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The map label for this gene is moeA [H]

Identifier: 222525520

GI number: 222525520

Start: 2870047

End: 2871276

Strand: Reverse

Name: moeA [H]

Synonym: Chy400_2269

Alternate gene names: 222525520

Gene position: 2871276-2870047 (Counterclockwise)

Preceding gene: 222525521

Following gene: 222525519

Centisome position: 54.49

GC content: 62.44

Gene sequence:

>1230_bases
ATGGCTGAGATGCTCCGCGAATCGCCGTATCCAATGGTCAGCATCGCCGAAGCCACAGCGACGATCATGGCGCAGGCTCG
TCCGCTGGCGAGTGAGGAGATTGAAGCGTTTTCCGCGCTCGGTCGAGTATTGGCCGGTGACATCACGTCACCGGAAGATA
TTCCTGACGTGCCCAAGTCGGCGATGGACGGCTATGCCCTCCGCGCCGCCGATGGTCTTACCCCTCGGCGCGTGGTGGGT
GAATTGACCGCAGGCGGTGCCGCAGCAGTTATGCTTGCGCCCGGTGAAGCCACTCGCATTATGACCGGTGCCCCACTACC
ACCCGGTGCCGATGCAATGATCCCGGTCGAACTGACCACAGAACGCGATGGAATGCTCTACATCCAGCGCGAGCTACAAC
CCGGCGATTACGTCCACGTTGTCGGCCAGGACGTCAGACGCGGTCAGACCGTCTTGACCGCCGGTACTACCATTGGCGCC
GCCGAGATTGGTATCTTAGCGACCCTCGGCATCACCCGGATTCCCGTGTATCGCCAGCCCCGGGTCGCCATTCTGGCAAC
CGGTGATGAAGTGGTCGAGCCGGGCAGTCCCCGTCCTGCCGGTGCCGTGCGCGATAGCAACCGGTATGCGTTGATGGCCG
CAGTCCGCGAGGCCGGCGGCATCCCGATCTCACTCGGTATCGCCCGCGATGATCGGGATGTACAACGTCAGGCGATCCTG
CACGGTCTGGATCAGGCCGATGTCCTGATCACCAGTGGCGGGGTCAGTATGGGGACGCGCGATCTGATCAAACCGTTACT
GGCCGAACTCGGCACCGTCCATTTTGGTCGGATTGCCTTCAAGCCGGGGAAACCAACCACCTTCGCCACCATCGGCGGCA
AGCTGGTCTTCGGCTTACCGGGCTATCCGGTCTCTTCACTGGTATCGTTCGAGGTCTTCGTTCGCCCGGCGCTGCGGGCA
TTGCAAGGTGATGCCTCACCGTTCCGCCCCCAGATCGAGGTCACCCTGGCCGAACCGGTCCGCCCATCACCTGATCGCCC
TGAGTATCAGCGCATTATCGTGCGCTATCAGGAAGGACGCTTCACCGCAGTCACAACCGGTAGCCAGAGCAGCTCGCGCC
TGCTCTCGCTACGTGGTGCCAATGGTCTGTTGCTCGTACCGGCTGGCGACACGGTATATCCTGCCGGTAGCACCTTGCCC
GCACTCCTGACCGGTCCGCTCATTGTGTAG

Upstream 100 bases:

>100_bases
GCTTCAACCGTTTGGTGTACGGCACATAGATATTCCGTTGCGGCCCGAAAAGGTCTGGCGGGCAATCAACAATGGACACC
TCGAAAAAGGAGAGTGATCG

Downstream 100 bases:

>100_bases
AGGATACAACTCGTGGAATGGTTTCTGCTCCAAACCGTCGAACCGTGGCCCGGTCCACTGACATATCTTGGTATCGCCCT
TTTACTGATTGCGGCGCTGA

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MAEMLRESPYPMVSIAEATATIMAQARPLASEEIEAFSALGRVLAGDITSPEDIPDVPKSAMDGYALRAADGLTPRRVVG
ELTAGGAAAVMLAPGEATRIMTGAPLPPGADAMIPVELTTERDGMLYIQRELQPGDYVHVVGQDVRRGQTVLTAGTTIGA
AEIGILATLGITRIPVYRQPRVAILATGDEVVEPGSPRPAGAVRDSNRYALMAAVREAGGIPISLGIARDDRDVQRQAIL
HGLDQADVLITSGGVSMGTRDLIKPLLAELGTVHFGRIAFKPGKPTTFATIGGKLVFGLPGYPVSSLVSFEVFVRPALRA
LQGDASPFRPQIEVTLAEPVRPSPDRPEYQRIIVRYQEGRFTAVTTGSQSSSRLLSLRGANGLLLVPAGDTVYPAGSTLP
ALLTGPLIV

Sequences:

>Translated_409_residues
MAEMLRESPYPMVSIAEATATIMAQARPLASEEIEAFSALGRVLAGDITSPEDIPDVPKSAMDGYALRAADGLTPRRVVG
ELTAGGAAAVMLAPGEATRIMTGAPLPPGADAMIPVELTTERDGMLYIQRELQPGDYVHVVGQDVRRGQTVLTAGTTIGA
AEIGILATLGITRIPVYRQPRVAILATGDEVVEPGSPRPAGAVRDSNRYALMAAVREAGGIPISLGIARDDRDVQRQAIL
HGLDQADVLITSGGVSMGTRDLIKPLLAELGTVHFGRIAFKPGKPTTFATIGGKLVFGLPGYPVSSLVSFEVFVRPALRA
LQGDASPFRPQIEVTLAEPVRPSPDRPEYQRIIVRYQEGRFTAVTTGSQSSSRLLSLRGANGLLLVPAGDTVYPAGSTLP
ALLTGPLIV
>Mature_408_residues
AEMLRESPYPMVSIAEATATIMAQARPLASEEIEAFSALGRVLAGDITSPEDIPDVPKSAMDGYALRAADGLTPRRVVGE
LTAGGAAAVMLAPGEATRIMTGAPLPPGADAMIPVELTTERDGMLYIQRELQPGDYVHVVGQDVRRGQTVLTAGTTIGAA
EIGILATLGITRIPVYRQPRVAILATGDEVVEPGSPRPAGAVRDSNRYALMAAVREAGGIPISLGIARDDRDVQRQAILH
GLDQADVLITSGGVSMGTRDLIKPLLAELGTVHFGRIAFKPGKPTTFATIGGKLVFGLPGYPVSSLVSFEVFVRPALRAL
QGDASPFRPQIEVTLAEPVRPSPDRPEYQRIIVRYQEGRFTAVTTGSQSSSRLLSLRGANGLLLVPAGDTVYPAGSTLPA
LLTGPLIV

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=409, Percent_Identity=42.2982885085575, Blast_Score=295, Evalue=6e-80,
Organism=Homo sapiens, GI10880983, Length=409, Percent_Identity=42.2982885085575, Blast_Score=295, Evalue=7e-80,
Organism=Escherichia coli, GI1787049, Length=380, Percent_Identity=37.3684210526316, Blast_Score=235, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI25147659, Length=424, Percent_Identity=35.6132075471698, Blast_Score=210, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI17562606, Length=364, Percent_Identity=26.9230769230769, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17136978, Length=413, Percent_Identity=32.9297820823245, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24638841, Length=413, Percent_Identity=32.9297820823245, Blast_Score=179, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42995; Mature: 42864

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEMLRESPYPMVSIAEATATIMAQARPLASEEIEAFSALGRVLAGDITSPEDIPDVPKS
CCHHHHCCCCCEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
AMDGYALRAADGLTPRRVVGELTAGGAAAVMLAPGEATRIMTGAPLPPGADAMIPVELTT
HHCCEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCCCEEEEEEEC
ERDGMLYIQRELQPGDYVHVVGQDVRRGQTVLTAGTTIGAAEIGILATLGITRIPVYRQP
CCCCEEEEEEECCCCCEEEEECCHHHCCCEEEEECCCCCHHHHHHHHHCCHHCCCCCCCC
RVAILATGDEVVEPGSPRPAGAVRDSNRYALMAAVREAGGIPISLGIARDDRDVQRQAIL
CEEEEECCHHHCCCCCCCCCCCEECCCCEEEEEEHHHHCCCEEEEEECCCCHHHHHHHHH
HGLDQADVLITSGGVSMGTRDLIKPLLAELGTVHFGRIAFKPGKPTTFATIGGKLVFGLP
HCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCEEECEEEECCCCCCEEEEECCEEEEECC
GYPVSSLVSFEVFVRPALRALQGDASPFRPQIEVTLAEPVRPSPDRPEYQRIIVRYQEGR
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEEEEECCE
FTAVTTGSQSSSRLLSLRGANGLLLVPAGDTVYPAGSTLPALLTGPLIV
EEEEECCCCCCCEEEEEECCCCEEEEECCCEECCCCCCCHHHHCCCCCC
>Mature Secondary Structure 
AEMLRESPYPMVSIAEATATIMAQARPLASEEIEAFSALGRVLAGDITSPEDIPDVPKS
CHHHHCCCCCEEEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHH
AMDGYALRAADGLTPRRVVGELTAGGAAAVMLAPGEATRIMTGAPLPPGADAMIPVELTT
HHCCEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCCCCEEEEEEEC
ERDGMLYIQRELQPGDYVHVVGQDVRRGQTVLTAGTTIGAAEIGILATLGITRIPVYRQP
CCCCEEEEEEECCCCCEEEEECCHHHCCCEEEEECCCCCHHHHHHHHHCCHHCCCCCCCC
RVAILATGDEVVEPGSPRPAGAVRDSNRYALMAAVREAGGIPISLGIARDDRDVQRQAIL
CEEEEECCHHHCCCCCCCCCCCEECCCCEEEEEEHHHHCCCEEEEEECCCCHHHHHHHHH
HGLDQADVLITSGGVSMGTRDLIKPLLAELGTVHFGRIAFKPGKPTTFATIGGKLVFGLP
HCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCEEECEEEECCCCCCEEEEECCEEEEECC
GYPVSSLVSFEVFVRPALRALQGDASPFRPQIEVTLAEPVRPSPDRPEYQRIIVRYQEGR
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEEEEECCE
FTAVTTGSQSSSRLLSLRGANGLLLVPAGDTVYPAGSTLPALLTGPLIV
EEEEECCCCCCCEEEEEECCCCEEEEECCCEECCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]