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The map label for this gene is adhA [H]

Identifier: 225851734

GI number: 225851734

Start: 215528

End: 216562

Strand: Direct

Name: adhA [H]

Synonym: BMEA_A0212

Alternate gene names: 225851734

Gene position: 215528-216562 (Clockwise)

Preceding gene: 225851733

Following gene: 225851735

Centisome position: 10.14

GC content: 59.03

Gene sequence:

>1035_bases
ATGGCAAAGACGATGAAAGCTGCGGTCGTGCGTGCCTTCGGCAAACCGCTGACGATTGATGAAGTGCCGATACCTCAACC
CGGTCCCGGCCAGATTCAGGTTGCCATTCAGGCTTCCGGCGTATGCCATACCGACCTTCATGCCGCCGAGGGCGATTGGC
CGGTAAAACCCAATCCGCCCTTCATTCCGGGTCATGAGGGTGTCGGTTTCGTTTCCGCCGTGGGCAGCGGCGTCAAGCAT
GTCAAGGAAGGCGACCGTGTCGGCATTCCATGGCTTTACACTGCCTGCGGCCATTGCCGCCATTGCCTTGGTGGCTGGGA
AACGCTTTGCGAGGAACAGCTCAATACCGGCTATTCCGTCAATGGCGGCTTTGCCGAATATGTGGTGGCCGATCCGAATT
TCGTCGGCCACTTGCCGAAGAATATCGATTTCAACGAGATTGCGCCGGTGCTCTGCGCGGGCGTGACGGTCTATAAGGGC
CTCAAGGTCACGGATACGAAGCCCGGTGACTGGGTGGTCATTTCAGGCATAGGCGGGCTCGGCCACATGGCTGTGCAATA
TGCCAGGGCCATGGGGCTGAATGTTGCCGCCGTCGATATTGACGACCGCAAGCTCGATCTCGCCCGCAGACTTGGCGCAA
CCGTTACGGTCAACGCTAAGACGGTTGCCGACCCGGCAGCCTATATTCGCAAGGAAACCGATGGCGGTGCGCAAGGCGTG
CTGGTGACGGCGGTTTCGCCCAAGGCTTTTGAACAGGCGCTGGGCATGGTTGCGCGCGGCGGTACTGTTTCGCTGAATGG
CCTGCCGCCTGGCGATTTCCCGCTTTCCATCTTCAACATGGTGCTCAATGGCGTAACGGTGCGCGGCTCCATCGTGGGGA
CGCGGCTTGATTTGCAGGAATCGCTCGATTTTGCAGCCGACGGCAAGGTCAAGGCCACCATCCAAACCGGCAAGCTGGAA
GACATCAACGCCATCTTCGACGATATGCGGCAAGGCAATATCGAAGGCCGCATCGTGATGGACCTGACTCAATAG

Upstream 100 bases:

>100_bases
GCCGGTGTGGCAGCCAGCAGTTTCAAGCCCTGCGTCTCTCATGCTTGTTTCTTCGCATTCCCCTGGAACGATGCAAGTTC
GACAACGAAGGAGTAACTCT

Downstream 100 bases:

>100_bases
GCGGCTTGGGTTAATATGCGAATGGGCGGTGAATTGCCGCCCTTTCGCATCATGGAGGAGGATATGGTTGAGGAGGTTTC
CGGCGACGGCATGGGACAGG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 343

Protein sequence:

>344_residues
MAKTMKAAVVRAFGKPLTIDEVPIPQPGPGQIQVAIQASGVCHTDLHAAEGDWPVKPNPPFIPGHEGVGFVSAVGSGVKH
VKEGDRVGIPWLYTACGHCRHCLGGWETLCEEQLNTGYSVNGGFAEYVVADPNFVGHLPKNIDFNEIAPVLCAGVTVYKG
LKVTDTKPGDWVVISGIGGLGHMAVQYARAMGLNVAAVDIDDRKLDLARRLGATVTVNAKTVADPAAYIRKETDGGAQGV
LVTAVSPKAFEQALGMVARGGTVSLNGLPPGDFPLSIFNMVLNGVTVRGSIVGTRLDLQESLDFAADGKVKATIQTGKLE
DINAIFDDMRQGNIEGRIVMDLTQ

Sequences:

>Translated_344_residues
MAKTMKAAVVRAFGKPLTIDEVPIPQPGPGQIQVAIQASGVCHTDLHAAEGDWPVKPNPPFIPGHEGVGFVSAVGSGVKH
VKEGDRVGIPWLYTACGHCRHCLGGWETLCEEQLNTGYSVNGGFAEYVVADPNFVGHLPKNIDFNEIAPVLCAGVTVYKG
LKVTDTKPGDWVVISGIGGLGHMAVQYARAMGLNVAAVDIDDRKLDLARRLGATVTVNAKTVADPAAYIRKETDGGAQGV
LVTAVSPKAFEQALGMVARGGTVSLNGLPPGDFPLSIFNMVLNGVTVRGSIVGTRLDLQESLDFAADGKVKATIQTGKLE
DINAIFDDMRQGNIEGRIVMDLTQ
>Mature_343_residues
AKTMKAAVVRAFGKPLTIDEVPIPQPGPGQIQVAIQASGVCHTDLHAAEGDWPVKPNPPFIPGHEGVGFVSAVGSGVKHV
KEGDRVGIPWLYTACGHCRHCLGGWETLCEEQLNTGYSVNGGFAEYVVADPNFVGHLPKNIDFNEIAPVLCAGVTVYKGL
KVTDTKPGDWVVISGIGGLGHMAVQYARAMGLNVAAVDIDDRKLDLARRLGATVTVNAKTVADPAAYIRKETDGGAQGVL
VTAVSPKAFEQALGMVARGGTVSLNGLPPGDFPLSIFNMVLNGVTVRGSIVGTRLDLQESLDFAADGKVKATIQTGKLED
INAIFDDMRQGNIEGRIVMDLTQ

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=361, Percent_Identity=31.5789473684211, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI34577061, Length=360, Percent_Identity=30.2777777777778, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI4501929, Length=367, Percent_Identity=29.9727520435967, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI71565152, Length=365, Percent_Identity=27.3972602739726, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI71565154, Length=280, Percent_Identity=29.6428571428571, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI71743840, Length=315, Percent_Identity=27.3015873015873, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI262073058, Length=315, Percent_Identity=27.3015873015873, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4501939, Length=359, Percent_Identity=24.7910863509749, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI156523966, Length=359, Percent_Identity=24.7910863509749, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI156627571, Length=214, Percent_Identity=30.3738317757009, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI194239674, Length=270, Percent_Identity=25.5555555555556, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI13236495, Length=270, Percent_Identity=25.5555555555556, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI194239676, Length=244, Percent_Identity=27.4590163934426, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI87081918, Length=341, Percent_Identity=42.2287390029325, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1786518, Length=351, Percent_Identity=32.4786324786325, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1790045, Length=351, Percent_Identity=30.7692307692308, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI87082401, Length=338, Percent_Identity=30.7692307692308, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1788073, Length=271, Percent_Identity=33.9483394833948, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI87082125, Length=245, Percent_Identity=31.8367346938775, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1786552, Length=245, Percent_Identity=36.734693877551, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788407, Length=268, Percent_Identity=31.3432835820896, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788075, Length=319, Percent_Identity=28.5266457680251, Blast_Score=88, Evalue=6e-19,
Organism=Escherichia coli, GI1787863, Length=304, Percent_Identity=26.6447368421053, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI226510992, Length=304, Percent_Identity=28.2894736842105, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790485, Length=278, Percent_Identity=27.6978417266187, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1786825, Length=305, Percent_Identity=29.5081967213115, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790718, Length=320, Percent_Identity=25, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI48994910, Length=361, Percent_Identity=24.3767313019391, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17562584, Length=342, Percent_Identity=41.5204678362573, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI71988145, Length=343, Percent_Identity=38.4839650145773, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17562582, Length=345, Percent_Identity=37.3913043478261, Blast_Score=215, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17562876, Length=334, Percent_Identity=31.1377245508982, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17562878, Length=209, Percent_Identity=35.4066985645933, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25146526, Length=366, Percent_Identity=25.9562841530055, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=368, Percent_Identity=25.8152173913043, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17507255, Length=189, Percent_Identity=32.2751322751323, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=338, Percent_Identity=25.1479289940828, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323961, Length=344, Percent_Identity=40.6976744186046, Blast_Score=260, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6319621, Length=344, Percent_Identity=41.2790697674419, Blast_Score=259, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6323729, Length=344, Percent_Identity=40.1162790697674, Blast_Score=258, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6324486, Length=344, Percent_Identity=40.1162790697674, Blast_Score=257, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6319949, Length=332, Percent_Identity=30.421686746988, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323980, Length=319, Percent_Identity=27.8996865203762, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=372, Percent_Identity=29.8387096774194, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=238, Percent_Identity=30.672268907563, Blast_Score=83, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6319955, Length=238, Percent_Identity=30.672268907563, Blast_Score=82, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6319258, Length=323, Percent_Identity=25.3869969040248, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17737895, Length=266, Percent_Identity=31.5789473684211, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17137530, Length=250, Percent_Identity=30.4, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17737897, Length=211, Percent_Identity=29.3838862559242, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36247; Mature: 36116

