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The map label for this gene is uvrB [H]

Identifier: 225630549

GI number: 225630549

Start: 868160

End: 870073

Strand: Reverse

Name: uvrB [H]

Synonym: WRi_008060

Alternate gene names: 225630549

Gene position: 870073-868160 (Counterclockwise)

Preceding gene: 225630550

Following gene: 225630540

Centisome position: 60.18

GC content: 38.19

Gene sequence:

>1914_bases
ATGGAATTTCAAATCGCTACACATTTTCAACCGGCTGGGGATCAACCACAGGCAATCGATAGCTTAATTGCAGGGCTAAA
TAGCAATAAAAGAGATCAGGTTTTGCTTGGAGTTACTGGTTCTGGGAAAACTTTTACTATGGCAAATGTTATTGCAAGGA
CAAACAGGCCTGCATTAATTATGGCACACAATAAAACTTTAGCAGCACAGCTTTATGAGGAAATGAAAGGATTGTTTCCC
CATAATGCTGTTGAATACTTCATTTCTTATTATGATTATTATCAACCTGAAGCCTATTTACCACAAACTGATACTTATAT
CGAAAAAGATTCTGCAATTAACGAAAGAATTGAGATGCTGCGTTATTCCACCGTCTGCTCCCTTTTGGAGCGCAGGGATA
CGATCGTAGTTGCCAGTGTTTCCTGCATATACGGTCTTGGTTCGCCTGAGAGCTACCGCAGCATGATCATACCGCTTAGT
GTTGGAAATAAAATTCGTATTAATGATTTCCTGAGCAACTTAACTGATCTTCAATACAAGCGCTCTGATGCCAGGTTTGA
GAGAGGATATTTCAGAGTGCGCGGCGATATTGTTGATATATTTCTTTCCCATTATGAAAATAAAGCTTGGCGTTTATCGT
TATTTGGCGATGAAATAGAAGAAATTTCTGAAGTTGATGCTATAACGGGCAATGTTACCAAAGGCGTAAATAAAATCACC
ATTTTTCCAAATAGCTATTACATAACCCCGCGTGAGGCTTTGTTGCAGGCAATTGAACTAGTCAAAAAAGAGCTGCATGA
ACGCTTGGATTATTACTACTCGCAAAATAAGATTGTTGAAGCAAAGCGCCTCGAGCAACGCACTAATTTTGATATCGAAA
TGATGAGAACAACAGGAATATGTAAAGGTATTGAAAATTATTCGCGTTATCTCTATGGAATGGAAGCTGGGGATCCACCG
CCTACTTTGTTTGAATATTTACCCAAAGACGTAATTTTATTTGTTGATGAGAGTCATGTCACCGTTCCTCAGGTTGGTGC
GATGTACAGCGGTAATGAGGCGCGTAAAAAGAAATTGATTGACTATGGCTTCAGGCTCCCTTCCGCTTTTGATAATCGTC
CATTAAAATTTGAAGAGTGGGAGGGAGTTAGGCCGCAGACTGTTTACATTTCAGCCACTCCAGGAAAGTATGAGTTGGCA
AAGACCAATAATGTATTTATAGAGCAAGTTATCCGTCCAACAGGGCTTACAGACCCAATCTGCATTGTGAAACCAATAGA
GAGTCAAATTGATGATGTAATTCATGAGGCACAAGTGACAATAGGGAAGGGATTTTGTGTTTTAATCACTACATTGACGA
AAAAAATGGCTGAAAATTTAGCTGAATATATGAGTGAATTGAATATGAAAGTGAGTTATTTGCATTCTGATATTGCTGCG
CTGGAGAGAATAGAAATTATATACAAATTGAGATCTAAAGAAATCGATGTTTTAGTAGGTGTTAACTTGCTGAGGGAAGG
TCTTGATATTCCAGAGTGTGGGTTGGTTGCAATTTTGGATGCTGATAAAGAAGGATTTTTGCGATCGGAAACTTCATTAA
TTCAAACGATCGGTCGTGCTGCGCGTAATGCTGAAGGTAGAGTAATTTTGTATGCAGATAAAATCACTGGTTCTCTGGAC
CGTGCATTAAGAGAGACCGAAAGAAGAAGAAAAAAACAAGAAGAACATAATATATTGCACAATATTATCCCGAAGACTAT
AATAAAACCTATATCAAACACCTTACAGGAGAGGGCAATAGCAGAACCGAAAGTAAATACTAATAAGGATGATTTGAGAA
AGCAAATGATAGAGCATGCTGAAAATTTAGAGTTCGAAGAAGCAGCAAGAATAAAAAAATTATTGCAAGGTTAA

Upstream 100 bases:

>100_bases
TGTTGGTTAATGTTTTATGGCTTTACGATAGCTATACAACTTATCTTAAAAGCAATATAGTGTTTACTATACAATGAATC
AAAGATAGTAAGTAAAGTCT

Downstream 100 bases:

>100_bases
GTAATATATGATGCTATGGGCATAGTATAAAAATGGTATCCGTTCAGGAGAGTGGTTTAAGAAACAATAGATAGGAGATT
TTGGAAAGGATTGAGACCCC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MEFQIATHFQPAGDQPQAIDSLIAGLNSNKRDQVLLGVTGSGKTFTMANVIARTNRPALIMAHNKTLAAQLYEEMKGLFP
HNAVEYFISYYDYYQPEAYLPQTDTYIEKDSAINERIEMLRYSTVCSLLERRDTIVVASVSCIYGLGSPESYRSMIIPLS
VGNKIRINDFLSNLTDLQYKRSDARFERGYFRVRGDIVDIFLSHYENKAWRLSLFGDEIEEISEVDAITGNVTKGVNKIT
IFPNSYYITPREALLQAIELVKKELHERLDYYYSQNKIVEAKRLEQRTNFDIEMMRTTGICKGIENYSRYLYGMEAGDPP
PTLFEYLPKDVILFVDESHVTVPQVGAMYSGNEARKKKLIDYGFRLPSAFDNRPLKFEEWEGVRPQTVYISATPGKYELA
KTNNVFIEQVIRPTGLTDPICIVKPIESQIDDVIHEAQVTIGKGFCVLITTLTKKMAENLAEYMSELNMKVSYLHSDIAA
LERIEIIYKLRSKEIDVLVGVNLLREGLDIPECGLVAILDADKEGFLRSETSLIQTIGRAARNAEGRVILYADKITGSLD
RALRETERRRKKQEEHNILHNIIPKTIIKPISNTLQERAIAEPKVNTNKDDLRKQMIEHAENLEFEEAARIKKLLQG

Sequences:

>Translated_637_residues
MEFQIATHFQPAGDQPQAIDSLIAGLNSNKRDQVLLGVTGSGKTFTMANVIARTNRPALIMAHNKTLAAQLYEEMKGLFP
HNAVEYFISYYDYYQPEAYLPQTDTYIEKDSAINERIEMLRYSTVCSLLERRDTIVVASVSCIYGLGSPESYRSMIIPLS
VGNKIRINDFLSNLTDLQYKRSDARFERGYFRVRGDIVDIFLSHYENKAWRLSLFGDEIEEISEVDAITGNVTKGVNKIT
IFPNSYYITPREALLQAIELVKKELHERLDYYYSQNKIVEAKRLEQRTNFDIEMMRTTGICKGIENYSRYLYGMEAGDPP
PTLFEYLPKDVILFVDESHVTVPQVGAMYSGNEARKKKLIDYGFRLPSAFDNRPLKFEEWEGVRPQTVYISATPGKYELA
KTNNVFIEQVIRPTGLTDPICIVKPIESQIDDVIHEAQVTIGKGFCVLITTLTKKMAENLAEYMSELNMKVSYLHSDIAA
LERIEIIYKLRSKEIDVLVGVNLLREGLDIPECGLVAILDADKEGFLRSETSLIQTIGRAARNAEGRVILYADKITGSLD
RALRETERRRKKQEEHNILHNIIPKTIIKPISNTLQERAIAEPKVNTNKDDLRKQMIEHAENLEFEEAARIKKLLQG
>Mature_637_residues
MEFQIATHFQPAGDQPQAIDSLIAGLNSNKRDQVLLGVTGSGKTFTMANVIARTNRPALIMAHNKTLAAQLYEEMKGLFP
HNAVEYFISYYDYYQPEAYLPQTDTYIEKDSAINERIEMLRYSTVCSLLERRDTIVVASVSCIYGLGSPESYRSMIIPLS
VGNKIRINDFLSNLTDLQYKRSDARFERGYFRVRGDIVDIFLSHYENKAWRLSLFGDEIEEISEVDAITGNVTKGVNKIT
IFPNSYYITPREALLQAIELVKKELHERLDYYYSQNKIVEAKRLEQRTNFDIEMMRTTGICKGIENYSRYLYGMEAGDPP
PTLFEYLPKDVILFVDESHVTVPQVGAMYSGNEARKKKLIDYGFRLPSAFDNRPLKFEEWEGVRPQTVYISATPGKYELA
KTNNVFIEQVIRPTGLTDPICIVKPIESQIDDVIHEAQVTIGKGFCVLITTLTKKMAENLAEYMSELNMKVSYLHSDIAA
LERIEIIYKLRSKEIDVLVGVNLLREGLDIPECGLVAILDADKEGFLRSETSLIQTIGRAARNAEGRVILYADKITGSLD
RALRETERRRKKQEEHNILHNIIPKTIIKPISNTLQERAIAEPKVNTNKDDLRKQMIEHAENLEFEEAARIKKLLQG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=659, Percent_Identity=54.1729893778452, Blast_Score=716, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 72705; Mature: 72705

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFQIATHFQPAGDQPQAIDSLIAGLNSNKRDQVLLGVTGSGKTFTMANVIARTNRPALI
CCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCEEHHHHHHHHCCCCEEE
MAHNKTLAAQLYEEMKGLFPHNAVEYFISYYDYYQPEAYLPQTDTYIEKDSAINERIEML
EECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCCHHHHHHHHHHH
RYSTVCSLLERRDTIVVASVSCIYGLGSPESYRSMIIPLSVGNKIRINDFLSNLTDLQYK
HHHHHHHHHHCCCEEEEEEEHHHHCCCCCCCCCEEEEEEECCCEEEHHHHHHHHHHHHHH
RSDARFERGYFRVRGDIVDIFLSHYENKAWRLSLFGDEIEEISEVDAITGNVTKGVNKIT
HCCHHHHCCEEEEEHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCHHHCCCEEEE
IFPNSYYITPREALLQAIELVKKELHERLDYYYSQNKIVEAKRLEQRTNFDIEMMRTTGI
ECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEHHHHHH
CKGIENYSRYLYGMEAGDPPPTLFEYLPKDVILFVDESHVTVPQVGAMYSGNEARKKKLI
HHHHHHHHHHEEECCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHH
DYGFRLPSAFDNRPLKFEEWEGVRPQTVYISATPGKYELAKTNNVFIEQVIRPTGLTDPI
HHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHCCCCCCCCE
CIVKPIESQIDDVIHEAQVTIGKGFCVLITTLTKKMAENLAEYMSELNMKVSYLHSDIAA
EEEECHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LERIEIIYKLRSKEIDVLVGVNLLREGLDIPECGLVAILDADKEGFLRSETSLIQTIGRA
HHHHHHHHHHHCCCCCCEECHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
ARNAEGRVILYADKITGSLDRALRETERRRKKQEEHNILHNIIPKTIIKPISNTLQERAI
HCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AEPKVNTNKDDLRKQMIEHAENLEFEEAARIKKLLQG
CCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MEFQIATHFQPAGDQPQAIDSLIAGLNSNKRDQVLLGVTGSGKTFTMANVIARTNRPALI
CCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCEEHHHHHHHHCCCCEEE
MAHNKTLAAQLYEEMKGLFPHNAVEYFISYYDYYQPEAYLPQTDTYIEKDSAINERIEML
EECCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHCCHHHHHHHHHHH
RYSTVCSLLERRDTIVVASVSCIYGLGSPESYRSMIIPLSVGNKIRINDFLSNLTDLQYK
HHHHHHHHHHCCCEEEEEEEHHHHCCCCCCCCCEEEEEEECCCEEEHHHHHHHHHHHHHH
RSDARFERGYFRVRGDIVDIFLSHYENKAWRLSLFGDEIEEISEVDAITGNVTKGVNKIT
HCCHHHHCCEEEEEHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCHHHCCCEEEE
IFPNSYYITPREALLQAIELVKKELHERLDYYYSQNKIVEAKRLEQRTNFDIEMMRTTGI
ECCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEHHHHHH
CKGIENYSRYLYGMEAGDPPPTLFEYLPKDVILFVDESHVTVPQVGAMYSGNEARKKKLI
HHHHHHHHHHEEECCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHH
DYGFRLPSAFDNRPLKFEEWEGVRPQTVYISATPGKYELAKTNNVFIEQVIRPTGLTDPI
HHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEECCCCHHHHHHHCCCCCCCCE
CIVKPIESQIDDVIHEAQVTIGKGFCVLITTLTKKMAENLAEYMSELNMKVSYLHSDIAA
EEEECHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LERIEIIYKLRSKEIDVLVGVNLLREGLDIPECGLVAILDADKEGFLRSETSLIQTIGRA
HHHHHHHHHHHCCCCCCEECHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
ARNAEGRVILYADKITGSLDRALRETERRRKKQEEHNILHNIIPKTIIKPISNTLQERAI
HCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AEPKVNTNKDDLRKQMIEHAENLEFEEAARIKKLLQG
CCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA