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The map label for this gene is dxr [H]

Identifier: 225630656

GI number: 225630656

Start: 1012091

End: 1013254

Strand: Direct

Name: dxr [H]

Synonym: WRi_009400

Alternate gene names: 225630656

Gene position: 1012091-1013254 (Clockwise)

Preceding gene: 225630655

Following gene: 225630657

Centisome position: 70.0

GC content: 36.34

Gene sequence:

>1164_bases
GTGAAAAAGGTTTCAGTTTTAGGGTCAACAGGAAGTGTTGGAAAAAAGACTGTAGATTTGCTCTCAAAGAGAAAAGAAGA
ATACCAAGTGGAAGCACTAAGTGCCCATTCGAACTTTGCTCTACTGGCACACCAAGCAAAACTGCTGAATGCAAAATATG
TTGCTATCTCCGATGAAAGACTTTACAAAGATTTGAAAGAAAGTCTACTTGGTACAGATGTAAAAATAGCAATTGGTGCT
ACAAATGTTGCTGCTATACCTGTTGATCTCTCAGTTGTTGCAATAGTTGGCATTGCAGGCCTTGGGCCAGTTATGGAGGT
TATAGAAAGCGGTACCAAAGTCATTGCATTGGCAAACAAAGAAAGCATTGTTTGCGGTGGAAAGTTATTACTCAAAAAAG
CTAAAGAAAAAAATGTACAAATAATCCCTATTGACTCTGAGCACAATGCAATTTTTCAAATTTTGCAAAATGACGACAAA
TGCGTAGAAAAGATCATACTTACTGCTTCTGGTGGACCATTCTTAAATTATAGCCTTGAGCAATTAAGAAATATCATGGT
AGATCAGGCGCTTAGTCACCCCACTTGGAATATGGGAAAGAAAATCTCGGTTGATAGCGCAACAATGATGAATAAGGCAC
TAGAGATAATAGAAGCACATAACTTGTTTAACATCAGCCCGGATAAAATTGAAGCAGTAGTGCATCCTGAGTCAATAGTA
CATGGAATTGTAACTTATAAGGATGGGTTCAACTTTGCTGTGCTTGCAGAAACTGACATGGCAATTCCTATTTCATATGC
TCTATCTTGGCCAGAAAGATTAGTTTTAAATTATAAATTAGATTTAACAAAGCAAGGAAAATTGACCTTTCAAGAGCCAG
ACCATAAGCATTTCCCTGTGCTAAAGCTTAGCATGGAAGTGTTAAACTCTTCTACTCCACAAACAAACAGTATTGTGCTC
AATGCTGCAAATGAAATAGCTGTTAATGAATTTTTGAAGTCACGAATCGGCTTTTTGGAAATAGTAGAGGTAGTGGAATC
AACAATGGAAAGTTTTGGTAGTTATACCGATATTAATTCACTATCTGATATAATAAATATTGATTGTGAAAGTCGTATTA
TTGCTCACAAAATTGTTGAAAGTAAAGTTGTTGCGTATAGCTAG

Upstream 100 bases:

>100_bases
CTGTTGGCGATGACCACGGGCATGAACTTGGTTAAACGCTTAAAAACTATTGAATAGTTGGGTTCGCAAGAAAAGTTGCT
ATTGTTATGAGTTTGTCTTA

Downstream 100 bases:

>100_bases
AGTAATGTAACCAGACTGCATTCTGTGATTTTTAGCAAAACACGATACACAATCGTCATTCCGCTACTAATTAGCGGAAT
CTATGCCGAGATACCGCGGC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKKVSVLGSTGSVGKKTVDLLSKRKEEYQVEALSAHSNFALLAHQAKLLNAKYVAISDERLYKDLKESLLGTDVKIAIGA
TNVAAIPVDLSVVAIVGIAGLGPVMEVIESGTKVIALANKESIVCGGKLLLKKAKEKNVQIIPIDSEHNAIFQILQNDDK
CVEKIILTASGGPFLNYSLEQLRNIMVDQALSHPTWNMGKKISVDSATMMNKALEIIEAHNLFNISPDKIEAVVHPESIV
HGIVTYKDGFNFAVLAETDMAIPISYALSWPERLVLNYKLDLTKQGKLTFQEPDHKHFPVLKLSMEVLNSSTPQTNSIVL
NAANEIAVNEFLKSRIGFLEIVEVVESTMESFGSYTDINSLSDIINIDCESRIIAHKIVESKVVAYS

Sequences:

>Translated_387_residues
MKKVSVLGSTGSVGKKTVDLLSKRKEEYQVEALSAHSNFALLAHQAKLLNAKYVAISDERLYKDLKESLLGTDVKIAIGA
TNVAAIPVDLSVVAIVGIAGLGPVMEVIESGTKVIALANKESIVCGGKLLLKKAKEKNVQIIPIDSEHNAIFQILQNDDK
CVEKIILTASGGPFLNYSLEQLRNIMVDQALSHPTWNMGKKISVDSATMMNKALEIIEAHNLFNISPDKIEAVVHPESIV
HGIVTYKDGFNFAVLAETDMAIPISYALSWPERLVLNYKLDLTKQGKLTFQEPDHKHFPVLKLSMEVLNSSTPQTNSIVL
NAANEIAVNEFLKSRIGFLEIVEVVESTMESFGSYTDINSLSDIINIDCESRIIAHKIVESKVVAYS
>Mature_387_residues
MKKVSVLGSTGSVGKKTVDLLSKRKEEYQVEALSAHSNFALLAHQAKLLNAKYVAISDERLYKDLKESLLGTDVKIAIGA
TNVAAIPVDLSVVAIVGIAGLGPVMEVIESGTKVIALANKESIVCGGKLLLKKAKEKNVQIIPIDSEHNAIFQILQNDDK
CVEKIILTASGGPFLNYSLEQLRNIMVDQALSHPTWNMGKKISVDSATMMNKALEIIEAHNLFNISPDKIEAVVHPESIV
HGIVTYKDGFNFAVLAETDMAIPISYALSWPERLVLNYKLDLTKQGKLTFQEPDHKHFPVLKLSMEVLNSSTPQTNSIVL
NAANEIAVNEFLKSRIGFLEIVEVVESTMESFGSYTDINSLSDIINIDCESRIIAHKIVESKVVAYS

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=397, Percent_Identity=40.8060453400504, Blast_Score=273, Evalue=1e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 42370; Mature: 42370

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVSVLGSTGSVGKKTVDLLSKRKEEYQVEALSAHSNFALLAHQAKLLNAKYVAISDER
CCCEEEECCCCCCCHHHHHHHHHHHHHHEEEEEECCCCEEEEEHHHHHCCEEEEEECHHH
LYKDLKESLLGTDVKIAIGATNVAAIPVDLSVVAIVGIAGLGPVMEVIESGTKVIALANK
HHHHHHHHHCCCCEEEEEECCCEEEEECCHHHHHHHHHCCCHHHHHHHHCCCEEEEEECC
ESIVCGGKLLLKKAKEKNVQIIPIDSEHNAIFQILQNDDKCVEKIILTASGGPFLNYSLE
CCEEECHHHHHHHHHHCCEEEEEECCCCHHHHHHHCCCHHHHHHEEEEECCCCCCCHHHH
QLRNIMVDQALSHPTWNMGKKISVDSATMMNKALEIIEAHNLFNISPDKIEAVVHPESIV
HHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCCCCCHHHEEEEECHHHHH
HGIVTYKDGFNFAVLAETDMAIPISYALSWPERLVLNYKLDLTKQGKLTFQEPDHKHFPV
EEEEEEECCCCEEEEEECCCEEEEHHHHCCCCCEEEEEEEEECCCCCEEEECCCCCCCCH
LKLSMEVLNSSTPQTNSIVLNAANEIAVNEFLKSRIGFLEIVEVVESTMESFGSYTDINS
HHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LSDIINIDCESRIIAHKIVESKVVAYS
HHHHHCCCCCHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MKKVSVLGSTGSVGKKTVDLLSKRKEEYQVEALSAHSNFALLAHQAKLLNAKYVAISDER
CCCEEEECCCCCCCHHHHHHHHHHHHHHEEEEEECCCCEEEEEHHHHHCCEEEEEECHHH
LYKDLKESLLGTDVKIAIGATNVAAIPVDLSVVAIVGIAGLGPVMEVIESGTKVIALANK
HHHHHHHHHCCCCEEEEEECCCEEEEECCHHHHHHHHHCCCHHHHHHHHCCCEEEEEECC
ESIVCGGKLLLKKAKEKNVQIIPIDSEHNAIFQILQNDDKCVEKIILTASGGPFLNYSLE
CCEEECHHHHHHHHHHCCEEEEEECCCCHHHHHHHCCCHHHHHHEEEEECCCCCCCHHHH
QLRNIMVDQALSHPTWNMGKKISVDSATMMNKALEIIEAHNLFNISPDKIEAVVHPESIV
HHHHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCCCCCHHHEEEEECHHHHH
HGIVTYKDGFNFAVLAETDMAIPISYALSWPERLVLNYKLDLTKQGKLTFQEPDHKHFPV
EEEEEEECCCCEEEEEECCCEEEEHHHHCCCCCEEEEEEEEECCCCCEEEECCCCCCCCH
LKLSMEVLNSSTPQTNSIVLNAANEIAVNEFLKSRIGFLEIVEVVESTMESFGSYTDINS
HHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHH
LSDIINIDCESRIIAHKIVESKVVAYS
HHHHHCCCCCHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA