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The map label for this gene is ahcY [H]

Identifier: 222526500

GI number: 222526500

Start: 4073808

End: 4075070

Strand: Reverse

Name: ahcY [H]

Synonym: Chy400_3267

Alternate gene names: 222526500

Gene position: 4075070-4073808 (Counterclockwise)

Preceding gene: 222526501

Following gene: 222526499

Centisome position: 77.34

GC content: 58.04

Gene sequence:

>1263_bases
ATGACCGTAAGCTACGACATCAAAGATATCAATCTGGCCGAGCAAGGCCGCAAGCGCATTGAGTGGGCCGAAAAAGAGAT
GCCCGTGCTGCGCCTGATCCGCGAGCGCTTTGCCCGCGAGCGCCCACTGGCCGGTCTGCGCATCAGCGCCTGTCTGCACG
TTACCACCGAGACTGCCAACCTCATGCGGACTTTGGCTGCTGGCGGTGCCGACGTGGTGCTGGTTGCATCCAACCCTCTG
AGCACGCAGGATGACGTTGCTGCTGCTCTGGTGGCCTATGAAGAGATTCCGGTTTTCGCAATCAAAGGCGAAAGCAACGA
GGTGTATTACAGCCACATCCGGGCTGCGCTCGATCACAATCCGCAGTTAACCATGGACGACGGCGCCGATCTGGTGACCG
GTGTGCTGAGGGATCGCCCCGATCTGATCCCACACATGGTCGGTAGCACCGAAGAGACTACAACCGGCGTCATTCGCCTG
AAGGCGATGGCCAAAGAGGGTGTCCTGCCGTTCCCGGTCATCGCTGTGAACGACAGTGACACCAAGCACATGTTCGATAA
CCGGTACGGCACCGGTCAAAGCACGCTCGACGGGATTATTCGCGCTACCAATATTCTGCTGGCCGGCAAGACCTTTGTGG
TTGCCGGTTATGGCTGGTGCTCACGCGGGATTGCCGAGCGCGCACGCGGCCTGGGGGCGAATGTGATTGTGACCGAAGTT
GATCCCATCAAGGCGCTTGAAGCAGTGATGGACGGCTTCCGGGTGATGCCAATGGAAGAGGCTGCATCTCAGGCCGATTT
CATCGTCACTGCAACCGGCAACAAGCACGTGATCGACAGCAATGCCTTTGCCGTTATGAAAGACGGTTGTGTGATCGCGA
ATAGTGGTCACTTCAACGTCGAGATCAATATTCCTGCGCTCGAGGCACTGAGTGTTGAAAAGCGGCAGCCGCGTGCGTTT
GTTGACCAGTACATTCTGCGCGATGGCCGGGCGATCAACCTGCTCGGTGAAGGACGGCTGATTAATCTGGCCAGTGCAGA
AGGCCATCCGAGCGCGGTGATGGATATGAGCTTCGCCAATCAGGCGCTGGCCAGCGAGTTTTTGTTGCGCAACCAGGGCA
AACTACCGGTTGGTGTGCATGCCCTGCCCAAAGAGCTGGATCGCGAGATTGCAGCGCTGAAGTTGGCGGCGATGGGCATC
AAGATCGACACCCTCACCGCCGAACAAGAGGCGTATCTCAATTCCTGGCAAGAGGGCACGTAA

Upstream 100 bases:

>100_bases
CTGCTACTGCCACACATACTGTTGTCCACCAGCCGACACTCACACCGGAATGGCCGGTCGGCACGTCGCCTGGTTATTAG
TAAAGGAGAGTCTACCAGCT

Downstream 100 bases:

>100_bases
TTCGTTGTTCTTCTACAGCGGCGTGACGGTGTGATCGGTGCATCACATCGCCACGCCGCAAGCAACCATCATTGCCTCGT
TGCAGCCTTCCATTAACAAG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTVSYDIKDINLAEQGRKRIEWAEKEMPVLRLIRERFARERPLAGLRISACLHVTTETANLMRTLAAGGADVVLVASNPL
STQDDVAAALVAYEEIPVFAIKGESNEVYYSHIRAALDHNPQLTMDDGADLVTGVLRDRPDLIPHMVGSTEETTTGVIRL
KAMAKEGVLPFPVIAVNDSDTKHMFDNRYGTGQSTLDGIIRATNILLAGKTFVVAGYGWCSRGIAERARGLGANVIVTEV
DPIKALEAVMDGFRVMPMEEAASQADFIVTATGNKHVIDSNAFAVMKDGCVIANSGHFNVEINIPALEALSVEKRQPRAF
VDQYILRDGRAINLLGEGRLINLASAEGHPSAVMDMSFANQALASEFLLRNQGKLPVGVHALPKELDREIAALKLAAMGI
KIDTLTAEQEAYLNSWQEGT

Sequences:

>Translated_420_residues
MTVSYDIKDINLAEQGRKRIEWAEKEMPVLRLIRERFARERPLAGLRISACLHVTTETANLMRTLAAGGADVVLVASNPL
STQDDVAAALVAYEEIPVFAIKGESNEVYYSHIRAALDHNPQLTMDDGADLVTGVLRDRPDLIPHMVGSTEETTTGVIRL
KAMAKEGVLPFPVIAVNDSDTKHMFDNRYGTGQSTLDGIIRATNILLAGKTFVVAGYGWCSRGIAERARGLGANVIVTEV
DPIKALEAVMDGFRVMPMEEAASQADFIVTATGNKHVIDSNAFAVMKDGCVIANSGHFNVEINIPALEALSVEKRQPRAF
VDQYILRDGRAINLLGEGRLINLASAEGHPSAVMDMSFANQALASEFLLRNQGKLPVGVHALPKELDREIAALKLAAMGI
KIDTLTAEQEAYLNSWQEGT
>Mature_419_residues
TVSYDIKDINLAEQGRKRIEWAEKEMPVLRLIRERFARERPLAGLRISACLHVTTETANLMRTLAAGGADVVLVASNPLS
TQDDVAAALVAYEEIPVFAIKGESNEVYYSHIRAALDHNPQLTMDDGADLVTGVLRDRPDLIPHMVGSTEETTTGVIRLK
AMAKEGVLPFPVIAVNDSDTKHMFDNRYGTGQSTLDGIIRATNILLAGKTFVVAGYGWCSRGIAERARGLGANVIVTEVD
PIKALEAVMDGFRVMPMEEAASQADFIVTATGNKHVIDSNAFAVMKDGCVIANSGHFNVEINIPALEALSVEKRQPRAFV
DQYILRDGRAINLLGEGRLINLASAEGHPSAVMDMSFANQALASEFLLRNQGKLPVGVHALPKELDREIAALKLAAMGIK
IDTLTAEQEAYLNSWQEGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=414, Percent_Identity=46.6183574879227, Blast_Score=348, Evalue=4e-96,
Organism=Homo sapiens, GI239937451, Length=390, Percent_Identity=46.6666666666667, Blast_Score=328, Evalue=4e-90,
Organism=Homo sapiens, GI298286489, Length=413, Percent_Identity=40.9200968523002, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI195539349, Length=413, Percent_Identity=40.9200968523002, Blast_Score=306, Evalue=3e-83,
Organism=Homo sapiens, GI195539337, Length=413, Percent_Identity=40.9200968523002, Blast_Score=305, Evalue=7e-83,
Organism=Homo sapiens, GI24308043, Length=413, Percent_Identity=40.9200968523002, Blast_Score=305, Evalue=7e-83,
Organism=Homo sapiens, GI21361647, Length=414, Percent_Identity=39.8550724637681, Blast_Score=283, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17506425, Length=417, Percent_Identity=44.8441247002398, Blast_Score=336, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6320882, Length=435, Percent_Identity=44.367816091954, Blast_Score=333, Evalue=3e-92,
Organism=Drosophila melanogaster, GI24642172, Length=420, Percent_Identity=46.9047619047619, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI24656245, Length=402, Percent_Identity=39.8009950248756, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI45553387, Length=412, Percent_Identity=40.7766990291262, Blast_Score=271, Evalue=4e-73,
Organism=Drosophila melanogaster, GI45553385, Length=412, Percent_Identity=40.2912621359223, Blast_Score=271, Evalue=5e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 45604; Mature: 45473

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00738 ADOHCYASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSYDIKDINLAEQGRKRIEWAEKEMPVLRLIRERFARERPLAGLRISACLHVTTETAN
CEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEHHHHH
LMRTLAAGGADVVLVASNPLSTQDDVAAALVAYEEIPVFAIKGESNEVYYSHIRAALDHN
HHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHCCC
PQLTMDDGADLVTGVLRDRPDLIPHMVGSTEETTTGVIRLKAMAKEGVLPFPVIAVNDSD
CCEEECCCHHHHHHHHHCCCCHHHHHCCCCCCCHHEEEEEEEHHHCCCCCCEEEEECCCC
TKHMFDNRYGTGQSTLDGIIRATNILLAGKTFVVAGYGWCSRGIAERARGLGANVIVTEV
CHHHHCCCCCCCHHHHHHHHHHHEEEEECCEEEEEECCHHHHHHHHHHHCCCCEEEEECC
DPIKALEAVMDGFRVMPMEEAASQADFIVTATGNKHVIDSNAFAVMKDGCVIANSGHFNV
CHHHHHHHHHCCCEECCHHHHCCCCCEEEEECCCCEEECCCCEEEEECCEEEECCCEEEE
EINIPALEALSVEKRQPRAFVDQYILRDGRAINLLGEGRLINLASAEGHPSAVMDMSFAN
EEECCCHHHHCCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCCCEEEHHHHH
QALASEFLLRNQGKLPVGVHALPKELDREIAALKLAAMGIKIDTLTAEQEAYLNSWQEGT
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEEECCHHHHHHHCCCCCC
>Mature Secondary Structure 
TVSYDIKDINLAEQGRKRIEWAEKEMPVLRLIRERFARERPLAGLRISACLHVTTETAN
EEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEEEEEEHHHHH
LMRTLAAGGADVVLVASNPLSTQDDVAAALVAYEEIPVFAIKGESNEVYYSHIRAALDHN
HHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHCCC
PQLTMDDGADLVTGVLRDRPDLIPHMVGSTEETTTGVIRLKAMAKEGVLPFPVIAVNDSD
CCEEECCCHHHHHHHHHCCCCHHHHHCCCCCCCHHEEEEEEEHHHCCCCCCEEEEECCCC
TKHMFDNRYGTGQSTLDGIIRATNILLAGKTFVVAGYGWCSRGIAERARGLGANVIVTEV
CHHHHCCCCCCCHHHHHHHHHHHEEEEECCEEEEEECCHHHHHHHHHHHCCCCEEEEECC
DPIKALEAVMDGFRVMPMEEAASQADFIVTATGNKHVIDSNAFAVMKDGCVIANSGHFNV
CHHHHHHHHHCCCEECCHHHHCCCCCEEEEECCCCEEECCCCEEEEECCEEEECCCEEEE
EINIPALEALSVEKRQPRAFVDQYILRDGRAINLLGEGRLINLASAEGHPSAVMDMSFAN
EEECCCHHHHCCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEEECCCCCCCCEEEHHHHH
QALASEFLLRNQGKLPVGVHALPKELDREIAALKLAAMGIKIDTLTAEQEAYLNSWQEGT
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEEEEEECCHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]