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The map label for this gene is pyrC [H]

Identifier: 225852189

GI number: 225852189

Start: 676542

End: 677876

Strand: Direct

Name: pyrC [H]

Synonym: BMEA_A0705

Alternate gene names: 225852189

Gene position: 676542-677876 (Clockwise)

Preceding gene: 225852185

Following gene: 225852194

Centisome position: 31.83

GC content: 59.85

Gene sequence:

>1335_bases
ATGGCCGCAACATTCGATACGATTTTGAAAGGCGCAACCATCGTCAATCATGACGGTATCGGCCAGCGCGACATTGGCAT
TCGTAACGGACGCATCGCCGCTATCGGGTCGCTTGCAGGGAACTCAGCCGGTGAAGTGATTGACTGCACTGGCCTGCATA
TCCTACCCGGCGTTGTGGATAGCCAGGTTCATTTCCGCGAGCCGGGTCTTGAGCACAAGGAAGATCTGGAAACCGGGTCA
CTTGCCGCCGTGCTGGGCGGCGTGACGGCCGTTTTTGAAATGCCGAACACCAAGCCGCTGACCACTTCGGCCGAAATGCT
GGAAGACAAGATTCGCCGTGGCCGCCATCGGATGCATTGCGATTTCGCCTTCTGGGTCGGCGGCACGCGCGATAATGCGA
AGGACGTGGCCGAACTGGAGCGCCTGCCGGGCGCGGCGGGCATCAAGGTATTCATGGGTTCGTCCACCGGCGATCTTCTG
GTTGAGGACGATGATGGCGTACGCTCGATCCTGAGGAATACGCGCCGCCGCGCGGCTTTTCATTCCGAAGACGAATTTCG
GCTCAAGGAACGTGAAGGATTGCGCGTTGAGGGTGATCCATCGAGCCATCCGGTATGGCGCGACGAGATTGCCGCGCTTC
AATGCACGCAGCGCCTGGTACGCATCGCCCGCGAGACTGGCGCGCGCATTCATGTGCTGCATATTTCGACCGCCGAGGAA
ATCGACTTCCTGAAAGATTACAAGGACGTCGCCACCTGCGAGGCGACGCCGCATCACCTCACCCTGTCGGCGGATGATTA
CAAGGCGCTTGGCAATCTCATCCAGATGAACCCGCCGGTGCGTGACAAGCGCCACCGTGAAGGTGTGTGGAAGGGGATCG
ATCAGGGTATCGTGGATGTGCTGGGTTCAGACCATGCCCCGCACACGCTGGAAGAAAAGCAGAAGTCTTATCCGGCTTCC
CCATCGGGCATGACCGGCGTGCAGACGCTGGTGCCGATCATGCTGGACCATGTGAATGCCGGTAAGCTTTCACTGGAGCG
TTTTGTCGATCTTTCCAGCCACGGCCCGAACCGCATTTTCGGCATGGCGCGCAAGGGGCGCATCGCGGTCGGCTACGATG
CCGATCTGACGATCGTGGACATGAAACGCCGCGAAACGATCACGCATGAACAGGCAGGATCGAAAGCCGGCTGGACGCCC
TATCATGGCAAGACCGTCACCGGATGGCCGGTTGGCACTTTCGTGCGCGGCATCAAGGTGATGTGGGAGGCGGAAATCGT
CAATCCTCACAAGGGCGAGCCGGTGGAGTTCCTCGAAGCGCTGCCCCGTCGCTGA

Upstream 100 bases:

>100_bases
GGATGCCGTCATCATCGCTTCGTCCTTGCCTTTCGCGCCCTCGTTACGTAAGCCCCAATGTAAAGGCTCGCAAGTCCCAT
CCGAAAAGCAGGAGACACCC

Downstream 100 bases:

>100_bases
CGGTGAAAAACAAAGAGTTGTAGCGGTTCGCTCGTAACGGGAGCAGCTCTATTGCCCGGCGGTGAAGAAGCGCCAGCTTC
CGTCAGGGCCGATGCCGATA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MAATFDTILKGATIVNHDGIGQRDIGIRNGRIAAIGSLAGNSAGEVIDCTGLHILPGVVDSQVHFREPGLEHKEDLETGS
LAAVLGGVTAVFEMPNTKPLTTSAEMLEDKIRRGRHRMHCDFAFWVGGTRDNAKDVAELERLPGAAGIKVFMGSSTGDLL
VEDDDGVRSILRNTRRRAAFHSEDEFRLKEREGLRVEGDPSSHPVWRDEIAALQCTQRLVRIARETGARIHVLHISTAEE
IDFLKDYKDVATCEATPHHLTLSADDYKALGNLIQMNPPVRDKRHREGVWKGIDQGIVDVLGSDHAPHTLEEKQKSYPAS
PSGMTGVQTLVPIMLDHVNAGKLSLERFVDLSSHGPNRIFGMARKGRIAVGYDADLTIVDMKRRETITHEQAGSKAGWTP
YHGKTVTGWPVGTFVRGIKVMWEAEIVNPHKGEPVEFLEALPRR

Sequences:

>Translated_444_residues
MAATFDTILKGATIVNHDGIGQRDIGIRNGRIAAIGSLAGNSAGEVIDCTGLHILPGVVDSQVHFREPGLEHKEDLETGS
LAAVLGGVTAVFEMPNTKPLTTSAEMLEDKIRRGRHRMHCDFAFWVGGTRDNAKDVAELERLPGAAGIKVFMGSSTGDLL
VEDDDGVRSILRNTRRRAAFHSEDEFRLKEREGLRVEGDPSSHPVWRDEIAALQCTQRLVRIARETGARIHVLHISTAEE
IDFLKDYKDVATCEATPHHLTLSADDYKALGNLIQMNPPVRDKRHREGVWKGIDQGIVDVLGSDHAPHTLEEKQKSYPAS
PSGMTGVQTLVPIMLDHVNAGKLSLERFVDLSSHGPNRIFGMARKGRIAVGYDADLTIVDMKRRETITHEQAGSKAGWTP
YHGKTVTGWPVGTFVRGIKVMWEAEIVNPHKGEPVEFLEALPRR
>Mature_443_residues
AATFDTILKGATIVNHDGIGQRDIGIRNGRIAAIGSLAGNSAGEVIDCTGLHILPGVVDSQVHFREPGLEHKEDLETGSL
AAVLGGVTAVFEMPNTKPLTTSAEMLEDKIRRGRHRMHCDFAFWVGGTRDNAKDVAELERLPGAAGIKVFMGSSTGDLLV
EDDDGVRSILRNTRRRAAFHSEDEFRLKEREGLRVEGDPSSHPVWRDEIAALQCTQRLVRIARETGARIHVLHISTAEEI
DFLKDYKDVATCEATPHHLTLSADDYKALGNLIQMNPPVRDKRHREGVWKGIDQGIVDVLGSDHAPHTLEEKQKSYPASP
SGMTGVQTLVPIMLDHVNAGKLSLERFVDLSSHGPNRIFGMARKGRIAVGYDADLTIVDMKRRETITHEQAGSKAGWTPY
HGKTVTGWPVGTFVRGIKVMWEAEIVNPHKGEPVEFLEALPRR

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=414, Percent_Identity=30.9178743961353, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI19923821, Length=446, Percent_Identity=26.0089686098655, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI4503375, Length=461, Percent_Identity=24.5119305856833, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI4503379, Length=439, Percent_Identity=24.6013667425968, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4503051, Length=456, Percent_Identity=23.4649122807018, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI62422571, Length=456, Percent_Identity=23.4649122807018, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI190194363, Length=435, Percent_Identity=25.0574712643678, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI4503377, Length=438, Percent_Identity=24.2009132420091, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI1786722, Length=446, Percent_Identity=30.9417040358744, Blast_Score=197, Evalue=9e-52,
Organism=Escherichia coli, GI87082175, Length=445, Percent_Identity=25.6179775280899, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI193204318, Length=394, Percent_Identity=29.6954314720812, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71989490, Length=444, Percent_Identity=25.9009009009009, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17539558, Length=445, Percent_Identity=26.9662921348315, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI86575075, Length=447, Percent_Identity=23.9373601789709, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322218, Length=403, Percent_Identity=29.7766749379653, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24642586, Length=386, Percent_Identity=31.0880829015544, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI18859883, Length=450, Percent_Identity=25.5555555555556, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI221377917, Length=450, Percent_Identity=27.1111111111111, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24644287, Length=245, Percent_Identity=27.3469387755102, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 48858; Mature: 48727

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAATFDTILKGATIVNHDGIGQRDIGIRNGRIAAIGSLAGNSAGEVIDCTGLHILPGVVD
CCCCHHHHHCCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCEEECCCCC
SQVHFREPGLEHKEDLETGSLAAVLGGVTAVFEMPNTKPLTTSAEMLEDKIRRGRHRMHC
CCEEECCCCCCCHHHCCCCHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHCCCCCEEE
DFAFWVGGTRDNAKDVAELERLPGAAGIKVFMGSSTGDLLVEDDDGVRSILRNTRRRAAF
EEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHC
HSEDEFRLKEREGLRVEGDPSSHPVWRDEIAALQCTQRLVRIARETGARIHVLHISTAEE
CCCCHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHH
IDFLKDYKDVATCEATPHHLTLSADDYKALGNLIQMNPPVRDKRHREGVWKGIDQGIVDV
HHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHH
LGSDHAPHTLEEKQKSYPASPSGMTGVQTLVPIMLDHVNAGKLSLERFVDLSSHGPNRIF
HCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHCCCCCCCEE
GMARKGRIAVGYDADLTIVDMKRRETITHEQAGSKAGWTPYHGKTVTGWPVGTFVRGIKV
EECCCCEEEEECCCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCEEECCCHHHHHHHHHE
MWEAEIVNPHKGEPVEFLEALPRR
EEEEEECCCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
AATFDTILKGATIVNHDGIGQRDIGIRNGRIAAIGSLAGNSAGEVIDCTGLHILPGVVD
CCCHHHHHCCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEECCCEEECCCCC
SQVHFREPGLEHKEDLETGSLAAVLGGVTAVFEMPNTKPLTTSAEMLEDKIRRGRHRMHC
CCEEECCCCCCCHHHCCCCHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHHCCCCCEEE
DFAFWVGGTRDNAKDVAELERLPGAAGIKVFMGSSTGDLLVEDDDGVRSILRNTRRRAAF
EEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHC
HSEDEFRLKEREGLRVEGDPSSHPVWRDEIAALQCTQRLVRIARETGARIHVLHISTAEE
CCCCHHHHHHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHH
IDFLKDYKDVATCEATPHHLTLSADDYKALGNLIQMNPPVRDKRHREGVWKGIDQGIVDV
HHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHH
LGSDHAPHTLEEKQKSYPASPSGMTGVQTLVPIMLDHVNAGKLSLERFVDLSSHGPNRIF
HCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHHCCCCCCCEE
GMARKGRIAVGYDADLTIVDMKRRETITHEQAGSKAGWTPYHGKTVTGWPVGTFVRGIKV
EECCCCEEEEECCCCEEEEECHHHHHHHHHHCCCCCCCCCCCCCEEECCCHHHHHHHHHE
MWEAEIVNPHKGEPVEFLEALPRR
EEEEEECCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]