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The map label for this gene is cdd [H]

Identifier: 222525614

GI number: 222525614

Start: 2986398

End: 2986805

Strand: Reverse

Name: cdd [H]

Synonym: Chy400_2365

Alternate gene names: 222525614

Gene position: 2986805-2986398 (Counterclockwise)

Preceding gene: 222525615

Following gene: 222525611

Centisome position: 56.69

GC content: 59.8

Gene sequence:

>408_bases
ATGGATCCAGTGGCCCTTGAGCAATTGATCGCCGCGGCATTGCATGCCCGGCAGCGTGCATATGCACCCTATTCACACTT
CGCGGTTGGTGCCGCCGTCCTAACCGATGATGGCCGTATCTTTAGCGGTGCCAATATTGAGAACGCATCCTATCCTCTCA
CCATCTGTGCCGAGCGGGTAGCCCTGTTCTGCGCTCACATGGCGGCAGCCGGGCCGGTCGTTGCGCTGGCTGTGGTGACC
CCAACACCAACAGTTGCCAGCCCATGTGGCGCCTGTCGTCAGGTGATCTTTGAACTCGCGCCACAGGCGCAGATCGTTCT
CCTCAACCACGACGGTAGCGAACGCCGTCTGACCACGCCACAGGAGTTGTTGCCCTTCGGATTTGGGCCAGATCAGCTCA
CCAGATAG

Upstream 100 bases:

>100_bases
GCCGAACGATTACGGATTGTCCGGCAGGCACCGGCTGAAATAACAGCGGCAGCGCCGGTGGATGCCGAAAAACCGCTGTT
GCCGCTTCCTAAAGAATTGC

Downstream 100 bases:

>100_bases
AACCAGCGCAAGGCAGGGGTTGCTGTCGGCATCATCAACCAGGTAGATATGCAACGAGCGGAACGGCAATATGAACGGGC
ATATGTACAGTCCATAGGGG

Product: cytidine deaminase

Products: NA

Alternate protein names: CDA; Cytidine aminohydrolase [H]

Number of amino acids: Translated: 135; Mature: 135

Protein sequence:

>135_residues
MDPVALEQLIAAALHARQRAYAPYSHFAVGAAVLTDDGRIFSGANIENASYPLTICAERVALFCAHMAAAGPVVALAVVT
PTPTVASPCGACRQVIFELAPQAQIVLLNHDGSERRLTTPQELLPFGFGPDQLTR

Sequences:

>Translated_135_residues
MDPVALEQLIAAALHARQRAYAPYSHFAVGAAVLTDDGRIFSGANIENASYPLTICAERVALFCAHMAAAGPVVALAVVT
PTPTVASPCGACRQVIFELAPQAQIVLLNHDGSERRLTTPQELLPFGFGPDQLTR
>Mature_135_residues
MDPVALEQLIAAALHARQRAYAPYSHFAVGAAVLTDDGRIFSGANIENASYPLTICAERVALFCAHMAAAGPVVALAVVT
PTPTVASPCGACRQVIFELAPQAQIVLLNHDGSERRLTTPQELLPFGFGPDQLTR

Specific function: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis [H]

COG id: COG0295

COG function: function code F; Cytidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Homo sapiens, GI11386157, Length=136, Percent_Identity=44.8529411764706, Blast_Score=115, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17551074, Length=128, Percent_Identity=43.75, Blast_Score=99, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17540514, Length=126, Percent_Identity=43.6507936507937, Blast_Score=98, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323274, Length=132, Percent_Identity=45.4545454545455, Blast_Score=108, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24582741, Length=133, Percent_Identity=42.8571428571429, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19920920, Length=126, Percent_Identity=43.6507936507937, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24582744, Length=93, Percent_Identity=47.3118279569892, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR006262
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.5 [H]

Molecular weight: Translated: 14282; Mature: 14282

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPVALEQLIAAALHARQRAYAPYSHFAVGAAVLTDDGRIFSGANIENASYPLTICAERV
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHCEEEEECCCCEECCCCCCCCCCCHHHHHHHH
ALFCAHMAAAGPVVALAVVTPTPTVASPCGACRQVIFELAPQAQIVLLNHDGSERRLTTP
HHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCH
QELLPFGFGPDQLTR
HHHCCCCCCHHHCCC
>Mature Secondary Structure
MDPVALEQLIAAALHARQRAYAPYSHFAVGAAVLTDDGRIFSGANIENASYPLTICAERV
CCHHHHHHHHHHHHHHHHHCCCCCHHHHHCEEEEECCCCEECCCCCCCCCCCHHHHHHHH
ALFCAHMAAAGPVVALAVVTPTPTVASPCGACRQVIFELAPQAQIVLLNHDGSERRLTTP
HHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCH
QELLPFGFGPDQLTR
HHHCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2526291; 8969508; 9384377 [H]