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The map label for this gene is phoR [H]

Identifier: 225851845

GI number: 225851845

Start: 331167

End: 332483

Strand: Direct

Name: phoR [H]

Synonym: BMEA_A0334

Alternate gene names: 225851845

Gene position: 331167-332483 (Clockwise)

Preceding gene: 225851843

Following gene: 225851847

Centisome position: 15.58

GC content: 60.9

Gene sequence:

>1317_bases
ATGAGCGAAGACAGCGGCCGCGCCGGACCGGAAGCCAGAACGGAAACATCCCTTTTCGAGCCGCTCCTGCGGATCAAGGG
TGTGCTTTTCGTCAGCATGGTGCTGGCGATCTGTGTCATGGCGCTCGACCTTCCTTTCTGGTTCCGCGCCATATTGCTGG
CGCTCGTTGTGCTGGGCGCGGTCTGGGCGGCGGCGGGCATTGGCAATGGGGAGGATGAAAAGGTTCCCTTGCGGGAAGTG
GCCAGCCGTGAAATGGCGGCTGTCTCGGGCGAGCGGCTGGCCGATCTTCTGACCGATCCGATGATCGTCTTCGATCACAC
CGCAACGGTGCGTTTTGCCAACGTGGCGGCGCTTGAAGCGTTCCAGTCGCTGCAAAACGGCACCGCGCTTTATCTGCGCT
TTCGCGCCCCGGAAATGCTCGCGCTGATCCAGGGCGTGATTGCCGACGGCGAACCGCGCAATATCGAATATTTCGAGCGC
GTTCCCATCGATCGCTGGTACAAGGCAATGGTCAAGGCGCTGCGTGATGCGGAAGGAAAGCCGGAACTCTTCGTGCTTAT
TTTCCGCGACCAGAGCGAAACACGGCGTATCGACCGTATGCGTTCCGACTTTATCGCCAATGCAAGCCATGAGCTGCGCA
CCCCGCTTGCCTCGCTGCGCGGCTTCATCGAAACGCTGCAAGGCCCGGCGCGCAACGATGCCGCCGCCCGTGACCGCTTT
CTCGACATCATGCAGAAACAGGCCGAGCGCATGTCGCGTTTGATCGACGATCTCCTGTCGCTGTCGCGGCTTGAAATGCG
TGCTCATCTGGCGGTCAATGAAAGCGTGGATGTGGCGGCCACGCTGGCCCATGTGGCCGATACGCTGACGCCACTTGCCG
CCGGTCTCGGCGTGACCATCGAGCGCCACCTGCCGGAACATCCGGTTCATGTGATGGGCGCGCGTGATGAGCTGATTCAG
GTCTTCCAGAATCTTGTCGAAAATGCCTGCAAATACGGGCAGGAGGGCAAGCGCGTCATCATAAGATTAAGCGAGGAAGA
CACGGGAAATGCGACGGAAGTGGTCGCCTCCATACAGGATTTCGGGCCGGGCATTGCTGCCGAACACCTTCCGCGCCTCA
CAGAGCGTTTCTATCGCATCGACGTGGAGACAAGCCGCGCGCACAAGGGCACAGGTCTTGGCCTTGCCATCGTCAAGCAT
ATTCTGGCCCGCCATCGCGGCCGGCTTGTGGTGCGTTCGCAATTGGGGGAAGGCTCTACTTTCATGGTGCGCCTGCCGGG
GCAGAACGCGCGCTCCGCCGAGGCTGCAACAATATGA

Upstream 100 bases:

>100_bases
TATGGGCTGTTTGGAAGCCGCGTAAAGGACATGCAGAAGAAATCTGGCAGGGCGAAGGCTTTTGCCGGAAAATCCAGGCT
GTAGTGACGAAGGAGGCAGG

Downstream 100 bases:

>100_bases
AATACTCCAAGTATCTCGCAGGTTCATAAAAAGAAAAGTCCCGGCAACATTTCTGTTACCGGGACGAAGCTGGCAGGTTA
TTCCGGTCAAACGCCTTCGG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MSEDSGRAGPEARTETSLFEPLLRIKGVLFVSMVLAICVMALDLPFWFRAILLALVVLGAVWAAAGIGNGEDEKVPLREV
ASREMAAVSGERLADLLTDPMIVFDHTATVRFANVAALEAFQSLQNGTALYLRFRAPEMLALIQGVIADGEPRNIEYFER
VPIDRWYKAMVKALRDAEGKPELFVLIFRDQSETRRIDRMRSDFIANASHELRTPLASLRGFIETLQGPARNDAAARDRF
LDIMQKQAERMSRLIDDLLSLSRLEMRAHLAVNESVDVAATLAHVADTLTPLAAGLGVTIERHLPEHPVHVMGARDELIQ
VFQNLVENACKYGQEGKRVIIRLSEEDTGNATEVVASIQDFGPGIAAEHLPRLTERFYRIDVETSRAHKGTGLGLAIVKH
ILARHRGRLVVRSQLGEGSTFMVRLPGQNARSAEAATI

Sequences:

>Translated_438_residues
MSEDSGRAGPEARTETSLFEPLLRIKGVLFVSMVLAICVMALDLPFWFRAILLALVVLGAVWAAAGIGNGEDEKVPLREV
ASREMAAVSGERLADLLTDPMIVFDHTATVRFANVAALEAFQSLQNGTALYLRFRAPEMLALIQGVIADGEPRNIEYFER
VPIDRWYKAMVKALRDAEGKPELFVLIFRDQSETRRIDRMRSDFIANASHELRTPLASLRGFIETLQGPARNDAAARDRF
LDIMQKQAERMSRLIDDLLSLSRLEMRAHLAVNESVDVAATLAHVADTLTPLAAGLGVTIERHLPEHPVHVMGARDELIQ
VFQNLVENACKYGQEGKRVIIRLSEEDTGNATEVVASIQDFGPGIAAEHLPRLTERFYRIDVETSRAHKGTGLGLAIVKH
ILARHRGRLVVRSQLGEGSTFMVRLPGQNARSAEAATI
>Mature_437_residues
SEDSGRAGPEARTETSLFEPLLRIKGVLFVSMVLAICVMALDLPFWFRAILLALVVLGAVWAAAGIGNGEDEKVPLREVA
SREMAAVSGERLADLLTDPMIVFDHTATVRFANVAALEAFQSLQNGTALYLRFRAPEMLALIQGVIADGEPRNIEYFERV
PIDRWYKAMVKALRDAEGKPELFVLIFRDQSETRRIDRMRSDFIANASHELRTPLASLRGFIETLQGPARNDAAARDRFL
DIMQKQAERMSRLIDDLLSLSRLEMRAHLAVNESVDVAATLAHVADTLTPLAAGLGVTIERHLPEHPVHVMGARDELIQV
FQNLVENACKYGQEGKRVIIRLSEEDTGNATEVVASIQDFGPGIAAEHLPRLTERFYRIDVETSRAHKGTGLGLAIVKHI
LARHRGRLVVRSQLGEGSTFMVRLPGQNARSAEAATI

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=247, Percent_Identity=38.4615384615385, Blast_Score=157, Evalue=9e-40,
Organism=Escherichia coli, GI1788393, Length=235, Percent_Identity=33.6170212765957, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786783, Length=227, Percent_Identity=30.3964757709251, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI145693157, Length=230, Percent_Identity=31.304347826087, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790436, Length=241, Percent_Identity=31.1203319502075, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1789149, Length=228, Percent_Identity=30.7017543859649, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI48994928, Length=243, Percent_Identity=29.6296296296296, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788713, Length=229, Percent_Identity=27.5109170305677, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1790346, Length=223, Percent_Identity=27.8026905829596, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1789403, Length=202, Percent_Identity=31.6831683168317, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790861, Length=211, Percent_Identity=32.7014218009479, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786912, Length=240, Percent_Identity=29.1666666666667, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790551, Length=233, Percent_Identity=31.3304721030043, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1787374, Length=229, Percent_Identity=27.9475982532751, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788549, Length=227, Percent_Identity=27.3127753303965, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87082128, Length=237, Percent_Identity=25.7383966244726, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081816, Length=262, Percent_Identity=28.6259541984733, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787894, Length=206, Percent_Identity=31.5533980582524, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788279, Length=229, Percent_Identity=27.0742358078603, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 48427; Mature: 48296

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEDSGRAGPEARTETSLFEPLLRIKGVLFVSMVLAICVMALDLPFWFRAILLALVVLGA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VWAAAGIGNGEDEKVPLREVASREMAAVSGERLADLLTDPMIVFDHTATVRFANVAALEA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHH
FQSLQNGTALYLRFRAPEMLALIQGVIADGEPRNIEYFERVPIDRWYKAMVKALRDAEGK
HHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCC
PELFVLIFRDQSETRRIDRMRSDFIANASHELRTPLASLRGFIETLQGPARNDAAARDRF
CCEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LDIMQKQAERMSRLIDDLLSLSRLEMRAHLAVNESVDVAATLAHVADTLTPLAAGLGVTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCH
ERHLPEHPVHVMGARDELIQVFQNLVENACKYGQEGKRVIIRLSEEDTGNATEVVASIQD
HHCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHH
FGPGIAAEHLPRLTERFYRIDVETSRAHKGTGLGLAIVKHILARHRGRLVVRSQLGEGST
CCCCHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCE
FMVRLPGQNARSAEAATI
EEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SEDSGRAGPEARTETSLFEPLLRIKGVLFVSMVLAICVMALDLPFWFRAILLALVVLGA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VWAAAGIGNGEDEKVPLREVASREMAAVSGERLADLLTDPMIVFDHTATVRFANVAALEA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHH
FQSLQNGTALYLRFRAPEMLALIQGVIADGEPRNIEYFERVPIDRWYKAMVKALRDAEGK
HHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHHHHCCCCC
PELFVLIFRDQSETRRIDRMRSDFIANASHELRTPLASLRGFIETLQGPARNDAAARDRF
CCEEEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LDIMQKQAERMSRLIDDLLSLSRLEMRAHLAVNESVDVAATLAHVADTLTPLAAGLGVTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCH
ERHLPEHPVHVMGARDELIQVFQNLVENACKYGQEGKRVIIRLSEEDTGNATEVVASIQD
HHCCCCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHH
FGPGIAAEHLPRLTERFYRIDVETSRAHKGTGLGLAIVKHILARHRGRLVVRSQLGEGST
CCCCHHHHHHHHHHHHHHEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCE
FMVRLPGQNARSAEAATI
EEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]