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The map label for this gene is argD

Identifier: 225851847

GI number: 225851847

Start: 333759

End: 334970

Strand: Direct

Name: argD

Synonym: BMEA_A0336

Alternate gene names: 225851847

Gene position: 333759-334970 (Clockwise)

Preceding gene: 225851845

Following gene: 225851848

Centisome position: 15.7

GC content: 59.74

Gene sequence:

>1212_bases
ATGACCGATGCGACGACCGTGCACCCGCTTTACGACACCTATAATCGTGCGGCTCTGCGCTTCGAGCGAGGAGAAGGCAT
CTGGCTGATTACCGAGGATGGCGAGCGTTATATCGATTTTGCAGCCGGTATTGCGGTCAATTCGCTTGGCCATTCCCATC
CGCATCTGGTCGAGACCCTGAAGACGCAGGCCGAAAAGCTCTGGCACCTTTCCAATGTCTATGAAATTCCCGCGCAGGAA
AAGCTTGGCCGCCGTCTGGTGGAAAGCACCTTCGCCGACAAGGTGTTCTTCACCAATTCCGGCGCCGAGGCACTCGAATG
CGCGATCAAGACCGCGCGGCGCTATCAATATGTAAGCGGCCACCCGGAGCGCTTCCGTATCATCACCTTTGAGGGTGCGT
TCCATGGCCGCACGCTTGCAACTATCGCCGCTGGCGGCCAGGCCAAATATCTGGAAGGTTTTGGCCCGAAGGTCGAAGGC
TTCGATCAGGTGCCGTTCGGCGACGAGGCGGCCCTTCGCGCCGCCATCACGCCGGAAACGGCTGGCATCCTGCTTGAACC
CATTCAGGGTGAGGGCGGCTTGCGCGCCTTCCCGGAGGAATTCCTCCGCCTCGTGCGCCAGATCTGCGATGAAAATGGCT
TGCTTCTGCTTCTCGATGAAGTCCAGACGGGCGTTGGCCGCACGGGCAAGCTCTTCGCCCATGAATGGGCTGGCATCAGG
CCGGATATCATGGCGATTGCCAAGGGTATTGGCGGCGGTTTCCCGATCGGGGCCTGCCTTGCCACGGCTGAAGCCGCCAA
GGGCATGACCGCTGGCATGCATGGAACGACCTATGGCGGCAACCCGCTTGGCATGGCCGTTGGCAATGCCGTGCTGGATG
TTGTCCTTGCCGATGGCTTTATGGAGAATGTTCAGGCGACGGCGCTTGTGATGAAACAGGGCCTTGCCTCCCTCGTGGAC
CGTTATCCGAATGTGGTTTCTGAAATTCGCGGGCGCGGCCTTCTCATGGGCCTGAAATGCGTGGTGCCGAATACGAGTCT
CATTCAGGCCCTGCGCGACGAACACATCCTCAGTGTCGGTGCGGGCGACAATGTGGTGCGCCTTCTGCCGCCATTGATCA
CGACGCCGGAAGAAGCGCGTGAGGCATTGAAGCACATCGAAACGGCCGTCGAGCGGCTTTCCATTGCAAATCCGATCAGC
AAGACGGTGTGA

Upstream 100 bases:

>100_bases
CCGGACTGCACAGGTCCGGGATCAACGCAATAGGAACTCGCTGCTTGCCGGCCGCAGCCGGAGCCGCAGCACTTTAGAGG
GCTTATGGAGGCCTGATGCA

Downstream 100 bases:

>100_bases
TATCATGGCAAACGATAACGGTATCAAACACTTTATCGATCTCTCCACCGTTCCGGCGACGGAGCTTCGCGCCATTCTGG
AAGATGCCAAGGCGCGCAAG

Product: acetylornithine transaminase protein

Products: NA

Alternate protein names: ACOAT

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MTDATTVHPLYDTYNRAALRFERGEGIWLITEDGERYIDFAAGIAVNSLGHSHPHLVETLKTQAEKLWHLSNVYEIPAQE
KLGRRLVESTFADKVFFTNSGAEALECAIKTARRYQYVSGHPERFRIITFEGAFHGRTLATIAAGGQAKYLEGFGPKVEG
FDQVPFGDEAALRAAITPETAGILLEPIQGEGGLRAFPEEFLRLVRQICDENGLLLLLDEVQTGVGRTGKLFAHEWAGIR
PDIMAIAKGIGGGFPIGACLATAEAAKGMTAGMHGTTYGGNPLGMAVGNAVLDVVLADGFMENVQATALVMKQGLASLVD
RYPNVVSEIRGRGLLMGLKCVVPNTSLIQALRDEHILSVGAGDNVVRLLPPLITTPEEAREALKHIETAVERLSIANPIS
KTV

Sequences:

>Translated_403_residues
MTDATTVHPLYDTYNRAALRFERGEGIWLITEDGERYIDFAAGIAVNSLGHSHPHLVETLKTQAEKLWHLSNVYEIPAQE
KLGRRLVESTFADKVFFTNSGAEALECAIKTARRYQYVSGHPERFRIITFEGAFHGRTLATIAAGGQAKYLEGFGPKVEG
FDQVPFGDEAALRAAITPETAGILLEPIQGEGGLRAFPEEFLRLVRQICDENGLLLLLDEVQTGVGRTGKLFAHEWAGIR
PDIMAIAKGIGGGFPIGACLATAEAAKGMTAGMHGTTYGGNPLGMAVGNAVLDVVLADGFMENVQATALVMKQGLASLVD
RYPNVVSEIRGRGLLMGLKCVVPNTSLIQALRDEHILSVGAGDNVVRLLPPLITTPEEAREALKHIETAVERLSIANPIS
KTV
>Mature_402_residues
TDATTVHPLYDTYNRAALRFERGEGIWLITEDGERYIDFAAGIAVNSLGHSHPHLVETLKTQAEKLWHLSNVYEIPAQEK
LGRRLVESTFADKVFFTNSGAEALECAIKTARRYQYVSGHPERFRIITFEGAFHGRTLATIAAGGQAKYLEGFGPKVEGF
DQVPFGDEAALRAAITPETAGILLEPIQGEGGLRAFPEEFLRLVRQICDENGLLLLLDEVQTGVGRTGKLFAHEWAGIRP
DIMAIAKGIGGGFPIGACLATAEAAKGMTAGMHGTTYGGNPLGMAVGNAVLDVVLADGFMENVQATALVMKQGLASLVDR
YPNVVSEIRGRGLLMGLKCVVPNTSLIQALRDEHILSVGAGDNVVRLLPPLITTPEEAREALKHIETAVERLSIANPISK
TV

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=388, Percent_Identity=33.2474226804124, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI284507298, Length=302, Percent_Identity=34.7682119205298, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI13994255, Length=444, Percent_Identity=30.8558558558559, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI37574042, Length=422, Percent_Identity=27.4881516587678, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI24119277, Length=413, Percent_Identity=24.6973365617433, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI226442705, Length=422, Percent_Identity=26.7772511848341, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI226442709, Length=392, Percent_Identity=27.8061224489796, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI188536080, Length=411, Percent_Identity=25.0608272506083, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI38679950, Length=411, Percent_Identity=25.0608272506083, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI38679946, Length=411, Percent_Identity=25.0608272506083, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1789759, Length=398, Percent_Identity=42.713567839196, Blast_Score=315, Evalue=3e-87,
Organism=Escherichia coli, GI1788044, Length=377, Percent_Identity=42.9708222811671, Blast_Score=296, Evalue=2e-81,
Organism=Escherichia coli, GI145693181, Length=396, Percent_Identity=35.1010101010101, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1789016, Length=419, Percent_Identity=31.2649164677804, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1787560, Length=404, Percent_Identity=33.1683168316832, Blast_Score=184, Evalue=6e-48,
Organism=Escherichia coli, GI1786991, Length=395, Percent_Identity=31.6455696202532, Blast_Score=161, Evalue=8e-41,
Organism=Escherichia coli, GI1786349, Length=330, Percent_Identity=30.6060606060606, Blast_Score=118, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI25144271, Length=395, Percent_Identity=32.1518987341772, Blast_Score=203, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI32564660, Length=436, Percent_Identity=28.8990825688073, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25144274, Length=290, Percent_Identity=32.7586206896552, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71992977, Length=436, Percent_Identity=27.0642201834862, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17541228, Length=427, Percent_Identity=24.824355971897, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71981843, Length=158, Percent_Identity=31.6455696202532, Blast_Score=83, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324432, Length=396, Percent_Identity=37.8787878787879, Blast_Score=260, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6323470, Length=413, Percent_Identity=29.5399515738499, Blast_Score=186, Evalue=4e-48,
Organism=Saccharomyces cerevisiae, GI6324386, Length=313, Percent_Identity=24.9201277955272, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6321456, Length=367, Percent_Identity=25.0681198910082, Blast_Score=87, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21357415, Length=387, Percent_Identity=31.0077519379845, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI161085790, Length=444, Percent_Identity=30.4054054054054, Blast_Score=181, Evalue=9e-46,
Organism=Drosophila melanogaster, GI28574759, Length=434, Percent_Identity=30.4147465437788, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI21356575, Length=421, Percent_Identity=28.7410926365796, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI281366494, Length=416, Percent_Identity=26.9230769230769, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24667139, Length=416, Percent_Identity=26.9230769230769, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24667143, Length=416, Percent_Identity=26.9230769230769, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ARGD_BRUME (P63566)

Other databases:

- EMBL:   AE008917
- PIR:   AG3454
- RefSeq:   NP_540538.1
- ProteinModelPortal:   P63566
- SMR:   P63566
- GeneID:   1197332
- GenomeReviews:   AE008917_GR
- KEGG:   bme:BMEI1621
- HOGENOM:   HBG725944
- OMA:   VALVFRQ
- PhylomeDB:   P63566
- ProtClustDB:   PRK01278
- BioCyc:   BMEL224914:BMEI1621-MONOMER
- BRENDA:   2.6.1.11
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19
- TIGRFAMs:   TIGR00707

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11

Molecular weight: Translated: 43453; Mature: 43322

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 134-134 BINDING 137-137 BINDING 276-276 BINDING 277-277

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDATTVHPLYDTYNRAALRFERGEGIWLITEDGERYIDFAAGIAVNSLGHSHPHLVETL
CCCCCCCCHHHHHHCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHH
KTQAEKLWHLSNVYEIPAQEKLGRRLVESTFADKVFFTNSGAEALECAIKTARRYQYVSG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHCCC
HPERFRIITFEGAFHGRTLATIAAGGQAKYLEGFGPKVEGFDQVPFGDEAALRAAITPET
CCCEEEEEEEECCCCCCEEEEEECCCCCHHHHCCCCCCCCCCCCCCCCHHHHEEECCCCC
AGILLEPIQGEGGLRAFPEEFLRLVRQICDENGLLLLLDEVQTGVGRTGKLFAHEWAGIR
CCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCCCCHHHHHCCCC
PDIMAIAKGIGGGFPIGACLATAEAAKGMTAGMHGTTYGGNPLGMAVGNAVLDVVLADGF
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
MENVQATALVMKQGLASLVDRYPNVVSEIRGRGLLMGLKCVVPNTSLIQALRDEHILSVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHCCEEEEC
AGDNVVRLLPPLITTPEEAREALKHIETAVERLSIANPISKTV
CCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCC
>Mature Secondary Structure 
TDATTVHPLYDTYNRAALRFERGEGIWLITEDGERYIDFAAGIAVNSLGHSHPHLVETL
CCCCCCCHHHHHHCCCEEEEECCCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHH
KTQAEKLWHLSNVYEIPAQEKLGRRLVESTFADKVFFTNSGAEALECAIKTARRYQYVSG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHHHHCCC
HPERFRIITFEGAFHGRTLATIAAGGQAKYLEGFGPKVEGFDQVPFGDEAALRAAITPET
CCCEEEEEEEECCCCCCEEEEEECCCCCHHHHCCCCCCCCCCCCCCCCHHHHEEECCCCC
AGILLEPIQGEGGLRAFPEEFLRLVRQICDENGLLLLLDEVQTGVGRTGKLFAHEWAGIR
CCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEHHHCCCCCCCCCHHHHHCCCC
PDIMAIAKGIGGGFPIGACLATAEAAKGMTAGMHGTTYGGNPLGMAVGNAVLDVVLADGF
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
MENVQATALVMKQGLASLVDRYPNVVSEIRGRGLLMGLKCVVPNTSLIQALRDEHILSVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHCCEEEEC
AGDNVVRLLPPLITTPEEAREALKHIETAVERLSIANPISKTV
CCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11756688