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The map label for this gene is mrpB [H]

Identifier: 222525635

GI number: 222525635

Start: 3014822

End: 3015310

Strand: Direct

Name: mrpB [H]

Synonym: Chy400_2386

Alternate gene names: 222525635

Gene position: 3014822-3015310 (Clockwise)

Preceding gene: 222525634

Following gene: 222525636

Centisome position: 57.22

GC content: 52.35

Gene sequence:

>489_bases
ATGCCCAGAGATAGTGCCTTATACGACTCGTTAATTCTGCGCACGATTAGCCGGTTGATGATGCCGGTGCTGTTGTTGCT
TTCAATCTTTATGCTCCTGCGCGGCCATAATTTGCCGGGTGGTGGCTTTATCGGTGGTCTGCTGGCTTCAAGTGCGATCA
TTTTGCAGATAGTCGCCTTTGGCCCGAAAACGGCCAAACGCATTTTGCCGGTCAATTACCTGCTGCTGGCGGCTTTCGGT
GTCTTTTTCGGGGCAATCTGGGGGTTGCCGGCGCTGTTTGCCGGTCTCCCCTATATGCAGGCGTTCTGGATACCAGAACC
CATTCCCGGGGTAGGTAAGATTGGTACGCCGGTCTTGTTTGATGTTGGAGTCTACTTTACGGTTATTGGTGTAACCACGA
AGATTGCACTCCTGCTGGTAGAAGAGCCGACACTCTTCCCCTTGCCGGAAATGAAATCGGCATCTGTTGAGCAAGAGGAG
GTTGCATGA

Upstream 100 bases:

>100_bases
GCGCTCCTTGGTATCTATGGCTTGTTACGGTTACGACAGGGGAAAGACAATGCGACACCAGAGCGGGTCACCACAACCGA
ACCGGTCAACGAACCGGTCG

Downstream 100 bases:

>100_bases
TCATTCTGCTGGCGATAGCAATCGGCTCTCTGTTTGGTGGGGCCACTTATCTGATCTTGCGCCGTTCGGTAGTGAAGCTG
ATCCTGGGTCTGATTATGTT

Product: Na+/H+ antiporter MnhB subunit-like protein

Products: NA

Alternate protein names: Mrp complex subunit B; Multiple resistance and pH homeostasis protein B [H]

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MPRDSALYDSLILRTISRLMMPVLLLLSIFMLLRGHNLPGGGFIGGLLASSAIILQIVAFGPKTAKRILPVNYLLLAAFG
VFFGAIWGLPALFAGLPYMQAFWIPEPIPGVGKIGTPVLFDVGVYFTVIGVTTKIALLLVEEPTLFPLPEMKSASVEQEE
VA

Sequences:

>Translated_162_residues
MPRDSALYDSLILRTISRLMMPVLLLLSIFMLLRGHNLPGGGFIGGLLASSAIILQIVAFGPKTAKRILPVNYLLLAAFG
VFFGAIWGLPALFAGLPYMQAFWIPEPIPGVGKIGTPVLFDVGVYFTVIGVTTKIALLLVEEPTLFPLPEMKSASVEQEE
VA
>Mature_161_residues
PRDSALYDSLILRTISRLMMPVLLLLSIFMLLRGHNLPGGGFIGGLLASSAIILQIVAFGPKTAKRILPVNYLLLAAFGV
FFGAIWGLPALFAGLPYMQAFWIPEPIPGVGKIGTPVLFDVGVYFTVIGVTTKIALLLVEEPTLFPLPEMKSASVEQEEV
A

Specific function: Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual N

COG id: COG2111

COG function: function code P; Multisubunit Na+/H+ antiporter, MnhB subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005281
- InterPro:   IPR007182 [H]

Pfam domain/function: PF04039 MnhB [H]

EC number: NA

Molecular weight: Translated: 17470; Mature: 17339

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRDSALYDSLILRTISRLMMPVLLLLSIFMLLRGHNLPGGGFIGGLLASSAIILQIVAF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHC
GPKTAKRILPVNYLLLAAFGVFFGAIWGLPALFAGLPYMQAFWIPEPIPGVGKIGTPVLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCHHHH
DVGVYFTVIGVTTKIALLLVEEPTLFPLPEMKSASVEQEEVA
HHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHCC
>Mature Secondary Structure 
PRDSALYDSLILRTISRLMMPVLLLLSIFMLLRGHNLPGGGFIGGLLASSAIILQIVAF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHC
GPKTAKRILPVNYLLLAAFGVFFGAIWGLPALFAGLPYMQAFWIPEPIPGVGKIGTPVLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCHHHH
DVGVYFTVIGVTTKIALLLVEEPTLFPLPEMKSASVEQEEVA
HHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377; 10198001; 11356194 [H]