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The map label for this gene is serS [H]

Identifier: 225852397

GI number: 225852397

Start: 879179

End: 880462

Strand: Direct

Name: serS [H]

Synonym: BMEA_A0923

Alternate gene names: 225852397

Gene position: 879179-880462 (Clockwise)

Preceding gene: 225852396

Following gene: 225852398

Centisome position: 41.36

GC content: 59.42

Gene sequence:

>1284_bases
ATGCTCGACATCAAATGGATTCGCGAAAACCCGGAAACCCTCGACAAGGCGCTCGCAAAGCGTGGGGCTGCTCCGCTTTC
GTCCGAACTGATTGCGCTGGATGAAAAGCGCCGCGAGCATGTCGGCAAGGTGCAGGCAGCGCAGGAGCGCCGCAATGCCG
CCTCGAAGGAAATCGGCAAGGCCATGGCCGCAAAGGACATGGGCACGGCTGAAAAGCTGAAGGCCGAAGTGGGCGAACTG
AAAGATTTTCTCGCCCATGCGGAAGAAGACGAGCGCCGCCTCAGCAAGGAACTGAGCGACGCATTGTCCACCATTCCCAA
TATTCCGCTTGATGATGTGCCGCTCGGCAAGGATGAAAGCGACAATGTTGAGCTGCGCCGCATTGGCAACCCGCACAATT
TCTCCTTCCAGCCGAAAGAGCATTTTGAGCTTGGCGAGGCGCTTGGATACATGGATTTCGAGCGCGCGGCCAAGCTTGCC
GGTGCGCGCTTTACGGTGCTGAAAGGCCCGCTCGCCCGTCTTGAGCGCGCGCTTGGCCAGTTCATGCTCGATCTTCACAC
GACAGAACACGGTTATACCGAAGTCATGCCGCCGCTGATGGTGCGCGACGAAGCGGTCTATGGCACGGGGCAATTGCCGA
AGTTTTCAGAAGATCTTTTCCGCACGACGGATGGCCGCTGGCTGATCCCGACGGCGGAGGTGCCGCTCACCAATCTGGTT
GCCGAAGAAATTGTCGATATGAAGGGGCTGCCGCTGCGCTTCACGGCGCTGACCCCATGTTTTCGCTCGGAAGCGGGGTC
GGCCGGGCGCGATACGCGCGGCATGTTGCGCCAGCATCAGTTCCTGAAAGTGGAGATGGTATCGATCACCGATGCGGAAA
GCTCCGTTGCCGAGCATGAGCGCATGACGGCTTGCGCGGAAGAAGTGCTGAAGCGGCTGGGCCTGCCGTTCCGTACCGTT
GTGCTTTGCACGGGCGACATGGGCTTTGGCGCACAGCGGACCTATGATATCGAGGTCTGGTTGCCGGGGCAGAACACCTA
TCGCGAAATTTCAAGCTGTTCGACCTGCGGTGATTTCCAGGGCCGCCGCATGAATGCCCGCTATCGCCCGGAAGGCGAGA
AATCCACGCGCTTCGTGCACACCCTCAACGGGTCGGGCGCTGCTGTCGGGCGCGCGCTGATTGCGGTTATGGAAAATTAC
CAGCAGGAAGACGGCAGCATTCATATTCCTGAAGCATTACAGCCATATATGGGCGGCCTCACGCGGATCGAAAAAGCCGC
TTGA

Upstream 100 bases:

>100_bases
GATAACAACGCTTCCTCCACCTGATCTGACGTCAGGCATCTTTGGGGCTGAAGATCGTTTAGCCTCGCTTCTGTTCAATT
TCACGAAATGGCTTTTTTCC

Downstream 100 bases:

>100_bases
TCTGGAATTATAGCATGCCCCCAAAAGTGGGAACCGGTTTTGGGGACATGCGAAAGAACAAAGAGAGAGCAGTTTCAACG
ATCCCATTTCAACTGGAACC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MLDIKWIRENPETLDKALAKRGAAPLSSELIALDEKRREHVGKVQAAQERRNAASKEIGKAMAAKDMGTAEKLKAEVGEL
KDFLAHAEEDERRLSKELSDALSTIPNIPLDDVPLGKDESDNVELRRIGNPHNFSFQPKEHFELGEALGYMDFERAAKLA
GARFTVLKGPLARLERALGQFMLDLHTTEHGYTEVMPPLMVRDEAVYGTGQLPKFSEDLFRTTDGRWLIPTAEVPLTNLV
AEEIVDMKGLPLRFTALTPCFRSEAGSAGRDTRGMLRQHQFLKVEMVSITDAESSVAEHERMTACAEEVLKRLGLPFRTV
VLCTGDMGFGAQRTYDIEVWLPGQNTYREISSCSTCGDFQGRRMNARYRPEGEKSTRFVHTLNGSGAAVGRALIAVMENY
QQEDGSIHIPEALQPYMGGLTRIEKAA

Sequences:

>Translated_427_residues
MLDIKWIRENPETLDKALAKRGAAPLSSELIALDEKRREHVGKVQAAQERRNAASKEIGKAMAAKDMGTAEKLKAEVGEL
KDFLAHAEEDERRLSKELSDALSTIPNIPLDDVPLGKDESDNVELRRIGNPHNFSFQPKEHFELGEALGYMDFERAAKLA
GARFTVLKGPLARLERALGQFMLDLHTTEHGYTEVMPPLMVRDEAVYGTGQLPKFSEDLFRTTDGRWLIPTAEVPLTNLV
AEEIVDMKGLPLRFTALTPCFRSEAGSAGRDTRGMLRQHQFLKVEMVSITDAESSVAEHERMTACAEEVLKRLGLPFRTV
VLCTGDMGFGAQRTYDIEVWLPGQNTYREISSCSTCGDFQGRRMNARYRPEGEKSTRFVHTLNGSGAAVGRALIAVMENY
QQEDGSIHIPEALQPYMGGLTRIEKAA
>Mature_427_residues
MLDIKWIRENPETLDKALAKRGAAPLSSELIALDEKRREHVGKVQAAQERRNAASKEIGKAMAAKDMGTAEKLKAEVGEL
KDFLAHAEEDERRLSKELSDALSTIPNIPLDDVPLGKDESDNVELRRIGNPHNFSFQPKEHFELGEALGYMDFERAAKLA
GARFTVLKGPLARLERALGQFMLDLHTTEHGYTEVMPPLMVRDEAVYGTGQLPKFSEDLFRTTDGRWLIPTAEVPLTNLV
AEEIVDMKGLPLRFTALTPCFRSEAGSAGRDTRGMLRQHQFLKVEMVSITDAESSVAEHERMTACAEEVLKRLGLPFRTV
VLCTGDMGFGAQRTYDIEVWLPGQNTYREISSCSTCGDFQGRRMNARYRPEGEKSTRFVHTLNGSGAAVGRALIAVMENY
QQEDGSIHIPEALQPYMGGLTRIEKAA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI8923421, Length=433, Percent_Identity=31.8706697459584, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI16306548, Length=449, Percent_Identity=30.5122494432071, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI225579074, Length=440, Percent_Identity=31.1363636363636, Blast_Score=198, Evalue=6e-51,
Organism=Escherichia coli, GI1787120, Length=431, Percent_Identity=54.9883990719258, Blast_Score=464, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17539260, Length=465, Percent_Identity=32.6881720430108, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17542084, Length=342, Percent_Identity=28.0701754385965, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320226, Length=442, Percent_Identity=31.6742081447964, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6321799, Length=369, Percent_Identity=30.0813008130081, Blast_Score=187, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24581334, Length=464, Percent_Identity=29.3103448275862, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI17737985, Length=280, Percent_Identity=36.7857142857143, Blast_Score=174, Evalue=1e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47521; Mature: 47521

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKWIRENPETLDKALAKRGAAPLSSELIALDEKRREHVGKVQAAQERRNAASKEIGK
CCCCEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMAAKDMGTAEKLKAEVGELKDFLAHAEEDERRLSKELSDALSTIPNIPLDDVPLGKDES
HHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DNVELRRIGNPHNFSFQPKEHFELGEALGYMDFERAAKLAGARFTVLKGPLARLERALGQ
CCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCEEEEHHCHHHHHHHHHHH
FMLDLHTTEHGYTEVMPPLMVRDEAVYGTGQLPKFSEDLFRTTDGRWLIPTAEVPLTNLV
HHHHHHCCCCCCHHHCCCHHCCCCCEECCCCCCCHHHHHHHCCCCCEEECCCCCCHHHHH
AEEIVDMKGLPLRFTALTPCFRSEAGSAGRDTRGMLRQHQFLKVEMVSITDAESSVAEHE
HHHHHCCCCCCEEEHHHCHHHHHCCCCCCCHHHHHHHHHHHEEEEEEEECCCHHHHHHHH
RMTACAEEVLKRLGLPFRTVVLCTGDMGFGAQRTYDIEVWLPGQNTYREISSCSTCGDFQ
HHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHHCCCCCCCC
GRRMNARYRPEGEKSTRFVHTLNGSGAAVGRALIAVMENYQQEDGSIHIPEALQPYMGGL
CCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHH
TRIEKAA
HHHHHCC
>Mature Secondary Structure
MLDIKWIRENPETLDKALAKRGAAPLSSELIALDEKRREHVGKVQAAQERRNAASKEIGK
CCCCEEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMAAKDMGTAEKLKAEVGELKDFLAHAEEDERRLSKELSDALSTIPNIPLDDVPLGKDES
HHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DNVELRRIGNPHNFSFQPKEHFELGEALGYMDFERAAKLAGARFTVLKGPLARLERALGQ
CCEEEEECCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCEEEEHHCHHHHHHHHHHH
FMLDLHTTEHGYTEVMPPLMVRDEAVYGTGQLPKFSEDLFRTTDGRWLIPTAEVPLTNLV
HHHHHHCCCCCCHHHCCCHHCCCCCEECCCCCCCHHHHHHHCCCCCEEECCCCCCHHHHH
AEEIVDMKGLPLRFTALTPCFRSEAGSAGRDTRGMLRQHQFLKVEMVSITDAESSVAEHE
HHHHHCCCCCCEEEHHHCHHHHHCCCCCCCHHHHHHHHHHHEEEEEEEECCCHHHHHHHH
RMTACAEEVLKRLGLPFRTVVLCTGDMGFGAQRTYDIEVWLPGQNTYREISSCSTCGDFQ
HHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHHCCCCCCCC
GRRMNARYRPEGEKSTRFVHTLNGSGAAVGRALIAVMENYQQEDGSIHIPEALQPYMGGL
CCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHHHH
TRIEKAA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA