| Definition | Chloroflexus sp. Y-400-fl chromosome, complete genome. |
|---|---|
| Accession | NC_012032 |
| Length | 5,268,950 |
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The map label for this gene is ppiB [H]
Identifier: 222526299
GI number: 222526299
Start: 3783296
End: 3783778
Strand: Reverse
Name: ppiB [H]
Synonym: Chy400_3065
Alternate gene names: 222526299
Gene position: 3783778-3783296 (Counterclockwise)
Preceding gene: 222526300
Following gene: 222526297
Centisome position: 71.81
GC content: 55.49
Gene sequence:
>483_bases GTGGCAAAACAGTGGAGCAGTCCACCCGCAATGCAAATTGATGTCAGTAAGACATATCGGGTCACAATGGAAACAACGCG CGGGACGATTGAACTTGATCTCTACCCGCAACACGCCCCACTCACCGTCAACAACTTCGTCTTTCTGGTACGCGAAGGGT TCTACGATGGCCTGACATTCCACCGCGTTATTAAAGACTTTGTGATCCAGGGAGGCGACCCCACCGGACGCGGAAGCGGC GGCCCAGGCTACCGGTTTCGCGATGAGGTGGTTGGCAACCCGCTCACCCATGAAGCCGGCGTGATTTCGATGGCAAATGC CGGCCCCAACACCAACGGCAGCCAGTTCTTCATTACCCACACGCCACAGCCACACTTGAACGGGCGGCATACCGTCTTTG GGCGAGTTGTCGCCGGCATGGATGTCGTTTACGCCATTAAACAAGGCGACAAAATGACAAAAGTGACGGTGCAAGAGTTG TAG
Upstream 100 bases:
>100_bases GCCTGAGCAGGCTAGCCGGTATACTCCCTATGAGAGGTTTCCAACGCCGGTGAGAGGTATAATAACAGTGGTATCCGTCG AATAACACAGGAGAACAACC
Downstream 100 bases:
>100_bases GTAACGTCAGTTTAGGCTTTAGTCAAAATTGCAGGAATCGGGATTGCAGGTTCTCATACCTCAATCACGTTAAACTGACT CCGGGCACAGACATTCGTGG
Product: peptidylprolyl isomerase
Products: NA
Alternate protein names: PPIase; Rotamase [H]
Number of amino acids: Translated: 160; Mature: 159
Protein sequence:
>160_residues MAKQWSSPPAMQIDVSKTYRVTMETTRGTIELDLYPQHAPLTVNNFVFLVREGFYDGLTFHRVIKDFVIQGGDPTGRGSG GPGYRFRDEVVGNPLTHEAGVISMANAGPNTNGSQFFITHTPQPHLNGRHTVFGRVVAGMDVVYAIKQGDKMTKVTVQEL
Sequences:
>Translated_160_residues MAKQWSSPPAMQIDVSKTYRVTMETTRGTIELDLYPQHAPLTVNNFVFLVREGFYDGLTFHRVIKDFVIQGGDPTGRGSG GPGYRFRDEVVGNPLTHEAGVISMANAGPNTNGSQFFITHTPQPHLNGRHTVFGRVVAGMDVVYAIKQGDKMTKVTVQEL >Mature_159_residues AKQWSSPPAMQIDVSKTYRVTMETTRGTIELDLYPQHAPLTVNNFVFLVREGFYDGLTFHRVIKDFVIQGGDPTGRGSGG PGYRFRDEVVGNPLTHEAGVISMANAGPNTNGSQFFITHTPQPHLNGRHTVFGRVVAGMDVVYAIKQGDKMTKVTVQEL
Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]
COG id: COG0652
COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family
Gene ontology:
Cell location: Periplasmic Protein [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 PPIase cyclophilin-type domain [H]
Homologues:
Organism=Homo sapiens, GI7706339, Length=137, Percent_Identity=51.0948905109489, Blast_Score=139, Evalue=2e-33, Organism=Homo sapiens, GI24308049, Length=127, Percent_Identity=51.9685039370079, Blast_Score=124, Evalue=3e-29, Organism=Homo sapiens, GI19557636, Length=142, Percent_Identity=44.3661971830986, Blast_Score=122, Evalue=1e-28, Organism=Homo sapiens, GI64276486, Length=130, Percent_Identity=43.8461538461538, Blast_Score=115, Evalue=2e-26, Organism=Homo sapiens, GI22547215, Length=152, Percent_Identity=45.3947368421053, Blast_Score=105, Evalue=2e-23, Organism=Homo sapiens, GI4505991, Length=128, Percent_Identity=52.34375, Blast_Score=103, Evalue=1e-22, Organism=Homo sapiens, GI4758950, Length=155, Percent_Identity=44.5161290322581, Blast_Score=102, Evalue=2e-22, Organism=Homo sapiens, GI22547212, Length=137, Percent_Identity=48.1751824817518, Blast_Score=101, Evalue=2e-22, Organism=Homo sapiens, GI7657473, Length=137, Percent_Identity=48.1751824817518, Blast_Score=101, Evalue=2e-22, Organism=Homo sapiens, GI4826932, Length=149, Percent_Identity=42.2818791946309, Blast_Score=100, Evalue=9e-22, Organism=Homo sapiens, GI10863927, Length=146, Percent_Identity=41.7808219178082, Blast_Score=96, Evalue=1e-20, Organism=Homo sapiens, GI6631100, Length=136, Percent_Identity=44.1176470588235, Blast_Score=96, Evalue=1e-20, Organism=Homo sapiens, GI5031987, Length=146, Percent_Identity=45.8904109589041, Blast_Score=95, Evalue=3e-20, Organism=Homo sapiens, GI5174637, Length=160, Percent_Identity=40.625, Blast_Score=94, Evalue=4e-20, Organism=Homo sapiens, GI45439316, Length=166, Percent_Identity=38.5542168674699, Blast_Score=94, Evalue=4e-20, Organism=Homo sapiens, GI303305009, Length=155, Percent_Identity=40, Blast_Score=94, Evalue=6e-20, Organism=Homo sapiens, GI20911035, Length=139, Percent_Identity=38.1294964028777, Blast_Score=93, Evalue=9e-20, Organism=Homo sapiens, GI310127646, Length=144, Percent_Identity=39.5833333333333, Blast_Score=93, Evalue=1e-19, Organism=Homo sapiens, GI310114371, Length=144, Percent_Identity=39.5833333333333, Blast_Score=93, Evalue=1e-19, Organism=Homo sapiens, GI310119221, Length=144, Percent_Identity=39.5833333333333, Blast_Score=93, Evalue=1e-19, Organism=Homo sapiens, GI42560244, Length=135, Percent_Identity=41.4814814814815, Blast_Score=92, Evalue=2e-19, Organism=Homo sapiens, GI5454154, Length=163, Percent_Identity=41.1042944785276, Blast_Score=89, Evalue=1e-18, Organism=Homo sapiens, GI256017253, Length=137, Percent_Identity=42.3357664233577, Blast_Score=87, Evalue=5e-18, Organism=Homo sapiens, GI221139811, Length=137, Percent_Identity=42.3357664233577, Blast_Score=87, Evalue=5e-18, Organism=Homo sapiens, GI256017251, Length=137, Percent_Identity=42.3357664233577, Blast_Score=87, Evalue=5e-18, Organism=Homo sapiens, GI310129267, Length=146, Percent_Identity=39.041095890411, Blast_Score=87, Evalue=7e-18, Organism=Homo sapiens, GI310120620, Length=146, Percent_Identity=39.041095890411, Blast_Score=87, Evalue=7e-18, Organism=Homo sapiens, GI150418007, Length=145, Percent_Identity=41.3793103448276, Blast_Score=86, Evalue=1e-17, Organism=Homo sapiens, GI178057341, Length=128, Percent_Identity=41.40625, Blast_Score=85, Evalue=3e-17, Organism=Homo sapiens, GI310110104, Length=146, Percent_Identity=38.3561643835616, Blast_Score=84, Evalue=4e-17, Organism=Homo sapiens, GI209417936, Length=128, Percent_Identity=40.625, Blast_Score=84, Evalue=7e-17, Organism=Homo sapiens, GI30102944, Length=128, Percent_Identity=40.625, Blast_Score=84, Evalue=7e-17, Organism=Homo sapiens, GI219842199, Length=128, Percent_Identity=40.625, Blast_Score=84, Evalue=7e-17, Organism=Homo sapiens, GI169163387, Length=147, Percent_Identity=38.0952380952381, Blast_Score=81, Evalue=4e-16, Organism=Homo sapiens, GI169164185, Length=147, Percent_Identity=38.0952380952381, Blast_Score=81, Evalue=4e-16, Organism=Homo sapiens, GI169163623, Length=147, Percent_Identity=38.0952380952381, Blast_Score=81, Evalue=4e-16, Organism=Homo sapiens, GI310132444, Length=146, Percent_Identity=36.986301369863, Blast_Score=77, Evalue=7e-15, Organism=Homo sapiens, GI310113152, Length=146, Percent_Identity=36.986301369863, Blast_Score=77, Evalue=7e-15, Organism=Homo sapiens, GI169214050, Length=144, Percent_Identity=36.1111111111111, Blast_Score=75, Evalue=2e-14, Organism=Homo sapiens, GI239751853, Length=126, Percent_Identity=39.6825396825397, Blast_Score=75, Evalue=3e-14, Organism=Homo sapiens, GI113428306, Length=126, Percent_Identity=39.6825396825397, Blast_Score=75, Evalue=3e-14, Organism=Homo sapiens, GI14277126, Length=86, Percent_Identity=46.5116279069767, Blast_Score=73, Evalue=1e-13, Organism=Homo sapiens, GI310127745, Length=144, Percent_Identity=36.1111111111111, Blast_Score=71, Evalue=5e-13, Organism=Homo sapiens, GI310119290, Length=144, Percent_Identity=36.1111111111111, Blast_Score=71, Evalue=5e-13, Organism=Homo sapiens, GI310114540, Length=144, Percent_Identity=36.1111111111111, Blast_Score=70, Evalue=6e-13, Organism=Homo sapiens, GI27735045, Length=134, Percent_Identity=34.3283582089552, Blast_Score=70, Evalue=7e-13, Organism=Escherichia coli, GI1789763, Length=135, Percent_Identity=42.2222222222222, Blast_Score=81, Evalue=4e-17, Organism=Escherichia coli, GI1786736, Length=138, Percent_Identity=37.6811594202899, Blast_Score=72, Evalue=2e-14, Organism=Caenorhabditis elegans, GI17539496, Length=126, Percent_Identity=56.3492063492063, Blast_Score=144, Evalue=2e-35, Organism=Caenorhabditis elegans, GI71980590, Length=131, Percent_Identity=46.5648854961832, Blast_Score=121, Evalue=2e-28, Organism=Caenorhabditis elegans, GI71980594, Length=131, Percent_Identity=46.5648854961832, Blast_Score=121, Evalue=2e-28, Organism=Caenorhabditis elegans, GI71997782, Length=143, Percent_Identity=41.958041958042, Blast_Score=119, Evalue=7e-28, Organism=Caenorhabditis elegans, GI17506311, Length=132, Percent_Identity=51.5151515151515, Blast_Score=119, Evalue=1e-27, Organism=Caenorhabditis elegans, GI17532641, Length=138, Percent_Identity=44.2028985507246, Blast_Score=118, Evalue=1e-27, Organism=Caenorhabditis elegans, GI17506307, Length=134, Percent_Identity=50.7462686567164, Blast_Score=107, Evalue=2e-24, Organism=Caenorhabditis elegans, GI17551284, Length=134, Percent_Identity=47.7611940298507, Blast_Score=101, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17551282, Length=134, Percent_Identity=47.7611940298507, Blast_Score=100, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17552780, Length=129, Percent_Identity=50.3875968992248, Blast_Score=98, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17559074, Length=147, Percent_Identity=42.8571428571429, Blast_Score=97, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17566266, Length=134, Percent_Identity=44.7761194029851, Blast_Score=94, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17552782, Length=135, Percent_Identity=43.7037037037037, Blast_Score=94, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17552784, Length=139, Percent_Identity=43.8848920863309, Blast_Score=93, Evalue=7e-20, Organism=Caenorhabditis elegans, GI17539498, Length=129, Percent_Identity=45.7364341085271, Blast_Score=92, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17565860, Length=158, Percent_Identity=41.1392405063291, Blast_Score=91, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17532643, Length=134, Percent_Identity=46.2686567164179, Blast_Score=89, Evalue=8e-19, Organism=Caenorhabditis elegans, GI32563659, Length=139, Percent_Identity=33.0935251798561, Blast_Score=81, Evalue=3e-16, Organism=Saccharomyces cerevisiae, GI6323562, Length=131, Percent_Identity=50.381679389313, Blast_Score=109, Evalue=2e-25, Organism=Saccharomyces cerevisiae, GI6320359, Length=130, Percent_Identity=50, Blast_Score=101, Evalue=6e-23, Organism=Saccharomyces cerevisiae, GI6320510, Length=131, Percent_Identity=48.0916030534351, Blast_Score=95, Evalue=6e-21, Organism=Saccharomyces cerevisiae, GI6323246, Length=139, Percent_Identity=43.8848920863309, Blast_Score=95, Evalue=6e-21, Organism=Saccharomyces cerevisiae, GI6321848, Length=136, Percent_Identity=47.7941176470588, Blast_Score=90, Evalue=1e-19, Organism=Saccharomyces cerevisiae, GI6322492, Length=158, Percent_Identity=36.7088607594937, Blast_Score=75, Evalue=4e-15, Organism=Drosophila melanogaster, GI17986117, Length=129, Percent_Identity=55.0387596899225, Blast_Score=143, Evalue=4e-35, Organism=Drosophila melanogaster, GI19922376, Length=133, Percent_Identity=48.1203007518797, Blast_Score=132, Evalue=1e-31, Organism=Drosophila melanogaster, GI21357249, Length=128, Percent_Identity=40.625, Blast_Score=110, Evalue=4e-25, Organism=Drosophila melanogaster, GI19922912, Length=129, Percent_Identity=51.937984496124, Blast_Score=109, Evalue=7e-25, Organism=Drosophila melanogaster, GI24652460, Length=131, Percent_Identity=39.6946564885496, Blast_Score=107, Evalue=3e-24, Organism=Drosophila melanogaster, GI20130249, Length=130, Percent_Identity=51.5384615384615, Blast_Score=105, Evalue=9e-24, Organism=Drosophila melanogaster, GI24664125, Length=146, Percent_Identity=43.8356164383562, Blast_Score=94, Evalue=5e-20, Organism=Drosophila melanogaster, GI21357783, Length=146, Percent_Identity=43.8356164383562, Blast_Score=94, Evalue=5e-20, Organism=Drosophila melanogaster, GI45549139, Length=128, Percent_Identity=46.875, Blast_Score=94, Evalue=5e-20, Organism=Drosophila melanogaster, GI24650807, Length=132, Percent_Identity=43.9393939393939, Blast_Score=92, Evalue=2e-19, Organism=Drosophila melanogaster, GI17136360, Length=153, Percent_Identity=38.562091503268, Blast_Score=90, Evalue=8e-19, Organism=Drosophila melanogaster, GI17647301, Length=129, Percent_Identity=43.4108527131783, Blast_Score=88, Evalue=2e-18, Organism=Drosophila melanogaster, GI24586038, Length=137, Percent_Identity=40.1459854014599, Blast_Score=81, Evalue=2e-16, Organism=Drosophila melanogaster, GI21355677, Length=134, Percent_Identity=37.3134328358209, Blast_Score=81, Evalue=4e-16, Organism=Drosophila melanogaster, GI24661775, Length=159, Percent_Identity=34.5911949685535, Blast_Score=69, Evalue=1e-12, Organism=Drosophila melanogaster, GI21355237, Length=159, Percent_Identity=34.5911949685535, Blast_Score=69, Evalue=1e-12, Organism=Drosophila melanogaster, GI24661771, Length=159, Percent_Identity=34.5911949685535, Blast_Score=69, Evalue=1e-12,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR015891 - InterPro: IPR020892 - InterPro: IPR002130 [H]
Pfam domain/function: PF00160 Pro_isomerase [H]
EC number: =5.2.1.8 [H]
Molecular weight: Translated: 17637; Mature: 17506
Theoretical pI: Translated: 8.89; Mature: 8.89
Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.0 %Cys (Translated Protein) 3.8 %Met (Translated Protein) 3.8 %Cys+Met (Translated Protein) 0.0 %Cys (Mature Protein) 3.1 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAKQWSSPPAMQIDVSKTYRVTMETTRGTIELDLYPQHAPLTVNNFVFLVREGFYDGLTF CCCCCCCCCCEEEECCCEEEEEEECCCCEEEEEEECCCCCEEECCEEEEEECCCCCCHHH HRVIKDFVIQGGDPTGRGSGGPGYRFRDEVVGNPLTHEAGVISMANAGPNTNGSQFFITH HHHHHHHHEECCCCCCCCCCCCCCEEEHHHCCCCCCCCCCEEEEECCCCCCCCCEEEEEE TPQPHLNGRHTVFGRVVAGMDVVYAIKQGDKMTKVTVQEL CCCCCCCCCEEHHHHHHHCCEEEEEECCCCEEEEEEEECC >Mature Secondary Structure AKQWSSPPAMQIDVSKTYRVTMETTRGTIELDLYPQHAPLTVNNFVFLVREGFYDGLTF CCCCCCCCCEEEECCCEEEEEEECCCCEEEEEEECCCCCEEECCEEEEEECCCCCCHHH HRVIKDFVIQGGDPTGRGSGGPGYRFRDEVVGNPLTHEAGVISMANAGPNTNGSQFFITH HHHHHHHHEECCCCCCCCCCCCCCEEEHHHCCCCCCCCCCEEEEECCCCCCCCCEEEEEE TPQPHLNGRHTVFGRVVAGMDVVYAIKQGDKMTKVTVQEL CCCCCCCCCEEHHHHHHHCCEEEEEECCCCEEEEEEEECC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9317025; 9665876 [H]