Click here to switch to the map view.

The map label for this gene is uppS [H]

Identifier: 225630153

GI number: 225630153

Start: 367785

End: 368480

Strand: Reverse

Name: uppS [H]

Synonym: WRi_003420

Alternate gene names: 225630153

Gene position: 368480-367785 (Counterclockwise)

Preceding gene: 225630154

Following gene: 225630152

Centisome position: 25.48

GC content: 31.61

Gene sequence:

>696_bases
ATGTTGAATCAAGAATCTTTACCGAAACATTTAGCAATTATTATGGATGGTAATGGTAGATGGGCAAACAATCAAGGAAG
AGTAAAAATTGATGGTTATAAAAAGGGCAGTGAAGTTGCATACGATATTGCCAAGTATTGTACGGACTTAACCATACCCT
ACTTAACTTTGTATGCATTCTCTATGGAGAATTGGCTTAGACCTAAAAACGAAACTGACTGTCTATTTGATTTATTTTAC
TCCGTTTTAACTAATGAAGATAAAGTCAATTTCATTTGCAACTGTAACATTAAGTTGAATTTTATTGGCAATTTAAGTCT
GTTACCCAGTAAAATATTGGATCAAATTAAAAAAGCAGAAGAAATGACACATAAGAACGATGGTTTATTACTCACTGTGG
CAGTCAGTTACGGAGCAAAGCAAGAAATTACACAAGCTATAAGCAATATTATAAAAGAAAATATTGCTTATGTATCAGAA
GAGGAATTTGAAAAATTTCTGTATACTAAAGATTTGCCAAAATTGGATTTATTAATTCGCACTGGCGGCGAAAAAAGGTT
AAGCAACTTTTTATTATGGCAAGCAGCTTATGCTGAATTGTATTTTTGTGATACTTTGTGGCCTGATTTTTCTTGTCAAG
ATTTGAGCAAAGCATTAGAAGATTATACAAAAAGAGAGAAGAAATATGGTAGATAA

Upstream 100 bases:

>100_bases
CTACAGTAACTCTCTTCCTGTCATGCAAGTAGCTGACACCTTCCAGGTGTCCATTGAAATCCAAAAAATTTCACTCAAGT
CAAAATTAGGTTAAATTTAA

Downstream 100 bases:

>100_bases
TAATTTTATAGTTAGAATGTTGTCCTCAATAGTAATATTATTCATATTTTCTTTTGCTACATATTTCAGTGATTTATCGT
TTTACCTATTGATTTTTTCG

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase 1; Di-trans,poly-cis-decaprenylcistransferase 1; Undecaprenyl diphosphate synthase 1; UDS 1 [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MLNQESLPKHLAIIMDGNGRWANNQGRVKIDGYKKGSEVAYDIAKYCTDLTIPYLTLYAFSMENWLRPKNETDCLFDLFY
SVLTNEDKVNFICNCNIKLNFIGNLSLLPSKILDQIKKAEEMTHKNDGLLLTVAVSYGAKQEITQAISNIIKENIAYVSE
EEFEKFLYTKDLPKLDLLIRTGGEKRLSNFLLWQAAYAELYFCDTLWPDFSCQDLSKALEDYTKREKKYGR

Sequences:

>Translated_231_residues
MLNQESLPKHLAIIMDGNGRWANNQGRVKIDGYKKGSEVAYDIAKYCTDLTIPYLTLYAFSMENWLRPKNETDCLFDLFY
SVLTNEDKVNFICNCNIKLNFIGNLSLLPSKILDQIKKAEEMTHKNDGLLLTVAVSYGAKQEITQAISNIIKENIAYVSE
EEFEKFLYTKDLPKLDLLIRTGGEKRLSNFLLWQAAYAELYFCDTLWPDFSCQDLSKALEDYTKREKKYGR
>Mature_231_residues
MLNQESLPKHLAIIMDGNGRWANNQGRVKIDGYKKGSEVAYDIAKYCTDLTIPYLTLYAFSMENWLRPKNETDCLFDLFY
SVLTNEDKVNFICNCNIKLNFIGNLSLLPSKILDQIKKAEEMTHKNDGLLLTVAVSYGAKQEITQAISNIIKENIAYVSE
EEFEKFLYTKDLPKLDLLIRTGGEKRLSNFLLWQAAYAELYFCDTLWPDFSCQDLSKALEDYTKREKKYGR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=223, Percent_Identity=34.0807174887892, Blast_Score=131, Evalue=5e-31,
Organism=Homo sapiens, GI45580738, Length=223, Percent_Identity=34.0807174887892, Blast_Score=131, Evalue=6e-31,
Organism=Escherichia coli, GI1786371, Length=236, Percent_Identity=41.9491525423729, Blast_Score=197, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI71993029, Length=229, Percent_Identity=34.9344978165939, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6319474, Length=210, Percent_Identity=32.8571428571429, Blast_Score=113, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323748, Length=216, Percent_Identity=31.4814814814815, Blast_Score=107, Evalue=1e-24,
Organism=Drosophila melanogaster, GI18857969, Length=214, Percent_Identity=36.9158878504673, Blast_Score=149, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 26694; Mature: 26694

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNQESLPKHLAIIMDGNGRWANNQGRVKIDGYKKGSEVAYDIAKYCTDLTIPYLTLYAF
CCCCCCCCCEEEEEECCCCCEECCCCCEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
SMENWLRPKNETDCLFDLFYSVLTNEDKVNFICNCNIKLNFIGNLSLLPSKILDQIKKAE
HHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCEEEEEECCCCCCHHHHHHHHHHHH
EMTHKNDGLLLTVAVSYGAKQEITQAISNIIKENIAYVSEEEFEKFLYTKDLPKLDLLIR
HHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEE
TGGEKRLSNFLLWQAAYAELYFCDTLWPDFSCQDLSKALEDYTKREKKYGR
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLNQESLPKHLAIIMDGNGRWANNQGRVKIDGYKKGSEVAYDIAKYCTDLTIPYLTLYAF
CCCCCCCCCEEEEEECCCCCEECCCCCEEECCCCCCHHHHHHHHHHHHHCCHHHHHHHHH
SMENWLRPKNETDCLFDLFYSVLTNEDKVNFICNCNIKLNFIGNLSLLPSKILDQIKKAE
HHHHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCEEEEEECCCCCCHHHHHHHHHHHH
EMTHKNDGLLLTVAVSYGAKQEITQAISNIIKENIAYVSEEEFEKFLYTKDLPKLDLLIR
HHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEE
TGGEKRLSNFLLWQAAYAELYFCDTLWPDFSCQDLSKALEDYTKREKKYGR
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]