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The map label for this gene is pncB

Identifier: 225851652

GI number: 225851652

Start: 122866

End: 124170

Strand: Direct

Name: pncB

Synonym: BMEA_A0119

Alternate gene names: 225851652

Gene position: 122866-124170 (Clockwise)

Preceding gene: 225851651

Following gene: 225851662

Centisome position: 5.78

GC content: 58.31

Gene sequence:

>1305_bases
ATGGCCAAAACCGATCTTGCGCGGCGCGTCTATAACCATACCTGGAAGCTGGATCCGATCATCCGCAGCCTGCTGGATAC
GGATTTTTACAAGCTCCTGATGCTCCAGATGATCTGGGGGCTTTATCCCAGGGTGGATGCCACCTTCTCGCTCATCAACC
GCACGAGTTCCGTGCGCCTTGCCGACGAGATTGATGAAGGTGAACTGCGCGCGCAGCTTGACCATGCGCGCACATTGCGT
TTTTCCAAGAAGGAAATGATCTGGCTTGCCGGTAACACGTTTTATGGCCGCAAGCAGATTTTTCAGCCGGAATTTCTGGC
ATGGCTGCATGATTTCCAACTGCCGGAATATGAACTGCGCCGCAAGGACGGCCAGTATGAACTGCATTTCCACGGGCCAT
GGACCCACACGACCATGTGGGAAATTCCGGCGCTGGCCATCATCAACGAGCTTCGCTCGCGCGCGGCAATGAAAAATCTG
GGGCCGTTCTCGCTCGATGTGCTCTATGCCCGGGCCAAGGCGAAGATGTGGAGCAAGGTGGAGCGGCTGCGCCAACTGCC
TGATTTGAAGATTTCTGACTTCGGCACCCGCCGCCGCCATTCCTTCCTGTGGCAACGCTGGTGCGTGGAAGCCTTGAAGG
AGGGGATCGGCAGCGCCTTTACCGGCACGTCAAACGTGCTGCTTGCCATGGATACGGATCTCGAAGCTCTCGGCACCAAT
GCACACGAATTGCCGATGGTGCTGGCCGCACTTGCAAAAACGGACGACGAATTGCGCAGCGCCCCCTATCGTGTGTTGCA
GGACTGGAACCGTTATTATGGCGGCAATCTTCTGATCGTGCTGCCCGACGCCTTCGGCACGGCGGCGTTTCTGCGCAATG
CGCCGGACTGGGTGGCTGACTGGACGGGCTTCCGCCCGGACAGCGCCCCGCCGATTGAGGGCGGCGAGCGCATTATCGAA
TGGTGGAAATCGAAGGGCAAGGACCCGCGCGAAAAGCTTTTGATCTTTTCCGATGCGCTCGATGTGGACACCATCGAGGA
GACCTATCGCCATTTCGAGGGCCGTGTGCGCATGGGCTTCGGCTGGGGCACCAACCTCACCAATGATTTTGCGGGCTGTG
CGCCGCAGAGCATTGATGGCCTCAAGGCCATTTCTTTGGTCTGCAAGGTAACGGACGCCAATGGCCATCCGGCGGTCAAG
CTTTCCGACAATCCGCAAAAAGCGACAGGCGATCCGAAGGAAGTGGCGCGCTATCTCAGGTTCTTCGGCAATGAGGAACG
CGTGGAGCAGCTCGTCCGCGTCTGA

Upstream 100 bases:

>100_bases
CCAAACAGTAGCGAACCGATTAGAAAGGCGGGTAAACCCCGCCTTTCTTTTGCCGTGGAATATGTGCCGCGGCCTGTCTG
TTTATGGAATGGATGCCTTC

Downstream 100 bases:

>100_bases
ATATCAGCGGATATTCGGCGTTATGAGCTGCATCGCAGGCTTTATTCCATCAGCCGGGCAGTGCCGGAAACACGGATGGA
ACCACCGCGTTCCGTGCCGA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MAKTDLARRVYNHTWKLDPIIRSLLDTDFYKLLMLQMIWGLYPRVDATFSLINRTSSVRLADEIDEGELRAQLDHARTLR
FSKKEMIWLAGNTFYGRKQIFQPEFLAWLHDFQLPEYELRRKDGQYELHFHGPWTHTTMWEIPALAIINELRSRAAMKNL
GPFSLDVLYARAKAKMWSKVERLRQLPDLKISDFGTRRRHSFLWQRWCVEALKEGIGSAFTGTSNVLLAMDTDLEALGTN
AHELPMVLAALAKTDDELRSAPYRVLQDWNRYYGGNLLIVLPDAFGTAAFLRNAPDWVADWTGFRPDSAPPIEGGERIIE
WWKSKGKDPREKLLIFSDALDVDTIEETYRHFEGRVRMGFGWGTNLTNDFAGCAPQSIDGLKAISLVCKVTDANGHPAVK
LSDNPQKATGDPKEVARYLRFFGNEERVEQLVRV

Sequences:

>Translated_434_residues
MAKTDLARRVYNHTWKLDPIIRSLLDTDFYKLLMLQMIWGLYPRVDATFSLINRTSSVRLADEIDEGELRAQLDHARTLR
FSKKEMIWLAGNTFYGRKQIFQPEFLAWLHDFQLPEYELRRKDGQYELHFHGPWTHTTMWEIPALAIINELRSRAAMKNL
GPFSLDVLYARAKAKMWSKVERLRQLPDLKISDFGTRRRHSFLWQRWCVEALKEGIGSAFTGTSNVLLAMDTDLEALGTN
AHELPMVLAALAKTDDELRSAPYRVLQDWNRYYGGNLLIVLPDAFGTAAFLRNAPDWVADWTGFRPDSAPPIEGGERIIE
WWKSKGKDPREKLLIFSDALDVDTIEETYRHFEGRVRMGFGWGTNLTNDFAGCAPQSIDGLKAISLVCKVTDANGHPAVK
LSDNPQKATGDPKEVARYLRFFGNEERVEQLVRV
>Mature_433_residues
AKTDLARRVYNHTWKLDPIIRSLLDTDFYKLLMLQMIWGLYPRVDATFSLINRTSSVRLADEIDEGELRAQLDHARTLRF
SKKEMIWLAGNTFYGRKQIFQPEFLAWLHDFQLPEYELRRKDGQYELHFHGPWTHTTMWEIPALAIINELRSRAAMKNLG
PFSLDVLYARAKAKMWSKVERLRQLPDLKISDFGTRRRHSFLWQRWCVEALKEGIGSAFTGTSNVLLAMDTDLEALGTNA
HELPMVLAALAKTDDELRSAPYRVLQDWNRYYGGNLLIVLPDAFGTAAFLRNAPDWVADWTGFRPDSAPPIEGGERIIEW
WKSKGKDPREKLLIFSDALDVDTIEETYRHFEGRVRMGFGWGTNLTNDFAGCAPQSIDGLKAISLVCKVTDANGHPAVKL
SDNPQKATGDPKEVARYLRFFGNEERVEQLVRV

Specific function: NAD biosynthesis; nicotinamide to NaMN; second step. [C]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family

Homologues:

Organism=Escherichia coli, GI1787162, Length=407, Percent_Identity=33.9066339066339, Blast_Score=189, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6324783, Length=434, Percent_Identity=29.0322580645161, Blast_Score=157, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PNCB_BRUA1 (B2S8A9)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001934136.1
- ProteinModelPortal:   B2S8A9
- SMR:   B2S8A9
- GeneID:   6328051
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I01040
- HOGENOM:   HBG325503
- OMA:   GNTFYGK
- ProtClustDB:   PRK05321
- GO:   GO:0005737
- HAMAP:   MF_00570
- InterPro:   IPR006406
- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR002638
- PANTHER:   PTHR11098:SF1
- PIRSF:   PIRSF000484
- TIGRFAMs:   TIGR01514

Pfam domain/function: PF04095 NAPRTase; SSF51690 Q_phspho_trans

EC number: =2.4.2.11

Molecular weight: Translated: 49910; Mature: 49778

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKTDLARRVYNHTWKLDPIIRSLLDTDFYKLLMLQMIWGLYPRVDATFSLINRTSSVRL
CCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEE
ADEIDEGELRAQLDHARTLRFSKKEMIWLAGNTFYGRKQIFQPEFLAWLHDFQLPEYELR
HHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHCCCHHHHHHHHHCCCCHHHHH
RKDGQYELHFHGPWTHTTMWEIPALAIINELRSRAAMKNLGPFSLDVLYARAKAKMWSKV
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
ERLRQLPDLKISDFGTRRRHSFLWQRWCVEALKEGIGSAFTGTSNVLLAMDTDLEALGTN
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHCCC
AHELPMVLAALAKTDDELRSAPYRVLQDWNRYYGGNLLIVLPDAFGTAAFLRNAPDWVAD
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHCCCHHHHH
WTGFRPDSAPPIEGGERIIEWWKSKGKDPREKLLIFSDALDVDTIEETYRHFEGRVRMGF
CCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHEEEEECCCCHHHHHHHHHHHCCCEEEEE
GWGTNLTNDFAGCAPQSIDGLKAISLVCKVTDANGHPAVKLSDNPQKATGDPKEVARYLR
CCCCCCCCCCCCCCCCCCHHHHHHHHHEEEECCCCCCEEEECCCCCCCCCCHHHHHHHHH
FFGNEERVEQLVRV
HCCCHHHHHHHHCC
>Mature Secondary Structure 
AKTDLARRVYNHTWKLDPIIRSLLDTDFYKLLMLQMIWGLYPRVDATFSLINRTSSVRL
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEE
ADEIDEGELRAQLDHARTLRFSKKEMIWLAGNTFYGRKQIFQPEFLAWLHDFQLPEYELR
HHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHCCCHHHHHHHHHCCCCHHHHH
RKDGQYELHFHGPWTHTTMWEIPALAIINELRSRAAMKNLGPFSLDVLYARAKAKMWSKV
CCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
ERLRQLPDLKISDFGTRRRHSFLWQRWCVEALKEGIGSAFTGTSNVLLAMDTDLEALGTN
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHHCCC
AHELPMVLAALAKTDDELRSAPYRVLQDWNRYYGGNLLIVLPDAFGTAAFLRNAPDWVAD
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHCCCHHHHH
WTGFRPDSAPPIEGGERIIEWWKSKGKDPREKLLIFSDALDVDTIEETYRHFEGRVRMGF
CCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHEEEEECCCCHHHHHHHHHHHCCCEEEEE
GWGTNLTNDFAGCAPQSIDGLKAISLVCKVTDANGHPAVKLSDNPQKATGDPKEVARYLR
CCCCCCCCCCCCCCCCCCHHHHHHHHHEEEECCCCCCEEEECCCCCCCCCCHHHHHHHHH
FFGNEERVEQLVRV
HCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA