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The map label for this gene is pccB [H]

Identifier: 222525794

GI number: 222525794

Start: 3198245

End: 3199798

Strand: Reverse

Name: pccB [H]

Synonym: Chy400_2547

Alternate gene names: 222525794

Gene position: 3199798-3198245 (Counterclockwise)

Preceding gene: 222525795

Following gene: 222525793

Centisome position: 60.73

GC content: 53.22

Gene sequence:

>1554_bases
ATGACGCAGACAACCGCAGAAAAGATTGCTGCATTGCGTGAACGACGCGAACGGGCACGAAATCAAGACCCGGTGGCAAT
CGCCCGGCAACACGAACGAGGGAAATTAACGGCGCGAGAGCGAATTGATCGTCTACTTGATCCCGGTTCCTTCGTCGAAC
TTGACGCATTTGCTGTTCATCGTACCTCTGCGTTTGGTATGGAACGGCGCAAACCATTGGGTGACGGCGTGATCACCGGG
CACGGTACGATTGATGGTAGACCCGTTTGTGTGTTTGCCCAGGATTTCACTGTGTTTGGTGGGTCATTAGGCGAGGTGTT
TGCCGAGAAGATTTGCAAAGTCATGGATCTGGCTTTGCGCATGGGTGTGCCCTGCATCGGCATCAACGATAGTGGTGGAG
CACGTATTCAGGAAGGTGTGGTAAGCCTGGGTGGTTATGCCGAGATCTTCTACCGTAACGTCCTCAGTAGTGGTGTGATA
CCACAATTATCGATTATTGCCGGGCCATGTGCAGGTGGGGCAGTCTACTCGCCGGCAATGACCGATTTTATCTTTATGGT
CAAAAACATTAGCCAGATGTTCATTACCGGGCCGGATGTGATCAAAACCGTCACCGGCGAAGAGGTTGGCTTTGAAGAGT
TAGGCGGGGCGATGACCCACAATACCCGCAGTGGAGTGGCGCATTTTGCCGCCGACAGTGAAGATGAATGCTTCGATCAG
TTGCGGACACTGCTCTCATTTTTGCCATCCAACAACATGGAAGACCCGCCGTATCAGGCGCCAACCGATGATCCGGAGCG
GATGGACGAAGATTTGCAAAGCATCATTCCCGACAATCCACGCAAAGCCTACGACATGATTAAGGTTATTGAGGCCGTGG
TAGATGATGGGTTCTTCTTCGAGGTGCAACCGGCATGGGCAAAGAACATCGTCATCGGCTTTGCCCGTCTGGATGGTCAC
GTGGTTGGGGTGGTTGGCAATCAACCGCTGCAAATGGCCGGTACGCTGGATATTGACAGTTCCGTGAAGGCAGCGCGCTT
TGTACGCTTTTGCGATGCGTTTAACATTCCGCTGGTTACATTCGTGGATGTACCGGGCTTCTTGCCGGGCACACAGCAGG
AATACGGCGGAATCATCCGTCATGGAGCCAAACTTCTGTACGCATACTGTGAAGCAACTGTACCGAAATTAACGGTTATT
ACCCGTAAAGCGTATGGCGGAGCCTATGATGTGATGGCGAGCAAGCACATTCGCGCCGACTTCAACTTTGCCTGGCCAAC
CGCTGAAATTGCCGTGATGGGTGTTGATGCAGCGGTACGCATTATCTTTCGCAAAGAGCTGGCTGAAGCAGATGATCCGG
CAGCACGGCTGGCCGAACTGGTTGAAGACTACCAGAATCGTTTTGCCAATCCGTATGTTGCCGCCGAACGTGGGTATATT
GATGCGGTTATCGAACCGCGTGAGACACGACCGGCCCTGATTCGCGCCTTACGCCTGGCACGCACGAAGCGTCAGAGTCT
GCCAGCCCGTAAGCATGGCAACATTCCATTGTGA

Upstream 100 bases:

>100_bases
ACAGGTACGGCCTTCATCCCTCAGAGTGTTCTATTCGCCATACTATGATGAGTTCGCATATTACCGGTAACGTCAGTTGA
TGAAAGAAATGGGGAATGCC

Downstream 100 bases:

>100_bases
TTTTTAAGCGTAACCTGTGCATCCCGATCTGTATTAAGCAGTCTCTTGAAACATTTCTGGTGAAATCTGGTAACAATTTT
ACCTGTCACTATGCTATGAT

Product: carboxyl transferase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MTQTTAEKIAALRERRERARNQDPVAIARQHERGKLTARERIDRLLDPGSFVELDAFAVHRTSAFGMERRKPLGDGVITG
HGTIDGRPVCVFAQDFTVFGGSLGEVFAEKICKVMDLALRMGVPCIGINDSGGARIQEGVVSLGGYAEIFYRNVLSSGVI
PQLSIIAGPCAGGAVYSPAMTDFIFMVKNISQMFITGPDVIKTVTGEEVGFEELGGAMTHNTRSGVAHFAADSEDECFDQ
LRTLLSFLPSNNMEDPPYQAPTDDPERMDEDLQSIIPDNPRKAYDMIKVIEAVVDDGFFFEVQPAWAKNIVIGFARLDGH
VVGVVGNQPLQMAGTLDIDSSVKAARFVRFCDAFNIPLVTFVDVPGFLPGTQQEYGGIIRHGAKLLYAYCEATVPKLTVI
TRKAYGGAYDVMASKHIRADFNFAWPTAEIAVMGVDAAVRIIFRKELAEADDPAARLAELVEDYQNRFANPYVAAERGYI
DAVIEPRETRPALIRALRLARTKRQSLPARKHGNIPL

Sequences:

>Translated_517_residues
MTQTTAEKIAALRERRERARNQDPVAIARQHERGKLTARERIDRLLDPGSFVELDAFAVHRTSAFGMERRKPLGDGVITG
HGTIDGRPVCVFAQDFTVFGGSLGEVFAEKICKVMDLALRMGVPCIGINDSGGARIQEGVVSLGGYAEIFYRNVLSSGVI
PQLSIIAGPCAGGAVYSPAMTDFIFMVKNISQMFITGPDVIKTVTGEEVGFEELGGAMTHNTRSGVAHFAADSEDECFDQ
LRTLLSFLPSNNMEDPPYQAPTDDPERMDEDLQSIIPDNPRKAYDMIKVIEAVVDDGFFFEVQPAWAKNIVIGFARLDGH
VVGVVGNQPLQMAGTLDIDSSVKAARFVRFCDAFNIPLVTFVDVPGFLPGTQQEYGGIIRHGAKLLYAYCEATVPKLTVI
TRKAYGGAYDVMASKHIRADFNFAWPTAEIAVMGVDAAVRIIFRKELAEADDPAARLAELVEDYQNRFANPYVAAERGYI
DAVIEPRETRPALIRALRLARTKRQSLPARKHGNIPL
>Mature_516_residues
TQTTAEKIAALRERRERARNQDPVAIARQHERGKLTARERIDRLLDPGSFVELDAFAVHRTSAFGMERRKPLGDGVITGH
GTIDGRPVCVFAQDFTVFGGSLGEVFAEKICKVMDLALRMGVPCIGINDSGGARIQEGVVSLGGYAEIFYRNVLSSGVIP
QLSIIAGPCAGGAVYSPAMTDFIFMVKNISQMFITGPDVIKTVTGEEVGFEELGGAMTHNTRSGVAHFAADSEDECFDQL
RTLLSFLPSNNMEDPPYQAPTDDPERMDEDLQSIIPDNPRKAYDMIKVIEAVVDDGFFFEVQPAWAKNIVIGFARLDGHV
VGVVGNQPLQMAGTLDIDSSVKAARFVRFCDAFNIPLVTFVDVPGFLPGTQQEYGGIIRHGAKLLYAYCEATVPKLTVIT
RKAYGGAYDVMASKHIRADFNFAWPTAEIAVMGVDAAVRIIFRKELAEADDPAARLAELVEDYQNRFANPYVAAERGYID
AVIEPRETRPALIRALRLARTKRQSLPARKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=493, Percent_Identity=60.446247464503, Blast_Score=598, Evalue=1e-171,
Organism=Homo sapiens, GI295821216, Length=513, Percent_Identity=58.0896686159844, Blast_Score=586, Evalue=1e-167,
Organism=Homo sapiens, GI11545863, Length=476, Percent_Identity=32.9831932773109, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI134142062, Length=361, Percent_Identity=25.7617728531856, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI38679971, Length=420, Percent_Identity=24.2857142857143, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38679960, Length=420, Percent_Identity=24.2857142857143, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38679977, Length=420, Percent_Identity=24.2857142857143, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38679967, Length=420, Percent_Identity=24.2857142857143, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI38679974, Length=420, Percent_Identity=24.2857142857143, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788655, Length=213, Percent_Identity=28.6384976525822, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI25147362, Length=488, Percent_Identity=59.0163934426229, Blast_Score=591, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI25147359, Length=488, Percent_Identity=59.0163934426229, Blast_Score=590, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17552936, Length=520, Percent_Identity=33.2692307692308, Blast_Score=261, Evalue=8e-70,
Organism=Caenorhabditis elegans, GI71997163, Length=389, Percent_Identity=26.2210796915167, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24586065, Length=507, Percent_Identity=34.7140039447732, Blast_Score=254, Evalue=9e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 56690; Mature: 56558

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTTAEKIAALRERRERARNQDPVAIARQHERGKLTARERIDRLLDPGSFVELDAFAVH
CCCCHHHHHHHHHHHHHHHCCCCCEEHHHCCCCCCCHHHHHHHHHCCCCCEEEEHHHHHH
RTSAFGMERRKPLGDGVITGHGTIDGRPVCVFAQDFTVFGGSLGEVFAEKICKVMDLALR
HHHHHCCHHCCCCCCCEEECCCCCCCCEEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHH
MGVPCIGINDSGGARIQEGVVSLGGYAEIFYRNVLSSGVIPQLSIIAGPCAGGAVYSPAM
CCCCEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCEEHEEECCCCCCCCCCHHH
TDFIFMVKNISQMFITGPDVIKTVTGEEVGFEELGGAMTHNTRSGVAHFAADSEDECFDQ
HHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHCCHHCCCCCCCHHHHCCCCHHHHHHH
LRTLLSFLPSNNMEDPPYQAPTDDPERMDEDLQSIIPDNPRKAYDMIKVIEAVVDDGFFF
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEE
EVQPAWAKNIVIGFARLDGHVVGVVGNQPLQMAGTLDIDSSVKAARFVRFCDAFNIPLVT
EECCCHHCCEEEEEEEECCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEE
FVDVPGFLPGTQQEYGGIIRHGAKLLYAYCEATVPKLTVITRKAYGGAYDVMASKHIRAD
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCHHCCC
FNFAWPTAEIAVMGVDAAVRIIFRKELAEADDPAARLAELVEDYQNRFANPYVAAERGYI
CCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCE
DAVIEPRETRPALIRALRLARTKRQSLPARKHGNIPL
EEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TQTTAEKIAALRERRERARNQDPVAIARQHERGKLTARERIDRLLDPGSFVELDAFAVH
CCCHHHHHHHHHHHHHHHCCCCCEEHHHCCCCCCCHHHHHHHHHCCCCCEEEEHHHHHH
RTSAFGMERRKPLGDGVITGHGTIDGRPVCVFAQDFTVFGGSLGEVFAEKICKVMDLALR
HHHHHCCHHCCCCCCCEEECCCCCCCCEEEEEECCHHHHCCCHHHHHHHHHHHHHHHHHH
MGVPCIGINDSGGARIQEGVVSLGGYAEIFYRNVLSSGVIPQLSIIAGPCAGGAVYSPAM
CCCCEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCEEHEEECCCCCCCCCCHHH
TDFIFMVKNISQMFITGPDVIKTVTGEEVGFEELGGAMTHNTRSGVAHFAADSEDECFDQ
HHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHCCHHCCCCCCCHHHHCCCCHHHHHHH
LRTLLSFLPSNNMEDPPYQAPTDDPERMDEDLQSIIPDNPRKAYDMIKVIEAVVDDGFFF
HHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEE
EVQPAWAKNIVIGFARLDGHVVGVVGNQPLQMAGTLDIDSSVKAARFVRFCDAFNIPLVT
EECCCHHCCEEEEEEEECCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEE
FVDVPGFLPGTQQEYGGIIRHGAKLLYAYCEATVPKLTVITRKAYGGAYDVMASKHIRAD
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCHHCCC
FNFAWPTAEIAVMGVDAAVRIIFRKELAEADDPAARLAELVEDYQNRFANPYVAAERGYI
CCCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEECCCCE
DAVIEPRETRPALIRALRLARTKRQSLPARKHGNIPL
EEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]