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The map label for this gene is ccmE

Identifier: 225852133

GI number: 225852133

Start: 616990

End: 617487

Strand: Direct

Name: ccmE

Synonym: BMEA_A0646

Alternate gene names: 225852133

Gene position: 616990-617487 (Clockwise)

Preceding gene: 225852132

Following gene: 225852134

Centisome position: 29.03

GC content: 59.44

Gene sequence:

>498_bases
ATGAGCGCGACCGCCGAACAAAATGCACGTAATCCCAAAGGCAAGGGCGGCTTTGCCCGCACGGTAAGCCAGAGAAAGCG
CAAGCGCCTTTTCCTGATTGGCGGTGCGCTGGCCGTGCTGGCTGTTGCGGTCGGGCTGATGCTGACGGCGTTCAATCAGG
ATATCCGTTTCTTCCGCACCCCGGCTGATCTTACTGAACAGGACATGACGTCCGGCGCGCGTTTCCGCCTTGGCGGCCTG
GTCGAGGAAGGTTCCGTCAGCCGCACGGGCAGCGAGCTGCGCTTTACCGTCACCGACACGATCAAGACCGTGAAAGTGGT
GTTTGAAGGCATTCCGCCTGATCTGTTCCGTGAGGGGCAGGGCGTGGTGGCGGAAGGGCGTTTCGGCTCCGATGGCCTGT
TCCGCGCTGATAATGTGCTTGCCAAGCATGACGAGAACTATGTTCCCAAAGATCTTGCCGACAGCCTGAAGAAAAAGGGC
GTATGGGAGGGCAAATGA

Upstream 100 bases:

>100_bases
ATGCGCTGGCTCGCGGCATGAAGGCTCTTCAGGGTGAAAACCGGACCGAACTTCAAAGCTTCGCCACCACACTTGGACTG
GACGTGGGGACTGCACAAGA

Downstream 100 bases:

>100_bases
CGGGCCGGGGAGACTGCATATGAGTGTCGAGATCGGCCATTTTGCTCTGGTGCTGGCGCTTGCGCTGTCGATTGTTCAAT
CCATCGTGCCGGTGGTCGGC

Product: cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MSATAEQNARNPKGKGGFARTVSQRKRKRLFLIGGALAVLAVAVGLMLTAFNQDIRFFRTPADLTEQDMTSGARFRLGGL
VEEGSVSRTGSELRFTVTDTIKTVKVVFEGIPPDLFREGQGVVAEGRFGSDGLFRADNVLAKHDENYVPKDLADSLKKKG
VWEGK

Sequences:

>Translated_165_residues
MSATAEQNARNPKGKGGFARTVSQRKRKRLFLIGGALAVLAVAVGLMLTAFNQDIRFFRTPADLTEQDMTSGARFRLGGL
VEEGSVSRTGSELRFTVTDTIKTVKVVFEGIPPDLFREGQGVVAEGRFGSDGLFRADNVLAKHDENYVPKDLADSLKKKG
VWEGK
>Mature_164_residues
SATAEQNARNPKGKGGFARTVSQRKRKRLFLIGGALAVLAVAVGLMLTAFNQDIRFFRTPADLTEQDMTSGARFRLGGLV
EEGSVSRTGSELRFTVTDTIKTVKVVFEGIPPDLFREGQGVVAEGRFGSDGLFRADNVLAKHDENYVPKDLADSLKKKGV
WEGK

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=141, Percent_Identity=41.8439716312057, Blast_Score=109, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_BRUA1 (B2SA93)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001934597.1
- ProteinModelPortal:   B2SA93
- SMR:   B2SA93
- GeneID:   6327752
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I05920
- HOGENOM:   HBG296631
- OMA:   HVEFAVH
- ProtClustDB:   PRK13254
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 17977; Mature: 17846

Theoretical pI: Translated: 10.52; Mature: 10.52

Prosite motif: NA

Important sites: BINDING 143-143

Signals:

None

Transmembrane regions:

HASH(0x20fcf7e0)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATAEQNARNPKGKGGFARTVSQRKRKRLFLIGGALAVLAVAVGLMLTAFNQDIRFFRT
CCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHCCCHHEEEC
PADLTEQDMTSGARFRLGGLVEEGSVSRTGSELRFTVTDTIKTVKVVFEGIPPDLFREGQ
CCCCCHHHHCCCCEEEECCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCHHHHHCCC
GVVAEGRFGSDGLFRADNVLAKHDENYVPKDLADSLKKKGVWEGK
CEEECCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCH
>Mature Secondary Structure 
SATAEQNARNPKGKGGFARTVSQRKRKRLFLIGGALAVLAVAVGLMLTAFNQDIRFFRT
CCCCCCCCCCCCCCCCHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHCCCHHEEEC
PADLTEQDMTSGARFRLGGLVEEGSVSRTGSELRFTVTDTIKTVKVVFEGIPPDLFREGQ
CCCCCHHHHCCCCEEEECCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCHHHHHCCC
GVVAEGRFGSDGLFRADNVLAKHDENYVPKDLADSLKKKGVWEGK
CEEECCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA