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The map label for this gene is hrcA [H]

Identifier: 222525490

GI number: 222525490

Start: 2829971

End: 2831089

Strand: Reverse

Name: hrcA [H]

Synonym: Chy400_2238

Alternate gene names: 222525490

Gene position: 2831089-2829971 (Counterclockwise)

Preceding gene: 222525491

Following gene: 222525489

Centisome position: 53.73

GC content: 58.36

Gene sequence:

>1119_bases
ATGAGCGGACCTCTGACCGAACGCCGGCAGATGATACTCAAGCTGGTCATTCAAGAGTTTGTTGATACGGCAACGCCAGT
TGCCTCCGAGACGCTGGTGCGTAAATATCGCCTTCCCGTCTCCTCGGCGACTGTGCGTAATGATATGGCTGCGCTCGAAG
AGTTGGGCTTTCTCACCCATCCGCATACGTCGGGCGGGCGGATTCCGACCGATGCCGGCTATCGCTTTTTTGTCGAGAAT
TTAATGGAGCGCACCACTCTCTCCCCCGCCGAGCAGCGCATGATCCGCCACCAGTTTTATCAGGTGCGTGGGGAACTCGA
TCAGTGGGTGCAACTGGCCTGTGCAGTGCTGGCCCGCACGGCGCACAATGCCTCGGTGGCTACTGCGCCCCGCGCCGAGC
AGCTCCGCTTTAAGAGCCTGGAGCTGATCGCCATCCACGAGACGATGGCGCTGGCGGTGATTGTCTTTCACGGCGGGATT
GTGAAGCAACAGACGCTGCCTATCGAGCCGGGACGGACTCCCGAAGACCTGCGTCGCGCTGCCGGGCTGGTGAGTGATTT
GCTGGCCGATGCTACGCTCAGCCGGGCCGAAGAGCTGGCCGCTATCGCAACCTTTAATGGGGTGCCACTGAGCGAGTTTG
AACGCACGCTTGTCGATCTGGTAGTGCGGGCAATGAGTGTGTTTGAAGAGCAGGCGCAGGAACAGATTTATTCCGATGGC
ATCCTGGAAATGCTGAGCCAGCCGGAATTTTTGCCTGCCAGTGGCCGTGATGATGCCGAGCGAGCCATTGAACGCCTGCG
CCGCACGCTGGAGATTTTGAAGAGTGGTCGTGGCCTGAGTCCACTGATCCCCCAGGCCCTCGCCTCTGGTGGCGTTCAGG
TGATTATCGGTGGCGAACACAGCGAAGATACCATGCGTGATTATAGTGTTATTCTGGCCCGCTACGGCGTGGAAGGCGCA
TTGGTAGGTGTGCTCGGTGTGATTGGGCCGACCCGGATGGCTTACCCACGCTCAATCTCAACCGTGCGTTATATTGCGTC
GCTGATGACTAATCTGCTGGCCGATCTGTACCACGTTAATACCCGTCCTTCTGATATAGAACCTGCCGCTGAACTATAG

Upstream 100 bases:

>100_bases
TAACGGCGTGCATCAGATGCACGCCAACCTTTTACGTTAGAAGACTTAGCACTCTCACCTCACGAGTGCTAACCAGCGAC
CAGCGAGGCAGGATACAGCG

Downstream 100 bases:

>100_bases
GCGGTGTATAGTAGATAATGAGAGGAACCTATGCCAGACACTGAGGAAGTGAAACCTGAGACAACCACCGAAGCTGCTGC
ACCTCAGTCAGCAGACAAGG

Product: heat-inducible transcription repressor HrcA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MSGPLTERRQMILKLVIQEFVDTATPVASETLVRKYRLPVSSATVRNDMAALEELGFLTHPHTSGGRIPTDAGYRFFVEN
LMERTTLSPAEQRMIRHQFYQVRGELDQWVQLACAVLARTAHNASVATAPRAEQLRFKSLELIAIHETMALAVIVFHGGI
VKQQTLPIEPGRTPEDLRRAAGLVSDLLADATLSRAEELAAIATFNGVPLSEFERTLVDLVVRAMSVFEEQAQEQIYSDG
ILEMLSQPEFLPASGRDDAERAIERLRRTLEILKSGRGLSPLIPQALASGGVQVIIGGEHSEDTMRDYSVILARYGVEGA
LVGVLGVIGPTRMAYPRSISTVRYIASLMTNLLADLYHVNTRPSDIEPAAEL

Sequences:

>Translated_372_residues
MSGPLTERRQMILKLVIQEFVDTATPVASETLVRKYRLPVSSATVRNDMAALEELGFLTHPHTSGGRIPTDAGYRFFVEN
LMERTTLSPAEQRMIRHQFYQVRGELDQWVQLACAVLARTAHNASVATAPRAEQLRFKSLELIAIHETMALAVIVFHGGI
VKQQTLPIEPGRTPEDLRRAAGLVSDLLADATLSRAEELAAIATFNGVPLSEFERTLVDLVVRAMSVFEEQAQEQIYSDG
ILEMLSQPEFLPASGRDDAERAIERLRRTLEILKSGRGLSPLIPQALASGGVQVIIGGEHSEDTMRDYSVILARYGVEGA
LVGVLGVIGPTRMAYPRSISTVRYIASLMTNLLADLYHVNTRPSDIEPAAEL
>Mature_371_residues
SGPLTERRQMILKLVIQEFVDTATPVASETLVRKYRLPVSSATVRNDMAALEELGFLTHPHTSGGRIPTDAGYRFFVENL
MERTTLSPAEQRMIRHQFYQVRGELDQWVQLACAVLARTAHNASVATAPRAEQLRFKSLELIAIHETMALAVIVFHGGIV
KQQTLPIEPGRTPEDLRRAAGLVSDLLADATLSRAEELAAIATFNGVPLSEFERTLVDLVVRAMSVFEEQAQEQIYSDGI
LEMLSQPEFLPASGRDDAERAIERLRRTLEILKSGRGLSPLIPQALASGGVQVIIGGEHSEDTMRDYSVILARYGVEGAL
VGVLGVIGPTRMAYPRSISTVRYIASLMTNLLADLYHVNTRPSDIEPAAEL

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons [H]

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01628 HrcA [H]

EC number: NA

Molecular weight: Translated: 40956; Mature: 40824

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGPLTERRQMILKLVIQEFVDTATPVASETLVRKYRLPVSSATVRNDMAALEELGFLTH
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
PHTSGGRIPTDAGYRFFVENLMERTTLSPAEQRMIRHQFYQVRGELDQWVQLACAVLART
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHNASVATAPRAEQLRFKSLELIAIHETMALAVIVFHGGIVKQQTLPIEPGRTPEDLRRA
HCCCCCCCCCCHHHHHHHHHHHEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
AGLVSDLLADATLSRAEELAAIATFNGVPLSEFERTLVDLVVRAMSVFEEQAQEQIYSDG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILEMLSQPEFLPASGRDDAERAIERLRRTLEILKSGRGLSPLIPQALASGGVQVIIGGEH
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEECCCC
SEDTMRDYSVILARYGVEGALVGVLGVIGPTRMAYPRSISTVRYIASLMTNLLADLYHVN
CHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
TRPSDIEPAAEL
CCCCCCCCCCCC
>Mature Secondary Structure 
SGPLTERRQMILKLVIQEFVDTATPVASETLVRKYRLPVSSATVRNDMAALEELGFLTH
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
PHTSGGRIPTDAGYRFFVENLMERTTLSPAEQRMIRHQFYQVRGELDQWVQLACAVLART
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHNASVATAPRAEQLRFKSLELIAIHETMALAVIVFHGGIVKQQTLPIEPGRTPEDLRRA
HCCCCCCCCCCHHHHHHHHHHHEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
AGLVSDLLADATLSRAEELAAIATFNGVPLSEFERTLVDLVVRAMSVFEEQAQEQIYSDG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILEMLSQPEFLPASGRDDAERAIERLRRTLEILKSGRGLSPLIPQALASGGVQVIIGGEH
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEECCCC
SEDTMRDYSVILARYGVEGALVGVLGVIGPTRMAYPRSISTVRYIASLMTNLLADLYHVN
CHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
TRPSDIEPAAEL
CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA