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The map label for this gene is argF

Identifier: 225851848

GI number: 225851848

Start: 334975

End: 335913

Strand: Direct

Name: argF

Synonym: BMEA_A0337

Alternate gene names: 225851848

Gene position: 334975-335913 (Clockwise)

Preceding gene: 225851847

Following gene: 225851849

Centisome position: 15.76

GC content: 57.51

Gene sequence:

>939_bases
ATGGCAAACGATAACGGTATCAAACACTTTATCGATCTCTCCACCGTTCCGGCGACGGAGCTTCGCGCCATTCTGGAAGA
TGCCAAGGCGCGCAAGGCGCGCCTGAAAGCTGGCGAAGTCGAACGGCCCTACGCCGGCAAGGTGCTGGCGATGATCTTTG
AAAAGCTTTCCACGCGTACGCGCGTTTCCTTTGACGTCGGAATGCGCCAGCTCGGCGGCGAAACGATCATGCTGACGGGT
TCGGAAATGCAGCTTGGCCGCAGCGAAACCATCGCCGACACGGCGAAGGTTCTCTCACGCTATGTGGATGCGATCATGAT
CCGCACCACCGCGCATGAACGCATGCTGGAACTGGCCGAATATGCCACTGTTCCCGTTATCAATGCGTTGACCGACGACA
CCCACCCTTGTCAGATCATGGCAGACGTTCTTACATATGAGGAACATCGCGGCCCGATCAAGGGCAAGACCTTTGCCTGG
ATGGGGGATGGCAACAACGTCCTGCATTCGCTTGTGGAAGCTGCAGCGCGGTTTGATTTCAACGTCAATATCGCGACACC
GAAAGGCAGTGAGCCGAAGTCGCAATATATCGACTGGGCGCGGGCCAACGGCGCGGGCATCATGTCCACCACCGACCCGG
AAAAGGCGGCAAGCGGCGCAGATTGCATCGTGACCGATACATGGGTGTCGATGGGGCAGGAAGATCATGCCCGTGGACAC
AATGTTTTCATACCATATCAGGTCAATGCGAACCTGATGGCAAAGGCTGACCCGAAGGCATTGTTCATGCACTGCCTGCC
CGCGCATCGCGGTGAGGAAGTGACCGATGAAGTCATCGACGGGCCGCAATCGGTCGTGTTCGATGAAGCGGAAAACAGGC
TCCACGCCCAGAAGGCCATTCTGGCCTGGTGCCTGCAAGACCGCGGTTTGGGAGCATAA

Upstream 100 bases:

>100_bases
ATCACGACGCCGGAAGAAGCGCGTGAGGCATTGAAGCACATCGAAACGGCCGTCGAGCGGCTTTCCATTGCAAATCCGAT
CAGCAAGACGGTGTGATATC

Downstream 100 bases:

>100_bases
TTTGTCCGACAAGACCAGTAATGAGCATACCGAAGGCGAAAATATCCAGACCGGTCTGGGCGGCTTCAATTTCGCAGGCG
ATGATGCCGTCGTGCCCTTC

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MANDNGIKHFIDLSTVPATELRAILEDAKARKARLKAGEVERPYAGKVLAMIFEKLSTRTRVSFDVGMRQLGGETIMLTG
SEMQLGRSETIADTAKVLSRYVDAIMIRTTAHERMLELAEYATVPVINALTDDTHPCQIMADVLTYEEHRGPIKGKTFAW
MGDGNNVLHSLVEAAARFDFNVNIATPKGSEPKSQYIDWARANGAGIMSTTDPEKAASGADCIVTDTWVSMGQEDHARGH
NVFIPYQVNANLMAKADPKALFMHCLPAHRGEEVTDEVIDGPQSVVFDEAENRLHAQKAILAWCLQDRGLGA

Sequences:

>Translated_312_residues
MANDNGIKHFIDLSTVPATELRAILEDAKARKARLKAGEVERPYAGKVLAMIFEKLSTRTRVSFDVGMRQLGGETIMLTG
SEMQLGRSETIADTAKVLSRYVDAIMIRTTAHERMLELAEYATVPVINALTDDTHPCQIMADVLTYEEHRGPIKGKTFAW
MGDGNNVLHSLVEAAARFDFNVNIATPKGSEPKSQYIDWARANGAGIMSTTDPEKAASGADCIVTDTWVSMGQEDHARGH
NVFIPYQVNANLMAKADPKALFMHCLPAHRGEEVTDEVIDGPQSVVFDEAENRLHAQKAILAWCLQDRGLGA
>Mature_311_residues
ANDNGIKHFIDLSTVPATELRAILEDAKARKARLKAGEVERPYAGKVLAMIFEKLSTRTRVSFDVGMRQLGGETIMLTGS
EMQLGRSETIADTAKVLSRYVDAIMIRTTAHERMLELAEYATVPVINALTDDTHPCQIMADVLTYEEHRGPIKGKTFAWM
GDGNNVLHSLVEAAARFDFNVNIATPKGSEPKSQYIDWARANGAGIMSTTDPEKAASGADCIVTDTWVSMGQEDHARGHN
VFIPYQVNANLMAKADPKALFMHCLPAHRGEEVTDEVIDGPQSVVFDEAENRLHAQKAILAWCLQDRGLGA

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI38788445, Length=306, Percent_Identity=41.1764705882353, Blast_Score=233, Evalue=2e-61,
Organism=Homo sapiens, GI18105007, Length=268, Percent_Identity=26.1194029850746, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI1790703, Length=329, Percent_Identity=40.1215805471125, Blast_Score=212, Evalue=2e-56,
Organism=Escherichia coli, GI1786469, Length=325, Percent_Identity=39.0769230769231, Blast_Score=198, Evalue=4e-52,
Organism=Escherichia coli, GI2367364, Length=312, Percent_Identity=31.0897435897436, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI48994908, Length=330, Percent_Identity=26.6666666666667, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193204318, Length=325, Percent_Identity=26.7692307692308, Blast_Score=82, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6322373, Length=325, Percent_Identity=35.6923076923077, Blast_Score=202, Evalue=4e-53,
Organism=Saccharomyces cerevisiae, GI6322331, Length=305, Percent_Identity=25.5737704918033, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24642586, Length=313, Percent_Identity=25.2396166134185, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): OTC_BRUA2 (Q2YPH2)

Other databases:

- EMBL:   AM040264
- RefSeq:   YP_413800.1
- HSSP:   P96108
- ProteinModelPortal:   Q2YPH2
- SMR:   Q2YPH2
- STRING:   Q2YPH2
- GeneID:   3787107
- GenomeReviews:   AM040264_GR
- KEGG:   bmf:BAB1_0332
- eggNOG:   COG0078
- HOGENOM:   HBG579429
- OMA:   CVVTDTW
- ProtClustDB:   PRK00779
- BioCyc:   BMEL359391:BAB1_0332-MONOMER
- HAMAP:   MF_01109
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292
- PRINTS:   PR00100
- PRINTS:   PR00102
- TIGRFAMs:   TIGR00658

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.3

Molecular weight: Translated: 34239; Mature: 34108

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: BINDING 108-108 BINDING 135-135

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANDNGIKHFIDLSTVPATELRAILEDAKARKARLKAGEVERPYAGKVLAMIFEKLSTRT
CCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
RVSFDVGMRQLGGETIMLTGSEMQLGRSETIADTAKVLSRYVDAIMIRTTAHERMLELAE
EEEHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YATVPVINALTDDTHPCQIMADVLTYEEHRGPIKGKTFAWMGDGNNVLHSLVEAAARFDF
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHCCC
NVNIATPKGSEPKSQYIDWARANGAGIMSTTDPEKAASGADCIVTDTWVSMGQEDHARGH
EEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEEHHHHHCCCHHCCCCC
NVFIPYQVNANLMAKADPKALFMHCLPAHRGEEVTDEVIDGPQSVVFDEAENRLHAQKAI
CEEEEEEECCCEEECCCHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LAWCLQDRGLGA
HHHHHHHCCCCC
>Mature Secondary Structure 
ANDNGIKHFIDLSTVPATELRAILEDAKARKARLKAGEVERPYAGKVLAMIFEKLSTRT
CCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
RVSFDVGMRQLGGETIMLTGSEMQLGRSETIADTAKVLSRYVDAIMIRTTAHERMLELAE
EEEHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YATVPVINALTDDTHPCQIMADVLTYEEHRGPIKGKTFAWMGDGNNVLHSLVEAAARFDF
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHCCC
NVNIATPKGSEPKSQYIDWARANGAGIMSTTDPEKAASGADCIVTDTWVSMGQEDHARGH
EEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEEHHHHHCCCHHCCCCC
NVFIPYQVNANLMAKADPKALFMHCLPAHRGEEVTDEVIDGPQSVVFDEAENRLHAQKAI
CEEEEEEECCCEEECCCHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LAWCLQDRGLGA
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA