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The map label for this gene is gmk

Identifier: 225852000

GI number: 225852000

Start: 483045

End: 483707

Strand: Direct

Name: gmk

Synonym: BMEA_A0500

Alternate gene names: 225852000

Gene position: 483045-483707 (Clockwise)

Preceding gene: 225851999

Following gene: 225852003

Centisome position: 22.72

GC content: 57.62

Gene sequence:

>663_bases
ATGGCCATATCTTCGGTTGAAAATGGCGTAGCTCGCAGAGGCTTGATGGTGGTGATCTCGTCGCCGTCGGGTGCGGGAAA
ATCCACCATTGCCCGGCTGCTTCTGGAAGACCCGAAGATGAAGCTCTCGCTCTCCATCAGTGTGACGACGCGCCAGCGTC
GCCCGAGCGAGATTGACGGCGTACATTATCATTTCATCACGATCCGCGAATTCGAGCGCCTGCGCGACAATGACGAGCTG
ATCGAATGGGCCGAAGTGCACGGCAATTTTTATGGTACGCTGCGCGAAACGGCCGAGATTGCGCTGGCCGATGGGCAGGA
CATGCTGTTCGATATCGATTGGCAGGGGGCGGACCAATTGCAGGCCAAGATGCCAGCCGATGTGGTGTCGATCTTCATCC
TGCCGCCGACCATGCGCGAATTGCAGCAGCGTCTCAACCGGCGCGCCGAAGACACGGCGGAAGTGATCGAAACGCGCCTG
CAGAATGCGCGCTTTGAAATCCAGAAATGGGTGAAATACGACTATATTGTCATCAATGAAGACCTCGACCGTTCCTATGC
GGCGATCAAGTCGATCATCAATGCGGAGCGGCTGCGCCGTGACCGCCGCCCCGGCCTGTTTGATTTTGTCACGGGGCTTC
TGGAGGAAGATCCGGGGATGTGA

Upstream 100 bases:

>100_bases
CCAAATCGAACGCAGCGTCGATCACGGCTATCGGACTGGGGCTGAAAGCGGTCGTCGATCAGTTCCGCGAACAAGTACAG
AATCTGGAGTAATAGGTATC

Downstream 100 bases:

>100_bases
GGCATCCTTCCATTCGTCACTACAGCCTAGACAGCAGTGCCTCCGACTGTGATTTGATCCATGCGCAGATGGGGCTGGCC
GACACCGACCGGCACCCACT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MAISSVENGVARRGLMVVISSPSGAGKSTIARLLLEDPKMKLSLSISVTTRQRRPSEIDGVHYHFITIREFERLRDNDEL
IEWAEVHGNFYGTLRETAEIALADGQDMLFDIDWQGADQLQAKMPADVVSIFILPPTMRELQQRLNRRAEDTAEVIETRL
QNARFEIQKWVKYDYIVINEDLDRSYAAIKSIINAERLRRDRRPGLFDFVTGLLEEDPGM

Sequences:

>Translated_220_residues
MAISSVENGVARRGLMVVISSPSGAGKSTIARLLLEDPKMKLSLSISVTTRQRRPSEIDGVHYHFITIREFERLRDNDEL
IEWAEVHGNFYGTLRETAEIALADGQDMLFDIDWQGADQLQAKMPADVVSIFILPPTMRELQQRLNRRAEDTAEVIETRL
QNARFEIQKWVKYDYIVINEDLDRSYAAIKSIINAERLRRDRRPGLFDFVTGLLEEDPGM
>Mature_219_residues
AISSVENGVARRGLMVVISSPSGAGKSTIARLLLEDPKMKLSLSISVTTRQRRPSEIDGVHYHFITIREFERLRDNDELI
EWAEVHGNFYGTLRETAEIALADGQDMLFDIDWQGADQLQAKMPADVVSIFILPPTMRELQQRLNRRAEDTAEVIETRLQ
NARFEIQKWVKYDYIVINEDLDRSYAAIKSIINAERLRRDRRPGLFDFVTGLLEEDPGM

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=194, Percent_Identity=34.5360824742268, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI226874833, Length=194, Percent_Identity=34.5360824742268, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI4504221, Length=194, Percent_Identity=34.5360824742268, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI14780902, Length=189, Percent_Identity=24.3386243386243, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI38570142, Length=195, Percent_Identity=26.1538461538462, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI111154074, Length=181, Percent_Identity=27.6243093922652, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1790080, Length=206, Percent_Identity=44.6601941747573, Blast_Score=178, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI193203132, Length=174, Percent_Identity=34.4827586206897, Blast_Score=103, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17508835, Length=174, Percent_Identity=34.4827586206897, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17557440, Length=184, Percent_Identity=25.5434782608696, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=35.5191256830601, Blast_Score=134, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21356141, Length=193, Percent_Identity=32.6424870466321, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI161077626, Length=181, Percent_Identity=28.1767955801105, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI85724806, Length=181, Percent_Identity=28.1767955801105, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI116007136, Length=181, Percent_Identity=28.1767955801105, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45554481, Length=181, Percent_Identity=28.1767955801105, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24640542, Length=181, Percent_Identity=28.1767955801105, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45554489, Length=181, Percent_Identity=28.1767955801105, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_BRUA2 (Q2YMJ2)

Other databases:

- EMBL:   AM040264
- RefSeq:   YP_413949.1
- ProteinModelPortal:   Q2YMJ2
- STRING:   Q2YMJ2
- GeneID:   3788736
- GenomeReviews:   AM040264_GR
- KEGG:   bmf:BAB1_0489
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- ProtClustDB:   PRK00300
- BioCyc:   BMEL359391:BAB1_0489-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 25223; Mature: 25092

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAISSVENGVARRGLMVVISSPSGAGKSTIARLLLEDPKMKLSLSISVTTRQRRPSEIDG
CCCCHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCC
VHYHFITIREFERLRDNDELIEWAEVHGNFYGTLRETAEIALADGQDMLFDIDWQGADQL
EEEEEEEHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHEEEEECCCEEEEEECCCCCHHH
QAKMPADVVSIFILPPTMRELQQRLNRRAEDTAEVIETRLQNARFEIQKWVKYDYIVINE
HHHCCHHHEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEC
DLDRSYAAIKSIINAERLRRDRRPGLFDFVTGLLEEDPGM
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AISSVENGVARRGLMVVISSPSGAGKSTIARLLLEDPKMKLSLSISVTTRQRRPSEIDG
CCCHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCC
VHYHFITIREFERLRDNDELIEWAEVHGNFYGTLRETAEIALADGQDMLFDIDWQGADQL
EEEEEEEHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHEEEEECCCEEEEEECCCCCHHH
QAKMPADVVSIFILPPTMRELQQRLNRRAEDTAEVIETRLQNARFEIQKWVKYDYIVINE
HHHCCHHHEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEC
DLDRSYAAIKSIINAERLRRDRRPGLFDFVTGLLEEDPGM
CCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA