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The map label for this gene is pyrC [H]

Identifier: 222526211

GI number: 222526211

Start: 3669236

End: 3670231

Strand: Reverse

Name: pyrC [H]

Synonym: Chy400_2972

Alternate gene names: 222526211

Gene position: 3670231-3669236 (Counterclockwise)

Preceding gene: 222526212

Following gene: 222526209

Centisome position: 69.66

GC content: 59.94

Gene sequence:

>996_bases
ATGACAGTTACATTATTTGCCCCACTTGACATGCATCTGCACCTGCGCGAAGGCGCCATGTTGCGCCTCGTCGCGCCATT
CTCTGCTGCGCAGTTCGCTGGTGCCGTGATCATGCCGAATCTCGTACCACCGGTGGATAACGCCGACCGCCTTGCCCGCT
ATCACGAGGAGATTCGGGCTGCGGTTGACCCGTACCCGTTTCTCCCGCTGATGACCCTGTTTTTTCGCCCCTACGATGCC
CAAACCTTGCAGGCATTGCGTGAGCATATCTTCGCGATTAAGCTCTACCCGGAAGGCGTAACGACCAATAGCGCCGGTGG
GGTCAGCGACCTGACGGCGATTGAGCCAACGCTGGCAATGATGGAAGAGTTGGGTATTCCGCTCCTGGTACACGGCGAGA
GTCACGGGTTTGTGCTGGATCGTGAAGCCGAGTTTTTGCCGGTGTATGAGCGTTGGGCCCGCACGTTCCCACGCCTGCGG
ATTGTAATGGAGCATATCACAACGGCTGCCGCCCTCGACCTGCTGGATCGTTATCCGAATTTGTTTGCCACCGTCACCCT
GCACCACCTCTTGATCACTCTCGACGATGTGGCCGGTGGTCTGTTGCAGCCGCATCTCTTCTGTAAGCCGATTGCCAAAC
GTCCGACTGACCGTGATGCACTGCTGGCTGCGGCATTAGCCGGCCATCCCAAACTGATGTTTGGCAGCGACTCGGCACCG
CATCCGATAGATCGCAAAGAAGCCGCGTTCTGCGCTGCCGGTGTCTTCTCAGCGCCGGTGTTGCTGCCGATGCTGGTCGA
ATTGTTCGAGCGTCACAACGCCCTCGACCGCCTGCCCGACTTCGTGAGTGGGAATGCCCGGCGGATTCACGGCCTGAACC
CGCCGCCCCGCACCGTGCGATTGGTCGAAGACCCCTGGCAGGTACCGATGCGTTATGGCGATGTCGTTCCGTTCGCCGCC
GGCCAGACGCTACGCTGGCAGGTGGTTGCTGAGTAG

Upstream 100 bases:

>100_bases
AAAGTGCCGAAATCAGTCGGATCACTGCTGCGATTAATTTGCCTCACGACAGTTTTGTGGCGGCGCGACTGCGCCTGCCA
CGCCAACCAGGAAAGCGTCT

Downstream 100 bases:

>100_bases
AGTGTAGCAAGCTGTTTCTCACCACAATGGACACCGACGAGGGCCGGCTGCCTCGTCAACCTGGGTGAACAGGTGGCAAT
CGCTGCTACAGGCAGCCCGG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MTVTLFAPLDMHLHLREGAMLRLVAPFSAAQFAGAVIMPNLVPPVDNADRLARYHEEIRAAVDPYPFLPLMTLFFRPYDA
QTLQALREHIFAIKLYPEGVTTNSAGGVSDLTAIEPTLAMMEELGIPLLVHGESHGFVLDREAEFLPVYERWARTFPRLR
IVMEHITTAAALDLLDRYPNLFATVTLHHLLITLDDVAGGLLQPHLFCKPIAKRPTDRDALLAAALAGHPKLMFGSDSAP
HPIDRKEAAFCAAGVFSAPVLLPMLVELFERHNALDRLPDFVSGNARRIHGLNPPPRTVRLVEDPWQVPMRYGDVVPFAA
GQTLRWQVVAE

Sequences:

>Translated_331_residues
MTVTLFAPLDMHLHLREGAMLRLVAPFSAAQFAGAVIMPNLVPPVDNADRLARYHEEIRAAVDPYPFLPLMTLFFRPYDA
QTLQALREHIFAIKLYPEGVTTNSAGGVSDLTAIEPTLAMMEELGIPLLVHGESHGFVLDREAEFLPVYERWARTFPRLR
IVMEHITTAAALDLLDRYPNLFATVTLHHLLITLDDVAGGLLQPHLFCKPIAKRPTDRDALLAAALAGHPKLMFGSDSAP
HPIDRKEAAFCAAGVFSAPVLLPMLVELFERHNALDRLPDFVSGNARRIHGLNPPPRTVRLVEDPWQVPMRYGDVVPFAA
GQTLRWQVVAE
>Mature_330_residues
TVTLFAPLDMHLHLREGAMLRLVAPFSAAQFAGAVIMPNLVPPVDNADRLARYHEEIRAAVDPYPFLPLMTLFFRPYDAQ
TLQALREHIFAIKLYPEGVTTNSAGGVSDLTAIEPTLAMMEELGIPLLVHGESHGFVLDREAEFLPVYERWARTFPRLRI
VMEHITTAAALDLLDRYPNLFATVTLHHLLITLDDVAGGLLQPHLFCKPIAKRPTDRDALLAAALAGHPKLMFGSDSAPH
PIDRKEAAFCAAGVFSAPVLLPMLVELFERHNALDRLPDFVSGNARRIHGLNPPPRTVRLVEDPWQVPMRYGDVVPFAAG
QTLRWQVVAE

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=334, Percent_Identity=39.5209580838323, Blast_Score=209, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6323452, Length=359, Percent_Identity=35.0974930362117, Blast_Score=195, Evalue=1e-50,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006992
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF04909 Amidohydro_2 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 36788; Mature: 36657

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTLFAPLDMHLHLREGAMLRLVAPFSAAQFAGAVIMPNLVPPVDNADRLARYHEEIRA
CEEEEEECCCEEEEECCCCEEEEECCCCHHHHCCEEECCCCCCCCCCHHHHHHHHHHHHH
AVDPYPFLPLMTLFFRPYDAQTLQALREHIFAIKLYPEGVTTNSAGGVSDLTAIEPTLAM
HCCCCCHHHHHHHHHCCCCHHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
MEELGIPLLVHGESHGFVLDREAEFLPVYERWARTFPRLRIVMEHITTAAALDLLDRYPN
HHHCCCCEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
LFATVTLHHLLITLDDVAGGLLQPHLFCKPIAKRPTDRDALLAAALAGHPKLMFGSDSAP
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCCCC
HPIDRKEAAFCAAGVFSAPVLLPMLVELFERHNALDRLPDFVSGNARRIHGLNPPPRTVR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHCCCCEEECCCCCCCCEEE
LVEDPWQVPMRYGDVVPFAAGQTLRWQVVAE
EECCCCCCCHHCCCCCCCCCCCEEEEEEEEC
>Mature Secondary Structure 
TVTLFAPLDMHLHLREGAMLRLVAPFSAAQFAGAVIMPNLVPPVDNADRLARYHEEIRA
EEEEEECCCEEEEECCCCEEEEECCCCHHHHCCEEECCCCCCCCCCHHHHHHHHHHHHH
AVDPYPFLPLMTLFFRPYDAQTLQALREHIFAIKLYPEGVTTNSAGGVSDLTAIEPTLAM
HCCCCCHHHHHHHHHCCCCHHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHHHHHHHHH
MEELGIPLLVHGESHGFVLDREAEFLPVYERWARTFPRLRIVMEHITTAAALDLLDRYPN
HHHCCCCEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
LFATVTLHHLLITLDDVAGGLLQPHLFCKPIAKRPTDRDALLAAALAGHPKLMFGSDSAP
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECCCCCC
HPIDRKEAAFCAAGVFSAPVLLPMLVELFERHNALDRLPDFVSGNARRIHGLNPPPRTVR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCHHHCCCCEEECCCCCCCCEEE
LVEDPWQVPMRYGDVVPFAAGQTLRWQVVAE
EECCCCCCCHHCCCCCCCCCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA