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The map label for this gene is ghrA [H]

Identifier: 225851551

GI number: 225851551

Start: 5869

End: 6825

Strand: Reverse

Name: ghrA [H]

Synonym: BMEA_A0005

Alternate gene names: 225851551

Gene position: 6825-5869 (Counterclockwise)

Preceding gene: 225851552

Following gene: NA

Centisome position: 0.32

GC content: 57.58

Gene sequence:

>957_bases
ATGAGCGATACGAAGGGAAATATCCTTCTTGCAACCACCGACTGGGACCCGGAAATCTGGCTGAAGACGTTCAAGGAAAG
TGCAAGCAATCGCAAGGTCGTGACGGAGCGGGCCGAAAACGACCCTTCCATCGAATATGCGCTTGTATGGAAGCAGAAGC
CGGGCTCGCTTGCCAACCTCCCCAATCTCAAGGTCATTTTCTCTCTCGGCGCGGGCGTGGATCATGTCTTCCGTGATCCG
CAGGTTCCCGATGTGCCGCTGGTGCGAATCATTTCCGACGATCTCACCATGCGGATGACCGAATATGTGGTCTGGCAGGT
CCTGGATCATCACCGCCTTGGGTCGCGCTATCGCAAGCAGCAGCAAAATCATGTCTGGCACGAGGATCGCCGCCAGCCCG
CCGCGCATGAAGTGACGGTCGGCATTATGGGCCTTGGTGTGCTTGGCCGCGATGCGGCGGAAAAACTGAAAATTCTCGGC
TTCAATATTACCGGCTGGAGCCGCCGCCCGCAGAAAATAGACGGTGTAAAGACCTATCACGGCGGGGATGGTTTTACCGA
ATTTCTCAAGACAGCCGATATTTTCGTCTGCCTGCTGCCACTGACGCCGGACACGAAGGGCATCCTGTCCATGTCGATGT
TTGCGCAACTGAAAAGCGACGGGCCACTCGGCGAGCCGGTTCTCATCAATGCCGGACGCGGCAGTTTACAGAATGAGCCG
GATATTCTGGCCGCACTCGACCGTGGGCTTCTTTCCGCCGTTACGCTCGATGTCTTCAATCAGGAACCGCTGCCGGCCAA
CAGCCCGCTTTGGGACCACCCCAAGGTAACGATCACGCCACATGTGGCGGCAATCTCGTCCGCTACCGTTCTCGTGCCCC
AGATCATCCGCCAGATCGAGGCATTCGAGCGCGACGGCACCCTGGAGCATGTGGTGGACCGTTCAACCCAGTATTGA

Upstream 100 bases:

>100_bases
GCCCGGCAAAGGATATCTTTGCCAATCCGCAAACCGACTATACCAAGGCTTTGATGGCGGCGGCTTTCCATATGGAGACC
AGGGAAGGAGGAATAAAACA

Downstream 100 bases:

>100_bases
GCCTGAAAATGCTCAATTATTTTGGTTTGCGGGCCTTGTAGCGGATGGTTTCAAAACGGACATTCAGCGCATTGTAGAGA
AGAAGCCGCCCGACCAGCGG

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MSDTKGNILLATTDWDPEIWLKTFKESASNRKVVTERAENDPSIEYALVWKQKPGSLANLPNLKVIFSLGAGVDHVFRDP
QVPDVPLVRIISDDLTMRMTEYVVWQVLDHHRLGSRYRKQQQNHVWHEDRRQPAAHEVTVGIMGLGVLGRDAAEKLKILG
FNITGWSRRPQKIDGVKTYHGGDGFTEFLKTADIFVCLLPLTPDTKGILSMSMFAQLKSDGPLGEPVLINAGRGSLQNEP
DILAALDRGLLSAVTLDVFNQEPLPANSPLWDHPKVTITPHVAAISSATVLVPQIIRQIEAFERDGTLEHVVDRSTQY

Sequences:

>Translated_318_residues
MSDTKGNILLATTDWDPEIWLKTFKESASNRKVVTERAENDPSIEYALVWKQKPGSLANLPNLKVIFSLGAGVDHVFRDP
QVPDVPLVRIISDDLTMRMTEYVVWQVLDHHRLGSRYRKQQQNHVWHEDRRQPAAHEVTVGIMGLGVLGRDAAEKLKILG
FNITGWSRRPQKIDGVKTYHGGDGFTEFLKTADIFVCLLPLTPDTKGILSMSMFAQLKSDGPLGEPVLINAGRGSLQNEP
DILAALDRGLLSAVTLDVFNQEPLPANSPLWDHPKVTITPHVAAISSATVLVPQIIRQIEAFERDGTLEHVVDRSTQY
>Mature_317_residues
SDTKGNILLATTDWDPEIWLKTFKESASNRKVVTERAENDPSIEYALVWKQKPGSLANLPNLKVIFSLGAGVDHVFRDPQ
VPDVPLVRIISDDLTMRMTEYVVWQVLDHHRLGSRYRKQQQNHVWHEDRRQPAAHEVTVGIMGLGVLGRDAAEKLKILGF
NITGWSRRPQKIDGVKTYHGGDGFTEFLKTADIFVCLLPLTPDTKGILSMSMFAQLKSDGPLGEPVLINAGRGSLQNEPD
ILAALDRGLLSAVTLDVFNQEPLPANSPLWDHPKVTITPHVAAISSATVLVPQIIRQIEAFERDGTLEHVVDRSTQY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=241, Percent_Identity=30.2904564315353, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI23308577, Length=229, Percent_Identity=27.0742358078603, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI87081824, Length=320, Percent_Identity=36.875, Blast_Score=188, Evalue=4e-49,
Organism=Escherichia coli, GI87082289, Length=157, Percent_Identity=36.3057324840764, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=146, Percent_Identity=28.7671232876712, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324055, Length=153, Percent_Identity=33.9869281045752, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28574286, Length=315, Percent_Identity=27.9365079365079, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28571528, Length=148, Percent_Identity=31.7567567567568, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24585516, Length=179, Percent_Identity=30.1675977653631, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585514, Length=247, Percent_Identity=27.5303643724696, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574282, Length=247, Percent_Identity=27.5303643724696, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45552429, Length=247, Percent_Identity=27.5303643724696, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI45551003, Length=247, Percent_Identity=27.5303643724696, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28574284, Length=247, Percent_Identity=27.5303643724696, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921140, Length=264, Percent_Identity=25.3787878787879, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 35449; Mature: 35318

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTKGNILLATTDWDPEIWLKTFKESASNRKVVTERAENDPSIEYALVWKQKPGSLANL
CCCCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEEHHCCCCCCEEEEEEEECCCCCCCCC
PNLKVIFSLGAGVDHVFRDPQVPDVPLVRIISDDLTMRMTEYVVWQVLDHHRLGSRYRKQ
CCEEEEEEECCCHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QQNHVWHEDRRQPAAHEVTVGIMGLGVLGRDAAEKLKILGFNITGWSRRPQKIDGVKTYH
HHCCCCCHHHCCCCHHHEEEEEEECCCCCCCHHHCEEEEEEEECCCCCCCCCCCCEEEEE
GGDGFTEFLKTADIFVCLLPLTPDTKGILSMSMFAQLKSDGPLGEPVLINAGRGSLQNEP
CCCHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCC
DILAALDRGLLSAVTLDVFNQEPLPANSPLWDHPKVTITPHVAAISSATVLVPQIIRQIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHH
AFERDGTLEHVVDRSTQY
HHHCCCCHHHHHHCCCCC
>Mature Secondary Structure 
SDTKGNILLATTDWDPEIWLKTFKESASNRKVVTERAENDPSIEYALVWKQKPGSLANL
CCCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEEHHCCCCCCEEEEEEEECCCCCCCCC
PNLKVIFSLGAGVDHVFRDPQVPDVPLVRIISDDLTMRMTEYVVWQVLDHHRLGSRYRKQ
CCEEEEEEECCCHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QQNHVWHEDRRQPAAHEVTVGIMGLGVLGRDAAEKLKILGFNITGWSRRPQKIDGVKTYH
HHCCCCCHHHCCCCHHHEEEEEEECCCCCCCHHHCEEEEEEEECCCCCCCCCCCCEEEEE
GGDGFTEFLKTADIFVCLLPLTPDTKGILSMSMFAQLKSDGPLGEPVLINAGRGSLQNEP
CCCHHHHHHHHHCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCC
DILAALDRGLLSAVTLDVFNQEPLPANSPLWDHPKVTITPHVAAISSATVLVPQIIRQIE
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHH
AFERDGTLEHVVDRSTQY
HHHCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA