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The map label for this gene is prs [H]

Identifier: 222525616

GI number: 222525616

Start: 2988225

End: 2989163

Strand: Reverse

Name: prs [H]

Synonym: Chy400_2367

Alternate gene names: 222525616

Gene position: 2989163-2988225 (Counterclockwise)

Preceding gene: 222525618

Following gene: 222525615

Centisome position: 56.73

GC content: 56.55

Gene sequence:

>939_bases
ATGGATGGTCGTTTGCTCATTTTTACCGGCAATGCCAACCCGGCATTAGCGCAAGAGATTGCCCGCAACCTGCGCATCAA
TCTGGGCCGGGCACTGGTTGGTACCTTCAAAAATGGCGAGACACGGGTCAAGATTCACGACAATGTCCGTGGCTGTGATG
TGTTTGTGATTCAACCCACCTGTACGCCGGTGGACCATCACCTGATGGAATTGCTCATCATGATCGATGCCTTCCGGCGA
GCCTCGGCAGCGCGGGTCACGGCGGTCATTCCCTACTATGGGTATGCCAAGCAAGAGAAGAAGACCTCGGGCCGTGAGCC
AATCTCGGCCAAGCTGGTAGCTAATCTGATCCGCACCGCCGGCGCTGACCGCGTTCTGACGATGGATCTGCACGCTCCAG
CCATTGAAGGGTTCTTCGATATTCCGGTTGACCACCTGCAAGCCTCGCCACTGCTGGCCGATTACATTCGCGAACTGAAC
CTGCCTAACCCGGTTGTCGTCTCTCCCGATACCGGGGGCGTGGGGCGGGCCAATCGCTTTCGTGAGCGGATTGGTGCCGG
ACTGGCGATTATTGCCAAACAACGACCCGAACCAGATACAGCCGAAGTTATCGAAATGGTCGGTGAGGTTGAGGGGAAGA
CGGCAATCATCGTCGATGATATGATCTCAACCGGGGGAACCCTGATTGAAGCAGCCCAAACGCTGCTGGCCCGTGGCGCA
CGGGCTGTGTATGCCTGTGCTACCCACGGTATTTTTGCCGAAAACGCCTTACAGTTGATCGCCGAGTCCGATCTCGTCGA
GACGGTAGTCACCAACACGATCCCTCAACCACCAACCGCCGCAGCAGCCCGGGTGCGCACGATTAGTGTGGCACCATTGT
TTGCTGAAGCGATTATGCGTATCCACAAAGATCTATCACTGAGCGCGCTTTTTTCCTGA

Upstream 100 bases:

>100_bases
CAACAACGTGGAAGAGGTCAGCACTTCTGGTCTCGCGTGTAACAGGTGCGCAGTGAGCATGCTCGCTGCGCGTTTCTATT
CAGGAAAGAACTGCTGAACC

Downstream 100 bases:

>100_bases
TGACGCGGTCGTTGTGCGCCCGAAGGGAGTATCAATTCGGGCGCCATTGTTGAGTGAAGCGCGCCACTCTGTTCCGCGAA
AGGAGGATGATTCTCTTGGA

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MDGRLLIFTGNANPALAQEIARNLRINLGRALVGTFKNGETRVKIHDNVRGCDVFVIQPTCTPVDHHLMELLIMIDAFRR
ASAARVTAVIPYYGYAKQEKKTSGREPISAKLVANLIRTAGADRVLTMDLHAPAIEGFFDIPVDHLQASPLLADYIRELN
LPNPVVVSPDTGGVGRANRFRERIGAGLAIIAKQRPEPDTAEVIEMVGEVEGKTAIIVDDMISTGGTLIEAAQTLLARGA
RAVYACATHGIFAENALQLIAESDLVETVVTNTIPQPPTAAAARVRTISVAPLFAEAIMRIHKDLSLSALFS

Sequences:

>Translated_312_residues
MDGRLLIFTGNANPALAQEIARNLRINLGRALVGTFKNGETRVKIHDNVRGCDVFVIQPTCTPVDHHLMELLIMIDAFRR
ASAARVTAVIPYYGYAKQEKKTSGREPISAKLVANLIRTAGADRVLTMDLHAPAIEGFFDIPVDHLQASPLLADYIRELN
LPNPVVVSPDTGGVGRANRFRERIGAGLAIIAKQRPEPDTAEVIEMVGEVEGKTAIIVDDMISTGGTLIEAAQTLLARGA
RAVYACATHGIFAENALQLIAESDLVETVVTNTIPQPPTAAAARVRTISVAPLFAEAIMRIHKDLSLSALFS
>Mature_312_residues
MDGRLLIFTGNANPALAQEIARNLRINLGRALVGTFKNGETRVKIHDNVRGCDVFVIQPTCTPVDHHLMELLIMIDAFRR
ASAARVTAVIPYYGYAKQEKKTSGREPISAKLVANLIRTAGADRVLTMDLHAPAIEGFFDIPVDHLQASPLLADYIRELN
LPNPVVVSPDTGGVGRANRFRERIGAGLAIIAKQRPEPDTAEVIEMVGEVEGKTAIIVDDMISTGGTLIEAAQTLLARGA
RAVYACATHGIFAENALQLIAESDLVETVVTNTIPQPPTAAAARVRTISVAPLFAEAIMRIHKDLSLSALFS

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI28557709, Length=310, Percent_Identity=46.7741935483871, Blast_Score=274, Evalue=7e-74,
Organism=Homo sapiens, GI4506129, Length=311, Percent_Identity=45.3376205787781, Blast_Score=273, Evalue=1e-73,
Organism=Homo sapiens, GI4506127, Length=309, Percent_Identity=46.2783171521036, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI84875539, Length=314, Percent_Identity=44.9044585987261, Blast_Score=268, Evalue=4e-72,
Organism=Homo sapiens, GI4506133, Length=347, Percent_Identity=37.463976945245, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI194018537, Length=347, Percent_Identity=37.463976945245, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI310128524, Length=145, Percent_Identity=29.6551724137931, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI310115209, Length=145, Percent_Identity=29.6551724137931, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI310118259, Length=145, Percent_Identity=29.6551724137931, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI310119946, Length=145, Percent_Identity=29.6551724137931, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1787458, Length=308, Percent_Identity=50, Blast_Score=305, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI17554704, Length=310, Percent_Identity=45.8064516129032, Blast_Score=270, Evalue=9e-73,
Organism=Caenorhabditis elegans, GI25149168, Length=310, Percent_Identity=45.8064516129032, Blast_Score=270, Evalue=9e-73,
Organism=Caenorhabditis elegans, GI17554702, Length=310, Percent_Identity=45.8064516129032, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI71989924, Length=310, Percent_Identity=45.8064516129032, Blast_Score=266, Evalue=7e-72,
Organism=Caenorhabditis elegans, GI17570245, Length=338, Percent_Identity=34.0236686390533, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6319403, Length=310, Percent_Identity=43.2258064516129, Blast_Score=247, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6320946, Length=309, Percent_Identity=41.747572815534, Blast_Score=241, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6321776, Length=299, Percent_Identity=40.8026755852843, Blast_Score=223, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6322667, Length=191, Percent_Identity=41.3612565445026, Blast_Score=142, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6324511, Length=94, Percent_Identity=42.5531914893617, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21355239, Length=310, Percent_Identity=46.7741935483871, Blast_Score=271, Evalue=4e-73,
Organism=Drosophila melanogaster, GI45551540, Length=333, Percent_Identity=43.5435435435435, Blast_Score=258, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24651458, Length=354, Percent_Identity=36.7231638418079, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24651456, Length=354, Percent_Identity=36.7231638418079, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI281362873, Length=354, Percent_Identity=36.7231638418079, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24651454, Length=354, Percent_Identity=36.7231638418079, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24651462, Length=202, Percent_Identity=42.0792079207921, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24651464, Length=202, Percent_Identity=42.0792079207921, Blast_Score=149, Evalue=2e-36,
Organism=Drosophila melanogaster, GI45552010, Length=202, Percent_Identity=42.0792079207921, Blast_Score=149, Evalue=3e-36,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33601; Mature: 33601

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGRLLIFTGNANPALAQEIARNLRINLGRALVGTFKNGETRVKIHDNVRGCDVFVIQPT
CCCEEEEEECCCCHHHHHHHHHHHEEECCHHEEEECCCCCEEEEEECCCCCCEEEEECCC
CTPVDHHLMELLIMIDAFRRASAARVTAVIPYYGYAKQEKKTSGREPISAKLVANLIRTA
CCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHC
GADRVLTMDLHAPAIEGFFDIPVDHLQASPLLADYIRELNLPNPVVVSPDTGGVGRANRF
CCCEEEEEECCCCHHCCHHCCCHHHHCCCHHHHHHHHHCCCCCCEEECCCCCCCCCHHHH
RERIGAGLAIIAKQRPEPDTAEVIEMVGEVEGKTAIIVDDMISTGGTLIEAAQTLLARGA
HHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECHHHCCCHHHHHHHHHHHCCC
RAVYACATHGIFAENALQLIAESDLVETVVTNTIPQPPTAAAARVRTISVAPLFAEAIMR
HHEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEEEEEEHHHHHHHHHH
IHKDLSLSALFS
HHHCCCHHHHCC
>Mature Secondary Structure
MDGRLLIFTGNANPALAQEIARNLRINLGRALVGTFKNGETRVKIHDNVRGCDVFVIQPT
CCCEEEEEECCCCHHHHHHHHHHHEEECCHHEEEECCCCCEEEEEECCCCCCEEEEECCC
CTPVDHHLMELLIMIDAFRRASAARVTAVIPYYGYAKQEKKTSGREPISAKLVANLIRTA
CCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHC
GADRVLTMDLHAPAIEGFFDIPVDHLQASPLLADYIRELNLPNPVVVSPDTGGVGRANRF
CCCEEEEEECCCCHHCCHHCCCHHHHCCCHHHHHHHHHCCCCCCEEECCCCCCCCCHHHH
RERIGAGLAIIAKQRPEPDTAEVIEMVGEVEGKTAIIVDDMISTGGTLIEAAQTLLARGA
HHHHCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECHHHCCCHHHHHHHHHHHCCC
RAVYACATHGIFAENALQLIAESDLVETVVTNTIPQPPTAAAARVRTISVAPLFAEAIMR
HHEEHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEEEEEEHHHHHHHHHH
IHKDLSLSALFS
HHHCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]