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The map label for this gene is ycgM [C]

Identifier: 225851605

GI number: 225851605

Start: 69476

End: 70165

Strand: Direct

Name: ycgM [C]

Synonym: BMEA_A0066

Alternate gene names: 225851605

Gene position: 69476-70165 (Clockwise)

Preceding gene: 225851604

Following gene: 225851606

Centisome position: 3.27

GC content: 59.13

Gene sequence:

>690_bases
ATGACGACTTATGTTTTTGCGCCACGCCCGCAGACGTTTCTGCCCGTGAAGGGAACGGATGCACGCTTTCCCGTGCACCG
CATTTATTGCGTCGGCCAGAACTATGCCGATCACGCTATAGAAATGGGCGGCGATCCCACGCGCAACCCGCCCTTCTTCT
TCCAGAAAAACCCGGATCGCCTTGTGATCGAGGGCGGCGATTTTCCTTATCCGCCAAAGACCGAGGATGTGCATCACGAG
ATCGAGCTGGTGGTGGCGTTGAAGAGCGGCGGCAGCGATATCCCTGTAGAAAAGGCGCTGGACCATGTTTACGGCTATGC
GGTCGGCATCGACATGACGCGCCGTGACTTGCAGGCCGTGGCCAAAAAGGCGGGCCGCCCGTGGGAAGTGGCCAAGGCGT
TTGAACATTCGGCCCCCTGTTCGGCTGTCGTGCCTGCCGGTGAAACAGGCCACCCGGAGCAGGCGGCGATTTCGCTTGCC
ATCAACGGTGAGATGCGCCAGTCCGGCAATCTCAACCAGATGATCTGGAAAGTGCCGGAAACCATTTCCTACCTGTCGTC
GCTCTTTGATCTGCAACCCGGCGATCTTATCTTTACAGGTACGCCTGCGGGCGTCGGGCCGGTGAAGCGCGGCGACCGTC
TGGAGGGCAAGGTGGATGGAGTGGGAATACTATCCGTAACCGTGGTTTGA

Upstream 100 bases:

>100_bases
ACAGGAATCACGCCTTTCAAGACTTGCGGTGCAGTGCTGGCGTCTGCATGATGGAGCGAACTTAGCACAATGCTCGCAAT
TCTGATCGGGACAGCCTTCC

Downstream 100 bases:

>100_bases
AACATGCGGAGGAGAGCGAATGAGCACCTATCTTCCCGAAGACGTGCATGATGCTCTGGAGCGGTTCATCGCCGAACGGT
ATTCCGGACTGAACCAGACT

Product: fumarylacetoacetate hydrolase domain-containing protein 1

Products: carboxylate; pyruvate

Alternate protein names: NA

Number of amino acids: Translated: 229; Mature: 228

Protein sequence:

>229_residues
MTTYVFAPRPQTFLPVKGTDARFPVHRIYCVGQNYADHAIEMGGDPTRNPPFFFQKNPDRLVIEGGDFPYPPKTEDVHHE
IELVVALKSGGSDIPVEKALDHVYGYAVGIDMTRRDLQAVAKKAGRPWEVAKAFEHSAPCSAVVPAGETGHPEQAAISLA
INGEMRQSGNLNQMIWKVPETISYLSSLFDLQPGDLIFTGTPAGVGPVKRGDRLEGKVDGVGILSVTVV

Sequences:

>Translated_229_residues
MTTYVFAPRPQTFLPVKGTDARFPVHRIYCVGQNYADHAIEMGGDPTRNPPFFFQKNPDRLVIEGGDFPYPPKTEDVHHE
IELVVALKSGGSDIPVEKALDHVYGYAVGIDMTRRDLQAVAKKAGRPWEVAKAFEHSAPCSAVVPAGETGHPEQAAISLA
INGEMRQSGNLNQMIWKVPETISYLSSLFDLQPGDLIFTGTPAGVGPVKRGDRLEGKVDGVGILSVTVV
>Mature_228_residues
TTYVFAPRPQTFLPVKGTDARFPVHRIYCVGQNYADHAIEMGGDPTRNPPFFFQKNPDRLVIEGGDFPYPPKTEDVHHEI
ELVVALKSGGSDIPVEKALDHVYGYAVGIDMTRRDLQAVAKKAGRPWEVAKAFEHSAPCSAVVPAGETGHPEQAAISLAI
NGEMRQSGNLNQMIWKVPETISYLSSLFDLQPGDLIFTGTPAGVGPVKRGDRLEGKVDGVGILSVTVV

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI13654274, Length=201, Percent_Identity=41.7910447761194, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI215422413, Length=194, Percent_Identity=42.7835051546392, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI66348062, Length=194, Percent_Identity=42.7835051546392, Blast_Score=162, Evalue=2e-40,
Organism=Homo sapiens, GI156231349, Length=211, Percent_Identity=34.1232227488152, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI40786394, Length=211, Percent_Identity=33.175355450237, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI1787428, Length=206, Percent_Identity=40.7766990291262, Blast_Score=159, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17557057, Length=189, Percent_Identity=38.0952380952381, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324161, Length=224, Percent_Identity=32.5892857142857, Blast_Score=123, Evalue=3e-29,
Organism=Drosophila melanogaster, GI28571789, Length=203, Percent_Identity=30.5418719211823, Blast_Score=107, Evalue=6e-24,
Organism=Drosophila melanogaster, GI28572127, Length=211, Percent_Identity=30.8056872037915, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24663695, Length=214, Percent_Identity=27.5700934579439, Blast_Score=70, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: 3.7.1.5

Molecular weight: Translated: 24866; Mature: 24734

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTYVFAPRPQTFLPVKGTDARFPVHRIYCVGQNYADHAIEMGGDPTRNPPFFFQKNPDR
CCEEEECCCCCEEEEECCCCCCCCEEEEEEECCCCCHHHEECCCCCCCCCCEEEECCCCE
LVIEGGDFPYPPKTEDVHHEIELVVALKSGGSDIPVEKALDHVYGYAVGIDMTRRDLQAV
EEEECCCCCCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHEEEECCHHHHHHHHH
AKKAGRPWEVAKAFEHSAPCSAVVPAGETGHPEQAAISLAINGEMRQSGNLNQMIWKVPE
HHHCCCCHHHHHHHHCCCCCCEEECCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHH
TISYLSSLFDLQPGDLIFTGTPAGVGPVKRGDRLEGKVDGVGILSVTVV
HHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEC
>Mature Secondary Structure 
TTYVFAPRPQTFLPVKGTDARFPVHRIYCVGQNYADHAIEMGGDPTRNPPFFFQKNPDR
CEEEECCCCCEEEEECCCCCCCCEEEEEEECCCCCHHHEECCCCCCCCCCEEEECCCCE
LVIEGGDFPYPPKTEDVHHEIELVVALKSGGSDIPVEKALDHVYGYAVGIDMTRRDLQAV
EEEECCCCCCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHHHHHHEEEECCHHHHHHHHH
AKKAGRPWEVAKAFEHSAPCSAVVPAGETGHPEQAAISLAINGEMRQSGNLNQMIWKVPE
HHHCCCCHHHHHHHHCCCCCCEEECCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHH
TISYLSSLFDLQPGDLIFTGTPAGVGPVKRGDRLEGKVDGVGILSVTVV
HHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-acylpyruvate; H2O

Specific reaction: A 3-acylpyruvate + H2O = a carboxylate + pyruvate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]