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The map label for this gene is yugH [H]

Identifier: 222525322

GI number: 222525322

Start: 2622604

End: 2623764

Strand: Direct

Name: yugH [H]

Synonym: Chy400_2064

Alternate gene names: 222525322

Gene position: 2622604-2623764 (Clockwise)

Preceding gene: 222525320

Following gene: 222525323

Centisome position: 49.77

GC content: 57.97

Gene sequence:

>1161_bases
ATGACCAGCCAACGCATTGCTCGCCGCATTCGCGCCGTCCCACCATCAGGCATTCGCCGTTTCTTCGATATTGCCGCCAC
CATGCCCGATGTCATTTCGCTCGGCGTTGGCGAGCCTGATTTTATCACGCCTGACCAGATTCGTGCTGCCGGTCAGGCAT
CGATTGACCGTACCACGGCTTATACCTCAAATTCTGGTCTGCTGGAATTGCGGGTTGCCCTCGCCGAACATCTGGCCCGC
CGCTATGGTGTGCAATACGATCCCGAAACCGAACTGCTGATTACCGTCGGTGTCAGCGAAGCGATGCTGGGGGCGGCTCT
GGCGCTTCTCGATCCTGATGATGAAGTGTTGGTGCCTGAACCCTGCTTTGTGGCGTATCCGGCCTGTGTTACCTTTGCCG
ATGCGCGTGTCGTCTACGTACCGACGAACGTAGCTGATGGCTTTCAAGTCAGTGGCGCAGCCCTGGAAGCGGCAGTAACA
CCACGCACCAAAGCGATTCTGATCGGCTATCCCAACAATCCAACCGGTGCTGTGCTCAGTCGTGAACGGTTGCTGGAAGT
CGCCGCGGTTGCCGAGCGGCACGATCTGATCGTCATCTCCGATGAAATCTACGACCGGTTAGTGTACGGCGTCGAACACA
CCTGCTTTGCCGCCTTGCCGGGTATGCGCGAGCGAACCGTCTTGCTGGGCGGCTTCTCGAAGGCATACGCCATGACCGGT
TGGCGCCTGGGTTGGCTGGCGGCACCGGCTGAGATCACGGCTGCCGTGCGCAAATTCCATCAATATGCGATTATGTCGGC
CCCGACGATGAGCCAATATGCCGGTCTGGAAGCATTACTGCACGGCGAAGAAGCGGTGCAGGCCATGGTACGCGAATATG
ATCGGCGGCGAAAAGTTATCGTCTCCGGCTTAAACAGCATCGGTCTGCCAACCTTTGAGCCACAGGGGGCATTCTACGCC
TTTCCCCAGGTTGGGCATCTTGGGCTAACCAGTGAAGCCTTCTGTGAACAATTGCTACACAGTGAACAGGTTGCCGTGGT
ACCAGGTGACGCCTTTGGGCCGAGCGGTGCCGGCTTTGTCCGTGCCTGTTATGCTACTGCCCTCAACAAGATTGAAGAGG
CCCTCGAACGGATCGAGCGCTTTGTGCGTCGTATTGCCTGA

Upstream 100 bases:

>100_bases
TCATCAAAAGCCGGCGACCAATGAGCAACATAGAACGCATATGGTAAGATTAAACACGCTGAGCAATGGCGCTCAGATAT
GTCACAAAAGGAGAACTGTT

Downstream 100 bases:

>100_bases
GGAGACAGGTTATGTCATTGCACGAGAATGAATCAACAACTGAGCTGCGCTGTGCACTGACCGGACGTCCACTGACACCC
GAAGAGGCGTACTGGGCGCC

Product: class I and II aminotransferase

Products: N-succinyl-2-L-amino-6-oxoheptanedioate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MTSQRIARRIRAVPPSGIRRFFDIAATMPDVISLGVGEPDFITPDQIRAAGQASIDRTTAYTSNSGLLELRVALAEHLAR
RYGVQYDPETELLITVGVSEAMLGAALALLDPDDEVLVPEPCFVAYPACVTFADARVVYVPTNVADGFQVSGAALEAAVT
PRTKAILIGYPNNPTGAVLSRERLLEVAAVAERHDLIVISDEIYDRLVYGVEHTCFAALPGMRERTVLLGGFSKAYAMTG
WRLGWLAAPAEITAAVRKFHQYAIMSAPTMSQYAGLEALLHGEEAVQAMVREYDRRRKVIVSGLNSIGLPTFEPQGAFYA
FPQVGHLGLTSEAFCEQLLHSEQVAVVPGDAFGPSGAGFVRACYATALNKIEEALERIERFVRRIA

Sequences:

>Translated_386_residues
MTSQRIARRIRAVPPSGIRRFFDIAATMPDVISLGVGEPDFITPDQIRAAGQASIDRTTAYTSNSGLLELRVALAEHLAR
RYGVQYDPETELLITVGVSEAMLGAALALLDPDDEVLVPEPCFVAYPACVTFADARVVYVPTNVADGFQVSGAALEAAVT
PRTKAILIGYPNNPTGAVLSRERLLEVAAVAERHDLIVISDEIYDRLVYGVEHTCFAALPGMRERTVLLGGFSKAYAMTG
WRLGWLAAPAEITAAVRKFHQYAIMSAPTMSQYAGLEALLHGEEAVQAMVREYDRRRKVIVSGLNSIGLPTFEPQGAFYA
FPQVGHLGLTSEAFCEQLLHSEQVAVVPGDAFGPSGAGFVRACYATALNKIEEALERIERFVRRIA
>Mature_385_residues
TSQRIARRIRAVPPSGIRRFFDIAATMPDVISLGVGEPDFITPDQIRAAGQASIDRTTAYTSNSGLLELRVALAEHLARR
YGVQYDPETELLITVGVSEAMLGAALALLDPDDEVLVPEPCFVAYPACVTFADARVVYVPTNVADGFQVSGAALEAAVTP
RTKAILIGYPNNPTGAVLSRERLLEVAAVAERHDLIVISDEIYDRLVYGVEHTCFAALPGMRERTVLLGGFSKAYAMTGW
RLGWLAAPAEITAAVRKFHQYAIMSAPTMSQYAGLEALLHGEEAVQAMVREYDRRRKVIVSGLNSIGLPTFEPQGAFYAF
PQVGHLGLTSEAFCEQLLHSEQVAVVPGDAFGPSGAGFVRACYATALNKIEEALERIERFVRRIA

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=344, Percent_Identity=34.0116279069767, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI169881279, Length=344, Percent_Identity=34.0116279069767, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI56713256, Length=409, Percent_Identity=28.1173594132029, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI56713254, Length=409, Percent_Identity=28.1173594132029, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI169881281, Length=341, Percent_Identity=28.7390029325513, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI4507369, Length=399, Percent_Identity=24.3107769423559, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1788722, Length=394, Percent_Identity=29.9492385786802, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1786816, Length=359, Percent_Identity=29.2479108635098, Blast_Score=158, Evalue=6e-40,
Organism=Escherichia coli, GI1788627, Length=377, Percent_Identity=29.7082228116711, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI1787710, Length=258, Percent_Identity=26.3565891472868, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787909, Length=250, Percent_Identity=27.2, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790797, Length=309, Percent_Identity=24.9190938511327, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71994472, Length=402, Percent_Identity=29.6019900497512, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI71994476, Length=402, Percent_Identity=29.6019900497512, Blast_Score=164, Evalue=9e-41,
Organism=Caenorhabditis elegans, GI17567369, Length=398, Percent_Identity=29.3969849246231, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17567663, Length=398, Percent_Identity=26.8844221105528, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71981209, Length=340, Percent_Identity=23.8235294117647, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=309, Percent_Identity=28.8025889967638, Blast_Score=139, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6323118, Length=339, Percent_Identity=24.188790560472, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6320317, Length=350, Percent_Identity=24.8571428571429, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28573069, Length=418, Percent_Identity=26.0765550239234, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24646114, Length=418, Percent_Identity=26.0765550239234, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI28573067, Length=418, Percent_Identity=26.0765550239234, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI28573065, Length=418, Percent_Identity=26.0765550239234, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI18859735, Length=389, Percent_Identity=26.7352185089974, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24641770, Length=371, Percent_Identity=24.7978436657682, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24641760, Length=371, Percent_Identity=24.7978436657682, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24641768, Length=371, Percent_Identity=24.7978436657682, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24641766, Length=371, Percent_Identity=24.7978436657682, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24641764, Length=371, Percent_Identity=24.7978436657682, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45551451, Length=370, Percent_Identity=24.5945945945946, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.17

Molecular weight: Translated: 41871; Mature: 41740

Theoretical pI: Translated: 5.28; Mature: 5.28

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQRIARRIRAVPPSGIRRFFDIAATMPDVISLGVGEPDFITPDQIRAAGQASIDRTTA
CCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCEE
YTSNSGLLELRVALAEHLARRYGVQYDPETELLITVGVSEAMLGAALALLDPDDEVLVPE
EECCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHEEECCCCCEECCC
PCFVAYPACVTFADARVVYVPTNVADGFQVSGAALEAAVTPRTKAILIGYPNNPTGAVLS
CHHHHHHHHHEEECCEEEEEECCCCCCCEECCHHEEEEECCCCCEEEEECCCCCCCHHHH
RERLLEVAAVAERHDLIVISDEIYDRLVYGVEHTCFAALPGMRERTVLLGGFSKAYAMTG
HHHHHHHHHHHHHCCEEEECHHHHHHHHHCCCHHHHHHCCCCCCCEEEEECCHHHHHHCC
WRLGWLAAPAEITAAVRKFHQYAIMSAPTMSQYAGLEALLHGEEAVQAMVREYDRRRKVI
CEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VSGLNSIGLPTFEPQGAFYAFPQVGHLGLTSEAFCEQLLHSEQVAVVPGDAFGPSGAGFV
HHHHHHCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCHHH
RACYATALNKIEEALERIERFVRRIA
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSQRIARRIRAVPPSGIRRFFDIAATMPDVISLGVGEPDFITPDQIRAAGQASIDRTTA
CHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCEE
YTSNSGLLELRVALAEHLARRYGVQYDPETELLITVGVSEAMLGAALALLDPDDEVLVPE
EECCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCHHHHHHHHHEEECCCCCEECCC
PCFVAYPACVTFADARVVYVPTNVADGFQVSGAALEAAVTPRTKAILIGYPNNPTGAVLS
CHHHHHHHHHEEECCEEEEEECCCCCCCEECCHHEEEEECCCCCEEEEECCCCCCCHHHH
RERLLEVAAVAERHDLIVISDEIYDRLVYGVEHTCFAALPGMRERTVLLGGFSKAYAMTG
HHHHHHHHHHHHHCCEEEECHHHHHHHHHCCCHHHHHHCCCCCCCEEEEECCHHHHHHCC
WRLGWLAAPAEITAAVRKFHQYAIMSAPTMSQYAGLEALLHGEEAVQAMVREYDRRRKVI
CEEEEEECCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VSGLNSIGLPTFEPQGAFYAFPQVGHLGLTSEAFCEQLLHSEQVAVVPGDAFGPSGAGFV
HHHHHHCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCHHH
RACYATALNKIEEALERIERFVRRIA
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-succinyl-L-2,6-diaminoheptanedioate; 2-oxoglutarate

Specific reaction: N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-2-L-amino-6-oxoheptanedioate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377 [H]