCEELGVALTTLEETPHLD
LTIDGADEVDGELSLIKGGGGALLREKIVAAASDSMIVIADQSKVVETLGRFPLPIEVNRFGLGATIRAIEAAAVKCGLA
GPLNLRLKDGSPFLTDGGHYIVDASFGRIPDPKTLSDALFAIPGVVEHGLFIELARAAIIAGTDGIRTMNRS

Specific function: Nonoxidative branch of the pentose phosphate pathway. [C]

COG id: COG0120

COG function: function code G; Ribose 5-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose 5-phosphate isomerase family

Homologues:

Organism=Homo sapiens, GI94536842, Length=232, Percent_Identity=39.2241379310345, Blast_Score=140, Evalue=9e-34,
Organism=Escherichia coli, GI1789280, Length=225, Percent_Identity=40, Blast_Score=133, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17551758, Length=238, Percent_Identity=39.9159663865546, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6324669, Length=243, Percent_Identity=33.3333333333333, Blast_Score=106, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281364072, Length=223, Percent_Identity=36.322869955157, Blast_Score=112, Evalue=2e-25,

Paralogues:

None

Copy number: 740 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): RPIA_BRUME (Q8YH30)

Other databases:

- EMBL:   AE008917
- PIR:   AH3373
- RefSeq:   NP_539891.1
- ProteinModelPortal:   Q8YH30
- SMR:   Q8YH30
- GeneID:   1196685
- GenomeReviews:   AE008917_GR
- KEGG:   bme:BMEI0974
- HOGENOM:   HBG515603
- OMA:   MVVIADA
- PhylomeDB:   Q8YH30
- ProtClustDB:   PRK00702
- BioCyc:   BMEL224914:BMEI0974-MONOMER
- BRENDA:   5.3.1.6
- HAMAP:   MF_00170
- InterPro:   IPR014036
- InterPro:   IPR004788
- InterPro:   IPR020672
- PANTHER:   PTHR11934
- TIGRFAMs:   TIGR00021

Pfam domain/function: PF00455 DeoR; PF06026 Rib_5-P_isom_A

EC number: =5.3.1.6

Molecular weight: Translated: 24336; Mature: 24336

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEARKLKIAAAAEALTYVKDGMRLGIGTGSTAEEFVRLLAEKVKGGFRVIGVPTSERTA
CCCHHEEEHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHH
KLCEELGVALTTLEETPHLDLTIDGADEVDGELSLIKGGGGALLREKIVAAASDSMIVIA
HHHHHHCCEEEECCCCCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEE
DQSKVVETLGRFPLPIEVNRFGLGATIRAIEAAAVKCGLAGPLNLRLKDGSPFLTDGGHY
CCHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCE
IVDASFGRIPDPKTLSDALFAIPGVVEHGLFIELARAAIIAGTDGIRTMNRS
EEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCCCCCCCCC
>Mature Secondary Structure
MDEARKLKIAAAAEALTYVKDGMRLGIGTGSTAEEFVRLLAEKVKGGFRVIGVPTSERTA
CCCHHEEEHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHCCCEEEEEECCCHHHH
KLCEELGVALTTLEETPHLDLTIDGADEVDGELSLIKGGGGALLREKIVAAASDSMIVIA
HHHHHHCCEEEECCCCCCEEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEE
DQSKVVETLGRFPLPIEVNRFGLGATIRAIEAAAVKCGLAGPLNLRLKDGSPFLTDGGHY
CCHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCE
IVDASFGRIPDPKTLSDALFAIPGVVEHGLFIELARAAIIAGTDGIRTMNRS
EEECCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688