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The map label for this gene is atpB [H]

Identifier: 225851922

GI number: 225851922

Start: 413493

End: 414242

Strand: Direct

Name: atpB [H]

Synonym: BMEA_A0416

Alternate gene names: 225851922

Gene position: 413493-414242 (Clockwise)

Preceding gene: 225851921

Following gene: 225851923

Centisome position: 19.45

GC content: 55.73

Gene sequence:

>750_bases
GTGGCGAACGATCCGATCCATCAGTTCCAGGTTTCCCGGTGGATTCCCATCGACGTAGGCGGTGTGGACCTTTCATTCAC
GAATGTTTCGGCCTTCATGGTTGCAACCGTCGTGCTTGCTTCGGGTTTCCTTTATCTGACCTCTTCGGGCCGCGGCCTTA
TCCCGACCCGCCTGCAGTCGGTTTCGGAAATGGCCTATGAATTCGTGGCGACAAGCCTGAGAGATTCGGCAGGGTCGAAG
GGCATGAAGTTCTTCCCTTTCGTCTTCTCGCTCTTCATGTTCGTCCTCGTTGCCAATTTCATCGGCCTGTTTCCCTACTT
CTATACGGTGACGAGCCAGATCATCGTGACCTTCGCACTGTCGCTTCTGGTCATCGGTACGGTCATCTTCTACGGTTTCT
TCAAGCACGGCTTCGGCTTCCTCAAGCTTTTCGTGCCAAGCGGCGTTCCGGGCATCATCGTGCCGCTCGTCGTCCTGATT
GAAATCATCTCGTTCCTGTCGCGTCCGATCAGCCTTTCGGTTCGTCTTTTCGCCAACATGCTCGCTGGCCACATCACGCT
CAAGGTTTTCGCCGGTTTCGTGGTTTCGCTGAGCTCGCTTGGCGCGCTTGGCATCGGTGGCGCTGTTCTGCCGCTCCTGA
TGACGGTTGCGATCACGGCTCTCGAATTCCTGGTGGCTTTCCTCCAGGCATATGTCTTTACCGTTCTCACCTGCATGTAC
ATCAACGACGCTGTGCATCCGGGACACTGA

Upstream 100 bases:

>100_bases
GGCACTTCACGTTAAAGTGCATTCAAGTGTAAGTGGTTATAAGTGGGCCTTCGGCCCAAGACTGAAACGCCTTCGGGCAG
GGAAGACAAACGAGGTTAAG

Downstream 100 bases:

>100_bases
GTTCTAACCGGCGGGCGACCGCCAGAACTGAAATCCGCGCTTATTTTCAATCCAGAAGGAGCTTAACATGGAAGCGGAAG
CAGCAAAGTACATCGGCGCC

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a 1; F-ATPase subunit 6 1 [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MANDPIHQFQVSRWIPIDVGGVDLSFTNVSAFMVATVVLASGFLYLTSSGRGLIPTRLQSVSEMAYEFVATSLRDSAGSK
GMKFFPFVFSLFMFVLVANFIGLFPYFYTVTSQIIVTFALSLLVIGTVIFYGFFKHGFGFLKLFVPSGVPGIIVPLVVLI
EIISFLSRPISLSVRLFANMLAGHITLKVFAGFVVSLSSLGALGIGGAVLPLLMTVAITALEFLVAFLQAYVFTVLTCMY
INDAVHPGH

Sequences:

>Translated_249_residues
MANDPIHQFQVSRWIPIDVGGVDLSFTNVSAFMVATVVLASGFLYLTSSGRGLIPTRLQSVSEMAYEFVATSLRDSAGSK
GMKFFPFVFSLFMFVLVANFIGLFPYFYTVTSQIIVTFALSLLVIGTVIFYGFFKHGFGFLKLFVPSGVPGIIVPLVVLI
EIISFLSRPISLSVRLFANMLAGHITLKVFAGFVVSLSSLGALGIGGAVLPLLMTVAITALEFLVAFLQAYVFTVLTCMY
INDAVHPGH
>Mature_248_residues
ANDPIHQFQVSRWIPIDVGGVDLSFTNVSAFMVATVVLASGFLYLTSSGRGLIPTRLQSVSEMAYEFVATSLRDSAGSKG
MKFFPFVFSLFMFVLVANFIGLFPYFYTVTSQIIVTFALSLLVIGTVIFYGFFKHGFGFLKLFVPSGVPGIIVPLVVLIE
IISFLSRPISLSVRLFANMLAGHITLKVFAGFVVSLSSLGALGIGGAVLPLLMTVAITALEFLVAFLQAYVFTVLTCMYI
NDAVHPGH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane [H]

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family [H]

Homologues:

Organism=Homo sapiens, GI251831112, Length=199, Percent_Identity=31.1557788944724, Blast_Score=99, Evalue=2e-21,
Organism=Escherichia coli, GI1790176, Length=209, Percent_Identity=26.7942583732057, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6226527, Length=248, Percent_Identity=32.6612903225806, Blast_Score=144, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000568
- InterPro:   IPR023011 [H]

Pfam domain/function: PF00119 ATP-synt_A [H]

EC number: 3.6.3.14

Molecular weight: Translated: 26980; Mature: 26848

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCCCCC
>Mature Secondary Structure 
ANDPIHQFQVSRWIPIDVGGVDLSFTNVSAFMVATVVLASGFLYLTSSGRGLIPTRLQS
CCCCHHHHHHCCCCEEECCCCEEEHHHHHHHHHHHHHHHCCHHEEECCCCCCCHHHHHH
VSEMAYEFVATSLRDSAGSKGMKFFPFVFSLFMFVLVANFIGLFPYFYTVTSQIIVTFAL
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLLVIGTVIFYGFFKHGFGFLKLFVPSGVPGIIVPLVVLIEIISFLSRPISLSVRLFANM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
LAGHITLKVFAGFVVSLSSLGALGIGGAVLPLLMTVAITALEFLVAFLQAYVFTVLTCMY
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
INDAVHPGH
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA