| Definition | Brucella melitensis ATCC 23457 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_012441 |
| Length | 2,125,701 |
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The map label for this gene is metH [H]
Identifier: 225851720
GI number: 225851720
Start: 197103
End: 200888
Strand: Direct
Name: metH [H]
Synonym: BMEA_A0196
Alternate gene names: 225851720
Gene position: 197103-200888 (Clockwise)
Preceding gene: 225851718
Following gene: 225851721
Centisome position: 9.27
GC content: 59.19
Gene sequence:
>3786_bases ATGGCGTCTTCCCTTGACGATCTTTTTGGTGCAACGGCGGCAAAGCCGGACGGTTCGGAAGTGCTGGCGGCACTGACCCA GGCGGCGCGCGAGCGCATCCTGATCCTCGACGGCGCCATGGGTACGCAGATTCAGGGCCTGGGTTTCCATGAAGAGCATT TTCGCGGCGATCGTTTCGCCACCTGTGACTGCCAGCTTCAGGGCAATAACGATCTTCTGACCTTGACCCAGCCGAAAGCC ATTGAGGAAATCCACTATGCCTATGCCATGGCGGGCGCGGATATTCTCGAAACCAATACTTTCTCCTCCACTTCCATCGC GCAGGCCGATTATGGCATGGAGGCGATGGTCTATGATCTCAATCGCGATGGCGCACGCCTTGCCCGCCGCGCAGCCTTGC GCGCCGAGCAGAAGGACGGCCGCCGCCGCTTTGTCGCGGGCGCACTGGGGCCGACGAACCGCACCGCCTCGCTGTCCCCG GATGTGAACAATCCGGGCTTTCGCGCCGTCACTTTCGATGATCTGCGCATTGCCTATTCCGAACAGATTCGCGGCCTGAT CGATGGCGGTTCCGACATCATCCTGATCGAAACCATTTTCGATACGCTGAACGCCAAGGCGGCTGTGTTCGCGACCGAGG AAGTCTTTGCCGAAAAGGGTGTTCGCCTTCCGGTCATGATCTCCGGTACGATCACCGATCTTTCCGGGCGCACGCTTTCC GGCCAGACGCCGACGGCCTTCTGGTATTCACTGCGCCATGCAAGACCGTTCACCATCGGACTGAATTGCGCCCTCGGCGC CAATGCCATGCGTGCGCATCTGGATGAATTGTCGGGCATTGCCGACACCTTTATCTGCGCCTATCCCAATGCCGGCCTTC CGAACGAATTCGGCCAGTATGATGAAACGCCGGAAGCCATGGCCGCGCAGATCGAGGGCTTTGCTCGCGACGGGCTGGTC AATGTTGTTGGCGGCTGCTGCGGCTCCACGCCTGACCATATTCGCGCCATCGCGCAAGCCGTCGCGAAATATGAGCCACG CAAGCCCGCAAAAGTGCCGCCGCTGATGCGCCTTTCCGGCCTTGAGCCCTTTACGCTCACCAAGGATATTCCTTTCGTCA ATATCGGCGAGCGCACCAATGTCACCGGCTCGGCCCGCTTCCGCAAGCTCGTCAAGGCCGGCGATTTCGCGGCTGCGCTC GATGTTGCGCGCGATCAGGTGGCCAACGGCGCCCAGATCATCGATATCAACATGGATGAAGGCCTGATCGATTCCGAAAA GGCCATGGTCGAGTTTTTGAACCTTATTGCCGCCGAGCCGGATATCGCCCGCGTGCCGATCATGCTCGACAGCTCCAAAT GGGAAGTGATCGAGGCTGGCCTGAAATGCGTTCAGGGCAAGGCAGTCGTCAATTCCATCTCGCTGAAAGAGGGTGAGGAA GCCTTTCTTCACCATGCGCGGCTGGTGCGTGCCTATGGTGCCGCTGTGGTCATCATGGCGTTCGATGAAACCGGACAGGC GGATACGCAGGCCCGCAAGATCGAAATCTGCACCCGCGCCTATAAAATCCTGACCGAACAGGTGGGTTTCCCGCCGGAAG ACATCATTTTCGATCCGAATATTTTTGCGGTCGCGACCGGCATCGAGGAACACAATAATTACGGCGTCGATTTCATCGAG GCCACGCGTGAAATCGTCCGCACACTGCCGCATGTCCATATTTCCGGCGGCGTTTCCAACCTCTCGTTCTCCTTCCGCGG CAATGAGCCGGTGCGTGAGGCGATGCATGCCGTTTTCCTCTACCACGCCATTCAGGCGGGCATGGATATGGGCATCGTCA ATGCGGGCCAGCTTGCGGTCTATGACACGATCGACGCTGAACTGCGTGAGGCTTGCGAGGATGTGGTGCTGAACCGCCCC ACAAAAACGGGCGAAAGCGCAACCGAACGGCTTCTGGAAATTGCCGAACGGTTCCGTGATTCCAGCTCCAGGGAAGCGCG GACGCAGGATTTGAGCTGGCGCGAATGGCCGGTCGAAAAGCGGCTTGAACATGCGCTGGTCAACGGCATCACCGAATATA TCGAGGCCGATACGGAAGAGGCGCGCCTTGCTGCCGAGCGCCCGTTGCATGTGATCGAAGGGCCGCTGATGGCAGGCATG AATGTGGTCGGCGACCTGTTCGGTTCCGGCAAGATGTTTCTGCCGCAGGTGGTGAAATCTGCCCGCGTGATGAAGCAGGC CGTGGCCGTGCTGCTGCCCTTCATGGAAGAGGAAAAGCGCCTCAATGGCGGCGAGGGCCGCCAGAGTGCGGGCAAGGTGC TGATGGCGACCGTCAAGGGCGATGTGCACGATATCGGCAAGAATATCGTGGGCGTGGTTCTGGCCTGCAATAATTATGAA ATCATCGATCTTGGCGTCATGGTGCCCTCGCAGAAAATCCTGCAGGTGGCGCGCGATGAAAAGGTGGATATCATCGGCCT TTCCGGCCTCATCACGCCTTCGCTTGATGAGATGGCGCATGTCGCCGCCGAAATGGAGCGCGAGGGCTTCGATATTCCGC TTTTGATTGGCGGTGCGACGACGAGCCGTGTTCATACGGCGGTGAAAATCCATTCGCGTTACGAGCGCGGGCAGGCTGTC TATGTCGTGGATGCAAGTCGTGCGGTGGGGGTCGTGTCAAACCTCCTGTCGCCGGAGGGCAAGCAGGCCTATATCGACGG TTTACGCAACGAATATGCCAAGGTGGCTGCTGCCCATGCCCGCAACGAGGCTGAAAAACAGCGCCTGCCAATTGCCCGCG CGCGCGCCAATCCGCATCAGCTCGACTGGGAAAACTACGAGCCGGTGAAGCCGACCTTCACCGGAACGAAGGTTTTTGAA ACCTATGATCTGGCGGAAATCGCGCGCTATATCGACTGGACCCTGTTCTTCCAGACCTGGGAACTGAGGGGCCGCTATCC GGCTATTCTCGAAGATGAAAAGCAGGGTGAGGCGGCGCGCCAGCTCTGGGCGGATGCGCAAGCGATGCTCCGGAAGATCA TCGATGAGAAATGGTTCACCCCGCGGGCGGTGGTCGGCTTCTGGCCTGCCAATGCGGTGGGCGATGATATCCGCCTCTTT ACGGATGAAAGCCGCAAGGAGGAGCTTGCCACCCTGTTCACGCTTCGCCAGCAGCTTACCAAGCGCGATGGCCGCCCGAA TGTCGCCATGGCGGATTTTGTGGCGCCTGTCGAAAGCGGCAAACAGGATTATGTTGGCGGTTTTGTCGTGACGGCGGGCA TTGGCGAGATTGCTATCGCAGAGCGTTTTGAACGCGCCAATGATGATTATTCCGCCATTCTTGTGAAGGCGCTTGCCGAT CGTTTCGCGGAAGCTTTCGCGGAACTGATGCATGAGCGTGTGCGCAAGGAATTCTGGGCCTATGCGCCGGATGAAGCCTT TACGCCGGAAGAACTGATCAGCGAGCCATATAAGGGCATCCGCCCGGCGCCGGGCTATCCGGCCCAGCCCGATCATACGG AAAAGACCACCTTGTTCCGCCTGCTCGATGCCACCGCCAATACCGGCGTGGAGCTTACCGAAAGCTACGCCATGTGGCCC GGCTCCTCGGTGTCGGGTCTCTATATCGGTCACCCTGAAAGCTATTATTTCGGTGTGGCAAAGGTGGAGCGCGATCAGGT CGAGGATTATGCCCGGCGCAAGGACATGGATGTGGAGGCTGTGGAGCGCTGGCTCACCCCGATCCTCAATTATGTCCCTG GGGCATCGAAAGACGAAGCGGCCTGA
Upstream 100 bases:
>100_bases ATCATGCGCGCCCATGCAATTCAGGGAAGAGGCTGGCGAACAGAGTTCGGCCCCTTTCCGGCATTACAACCAGACAATGT GAATACAGGCGGTATCCCTT
Downstream 100 bases:
>100_bases CAGCCGATCGTTCGAGAGGAAACGGCAAAACAGCCCTCATGGAGCAAACCTCCACGAGGGCTGTTTGCTTCAAGCTTTGC GGTGGAGTCTTCCGGTTTTA
Product: B12-dependent methionine synthase
Products: NA
Alternate protein names: 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12 dependent; MS [H]
Number of amino acids: Translated: 1261; Mature: 1260
Protein sequence:
>1261_residues MASSLDDLFGATAAKPDGSEVLAALTQAARERILILDGAMGTQIQGLGFHEEHFRGDRFATCDCQLQGNNDLLTLTQPKA IEEIHYAYAMAGADILETNTFSSTSIAQADYGMEAMVYDLNRDGARLARRAALRAEQKDGRRRFVAGALGPTNRTASLSP DVNNPGFRAVTFDDLRIAYSEQIRGLIDGGSDIILIETIFDTLNAKAAVFATEEVFAEKGVRLPVMISGTITDLSGRTLS GQTPTAFWYSLRHARPFTIGLNCALGANAMRAHLDELSGIADTFICAYPNAGLPNEFGQYDETPEAMAAQIEGFARDGLV NVVGGCCGSTPDHIRAIAQAVAKYEPRKPAKVPPLMRLSGLEPFTLTKDIPFVNIGERTNVTGSARFRKLVKAGDFAAAL DVARDQVANGAQIIDINMDEGLIDSEKAMVEFLNLIAAEPDIARVPIMLDSSKWEVIEAGLKCVQGKAVVNSISLKEGEE AFLHHARLVRAYGAAVVIMAFDETGQADTQARKIEICTRAYKILTEQVGFPPEDIIFDPNIFAVATGIEEHNNYGVDFIE ATREIVRTLPHVHISGGVSNLSFSFRGNEPVREAMHAVFLYHAIQAGMDMGIVNAGQLAVYDTIDAELREACEDVVLNRP TKTGESATERLLEIAERFRDSSSREARTQDLSWREWPVEKRLEHALVNGITEYIEADTEEARLAAERPLHVIEGPLMAGM NVVGDLFGSGKMFLPQVVKSARVMKQAVAVLLPFMEEEKRLNGGEGRQSAGKVLMATVKGDVHDIGKNIVGVVLACNNYE IIDLGVMVPSQKILQVARDEKVDIIGLSGLITPSLDEMAHVAAEMEREGFDIPLLIGGATTSRVHTAVKIHSRYERGQAV YVVDASRAVGVVSNLLSPEGKQAYIDGLRNEYAKVAAAHARNEAEKQRLPIARARANPHQLDWENYEPVKPTFTGTKVFE TYDLAEIARYIDWTLFFQTWELRGRYPAILEDEKQGEAARQLWADAQAMLRKIIDEKWFTPRAVVGFWPANAVGDDIRLF TDESRKEELATLFTLRQQLTKRDGRPNVAMADFVAPVESGKQDYVGGFVVTAGIGEIAIAERFERANDDYSAILVKALAD RFAEAFAELMHERVRKEFWAYAPDEAFTPEELISEPYKGIRPAPGYPAQPDHTEKTTLFRLLDATANTGVELTESYAMWP GSSVSGLYIGHPESYYFGVAKVERDQVEDYARRKDMDVEAVERWLTPILNYVPGASKDEAA
Sequences:
>Translated_1261_residues MASSLDDLFGATAAKPDGSEVLAALTQAARERILILDGAMGTQIQGLGFHEEHFRGDRFATCDCQLQGNNDLLTLTQPKA IEEIHYAYAMAGADILETNTFSSTSIAQADYGMEAMVYDLNRDGARLARRAALRAEQKDGRRRFVAGALGPTNRTASLSP DVNNPGFRAVTFDDLRIAYSEQIRGLIDGGSDIILIETIFDTLNAKAAVFATEEVFAEKGVRLPVMISGTITDLSGRTLS GQTPTAFWYSLRHARPFTIGLNCALGANAMRAHLDELSGIADTFICAYPNAGLPNEFGQYDETPEAMAAQIEGFARDGLV NVVGGCCGSTPDHIRAIAQAVAKYEPRKPAKVPPLMRLSGLEPFTLTKDIPFVNIGERTNVTGSARFRKLVKAGDFAAAL DVARDQVANGAQIIDINMDEGLIDSEKAMVEFLNLIAAEPDIARVPIMLDSSKWEVIEAGLKCVQGKAVVNSISLKEGEE AFLHHARLVRAYGAAVVIMAFDETGQADTQARKIEICTRAYKILTEQVGFPPEDIIFDPNIFAVATGIEEHNNYGVDFIE ATREIVRTLPHVHISGGVSNLSFSFRGNEPVREAMHAVFLYHAIQAGMDMGIVNAGQLAVYDTIDAELREACEDVVLNRP TKTGESATERLLEIAERFRDSSSREARTQDLSWREWPVEKRLEHALVNGITEYIEADTEEARLAAERPLHVIEGPLMAGM NVVGDLFGSGKMFLPQVVKSARVMKQAVAVLLPFMEEEKRLNGGEGRQSAGKVLMATVKGDVHDIGKNIVGVVLACNNYE IIDLGVMVPSQKILQVARDEKVDIIGLSGLITPSLDEMAHVAAEMEREGFDIPLLIGGATTSRVHTAVKIHSRYERGQAV YVVDASRAVGVVSNLLSPEGKQAYIDGLRNEYAKVAAAHARNEAEKQRLPIARARANPHQLDWENYEPVKPTFTGTKVFE TYDLAEIARYIDWTLFFQTWELRGRYPAILEDEKQGEAARQLWADAQAMLRKIIDEKWFTPRAVVGFWPANAVGDDIRLF TDESRKEELATLFTLRQQLTKRDGRPNVAMADFVAPVESGKQDYVGGFVVTAGIGEIAIAERFERANDDYSAILVKALAD RFAEAFAELMHERVRKEFWAYAPDEAFTPEELISEPYKGIRPAPGYPAQPDHTEKTTLFRLLDATANTGVELTESYAMWP GSSVSGLYIGHPESYYFGVAKVERDQVEDYARRKDMDVEAVERWLTPILNYVPGASKDEAA >Mature_1260_residues ASSLDDLFGATAAKPDGSEVLAALTQAARERILILDGAMGTQIQGLGFHEEHFRGDRFATCDCQLQGNNDLLTLTQPKAI EEIHYAYAMAGADILETNTFSSTSIAQADYGMEAMVYDLNRDGARLARRAALRAEQKDGRRRFVAGALGPTNRTASLSPD VNNPGFRAVTFDDLRIAYSEQIRGLIDGGSDIILIETIFDTLNAKAAVFATEEVFAEKGVRLPVMISGTITDLSGRTLSG QTPTAFWYSLRHARPFTIGLNCALGANAMRAHLDELSGIADTFICAYPNAGLPNEFGQYDETPEAMAAQIEGFARDGLVN VVGGCCGSTPDHIRAIAQAVAKYEPRKPAKVPPLMRLSGLEPFTLTKDIPFVNIGERTNVTGSARFRKLVKAGDFAAALD VARDQVANGAQIIDINMDEGLIDSEKAMVEFLNLIAAEPDIARVPIMLDSSKWEVIEAGLKCVQGKAVVNSISLKEGEEA FLHHARLVRAYGAAVVIMAFDETGQADTQARKIEICTRAYKILTEQVGFPPEDIIFDPNIFAVATGIEEHNNYGVDFIEA TREIVRTLPHVHISGGVSNLSFSFRGNEPVREAMHAVFLYHAIQAGMDMGIVNAGQLAVYDTIDAELREACEDVVLNRPT KTGESATERLLEIAERFRDSSSREARTQDLSWREWPVEKRLEHALVNGITEYIEADTEEARLAAERPLHVIEGPLMAGMN VVGDLFGSGKMFLPQVVKSARVMKQAVAVLLPFMEEEKRLNGGEGRQSAGKVLMATVKGDVHDIGKNIVGVVLACNNYEI IDLGVMVPSQKILQVARDEKVDIIGLSGLITPSLDEMAHVAAEMEREGFDIPLLIGGATTSRVHTAVKIHSRYERGQAVY VVDASRAVGVVSNLLSPEGKQAYIDGLRNEYAKVAAAHARNEAEKQRLPIARARANPHQLDWENYEPVKPTFTGTKVFET YDLAEIARYIDWTLFFQTWELRGRYPAILEDEKQGEAARQLWADAQAMLRKIIDEKWFTPRAVVGFWPANAVGDDIRLFT DESRKEELATLFTLRQQLTKRDGRPNVAMADFVAPVESGKQDYVGGFVVTAGIGEIAIAERFERANDDYSAILVKALADR FAEAFAELMHERVRKEFWAYAPDEAFTPEELISEPYKGIRPAPGYPAQPDHTEKTTLFRLLDATANTGVELTESYAMWPG SSVSGLYIGHPESYYFGVAKVERDQVEDYARRKDMDVEAVERWLTPILNYVPGASKDEAA
Specific function: Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate [H]
COG id: COG1410
COG function: function code E; Methionine synthase I, cobalamin-binding domain
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 pterin-binding domain [H]
Homologues:
Organism=Homo sapiens, GI169790923, Length=1277, Percent_Identity=54.894283476899, Blast_Score=1369, Evalue=0.0, Organism=Escherichia coli, GI1790450, Length=1223, Percent_Identity=61.9787408013083, Blast_Score=1515, Evalue=0.0, Organism=Escherichia coli, GI1786456, Length=323, Percent_Identity=26.0061919504644, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17535405, Length=1251, Percent_Identity=52.9176658673062, Blast_Score=1300, Evalue=0.0,
Paralogues:
None
Copy number: 513 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 1320 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR006158 - InterPro: IPR011005 - InterPro: IPR003759 - InterPro: IPR011822 - InterPro: IPR000489 - InterPro: IPR003726 - InterPro: IPR004223 [H]
Pfam domain/function: PF02310 B12-binding; PF02607 B12-binding_2; PF02965 Met_synt_B12; PF00809 Pterin_bind; PF02574 S-methyl_trans [H]
EC number: =2.1.1.13 [H]
Molecular weight: Translated: 138730; Mature: 138599
Theoretical pI: Translated: 4.78; Mature: 4.78
Prosite motif: PS50974 ADOMET_ACTIVATION ; PS50970 HCY ; PS50972 PTERIN_BINDING
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MASSLDDLFGATAAKPDGSEVLAALTQAARERILILDGAMGTQIQGLGFHEEHFRGDRFA CCCCHHHHHCCCCCCCCHHHHHHHHHHHHHCEEEEEECCCCCEEECCCCCHHHHCCCCEE TCDCQLQGNNDLLTLTQPKAIEEIHYAYAMAGADILETNTFSSTSIAQADYGMEAMVYDL EEEEEEECCCCEEEECCCHHHHHHHHHHHHHCCHHEECCCCCCCCHHHHCCCCEEEEEEC NRDGARLARRAALRAEQKDGRRRFVAGALGPTNRTASLSPDVNNPGFRAVTFDDLRIAYS CCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHH EQIRGLIDGGSDIILIETIFDTLNAKAAVFATEEVFAEKGVRLPVMISGTITDLSGRTLS HHHHHHHCCCCCEEEHHHHHHHHCCCEEEEEHHHHHHHCCCEEEEEEECEEECCCCCEEC GQTPTAFWYSLRHARPFTIGLNCALGANAMRAHLDELSGIADTFICAYPNAGLPNEFGQY CCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCHHHCCC DETPEAMAAQIEGFARDGLVNVVGGCCGSTPDHIRAIAQAVAKYEPRKPAKVPPLMRLSG CCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHCC LEPFTLTKDIPFVNIGERTNVTGSARFRKLVKAGDFAAALDVARDQVANGAQIIDINMDE CCCEEEECCCCEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCC GLIDSEKAMVEFLNLIAAEPDIARVPIMLDSSKWEVIEAGLKCVQGKAVVNSISLKEGEE CCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHCCCCCCHH AFLHHARLVRAYGAAVVIMAFDETGQADTQARKIEICTRAYKILTEQVGFPPEDIIFDPN HHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCC IFAVATGIEEHNNYGVDFIEATREIVRTLPHVHISGGVSNLSFSFRGNEPVREAMHAVFL EEEEEECCHHCCCCCCHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCHHHHHHHHHHH YHAIQAGMDMGIVNAGQLAVYDTIDAELREACEDVVLNRPTKTGESATERLLEIAERFRD HHHHHHCCCCCEECCCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC SSSREARTQDLSWREWPVEKRLEHALVNGITEYIEADTEEARLAAERPLHVIEGPLMAGM CCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHCCHHHHHH NVVGDLFGSGKMFLPQVVKSARVMKQAVAVLLPFMEEEKRLNGGEGRQSAGKVLMATVKG HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECC DVHDIGKNIVGVVLACNNYEIIDLGVMVPSQKILQVARDEKVDIIGLSGLITPSLDEMAH CHHHHHHHHEEEEEEECCEEEEEEEEECCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHH VAAEMEREGFDIPLLIGGATTSRVHTAVKIHSRYERGQAVYVVDASRAVGVVSNLLSPEG HHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCC KQAYIDGLRNEYAKVAAAHARNEAEKQRLPIARARANPHQLDWENYEPVKPTFTGTKVFE CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHH TYDLAEIARYIDWTLFFQTWELRGRYPAILEDEKQGEAARQLWADAQAMLRKIIDEKWFT HHCHHHHHHHHHHHHEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC PRAVVGFWPANAVGDDIRLFTDESRKEELATLFTLRQQLTKRDGRPNVAMADFVAPVESG CCEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC KQDYVGGFVVTAGIGEIAIAERFERANDDYSAILVKALADRFAEAFAELMHERVRKEFWA CCCCCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC YAPDEAFTPEELISEPYKGIRPAPGYPAQPDHTEKTTLFRLLDATANTGVELTESYAMWP CCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCEEECC GSSVSGLYIGHPESYYFGVAKVERDQVEDYARRKDMDVEAVERWLTPILNYVPGASKDEA CCCCCEEEECCCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCC A C >Mature Secondary Structure ASSLDDLFGATAAKPDGSEVLAALTQAARERILILDGAMGTQIQGLGFHEEHFRGDRFA CCCHHHHHCCCCCCCCHHHHHHHHHHHHHCEEEEEECCCCCEEECCCCCHHHHCCCCEE TCDCQLQGNNDLLTLTQPKAIEEIHYAYAMAGADILETNTFSSTSIAQADYGMEAMVYDL EEEEEEECCCCEEEECCCHHHHHHHHHHHHHCCHHEECCCCCCCCHHHHCCCCEEEEEEC NRDGARLARRAALRAEQKDGRRRFVAGALGPTNRTASLSPDVNNPGFRAVTFDDLRIAYS CCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHH EQIRGLIDGGSDIILIETIFDTLNAKAAVFATEEVFAEKGVRLPVMISGTITDLSGRTLS HHHHHHHCCCCCEEEHHHHHHHHCCCEEEEEHHHHHHHCCCEEEEEEECEEECCCCCEEC GQTPTAFWYSLRHARPFTIGLNCALGANAMRAHLDELSGIADTFICAYPNAGLPNEFGQY CCCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCHHHCCC DETPEAMAAQIEGFARDGLVNVVGGCCGSTPDHIRAIAQAVAKYEPRKPAKVPPLMRLSG CCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHCC LEPFTLTKDIPFVNIGERTNVTGSARFRKLVKAGDFAAALDVARDQVANGAQIIDINMDE CCCEEEECCCCEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEEEECCC GLIDSEKAMVEFLNLIAAEPDIARVPIMLDSSKWEVIEAGLKCVQGKAVVNSISLKEGEE CCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCHHHHHHCCCCCCHH AFLHHARLVRAYGAAVVIMAFDETGQADTQARKIEICTRAYKILTEQVGFPPEDIIFDPN HHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCC IFAVATGIEEHNNYGVDFIEATREIVRTLPHVHISGGVSNLSFSFRGNEPVREAMHAVFL EEEEEECCHHCCCCCCHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCCHHHHHHHHHHH YHAIQAGMDMGIVNAGQLAVYDTIDAELREACEDVVLNRPTKTGESATERLLEIAERFRD HHHHHHCCCCCEECCCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC SSSREARTQDLSWREWPVEKRLEHALVNGITEYIEADTEEARLAAERPLHVIEGPLMAGM CCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHCCHHHHHH NVVGDLFGSGKMFLPQVVKSARVMKQAVAVLLPFMEEEKRLNGGEGRQSAGKVLMATVKG HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECC DVHDIGKNIVGVVLACNNYEIIDLGVMVPSQKILQVARDEKVDIIGLSGLITPSLDEMAH CHHHHHHHHEEEEEEECCEEEEEEEEECCCHHHHHHHCCCCEEEEEECCCCCCCHHHHHH VAAEMEREGFDIPLLIGGATTSRVHTAVKIHSRYERGQAVYVVDASRAVGVVSNLLSPEG HHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHCCCC KQAYIDGLRNEYAKVAAAHARNEAEKQRLPIARARANPHQLDWENYEPVKPTFTGTKVFE CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCCCCCCCHHHH TYDLAEIARYIDWTLFFQTWELRGRYPAILEDEKQGEAARQLWADAQAMLRKIIDEKWFT HHCHHHHHHHHHHHHEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC PRAVVGFWPANAVGDDIRLFTDESRKEELATLFTLRQQLTKRDGRPNVAMADFVAPVESG CCEEEEECCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC KQDYVGGFVVTAGIGEIAIAERFERANDDYSAILVKALADRFAEAFAELMHERVRKEFWA CCCCCCCEEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC YAPDEAFTPEELISEPYKGIRPAPGYPAQPDHTEKTTLFRLLDATANTGVELTESYAMWP CCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEECCCEEECC GSSVSGLYIGHPESYYFGVAKVERDQVEDYARRKDMDVEAVERWLTPILNYVPGASKDEA CCCCCEEEECCCCCCEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCC A C
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 10984043 [H]