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The map label for this gene is murC

Identifier: 225630075

GI number: 225630075

Start: 261547

End: 262971

Strand: Direct

Name: murC

Synonym: WRi_002500

Alternate gene names: 225630075

Gene position: 261547-262971 (Clockwise)

Preceding gene: 225630070

Following gene: 225630076

Centisome position: 18.09

GC content: 33.75

Gene sequence:

>1425_bases
ATGAGGATTTTAAATTATACTATAATAAATTTAGTAATGAGTAAACATCTACTGCTAAATATTAACAAAACTCAAAAAGG
AATAATACATATTATTGGTATAGGTGGAATTGGAATGAGCGCTATTGCTGAAATTCTTCACAATTCCAATTACAAAGTTC
AAGGCAGTGATGCGCAGTCAAACAACAATGTAGATAGATTACAAAAGCTGGGTATAGAAGTTTACATTGGTCACAATGCT
AATAATATAAGCCAAGCTCAAATAGTTGTACATTCTTCTGCGATAGAATCTGATAATGTGGAATTAGTAACAGCGAGAAA
TAACAATAAAACCATTTTGCATAGATCAGACATACTTGCTGAACTTTTAAGAGATAAATATGTGATAGCGGTTTCAGGTT
CGAGCGGTAAGACAACGACAACAGCAATGATTGCTTCCATTTTTGATCATTCTAATATCGATGCAACTGTAATTGTGGGA
GGAATACTAAATTCGTATCAGAGTAATTCAAGACTTGGAAAGAGTGACATTTTTTTAATCGAAGCTGATGAGTCTGATGG
AACCATGCTAAAAATTCCTGCAAATATTACTGTCATAACGAGTATTAACGACGATCATATGGATCATTATGGTACATTTG
ACGATATTAAGCATGCATTCTCTCAATTTATAAATAAAGCAGATTTTGCAATTTTGCCTGATTCTGTAGGCATTAATTAT
GATGCAAGTAACTCTATGATGTTTGGGTTTGAAAGTGGTAACATTAGAGCCAGCAACATTAAACAGCATGCTAACAGCAT
AGAATTTGACGTGTTGATTGACAATAACCACAGAATAAAAAACGTAGTACTATCAAACACAATAGGAATGCATAAAGTCA
GTAACGCACTAGCTGCAATATCAGTTGCGATAAAGCTCGGAATTAGCGATGCAGAGATTAAAAAAGGCCTTTTGGAATTT
CAAGGAGTAGCAAGAAGATTCTCTTTGATTGCCGATATTAAAGGTGTTAAGTTAATTGAGGATTATGCCCATCATCCAAA
TGAAATATATGCAACTTTAACGGCTGCACGTTCGATTACTAAAGGAAAAGTAATAGGAATTATCGAACCACTTCGTTTTG
CCCGCATTCGTAATTTTTTTGATGAATTCATACGAATTTTCATGATGTTTGATTATGTCATCCTCACTCCTGTTCATCCC
CCAGAAGACAAGCCTATTCCTGGTTGTGGGATTGATGATATACAAAAAGCTTTAATCAGTAATGGATTTAATAACACAAA
AATTATGAATGATGCTTTGCTCATTTCACATTTTATTAGTGATTCGACAAGTCCAAGTGATATAGTATTATTTATTGGTG
CTGGTAGTAATATAGCTAAGCTAGCAAAAGAAACTGCAGCACTTATTGCGGAAGTTAAGGTTTAA

Upstream 100 bases:

>100_bases
TTAAACCTGTTGCTAAAACTGCAACTACTCATCAAAACGAATATTAGACATAGGAAGGCTAGGTTTTTTATCATTGTATT
CGGTAAGAGGGTTCGATACT

Downstream 100 bases:

>100_bases
TGTAATGAATAAGATAATCAATAACGTATTTGCAAGAGAAATTTTAGATAGCAGGGGTTACCCCACTATTGAGGTAGAAA
TTGAGCTCTGTGATGGCGCA

Product: UDP-N-acetylmuramate-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MRILNYTIINLVMSKHLLLNINKTQKGIIHIIGIGGIGMSAIAEILHNSNYKVQGSDAQSNNNVDRLQKLGIEVYIGHNA
NNISQAQIVVHSSAIESDNVELVTARNNNKTILHRSDILAELLRDKYVIAVSGSSGKTTTTAMIASIFDHSNIDATVIVG
GILNSYQSNSRLGKSDIFLIEADESDGTMLKIPANITVITSINDDHMDHYGTFDDIKHAFSQFINKADFAILPDSVGINY
DASNSMMFGFESGNIRASNIKQHANSIEFDVLIDNNHRIKNVVLSNTIGMHKVSNALAAISVAIKLGISDAEIKKGLLEF
QGVARRFSLIADIKGVKLIEDYAHHPNEIYATLTAARSITKGKVIGIIEPLRFARIRNFFDEFIRIFMMFDYVILTPVHP
PEDKPIPGCGIDDIQKALISNGFNNTKIMNDALLISHFISDSTSPSDIVLFIGAGSNIAKLAKETAALIAEVKV

Sequences:

>Translated_474_residues
MRILNYTIINLVMSKHLLLNINKTQKGIIHIIGIGGIGMSAIAEILHNSNYKVQGSDAQSNNNVDRLQKLGIEVYIGHNA
NNISQAQIVVHSSAIESDNVELVTARNNNKTILHRSDILAELLRDKYVIAVSGSSGKTTTTAMIASIFDHSNIDATVIVG
GILNSYQSNSRLGKSDIFLIEADESDGTMLKIPANITVITSINDDHMDHYGTFDDIKHAFSQFINKADFAILPDSVGINY
DASNSMMFGFESGNIRASNIKQHANSIEFDVLIDNNHRIKNVVLSNTIGMHKVSNALAAISVAIKLGISDAEIKKGLLEF
QGVARRFSLIADIKGVKLIEDYAHHPNEIYATLTAARSITKGKVIGIIEPLRFARIRNFFDEFIRIFMMFDYVILTPVHP
PEDKPIPGCGIDDIQKALISNGFNNTKIMNDALLISHFISDSTSPSDIVLFIGAGSNIAKLAKETAALIAEVKV
>Mature_474_residues
MRILNYTIINLVMSKHLLLNINKTQKGIIHIIGIGGIGMSAIAEILHNSNYKVQGSDAQSNNNVDRLQKLGIEVYIGHNA
NNISQAQIVVHSSAIESDNVELVTARNNNKTILHRSDILAELLRDKYVIAVSGSSGKTTTTAMIASIFDHSNIDATVIVG
GILNSYQSNSRLGKSDIFLIEADESDGTMLKIPANITVITSINDDHMDHYGTFDDIKHAFSQFINKADFAILPDSVGINY
DASNSMMFGFESGNIRASNIKQHANSIEFDVLIDNNHRIKNVVLSNTIGMHKVSNALAAISVAIKLGISDAEIKKGLLEF
QGVARRFSLIADIKGVKLIEDYAHHPNEIYATLTAARSITKGKVIGIIEPLRFARIRNFFDEFIRIFMMFDYVILTPVHP
PEDKPIPGCGIDDIQKALISNGFNNTKIMNDALLISHFISDSTSPSDIVLFIGAGSNIAKLAKETAALIAEVKV

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=472, Percent_Identity=32.8389830508475, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1790680, Length=365, Percent_Identity=29.3150684931507, Blast_Score=148, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_WOLWR (C0R5N3)

Other databases:

- EMBL:   CP001391
- RefSeq:   YP_002726866.1
- EnsemblBacteria:   EBWOLT00000002131
- GeneID:   7668991
- GenomeReviews:   CP001391_GR
- KEGG:   wri:WRi_002500
- GeneTree:   EBGT00050000031214
- OMA:   YQPHRYS
- ProtClustDB:   CLSK739925
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51837; Mature: 51837

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILNYTIINLVMSKHLLLNINKTQKGIIHIIGIGGIGMSAIAEILHNSNYKVQGSDAQS
CEEEHHHHHHHHHHCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEECCCCCC
NNNVDRLQKLGIEVYIGHNANNISQAQIVVHSSAIESDNVELVTARNNNKTILHRSDILA
CCCHHHHHHCCEEEEECCCCCCCCEEEEEEEECCCCCCCEEEEEEECCCCEEEEHHHHHH
ELLRDKYVIAVSGSSGKTTTTAMIASIFDHSNIDATVIVGGILNSYQSNSRLGKSDIFLI
HHHHCCEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEHHHHHHCCCCCCCCCEEEEE
EADESDGTMLKIPANITVITSINDDHMDHYGTFDDIKHAFSQFINKADFAILPDSVGINY
EECCCCCCEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCC
DASNSMMFGFESGNIRASNIKQHANSIEFDVLIDNNHRIKNVVLSNTIGMHKVSNALAAI
CCCCCEEEEEECCCEEHHHHHHHCCCEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHE
SVAIKLGISDAEIKKGLLEFQGVARRFSLIADIKGVKLIEDYAHHPNEIYATLTAARSIT
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHEEHHHHHHHCC
KGKVIGIIEPLRFARIRNFFDEFIRIFMMFDYVILTPVHPPEDKPIPGCGIDDIQKALIS
CCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHH
NGFNNTKIMNDALLISHFISDSTSPSDIVLFIGAGSNIAKLAKETAALIAEVKV
CCCCCCEEEHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MRILNYTIINLVMSKHLLLNINKTQKGIIHIIGIGGIGMSAIAEILHNSNYKVQGSDAQS
CEEEHHHHHHHHHHCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHHCCCCEEECCCCCC
NNNVDRLQKLGIEVYIGHNANNISQAQIVVHSSAIESDNVELVTARNNNKTILHRSDILA
CCCHHHHHHCCEEEEECCCCCCCCEEEEEEEECCCCCCCEEEEEEECCCCEEEEHHHHHH
ELLRDKYVIAVSGSSGKTTTTAMIASIFDHSNIDATVIVGGILNSYQSNSRLGKSDIFLI
HHHHCCEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEEEHHHHHHCCCCCCCCCEEEEE
EADESDGTMLKIPANITVITSINDDHMDHYGTFDDIKHAFSQFINKADFAILPDSVGINY
EECCCCCCEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEECCCCCCCC
DASNSMMFGFESGNIRASNIKQHANSIEFDVLIDNNHRIKNVVLSNTIGMHKVSNALAAI
CCCCCEEEEEECCCEEHHHHHHHCCCEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHE
SVAIKLGISDAEIKKGLLEFQGVARRFSLIADIKGVKLIEDYAHHPNEIYATLTAARSIT
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHEEHHHHHHHCC
KGKVIGIIEPLRFARIRNFFDEFIRIFMMFDYVILTPVHPPEDKPIPGCGIDDIQKALIS
CCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHHHHHH
NGFNNTKIMNDALLISHFISDSTSPSDIVLFIGAGSNIAKLAKETAALIAEVKV
CCCCCCEEEHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA