Click here to switch to the map view.

The map label for this gene is panE [C]

Identifier: 222526330

GI number: 222526330

Start: 3821021

End: 3821941

Strand: Reverse

Name: panE [C]

Synonym: Chy400_3096

Alternate gene names: 222526330

Gene position: 3821941-3821021 (Counterclockwise)

Preceding gene: 222526336

Following gene: 222526326

Centisome position: 72.54

GC content: 59.07

Gene sequence:

>921_bases
ATGAAGATCGCGATTATCGGCGCCGGTGCCCTGGGGAGCGTGATTGGATTCCATCTGGCAGCCAATCACGCCGTCACGCT
GGTAGACCCGTGGGAAGAGCACGTTAACACAATTAACGAGTATGGCCTGCGCTGTAGCTTTGACGATCAAGAGCAGGTGC
GTCTGTTACCGGCTACGACCAGCGCTGACAACCTTGAACCGGTTGAGGTTGCCCTGATTACGGTCAAAGCAGCCCAAACG
CCCTGGGCTGCTGAGATTGCCGCACAGATAGTACAACCGAACGGCGTTGCCTACACGCTGCAAAACGGTCTGGGCAACGC
CGAACGACTCGCCAGCCGGTTGGGAACACAACGGGTCGGGCAGGGGGTGACCACGATTGGTGCGACCTTGCTGGCGCCTG
GACACGTGCGGATGGCCGGTCGTGGCCCCACGACATTTGCCGCAACCCCCTCGCTGCAATTAGCCTACGCCGTCGCCGAT
GCCTTTCGCGCCAGTTCATTACCGGCGGGTGTCTCAACCGATCTGGCAAGTCTGGTATGGGGCAAATTGATCGTCAATAC
CGGGATCAATGCGTTAACGGCTCTACTGCGGGTGCCAAACGGAGCGTTGGCGAACATCCCGGCTGCAGAAAAACTGGTGC
GCCGTGCGGTGGAAGAGGCGGTCGCTGTAGCCTGTGCCGCCGGAATTACGATTGGATTGAGCGACCCGGTAGCCGAAACG
CTGGCAGTTGCGCGGGCTACGGCAACGAATCGCTCATCAATGCTTCAGGATGTACTACGTGGTGCGCCAACCGAAATTGA
CACGATTAACGGGGCAATTGTGCGCGAAGGGCAACGGCTTGGTGTACCAACACCGTTTAACGCCTTCCTCTGCGACTTGA
TCACTGCCCTCGAAGCGACTACACCGCTGCGGGTGAAGTGA

Upstream 100 bases:

>100_bases
GGGAACCAGCAATCAGCCATTTCCAGACATGCTTCATAAAGCACCTTTTCAGTTGCCGTGCTACCATGGTTGTGAGAATA
GTATACCAGAGGTAATTCCT

Downstream 100 bases:

>100_bases
AAATAAGGACGCGGATAAACACGGATGTGGCGGATTATCTGCGTGTATTCGCGTAAACCCGCGTGCATCCGTGTTCTATT
GAACAGGGTACGCGGATGGA

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKIAIIGAGALGSVIGFHLAANHAVTLVDPWEEHVNTINEYGLRCSFDDQEQVRLLPATTSADNLEPVEVALITVKAAQT
PWAAEIAAQIVQPNGVAYTLQNGLGNAERLASRLGTQRVGQGVTTIGATLLAPGHVRMAGRGPTTFAATPSLQLAYAVAD
AFRASSLPAGVSTDLASLVWGKLIVNTGINALTALLRVPNGALANIPAAEKLVRRAVEEAVAVACAAGITIGLSDPVAET
LAVARATATNRSSMLQDVLRGAPTEIDTINGAIVREGQRLGVPTPFNAFLCDLITALEATTPLRVK

Sequences:

>Translated_306_residues
MKIAIIGAGALGSVIGFHLAANHAVTLVDPWEEHVNTINEYGLRCSFDDQEQVRLLPATTSADNLEPVEVALITVKAAQT
PWAAEIAAQIVQPNGVAYTLQNGLGNAERLASRLGTQRVGQGVTTIGATLLAPGHVRMAGRGPTTFAATPSLQLAYAVAD
AFRASSLPAGVSTDLASLVWGKLIVNTGINALTALLRVPNGALANIPAAEKLVRRAVEEAVAVACAAGITIGLSDPVAET
LAVARATATNRSSMLQDVLRGAPTEIDTINGAIVREGQRLGVPTPFNAFLCDLITALEATTPLRVK
>Mature_306_residues
MKIAIIGAGALGSVIGFHLAANHAVTLVDPWEEHVNTINEYGLRCSFDDQEQVRLLPATTSADNLEPVEVALITVKAAQT
PWAAEIAAQIVQPNGVAYTLQNGLGNAERLASRLGTQRVGQGVTTIGATLLAPGHVRMAGRGPTTFAATPSLQLAYAVAD
AFRASSLPAGVSTDLASLVWGKLIVNTGINALTALLRVPNGALANIPAAEKLVRRAVEEAVAVACAAGITIGLSDPVAET
LAVARATATNRSSMLQDVLRGAPTEIDTINGAIVREGQRLGVPTPFNAFLCDLITALEATTPLRVK

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=238, Percent_Identity=29.4117647058824, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 31703; Mature: 31703

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAIIGAGALGSVIGFHLAANHAVTLVDPWEEHVNTINEYGLRCSFDDQEQVRLLPATT
CEEEEEECCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCEEEEECCC
SADNLEPVEVALITVKAAQTPWAAEIAAQIVQPNGVAYTLQNGLGNAERLASRLGTQRVG
CCCCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHC
QGVTTIGATLLAPGHVRMAGRGPTTFAATPSLQLAYAVADAFRASSLPAGVSTDLASLVW
CCHHHHHHHHCCCCCEEECCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GKLIVNTGINALTALLRVPNGALANIPAAEKLVRRAVEEAVAVACAAGITIGLSDPVAET
HHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHH
LAVARATATNRSSMLQDVLRGAPTEIDTINGAIVREGQRLGVPTPFNAFLCDLITALEAT
HHHHHHHHCCHHHHHHHHHCCCCCCEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCC
TPLRVK
CCCCCC
>Mature Secondary Structure
MKIAIIGAGALGSVIGFHLAANHAVTLVDPWEEHVNTINEYGLRCSFDDQEQVRLLPATT
CEEEEEECCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCCEEEEECCC
SADNLEPVEVALITVKAAQTPWAAEIAAQIVQPNGVAYTLQNGLGNAERLASRLGTQRVG
CCCCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHC
QGVTTIGATLLAPGHVRMAGRGPTTFAATPSLQLAYAVADAFRASSLPAGVSTDLASLVW
CCHHHHHHHHCCCCCEEECCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GKLIVNTGINALTALLRVPNGALANIPAAEKLVRRAVEEAVAVACAAGITIGLSDPVAET
HHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCEEECCCHHHHH
LAVARATATNRSSMLQDVLRGAPTEIDTINGAIVREGQRLGVPTPFNAFLCDLITALEAT
HHHHHHHHCCHHHHHHHHHCCCCCCEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCC
TPLRVK
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]