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The map label for this gene is ywrD [H]

Identifier: 222525457

GI number: 222525457

Start: 2795466

End: 2797076

Strand: Reverse

Name: ywrD [H]

Synonym: Chy400_2205

Alternate gene names: 222525457

Gene position: 2797076-2795466 (Counterclockwise)

Preceding gene: 222525458

Following gene: 222525456

Centisome position: 53.09

GC content: 59.4

Gene sequence:

>1611_bases
ATGGATCTCAACCTGCACCATTTTCCTTATCCCGGACGGCGAGTACCGGTGATTGCCGAGCGCGGAGTGGTTGCCAGCAG
TCACCCCCTGGCATCTCAAGCCGGTATGCACATATTGCAGGCTGGTGGGAATGCGGTTGATGCAGCTATTGCCACTGCCG
CGGCGCTAACCGTGCTGGAACCAACCTCAAATGGGCTGGGGGGTGATGGTTTCGCCCTGATTTGGGCTGGCGATCATCTG
TACGGCATCAATGGTTCGGGAGCAGCACCGGCCAGGTTGAGTCTTGACGCACTGAGCGCTGCCGGGCATACCGATATGCC
AGTTTATGGCTGGTTGCCGGTAACCGTGCCGGGCGTTGTGCGCATGTGGGGAGATATGCACGACCGGTTTGGGCGTTTGC
CGCTCGCGCAGGTCCTGGCCCCAGCCATCAGTTATGCCGCTGAAGGCGCGCCAACACCACCGATGGTCGCTTACTTCTGG
GCACGAGGGGTTGCAGCCGCGCACAACCGTCACGGGCCTGAGTTTGCCGGTTTCTTGCCCACGTTTAGTATTGATGGACG
GGCACCGCGACCGGGTGAGCGTTTCGTCAGCCCTGGTCACGCCCGTACCCTGCGCCTGATCGCCCGTCATGGCGCTGATG
TCTTCTATCAGGGTGAAATTGCCGAAGCGATTGACCGCTTTGCGCGCGCTACCGGCGGTCTGTTACGGGCAGATGATCTG
GCCCGCCACCGTTCGGAATGGGTAACACCAATCAGTATGCAGTACCGTGGCTATACCGTCCACGAGATTCCGCCGAACGG
TCAGGGGATTGCGGCGCTGATGGCACTTGGGATTCTCGATCACATCGAGCTTAACGGCTATGCCCGCGAATCGGCAGCAT
CGTTCCACCGCCAAATCGAAGCGATGAAACTGGCCTTTGCCGATGCCTTCGCCTATGTTGCCGACCCGGCCAGTGTAGCT
GTGCCCATCAATGAGATGTTGAATCGGCAGCGGCTGGCCGAACGTGCGCGCCTGATCGGTGAACAGGCCCAAACCTATGG
CCCGTCCGCCCTGCCACGCGGTGGTACAGTCTACTTCGCTGCGGTTGACCGTGACGGGATGATGGTGAGTATGATCCAAT
CAACGTATATGGGATTTGGTTCAGGGGTGGTGATCCCTGATTACGGTATCGCCCTGCACAACCGTGGTTGTGGCTTCGTA
TTAACACCCGGCCATCCGAATCAGGTCGCTCCCGGTAAACGACCATTTCACACGATTATTCCCGGTTTCCTGAGCAAAGA
TGGCGTTCCCATCGGCCCCTTCGGTGTAATGGGAGCACATATGCAACCACAAGGGCATGTGCAGGTTATCGTTAACACCC
TTGATTACGGAATGCACCCCCAGGCCGCACTGGATGCACCGCGCTGGCGCTGGGAGCGCGATGGCACGCTGCGGCTTGAG
CTGGAAACACCACGCCACGTCATTGAAGGGCTGGCCGCTCGCGGCCACCAGGTGGTGGTCGAAAGTGAATTGGGCGGCTT
TGGCCGGGGACAGATTATCTGGCGTCTGGCCAGTGGCAGCTATGTAGCAGGTACTGAACCTCGTTGTGATGGGCTGGCAA
TTGGATGGTGA

Upstream 100 bases:

>100_bases
CTTTGGATGAAATAAGTTCTTCTGTCAAGCCGGAACACAGTTCATTGTATAATCAAATATCTTTTCACAATCTGTCTGTC
GAGCGCGAAGGAGCCTTGCC

Downstream 100 bases:

>100_bases
TCATTACCGACGGCATACGAAACAATAAACGATGGGGGATGAAGACGATGTACCGTACCGTGTATGATCTCCTGACAACT
GGAAGCGATACCGATCCTGC

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MDLNLHHFPYPGRRVPVIAERGVVASSHPLASQAGMHILQAGGNAVDAAIATAAALTVLEPTSNGLGGDGFALIWAGDHL
YGINGSGAAPARLSLDALSAAGHTDMPVYGWLPVTVPGVVRMWGDMHDRFGRLPLAQVLAPAISYAAEGAPTPPMVAYFW
ARGVAAAHNRHGPEFAGFLPTFSIDGRAPRPGERFVSPGHARTLRLIARHGADVFYQGEIAEAIDRFARATGGLLRADDL
ARHRSEWVTPISMQYRGYTVHEIPPNGQGIAALMALGILDHIELNGYARESAASFHRQIEAMKLAFADAFAYVADPASVA
VPINEMLNRQRLAERARLIGEQAQTYGPSALPRGGTVYFAAVDRDGMMVSMIQSTYMGFGSGVVIPDYGIALHNRGCGFV
LTPGHPNQVAPGKRPFHTIIPGFLSKDGVPIGPFGVMGAHMQPQGHVQVIVNTLDYGMHPQAALDAPRWRWERDGTLRLE
LETPRHVIEGLAARGHQVVVESELGGFGRGQIIWRLASGSYVAGTEPRCDGLAIGW

Sequences:

>Translated_536_residues
MDLNLHHFPYPGRRVPVIAERGVVASSHPLASQAGMHILQAGGNAVDAAIATAAALTVLEPTSNGLGGDGFALIWAGDHL
YGINGSGAAPARLSLDALSAAGHTDMPVYGWLPVTVPGVVRMWGDMHDRFGRLPLAQVLAPAISYAAEGAPTPPMVAYFW
ARGVAAAHNRHGPEFAGFLPTFSIDGRAPRPGERFVSPGHARTLRLIARHGADVFYQGEIAEAIDRFARATGGLLRADDL
ARHRSEWVTPISMQYRGYTVHEIPPNGQGIAALMALGILDHIELNGYARESAASFHRQIEAMKLAFADAFAYVADPASVA
VPINEMLNRQRLAERARLIGEQAQTYGPSALPRGGTVYFAAVDRDGMMVSMIQSTYMGFGSGVVIPDYGIALHNRGCGFV
LTPGHPNQVAPGKRPFHTIIPGFLSKDGVPIGPFGVMGAHMQPQGHVQVIVNTLDYGMHPQAALDAPRWRWERDGTLRLE
LETPRHVIEGLAARGHQVVVESELGGFGRGQIIWRLASGSYVAGTEPRCDGLAIGW
>Mature_536_residues
MDLNLHHFPYPGRRVPVIAERGVVASSHPLASQAGMHILQAGGNAVDAAIATAAALTVLEPTSNGLGGDGFALIWAGDHL
YGINGSGAAPARLSLDALSAAGHTDMPVYGWLPVTVPGVVRMWGDMHDRFGRLPLAQVLAPAISYAAEGAPTPPMVAYFW
ARGVAAAHNRHGPEFAGFLPTFSIDGRAPRPGERFVSPGHARTLRLIARHGADVFYQGEIAEAIDRFARATGGLLRADDL
ARHRSEWVTPISMQYRGYTVHEIPPNGQGIAALMALGILDHIELNGYARESAASFHRQIEAMKLAFADAFAYVADPASVA
VPINEMLNRQRLAERARLIGEQAQTYGPSALPRGGTVYFAAVDRDGMMVSMIQSTYMGFGSGVVIPDYGIALHNRGCGFV
LTPGHPNQVAPGKRPFHTIIPGFLSKDGVPIGPFGVMGAHMQPQGHVQVIVNTLDYGMHPQAALDAPRWRWERDGTLRLE
LETPRHVIEGLAARGHQVVVESELGGFGRGQIIWRLASGSYVAGTEPRCDGLAIGW

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=548, Percent_Identity=27.5547445255474, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI73915090, Length=548, Percent_Identity=27.5547445255474, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI73915096, Length=548, Percent_Identity=27.5547445255474, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI73915094, Length=548, Percent_Identity=27.5547445255474, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI113429326, Length=556, Percent_Identity=26.0791366906475, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI113429324, Length=551, Percent_Identity=26.3157894736842, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI109148539, Length=509, Percent_Identity=28.6836935166994, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI153266885, Length=510, Percent_Identity=26.2745098039216, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI153266901, Length=511, Percent_Identity=26.4187866927593, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI153266907, Length=508, Percent_Identity=25.9842519685039, Blast_Score=103, Evalue=6e-22,
Organism=Escherichia coli, GI1789856, Length=550, Percent_Identity=32, Blast_Score=228, Evalue=8e-61,
Organism=Caenorhabditis elegans, GI72000294, Length=446, Percent_Identity=25.7847533632287, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI212646519, Length=446, Percent_Identity=25.7847533632287, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17506189, Length=542, Percent_Identity=26.5682656826568, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17542894, Length=447, Percent_Identity=26.6219239373602, Blast_Score=105, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI193208247, Length=564, Percent_Identity=24.290780141844, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI193208245, Length=564, Percent_Identity=24.290780141844, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24642670, Length=522, Percent_Identity=25.6704980842912, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24642666, Length=522, Percent_Identity=25.6704980842912, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI45551474, Length=522, Percent_Identity=25.6704980842912, Blast_Score=121, Evalue=2e-27,
Organism=Drosophila melanogaster, GI161077880, Length=522, Percent_Identity=25.6704980842912, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI161077878, Length=522, Percent_Identity=25.6704980842912, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI18859893, Length=437, Percent_Identity=26.3157894736842, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI161077496, Length=548, Percent_Identity=22.8102189781022, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 57374; Mature: 57374

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLNLHHFPYPGRRVPVIAERGVVASSHPLASQAGMHILQAGGNAVDAAIATAAALTVLE
CCCCCCCCCCCCCCCCEEECCCEEECCCCCHHHHCHHEECCCCCHHHHHHHHHHHEEEEC
PTSNGLGGDGFALIWAGDHLYGINGSGAAPARLSLDALSAAGHTDMPVYGWLPVTVPGVV
CCCCCCCCCCEEEEEECCEEEECCCCCCCCCEEEHHHHHCCCCCCCCEEEEECCCHHHHH
RMWGDMHDRFGRLPLAQVLAPAISYAAEGAPTPPMVAYFWARGVAAAHNRHGPEFAGFLP
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHCCCC
TFSIDGRAPRPGERFVSPGHARTLRLIARHGADVFYQGEIAEAIDRFARATGGLLRADDL
EEECCCCCCCCCHHCCCCCHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHCCCEEHHHH
ARHRSEWVTPISMQYRGYTVHEIPPNGQGIAALMALGILDHIELNGYARESAASFHRQIE
HHHHHHCCCCEEEEECCEEEEECCCCCCHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHH
AMKLAFADAFAYVADPASVAVPINEMLNRQRLAERARLIGEQAQTYGPSALPRGGTVYFA
HHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEE
AVDRDGMMVSMIQSTYMGFGSGVVIPDYGIALHNRGCGFVLTPGHPNQVAPGKRPFHTII
EECCCCEEHHHHHHHHHCCCCCEEECCCCEEEECCCCCEEECCCCCCCCCCCCCCHHHHC
PGFLSKDGVPIGPFGVMGAHMQPQGHVQVIVNTLDYGMHPQAALDAPRWRWERDGTLRLE
CHHHCCCCCCCCCHHHCCCCCCCCCCEEEEEEECCCCCCCHHHCCCCCCEECCCCEEEEE
LETPRHVIEGLAARGHQVVVESELGGFGRGQIIWRLASGSYVAGTEPRCDGLAIGW
ECCHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCEEECCCCCCCCEECCC
>Mature Secondary Structure
MDLNLHHFPYPGRRVPVIAERGVVASSHPLASQAGMHILQAGGNAVDAAIATAAALTVLE
CCCCCCCCCCCCCCCCEEECCCEEECCCCCHHHHCHHEECCCCCHHHHHHHHHHHEEEEC
PTSNGLGGDGFALIWAGDHLYGINGSGAAPARLSLDALSAAGHTDMPVYGWLPVTVPGVV
CCCCCCCCCCEEEEEECCEEEECCCCCCCCCEEEHHHHHCCCCCCCCEEEEECCCHHHHH
RMWGDMHDRFGRLPLAQVLAPAISYAAEGAPTPPMVAYFWARGVAAAHNRHGPEFAGFLP
HHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHCCCC
TFSIDGRAPRPGERFVSPGHARTLRLIARHGADVFYQGEIAEAIDRFARATGGLLRADDL
EEECCCCCCCCCHHCCCCCHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHCCCEEHHHH
ARHRSEWVTPISMQYRGYTVHEIPPNGQGIAALMALGILDHIELNGYARESAASFHRQIE
HHHHHHCCCCEEEEECCEEEEECCCCCCHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHH
AMKLAFADAFAYVADPASVAVPINEMLNRQRLAERARLIGEQAQTYGPSALPRGGTVYFA
HHHHHHHHHHHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEE
AVDRDGMMVSMIQSTYMGFGSGVVIPDYGIALHNRGCGFVLTPGHPNQVAPGKRPFHTII
EECCCCEEHHHHHHHHHCCCCCEEECCCCEEEECCCCCEEECCCCCCCCCCCCCCHHHHC
PGFLSKDGVPIGPFGVMGAHMQPQGHVQVIVNTLDYGMHPQAALDAPRWRWERDGTLRLE
CHHHCCCCCCCCCHHHCCCCCCCCCCEEEEEEECCCCCCCHHHCCCCCCEECCCCEEEEE
LETPRHVIEGLAARGHQVVVESELGGFGRGQIIWRLASGSYVAGTEPRCDGLAIGW
ECCHHHHHHHHHCCCCEEEEECCCCCCCCCEEEEEEECCCEEECCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]