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The map label for this gene is fabF [H]

Identifier: 225630861

GI number: 225630861

Start: 1257216

End: 1258487

Strand: Direct

Name: fabF [H]

Synonym: WRi_011670

Alternate gene names: 225630861

Gene position: 1257216-1258487 (Clockwise)

Preceding gene: 225630860

Following gene: 225630862

Centisome position: 86.95

GC content: 39.94

Gene sequence:

>1272_bases
ATGAGCAGAAGAGTAGTAGTCACTGGTGTTGGTTTAATCACTCCACTAGCGGCAGATGTTGACAACACTTGGTCAAGGCT
AATAAAAAGTGAGTCTGGCATAAAAGCAATCAATACGGATAGATTTGACTCTTCTGATCTTGCTTGCAAAATTGCAGGGC
AGGTGCCGTTGCAATCAGACAACATTGAGCACCATTTCAATCCACTAGATTATATTTCTGAGAAAGACTCAAAAAGGACA
GATCGTTTTATCCATTACGGTATTGCAGCAGCTATTCAGGCAGTAGATGATTCATTAATTTTGGAAAGCCAAAATATCAA
TCGGGAACGTGTTGGTGTGACTATTGGCTCTGGTATAGGTGGTCTTCCGTCAATTCAGGAAAATGTTATTACCATGCAGG
AAAAAGGGCCCAGACGTGTCAGTCCATTTTTTGTCCCTGCAAGTCTAATAAATTTGATATCTGGCCATGTTTCTATTAAA
TACGAATTTACAGGTCCAAACGATTCAGCAGTAACCGCATGTGCAACAGGTGCGCATGCAATCATAAACTCAGCAAGAAC
TATAAAACTTGGTGAAGCGGATGTTATGATTGCAGGTGGAGCAGAAAGTGCACTGTGTAGAGTTGGAATTGCAGGTTTTG
CGTCTATGAAGGCATTATCAACTAAATTCAATGATAAACCGGAAGAAGCTTCAAGGCCATGGGATGCAGAACGCGATGGT
TTTGTTATGGGTGAAGGAGCAGGTATATTGGTGCTGGAGGAATACGAACATGCAAAAAAAAGGGGAGCAAAAATACATGC
TGAACTGGTTGGGTACGGACTGACAGGAGATGCACACCACATTACAGCACCACATCCAGAAGGAAGAGGCGCATTTAAGG
CAATGCAGCTTGCCTTAAAAAGTGCGCAAATTAATCCAAATCAAGTAGGATATATCAATGCACATGGAACTTCAACGCCA
CTTGGAGATAAAATTGAAGTAATAGCAATGAAACAGTTATTTGGTGACTACGTTTATAAAATACCTGTTTCTTCAACTAA
ATCTTCTATAGGACATTTACTTGGTGCTGCAGGGAGCGTTGAAGCAATATTCAGTATTCTTGCGTTAAATAATGGAATTA
TTCCGCCAACCTTAAATTTACATAAACCTTCAGAAGGATGTGATTTAAATTTTGTACCGCTTAAAGCTCAAGAGCATAAA
ATTCAATATGCACTTTCTAATTCGTTTGGTTTTGGTGGCACTAATGCATCTCTCATCTTTGGACAAGTTTAG

Upstream 100 bases:

>100_bases
TTTGGAATAGAAATTCCAGATGAAGACGCACAAAAAATGGAAACTATGGAGCAAATAGTTGAGTACATTAATAATAAAAA
AGGCTAATAGTTAGTGTTAA

Downstream 100 bases:

>100_bases
TTGATGTCACCCCAGTGTCTTCCTCTTGTCATTCCAGTACCCTCCTCTTGTCATGCAAGCAGCTCTCCTACTGTCATCCC
AGCGCGTGACACTGGGATGA

Product: 3-oxoacyl-(acyl-carrier-protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MSRRVVVTGVGLITPLAADVDNTWSRLIKSESGIKAINTDRFDSSDLACKIAGQVPLQSDNIEHHFNPLDYISEKDSKRT
DRFIHYGIAAAIQAVDDSLILESQNINRERVGVTIGSGIGGLPSIQENVITMQEKGPRRVSPFFVPASLINLISGHVSIK
YEFTGPNDSAVTACATGAHAIINSARTIKLGEADVMIAGGAESALCRVGIAGFASMKALSTKFNDKPEEASRPWDAERDG
FVMGEGAGILVLEEYEHAKKRGAKIHAELVGYGLTGDAHHITAPHPEGRGAFKAMQLALKSAQINPNQVGYINAHGTSTP
LGDKIEVIAMKQLFGDYVYKIPVSSTKSSIGHLLGAAGSVEAIFSILALNNGIIPPTLNLHKPSEGCDLNFVPLKAQEHK
IQYALSNSFGFGGTNASLIFGQV

Sequences:

>Translated_423_residues
MSRRVVVTGVGLITPLAADVDNTWSRLIKSESGIKAINTDRFDSSDLACKIAGQVPLQSDNIEHHFNPLDYISEKDSKRT
DRFIHYGIAAAIQAVDDSLILESQNINRERVGVTIGSGIGGLPSIQENVITMQEKGPRRVSPFFVPASLINLISGHVSIK
YEFTGPNDSAVTACATGAHAIINSARTIKLGEADVMIAGGAESALCRVGIAGFASMKALSTKFNDKPEEASRPWDAERDG
FVMGEGAGILVLEEYEHAKKRGAKIHAELVGYGLTGDAHHITAPHPEGRGAFKAMQLALKSAQINPNQVGYINAHGTSTP
LGDKIEVIAMKQLFGDYVYKIPVSSTKSSIGHLLGAAGSVEAIFSILALNNGIIPPTLNLHKPSEGCDLNFVPLKAQEHK
IQYALSNSFGFGGTNASLIFGQV
>Mature_422_residues
SRRVVVTGVGLITPLAADVDNTWSRLIKSESGIKAINTDRFDSSDLACKIAGQVPLQSDNIEHHFNPLDYISEKDSKRTD
RFIHYGIAAAIQAVDDSLILESQNINRERVGVTIGSGIGGLPSIQENVITMQEKGPRRVSPFFVPASLINLISGHVSIKY
EFTGPNDSAVTACATGAHAIINSARTIKLGEADVMIAGGAESALCRVGIAGFASMKALSTKFNDKPEEASRPWDAERDGF
VMGEGAGILVLEEYEHAKKRGAKIHAELVGYGLTGDAHHITAPHPEGRGAFKAMQLALKSAQINPNQVGYINAHGTSTPL
GDKIEVIAMKQLFGDYVYKIPVSSTKSSIGHLLGAAGSVEAIFSILALNNGIIPPTLNLHKPSEGCDLNFVPLKAQEHKI
QYALSNSFGFGGTNASLIFGQV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=422, Percent_Identity=50, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=58.9041095890411, Blast_Score=166, Evalue=3e-41,
Organism=Homo sapiens, GI41872631, Length=279, Percent_Identity=26.1648745519713, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1787337, Length=422, Percent_Identity=54.2654028436019, Blast_Score=420, Evalue=1e-118,
Organism=Escherichia coli, GI1788663, Length=427, Percent_Identity=37.4707259953162, Blast_Score=249, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI71983541, Length=424, Percent_Identity=39.3867924528302, Blast_Score=280, Evalue=9e-76,
Organism=Caenorhabditis elegans, GI71983535, Length=260, Percent_Identity=46.5384615384615, Blast_Score=224, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI17550940, Length=274, Percent_Identity=27.7372262773723, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI212642053, Length=303, Percent_Identity=26.4026402640264, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=39.2857142857143, Blast_Score=298, Evalue=1e-81,
Organism=Drosophila melanogaster, GI24644341, Length=423, Percent_Identity=43.7352245862884, Blast_Score=341, Evalue=6e-94,
Organism=Drosophila melanogaster, GI221330659, Length=278, Percent_Identity=25.8992805755396, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19920632, Length=291, Percent_Identity=25.4295532646048, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24581345, Length=377, Percent_Identity=21.7506631299735, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 45081; Mature: 44950

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRVVVTGVGLITPLAADVDNTWSRLIKSESGIKAINTDRFDSSDLACKIAGQVPLQSD
CCCEEEEECCHHHHHHHHCCCHHHHHHHHCCCCCEEECCCCCCCCCCEEEEECCCCCCCC
NIEHHFNPLDYISEKDSKRTDRFIHYGIAAAIQAVDDSLILESQNINRERVGVTIGSGIG
CCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHEEEEECCCCC
GLPSIQENVITMQEKGPRRVSPFFVPASLINLISGHVSIKYEFTGPNDSAVTACATGAHA
CCCCCHHHEEEECCCCCCCCCCEEEHHHHHHHHCCCEEEEEEECCCCCCCEEEECCCHHH
IINSARTIKLGEADVMIAGGAESALCRVGIAGFASMKALSTKFNDKPEEASRPWDAERDG
HHCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCC
FVMGEGAGILVLEEYEHAKKRGAKIHAELVGYGLTGDAHHITAPHPEGRGAFKAMQLALK
EEEECCCCEEEECCHHHHHHCCCEEEEEEEEECCCCCCCEECCCCCCCCHHHHHHHHHHH
SAQINPNQVGYINAHGTSTPLGDKIEVIAMKQLFGDYVYKIPVSSTKSSIGHLLGAAGSV
HCCCCCCEEEEEECCCCCCCCCCCEEEEEHHHHHCCEEEEEECCCCHHHHHHHHCCCCCH
EAIFSILALNNGIIPPTLNLHKPSEGCDLNFVPLKAQEHKIQYALSNSFGFGGTNASLIF
HHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCEEEE
GQV
ECC
>Mature Secondary Structure 
SRRVVVTGVGLITPLAADVDNTWSRLIKSESGIKAINTDRFDSSDLACKIAGQVPLQSD
CCEEEEECCHHHHHHHHCCCHHHHHHHHCCCCCEEECCCCCCCCCCEEEEECCCCCCCC
NIEHHFNPLDYISEKDSKRTDRFIHYGIAAAIQAVDDSLILESQNINRERVGVTIGSGIG
CCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHEEEEECCCCC
GLPSIQENVITMQEKGPRRVSPFFVPASLINLISGHVSIKYEFTGPNDSAVTACATGAHA
CCCCCHHHEEEECCCCCCCCCCEEEHHHHHHHHCCCEEEEEEECCCCCCCEEEECCCHHH
IINSARTIKLGEADVMIAGGAESALCRVGIAGFASMKALSTKFNDKPEEASRPWDAERDG
HHCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCC
FVMGEGAGILVLEEYEHAKKRGAKIHAELVGYGLTGDAHHITAPHPEGRGAFKAMQLALK
EEEECCCCEEEECCHHHHHHCCCEEEEEEEEECCCCCCCEECCCCCCCCHHHHHHHHHHH
SAQINPNQVGYINAHGTSTPLGDKIEVIAMKQLFGDYVYKIPVSSTKSSIGHLLGAAGSV
HCCCCCCEEEEEECCCCCCCCCCCEEEEEHHHHHCCEEEEEECCCCHHHHHHHHCCCCCH
EAIFSILALNNGIIPPTLNLHKPSEGCDLNFVPLKAQEHKIQYALSNSFGFGGTNASLIF
HHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCCCCEEEE
GQV
ECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]