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTMKAAVVRAFGKPLTIDEVPIPQPGPGQIQVAIQASGVCHTDLHAAEGDWPVKPNPP
CCCHHHHHHHHHCCCCCEECCCCCCCCCCCCEEEEEEECCCEECCCCCCCCCCCCCCCCC
FIPGHEGVGFVSAVGSGVKHVKEGDRVGIPWLYTACGHCRHCLGGWETLCEEQLNTGYSV
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
NGGFAEYVVADPNFVGHLPKNIDFNEIAPVLCAGVTVYKGLKVTDTKPGDWVVISGIGGL
CCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEECCCCH
GHMAVQYARAMGLNVAAVDIDDRKLDLARRLGATVTVNAKTVADPAAYIRKETDGGAQGV
HHHHHHHHHHHCCEEEEEECCCHHHHHHHHCCCEEEEECHHHCCHHHHHEECCCCCCCEE
LVTAVSPKAFEQALGMVARGGTVSLNGLPPGDFPLSIFNMVLNGVTVRGSIVGTRLDLQE
EEEEECHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHCCEEEEEEEEEEEECHHH
SLDFAADGKVKATIQTGKLEDINAIFDDMRQGNIEGRIVMDLTQ
HCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEECC
>Mature Secondary Structure 
AKTMKAAVVRAFGKPLTIDEVPIPQPGPGQIQVAIQASGVCHTDLHAAEGDWPVKPNPP
CCHHHHHHHHHCCCCCEECCCCCCCCCCCCEEEEEEECCCEECCCCCCCCCCCCCCCCC
FIPGHEGVGFVSAVGSGVKHVKEGDRVGIPWLYTACGHCRHCLGGWETLCEEQLNTGYSV
CCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
NGGFAEYVVADPNFVGHLPKNIDFNEIAPVLCAGVTVYKGLKVTDTKPGDWVVISGIGGL
CCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEECCCCH
GHMAVQYARAMGLNVAAVDIDDRKLDLARRLGATVTVNAKTVADPAAYIRKETDGGAQGV
HHHHHHHHHHHCCEEEEEECCCHHHHHHHHCCCEEEEECHHHCCHHHHHEECCCCCCCEE
LVTAVSPKAFEQALGMVARGGTVSLNGLPPGDFPLSIFNMVLNGVTVRGSIVGTRLDLQE
EEEEECHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHCCEEEEEEEEEEEECHHH
SLDFAADGKVKATIQTGKLEDINAIFDDMRQGNIEGRIVMDLTQ
HCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9659380; 11481432 [H]