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The map label for this gene is thrC [H]

Identifier: 222525356

GI number: 222525356

Start: 2671057

End: 2672385

Strand: Direct

Name: thrC [H]

Synonym: Chy400_2101

Alternate gene names: 222525356

Gene position: 2671057-2672385 (Clockwise)

Preceding gene: 222525355

Following gene: 222525357

Centisome position: 50.69

GC content: 56.28

Gene sequence:

>1329_bases
ATGTATCACGCATGGTTTGCTGCCCAGGATGACCCAAACGAACGTTATCCTCTGACCGAGGTCGTGTACTACAGCCGGTC
GGGAGGCTTACTCGAAGTACAGCATGATATGGCAGCGTTGGCCCAACGCAGCCCGGAAGAATGGAAGCGCCTGTTTGATG
AGCGCTGGATGCGGACAGCCTGGCCCTATGGTAGTGGGGTGTGGGGGAAGAAAGAGTGGGTCTGCCCGATTGTATCTGAC
GACAACGTGGTCAGTATGTTTGAGGGTGGAACCAACCTGTTTTGGGCCGAGCGTTTCGGGCGTGAAATCGGGCTGGAAGA
CCTCTGGATCAAGATGTGTGGCAATTCTCACACCGGTTCGTTCAAAGATCTCGGTATGACAGTGCTGGTTAGTGTGGTCA
AGCAGATGATCAGCGAGGGCAAGCCGATCCGGGCAATCGCCTGCGCCTCAACCGGCGATACGTCTGCGGCACTGGCGGCC
TACGGAGCAGCAGCCGGCATTCCTACCATTGTCTTCCTGCCGAAAGGGAAGGTAAGTATCGCTCAACTGGTACAACCGGT
GGCCCACGGTGCGCTGGTACTGGCGCTTGATACCGATTTTGATGGCTGTATGCGGATCGTGCGCGAGATTACTGCCAATC
CCGACAACGGTATCTACCTTGCCAATTCGCTCAATTCACTGCGGGTCGAAGGGCAGAAGACGGTTGGGATCGAGATTGTA
CAGCAATTTGACTGGGAAGTGCCAGACTGGATCATCATTCCGGGTGGCAATCTAGGCAACACCTTTGCTCTGGGCAAGGG
TTTGTTGATGATGCACGAACTGGGCCTGATTGATCGACTGCCACGGATCGTCACGGCGCAGGCCGCCAATGCCAACCCAC
TCTACCGCTCGTACCTAACCGGTTTTCGCGAGTATGAGCCGATTAAGGCTCAGCCTACTGCCGCCAGTGCAATTCAGATT
GGCGATCCGGTAAGCATCAATCGCGCAATCAGCATTCTCAAACGCTTCAACGGCATCGTCGAACAGGCGACCGAACAGGA
GCTGGCCGATGCTGCGGCTCGCGCTGATCGAACTGGCGCTTACGCCTGTCCACATACTGGGGTCGCGCTGGCAGCCCTGA
TCAAACTGGTGGAACGGGGTGAGATCAAGCGAAGTGATCGGGTTGTTGTCATCTCAACTGCTCACGGCCTCAAGTTCAGC
CGCTTCAAAGTAGAGTATCATGAAGGTACGCTCCGCGATGTTGTCGGGCAGTACACCAATCCCCCAATAGAATTACCGCC
TGACGTGGACGCGGTGCGCCGGGCAATTGCCCAGCGGTTTGGAGATTGA

Upstream 100 bases:

>100_bases
GTACGTGCGGCTGGCCCCACCCGGATTTTGGCGCACCGAGGCTGAACGGATTCTGGCCCAAATTCAGGCTGAACTGGAAT
AGGTTGCAGGAGCGAATGAT

Downstream 100 bases:

>100_bases
GGCTCGAACTAAAGAATGTCGGACAATCACCGACGATGAGAGCAACAGCAGTGTGATACAGGTGCAACTGTCATCTGCCT
TGCTCTTCATCGGTGCGGTG

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MYHAWFAAQDDPNERYPLTEVVYYSRSGGLLEVQHDMAALAQRSPEEWKRLFDERWMRTAWPYGSGVWGKKEWVCPIVSD
DNVVSMFEGGTNLFWAERFGREIGLEDLWIKMCGNSHTGSFKDLGMTVLVSVVKQMISEGKPIRAIACASTGDTSAALAA
YGAAAGIPTIVFLPKGKVSIAQLVQPVAHGALVLALDTDFDGCMRIVREITANPDNGIYLANSLNSLRVEGQKTVGIEIV
QQFDWEVPDWIIIPGGNLGNTFALGKGLLMMHELGLIDRLPRIVTAQAANANPLYRSYLTGFREYEPIKAQPTAASAIQI
GDPVSINRAISILKRFNGIVEQATEQELADAAARADRTGAYACPHTGVALAALIKLVERGEIKRSDRVVVISTAHGLKFS
RFKVEYHEGTLRDVVGQYTNPPIELPPDVDAVRRAIAQRFGD

Sequences:

>Translated_442_residues
MYHAWFAAQDDPNERYPLTEVVYYSRSGGLLEVQHDMAALAQRSPEEWKRLFDERWMRTAWPYGSGVWGKKEWVCPIVSD
DNVVSMFEGGTNLFWAERFGREIGLEDLWIKMCGNSHTGSFKDLGMTVLVSVVKQMISEGKPIRAIACASTGDTSAALAA
YGAAAGIPTIVFLPKGKVSIAQLVQPVAHGALVLALDTDFDGCMRIVREITANPDNGIYLANSLNSLRVEGQKTVGIEIV
QQFDWEVPDWIIIPGGNLGNTFALGKGLLMMHELGLIDRLPRIVTAQAANANPLYRSYLTGFREYEPIKAQPTAASAIQI
GDPVSINRAISILKRFNGIVEQATEQELADAAARADRTGAYACPHTGVALAALIKLVERGEIKRSDRVVVISTAHGLKFS
RFKVEYHEGTLRDVVGQYTNPPIELPPDVDAVRRAIAQRFGD
>Mature_442_residues
MYHAWFAAQDDPNERYPLTEVVYYSRSGGLLEVQHDMAALAQRSPEEWKRLFDERWMRTAWPYGSGVWGKKEWVCPIVSD
DNVVSMFEGGTNLFWAERFGREIGLEDLWIKMCGNSHTGSFKDLGMTVLVSVVKQMISEGKPIRAIACASTGDTSAALAA
YGAAAGIPTIVFLPKGKVSIAQLVQPVAHGALVLALDTDFDGCMRIVREITANPDNGIYLANSLNSLRVEGQKTVGIEIV
QQFDWEVPDWIIIPGGNLGNTFALGKGLLMMHELGLIDRLPRIVTAQAANANPLYRSYLTGFREYEPIKAQPTAASAIQI
GDPVSINRAISILKRFNGIVEQATEQELADAAARADRTGAYACPHTGVALAALIKLVERGEIKRSDRVVVISTAHGLKFS
RFKVEYHEGTLRDVVGQYTNPPIELPPDVDAVRRAIAQRFGD

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786185, Length=343, Percent_Identity=25.9475218658892, Blast_Score=76, Evalue=5e-15,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 48574; Mature: 48574

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYHAWFAAQDDPNERYPLTEVVYYSRSGGLLEVQHDMAALAQRSPEEWKRLFDERWMRTA
CCCEEEECCCCCCCCCCHHHEEEEECCCCEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHC
WPYGSGVWGKKEWVCPIVSDDNVVSMFEGGTNLFWAERFGREIGLEDLWIKMCGNSHTGS
CCCCCCCCCCCCEEEEEECCCCEEEEECCCCCEEHHHHHCHHCCHHHHHHHHCCCCCCCC
FKDLGMTVLVSVVKQMISEGKPIRAIACASTGDTSAALAAYGAAAGIPTIVFLPKGKVSI
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCHH
AQLVQPVAHGALVLALDTDFDGCMRIVREITANPDNGIYLANSLNSLRVEGQKTVGIEIV
HHHHHHHHCCEEEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCCEEECCCCHHHHHHH
QQFDWEVPDWIIIPGGNLGNTFALGKGLLMMHELGLIDRLPRIVTAQAANANPLYRSYLT
HHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCHHHHHHHH
GFREYEPIKAQPTAASAIQIGDPVSINRAISILKRFNGIVEQATEQELADAAARADRTGA
HHHHCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
YACPHTGVALAALIKLVERGEIKRSDRVVVISTAHGLKFSRFKVEYHEGTLRDVVGQYTN
CCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEEEECCCHHHHHHHHCCC
PPIELPPDVDAVRRAIAQRFGD
CCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MYHAWFAAQDDPNERYPLTEVVYYSRSGGLLEVQHDMAALAQRSPEEWKRLFDERWMRTA
CCCEEEECCCCCCCCCCHHHEEEEECCCCEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHC
WPYGSGVWGKKEWVCPIVSDDNVVSMFEGGTNLFWAERFGREIGLEDLWIKMCGNSHTGS
CCCCCCCCCCCCEEEEEECCCCEEEEECCCCCEEHHHHHCHHCCHHHHHHHHCCCCCCCC
FKDLGMTVLVSVVKQMISEGKPIRAIACASTGDTSAALAAYGAAAGIPTIVFLPKGKVSI
HHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCHH
AQLVQPVAHGALVLALDTDFDGCMRIVREITANPDNGIYLANSLNSLRVEGQKTVGIEIV
HHHHHHHHCCEEEEEEECCHHHHHHHHHHHHCCCCCCEEEECCCCCEEECCCCHHHHHHH
QQFDWEVPDWIIIPGGNLGNTFALGKGLLMMHELGLIDRLPRIVTAQAANANPLYRSYLT
HHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCHHHHHHHH
GFREYEPIKAQPTAASAIQIGDPVSINRAISILKRFNGIVEQATEQELADAAARADRTGA
HHHHCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
YACPHTGVALAALIKLVERGEIKRSDRVVVISTAHGLKFSRFKVEYHEGTLRDVVGQYTN
CCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEEEEECCCHHHHHHHHCCC
PPIELPPDVDAVRRAIAQRFGD
CCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]