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The map label for this gene is dnaA [H]

Identifier: 225851547

GI number: 225851547

Start: 634

End: 2274

Strand: Direct

Name: dnaA [H]

Synonym: BMEA_A0001

Alternate gene names: 225851547

Gene position: 634-2274 (Clockwise)

Preceding gene: NA

Following gene: 225851548

Centisome position: 0.03

GC content: 59.54

Gene sequence:

>1641_bases
ATGACAAGCGCCCGAACAATGGCGCGTACGAATGTGAAGGCAGGCGAGACGATGGCAATGATGACCGGTAAATCGACGGC
AACGATAGGTGATAATGCACATGCGAACCGTATCCATGGATCTTCTGCTACCGGAAATGACAAGAGCCTGATGAAAATGG
ACAGTGCCGTCAGCGAGGAAGCTTTCGAGCGTTTGACGGCCAAGCTCAAGGCACGGGTTGGCGGCGAGATTTATTCGAGC
TGGTTTGGCCGGCTGAAGCTGGACGATATTTCCAAGAGCATCGTGCGCCTTTCGGTTCCCACCGCATTTTTGCGCTCCTG
GATCAACAATCATTATTCCGAACTGCTGACCGAGCTTTGGCAGGAAGAAAATCCGCAGATCCTGAAGGTCGAGGTCGTGG
TGCGTGGCGTAAGCCGCGTGGTGCGCAGTGCAGCACCCGCCGAAACCTGCGACAATGCCGAAGCAAAGCCCGCCGTCACC
CCGCGTGAAAAGATGGTGTTCCCTGTTGGGCAGTCTTTTGGCGGCCAGTCGCTTGGCGAAAAGCGCGGCTCCGCCGTGGT
CGCAGAATCGGCTGCCGCCACCGGCGCCGTTCTGGGCTCCCCGCTTGATCCGCGCTATACGTTCGACACATTTGTCGATG
GCGCCTCCAACCGCGTCGCCCTTGCCGCCGCCCGCACCATCGCGGAAGCCGGTTCCAGTGCCGTTCGCTTCAATCCGCTT
TTCATTCATGCCTCCGTCGGCCTCGGCAAGACACATCTTTTGCAGGCCATTGCCGCCGCCGCTCTCCAGCGCCAGGAAAA
GGCCCGCGTCGTCTATCTGACGGCTGAATATTTCATGTGGCGCTTTGCCACCGCTATCCGCGACAACAATGCGCTCTCCT
TCAAGGAACAGCTTCGCGATATCGACCTTCTGGTGATCGACGACATGCAGTTCCTGCAGGGCAAGTCGATCCAGCACGAG
TTCTGCCATCTTCTGAATACGCTGCTCGACAGCGCAAAACAGGTCGTGGTTGCCGCCGACCGCGCCCCTTCGGAACTGGA
ATCGCTCGACGTTCGCGTCCGTTCCCGCCTTCAGGGCGGTGTCGCTCTGGAAGTGGCCGCACCCGATTATGAAATGCGCC
TGGAAATGCTGCGTCGCCGTCTGGCCAGCGCACAGTGCGAGGATGCAAGCCTCGATATCGGTGAAGAGATTCTCGCCCAT
GTCGCGCGCACGGTCACGGGTTCCGGCCGTGAACTGGAAGGCGCATTCAACCAGCTTCTGTTCCGCCAGTCTTTCGAGCC
GAATATTTCCATCGACCGCGTGGACGAGTTGCTCGGCCATCTGACCCGCGCAGGCGAGCCGAAGCGCATCCGTATCGAGG
AAATCCAGCGCATCGTGGCGCGCCATTATAATGTGTCGAAGCAGGATCTGCTGTCGAACCGCCGCACGCGCACCATCGTA
AAGCCGCGTCAGGTGGCAATGTATCTCGCCAAGATGATGACGCCGCGTTCCCTGCCGGAAATTGGCCGCCGCTTCGGTGG
GCGCGACCATACCACCGTTCTTCATGCCGTGCGCAAGATTGAGGATCTGGTCGGTGCCGACACCAAGCTGGCGCAGGAGC
TGGAGCTTTTGAAGCGCCTCATCAACGATCAGGCTGCCTGA

Upstream 100 bases:

>100_bases
ACCGATTGAGTTTGTGTGTGGCCCGCTTTGAAGGGCTGCGATGTGTAAATACCCGCCAGGGCCCGCGGTCGGAAGATTTA
GGGTTCTATGCAGGATAAAA

Downstream 100 bases:

>100_bases
CCGGCGGACTTGCACCTCGTAGCGGGCGGTTATCAACAAAAAGCCCACGCCTTGACGTTTTGCGGCATGGCGCGGGCTTG
CTTTTCTCCTTAAAAATCTG

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MTSARTMARTNVKAGETMAMMTGKSTATIGDNAHANRIHGSSATGNDKSLMKMDSAVSEEAFERLTAKLKARVGGEIYSS
WFGRLKLDDISKSIVRLSVPTAFLRSWINNHYSELLTELWQEENPQILKVEVVVRGVSRVVRSAAPAETCDNAEAKPAVT
PREKMVFPVGQSFGGQSLGEKRGSAVVAESAAATGAVLGSPLDPRYTFDTFVDGASNRVALAAARTIAEAGSSAVRFNPL
FIHASVGLGKTHLLQAIAAAALQRQEKARVVYLTAEYFMWRFATAIRDNNALSFKEQLRDIDLLVIDDMQFLQGKSIQHE
FCHLLNTLLDSAKQVVVAADRAPSELESLDVRVRSRLQGGVALEVAAPDYEMRLEMLRRRLASAQCEDASLDIGEEILAH
VARTVTGSGRELEGAFNQLLFRQSFEPNISIDRVDELLGHLTRAGEPKRIRIEEIQRIVARHYNVSKQDLLSNRRTRTIV
KPRQVAMYLAKMMTPRSLPEIGRRFGGRDHTTVLHAVRKIEDLVGADTKLAQELELLKRLINDQAA

Sequences:

>Translated_546_residues
MTSARTMARTNVKAGETMAMMTGKSTATIGDNAHANRIHGSSATGNDKSLMKMDSAVSEEAFERLTAKLKARVGGEIYSS
WFGRLKLDDISKSIVRLSVPTAFLRSWINNHYSELLTELWQEENPQILKVEVVVRGVSRVVRSAAPAETCDNAEAKPAVT
PREKMVFPVGQSFGGQSLGEKRGSAVVAESAAATGAVLGSPLDPRYTFDTFVDGASNRVALAAARTIAEAGSSAVRFNPL
FIHASVGLGKTHLLQAIAAAALQRQEKARVVYLTAEYFMWRFATAIRDNNALSFKEQLRDIDLLVIDDMQFLQGKSIQHE
FCHLLNTLLDSAKQVVVAADRAPSELESLDVRVRSRLQGGVALEVAAPDYEMRLEMLRRRLASAQCEDASLDIGEEILAH
VARTVTGSGRELEGAFNQLLFRQSFEPNISIDRVDELLGHLTRAGEPKRIRIEEIQRIVARHYNVSKQDLLSNRRTRTIV
KPRQVAMYLAKMMTPRSLPEIGRRFGGRDHTTVLHAVRKIEDLVGADTKLAQELELLKRLINDQAA
>Mature_545_residues
TSARTMARTNVKAGETMAMMTGKSTATIGDNAHANRIHGSSATGNDKSLMKMDSAVSEEAFERLTAKLKARVGGEIYSSW
FGRLKLDDISKSIVRLSVPTAFLRSWINNHYSELLTELWQEENPQILKVEVVVRGVSRVVRSAAPAETCDNAEAKPAVTP
REKMVFPVGQSFGGQSLGEKRGSAVVAESAAATGAVLGSPLDPRYTFDTFVDGASNRVALAAARTIAEAGSSAVRFNPLF
IHASVGLGKTHLLQAIAAAALQRQEKARVVYLTAEYFMWRFATAIRDNNALSFKEQLRDIDLLVIDDMQFLQGKSIQHEF
CHLLNTLLDSAKQVVVAADRAPSELESLDVRVRSRLQGGVALEVAAPDYEMRLEMLRRRLASAQCEDASLDIGEEILAHV
ARTVTGSGRELEGAFNQLLFRQSFEPNISIDRVDELLGHLTRAGEPKRIRIEEIQRIVARHYNVSKQDLLSNRRTRTIVK
PRQVAMYLAKMMTPRSLPEIGRRFGGRDHTTVLHAVRKIEDLVGADTKLAQELELLKRLINDQAA

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=474, Percent_Identity=34.3881856540084, Blast_Score=258, Evalue=6e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 60258; Mature: 60127

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS01008 DNAA ; PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSARTMARTNVKAGETMAMMTGKSTATIGDNAHANRIHGSSATGNDKSLMKMDSAVSEE
CCCCHHHHHCCCCCCCEEEEEECCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
AFERLTAKLKARVGGEIYSSWFGRLKLDDISKSIVRLSVPTAFLRSWINNHYSELLTELW
HHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QEENPQILKVEVVVRGVSRVVRSAAPAETCDNAEAKPAVTPREKMVFPVGQSFGGQSLGE
HCCCCCEEEHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCHHHEEEECCCCCCCCCHHH
KRGSAVVAESAAATGAVLGSPLDPRYTFDTFVDGASNRVALAAARTIAEAGSSAVRFNPL
HCCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEE
FIHASVGLGKTHLLQAIAAAALQRQEKARVVYLTAEYFMWRFATAIRDNNALSFKEQLRD
EEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHCC
IDLLVIDDMQFLQGKSIQHEFCHLLNTLLDSAKQVVVAADRAPSELESLDVRVRSRLQGG
CCEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCC
VALEVAAPDYEMRLEMLRRRLASAQCEDASLDIGEEILAHVARTVTGSGRELEGAFNQLL
EEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
FRQSFEPNISIDRVDELLGHLTRAGEPKRIRIEEIQRIVARHYNVSKQDLLSNRRTRTIV
HHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCHHHHHHCCCHHHHC
KPRQVAMYLAKMMTPRSLPEIGRRFGGRDHTTVLHAVRKIEDLVGADTKLAQELELLKRL
CHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
INDQAA
HCCCCC
>Mature Secondary Structure 
TSARTMARTNVKAGETMAMMTGKSTATIGDNAHANRIHGSSATGNDKSLMKMDSAVSEE
CCCHHHHHCCCCCCCEEEEEECCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
AFERLTAKLKARVGGEIYSSWFGRLKLDDISKSIVRLSVPTAFLRSWINNHYSELLTELW
HHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QEENPQILKVEVVVRGVSRVVRSAAPAETCDNAEAKPAVTPREKMVFPVGQSFGGQSLGE
HCCCCCEEEHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCHHHEEEECCCCCCCCCHHH
KRGSAVVAESAAATGAVLGSPLDPRYTFDTFVDGASNRVALAAARTIAEAGSSAVRFNPL
HCCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHCCCCCEEEEEE
FIHASVGLGKTHLLQAIAAAALQRQEKARVVYLTAEYFMWRFATAIRDNNALSFKEQLRD
EEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHCC
IDLLVIDDMQFLQGKSIQHEFCHLLNTLLDSAKQVVVAADRAPSELESLDVRVRSRLQGG
CCEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHCCC
VALEVAAPDYEMRLEMLRRRLASAQCEDASLDIGEEILAHVARTVTGSGRELEGAFNQLL
EEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHH
FRQSFEPNISIDRVDELLGHLTRAGEPKRIRIEEIQRIVARHYNVSKQDLLSNRRTRTIV
HHHCCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCHHHHHHCCCHHHHC
KPRQVAMYLAKMMTPRSLPEIGRRFGGRDHTTVLHAVRKIEDLVGADTKLAQELELLKRL
CHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
INDQAA
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA